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Q8BH43

- WASF2_MOUSE

UniProt

Q8BH43 - WASF2_MOUSE

Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

Wasf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. actin filament-based movement Source: MGI
    3. ameboidal cell migration Source: MGI
    4. angiogenesis Source: MGI
    5. cellular component movement Source: MGI
    6. endocytosis Source: MGI
    7. lamellipodium assembly Source: MGI
    8. lamellipodium morphogenesis Source: MGI
    9. megakaryocyte development Source: MGI
    10. Rac protein signal transduction Source: MGI

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_198374. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Wiskott-Aldrich syndrome protein family member 2
    Short name:
    WASP family protein member 2
    Alternative name(s):
    Protein WAVE-2
    Gene namesi
    Name:Wasf2
    Synonyms:Wave2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1098641. Wasf2.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cytoskeleton Source: UniProtKB-SubCell
    3. early endosome Source: MGI
    4. intracellular Source: MGI
    5. lamellipodium Source: MGI
    6. ruffle Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Wiskott-Aldrich syndrome protein family member 2PRO_0000188995Add
    BLAST

    Proteomic databases

    MaxQBiQ8BH43.
    PaxDbiQ8BH43.
    PRIDEiQ8BH43.

    PTM databases

    PhosphoSiteiQ8BH43.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BH43.
    BgeeiQ8BH43.
    CleanExiMM_WASF2.
    GenevestigatoriQ8BH43.

    Interactioni

    Subunit structurei

    Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gcc2Q8CHG36EBI-643162,EBI-643470
    SlmapQ3URD3-43EBI-643162,EBI-3294998
    Smc2Q8CG484EBI-643162,EBI-643436

    Protein-protein interaction databases

    BioGridi232443. 2 interactions.
    DIPiDIP-29535N.
    IntActiQ8BH43. 17 interactions.
    MINTiMINT-3390198.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH43.
    SMRiQ8BH43. Positions 23-197, 434-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini435 – 45218WH2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi247 – 2504Poly-Pro
    Compositional biasi268 – 2714Poly-Pro
    Compositional biasi318 – 32710Poly-Pro
    Compositional biasi345 – 3517Poly-Pro
    Compositional biasi362 – 3698Poly-Pro
    Compositional biasi374 – 3796Poly-Pro
    Compositional biasi388 – 40316Poly-ProAdd
    BLAST
    Compositional biasi414 – 4196Poly-Pro

    Domaini

    Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain By similarity.By similarity

    Sequence similaritiesi

    Belongs to the SCAR/WAVE family.Curated
    Contains 1 WH2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG299696.
    GeneTreeiENSGT00730000110593.
    HOGENOMiHOG000214057.
    HOVERGENiHBG058482.
    InParanoidiQ8BH43.
    KOiK05748.
    OMAiDTSELEC.
    OrthoDBiEOG7VHSXK.
    PhylomeDBiQ8BH43.
    TreeFamiTF315031.

