Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coronin-2B

Gene

Coro2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the reorganization of neuronal actin structure.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2B
Gene namesi
Name:Coro2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444283. Coro2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Coronin-2BPRO_0000050931Add
BLAST

Proteomic databases

EPDiQ8BH44.
MaxQBiQ8BH44.
PaxDbiQ8BH44.
PRIDEiQ8BH44.

PTM databases

iPTMnetiQ8BH44.
PhosphoSiteiQ8BH44.
SwissPalmiQ8BH44.

Expressioni

Gene expression databases

BgeeiQ8BH44.
CleanExiMM_CORO2B.
ExpressionAtlasiQ8BH44. baseline and differential.
GenevisibleiQ8BH44. MM.

Interactioni

Subunit structurei

Binds to F-actin and to vinculin.By similarity

Protein-protein interaction databases

IntActiQ8BH44. 1 interaction.
MINTiMINT-4091623.
STRINGi10090.ENSMUSP00000041826.

Structurei

3D structure databases

ProteinModelPortaliQ8BH44.
SMRiQ8BH44. Positions 15-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 12541WD 1Add
BLAST
Repeati135 – 17743WD 2Add
BLAST
Repeati179 – 21739WD 3Add
BLAST
Repeati220 – 26344WD 4Add
BLAST
Repeati265 – 30844WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 47944Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ8BH44.
KOiK13887.
OMAiCTIKLWH.
OrthoDBiEOG7J70FB.
PhylomeDBiQ8BH44.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF17. PTHR10856:SF17. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTKMSWRP QYRSSKFRNV YGKAANREHC FDGIPITKNV HDNHFCAVNA
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPDG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDIG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PMIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKVVFK APIREKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRLRQLQLEL KNLRNNPKNC
Length:480
Mass (Da):54,936
Last modified:July 28, 2009 - v2
Checksum:iDD3D9E9C12EF41FE
GO

Sequence cautioni

The sequence AAH62649.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC33080.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC39865.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031K → N in AAH62649 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047527 mRNA. Translation: BAC33080.1. Different initiation.
AK087414 mRNA. Translation: BAC39865.1. Different initiation.
BC062649 mRNA. Translation: AAH62649.1. Different initiation.
CCDSiCCDS23264.2.
RefSeqiNP_780693.2. NM_175484.3.
XP_006511157.2. XM_006511094.2.
XP_006511160.1. XM_006511097.2.
XP_006511161.1. XM_006511098.2.
XP_006511162.1. XM_006511099.2.
XP_006511163.1. XM_006511100.1.
UniGeneiMm.335229.

Genome annotation databases

EnsembliENSMUST00000048043; ENSMUSP00000041826; ENSMUSG00000041729.
GeneIDi235431.
KEGGimmu:235431.
UCSCiuc009qaj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047527 mRNA. Translation: BAC33080.1. Different initiation.
AK087414 mRNA. Translation: BAC39865.1. Different initiation.
BC062649 mRNA. Translation: AAH62649.1. Different initiation.
CCDSiCCDS23264.2.
RefSeqiNP_780693.2. NM_175484.3.
XP_006511157.2. XM_006511094.2.
XP_006511160.1. XM_006511097.2.
XP_006511161.1. XM_006511098.2.
XP_006511162.1. XM_006511099.2.
XP_006511163.1. XM_006511100.1.
UniGeneiMm.335229.

3D structure databases

ProteinModelPortaliQ8BH44.
SMRiQ8BH44. Positions 15-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH44. 1 interaction.
MINTiMINT-4091623.
STRINGi10090.ENSMUSP00000041826.

PTM databases

iPTMnetiQ8BH44.
PhosphoSiteiQ8BH44.
SwissPalmiQ8BH44.

Proteomic databases

EPDiQ8BH44.
MaxQBiQ8BH44.
PaxDbiQ8BH44.
PRIDEiQ8BH44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048043; ENSMUSP00000041826; ENSMUSG00000041729.
GeneIDi235431.
KEGGimmu:235431.
UCSCiuc009qaj.1. mouse.

Organism-specific databases

CTDi10391.
MGIiMGI:2444283. Coro2b.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ8BH44.
KOiK13887.
OMAiCTIKLWH.
OrthoDBiEOG7J70FB.
PhylomeDBiQ8BH44.
TreeFamiTF314280.

Miscellaneous databases

PROiQ8BH44.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BH44.
CleanExiMM_CORO2B.
ExpressionAtlasiQ8BH44. baseline and differential.
GenevisibleiQ8BH44. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF17. PTHR10856:SF17. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCOR2B_MOUSE
AccessioniPrimary (citable) accession number: Q8BH44
Secondary accession number(s): Q6P5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 28, 2009
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.