    Family and domain databases

    InterProiIPR028288. SCAR/WAVE_fam.
    IPR003124. WH2_dom.
    [Graphical view]
    PANTHERiPTHR12902. PTHR12902. 1 hit.
    PfamiPF02205. WH2. 1 hit.
    [Graphical view]
    SMARTiSM00246. WH2. 1 hit.
    [Graphical view]
    PROSITEiPS51082. WH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BH43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLVTRNIEP RHLCRQTLPS DTSELECRTN ITLANVIRQL GSLSKYAEDI    50
    FGEICTQASA FASRVNSLAE RVDRVQVKVT QLDPKEEEVS LQGINTRKAF 100
    RSSTTQDQKL FDRNSLPVPV LETYNSCDAP PPLNNLSPYR DDGKEALKFY 150
    TNPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK 200
    EEWEKMKMGQ EFVESKERLG PSGYSSTLVY QNGSIGSVEN VDAASYPPPP 250
    QSDSASSPSP SFSEDNLPPP PAEFSYPADN QRGSVLAGPK RTSMVSPSHP 300
    PPAPPLSSPP GPKPGFAPPP APPPPPPMSV PPPLPSMGFG SPGTPPPPSP 350
    PSFPPHPDFA APPPPPPPPA ADYPMPPPPL SQPSGGAPPP PPPPPPPGPP 400
    PLPFSGADGQ PAAPPPPPPS EATKPKSSLP AVSDARSDLL SAIRQGFQLR 450
    RVEEQREQEK RDVVGNDVAT ILSRRIAVEY SDSEDDSSEF DEDDWSD 497
    Length:497
    Mass (Da):54,074
    Last modified:March 1, 2003 - v1
    Checksum:i4F970D0577792503
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135643 mRNA. Translation: AAN10152.1.
    AK085458 mRNA. Translation: BAC39451.1.
    CCDSiCCDS18742.1.
    RefSeqiNP_700472.1. NM_153423.6.
    XP_006538911.1. XM_006538848.1.
    XP_006538912.1. XM_006538849.1.
    XP_006538913.1. XM_006538850.1.
    UniGeneiMm.23566.

    Genome annotation databases

    EnsembliENSMUST00000084241; ENSMUSP00000081263; ENSMUSG00000028868.
    ENSMUST00000105912; ENSMUSP00000101532; ENSMUSG00000028868.
    GeneIDi242687.
    KEGGimmu:242687.
    UCSCiuc008vcf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135643 mRNA. Translation: AAN10152.1 .
    AK085458 mRNA. Translation: BAC39451.1 .
    CCDSi CCDS18742.1.
    RefSeqi NP_700472.1. NM_153423.6.
    XP_006538911.1. XM_006538848.1.
    XP_006538912.1. XM_006538849.1.
    XP_006538913.1. XM_006538850.1.
    UniGenei Mm.23566.

    3D structure databases

    ProteinModelPortali Q8BH43.
    SMRi Q8BH43. Positions 23-197, 434-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232443. 2 interactions.
    DIPi DIP-29535N.
    IntActi Q8BH43. 17 interactions.
    MINTi MINT-3390198.

    PTM databases

    PhosphoSitei Q8BH43.

    Proteomic databases

    MaxQBi Q8BH43.
    PaxDbi Q8BH43.
    PRIDEi Q8BH43.

    Protocols and materials databases

    DNASUi 242687.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084241 ; ENSMUSP00000081263 ; ENSMUSG00000028868 .
    ENSMUST00000105912 ; ENSMUSP00000101532 ; ENSMUSG00000028868 .
    GeneIDi 242687.
    KEGGi mmu:242687.
    UCSCi uc008vcf.1. mouse.

    Organism-specific databases

    CTDi 10163.
    MGIi MGI:1098641. Wasf2.

    Phylogenomic databases

    eggNOGi NOG299696.
    GeneTreei ENSGT00730000110593.
    HOGENOMi HOG000214057.
    HOVERGENi HBG058482.
    InParanoidi Q8BH43.
    KOi K05748.
    OMAi DTSELEC.
    OrthoDBi EOG7VHSXK.
    PhylomeDBi Q8BH43.
    TreeFami TF315031.

    Enzyme and pathway databases

    Reactomei REACT_198374. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    NextBioi 385492.
    PROi Q8BH43.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BH43.
    Bgeei Q8BH43.
    CleanExi MM_WASF2.
    Genevestigatori Q8BH43.

    Family and domain databases

    InterProi IPR028288. SCAR/WAVE_fam.
    IPR003124. WH2_dom.
    [Graphical view ]
    PANTHERi PTHR12902. PTHR12902. 1 hit.
    Pfami PF02205. WH2. 1 hit.
    [Graphical view ]
    SMARTi SM00246. WH2. 1 hit.
    [Graphical view ]
    PROSITEi PS51082. WH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and expression profile of the human and mouse WAVE gene family."
      Sossey-Alaoui K., Head K., Nowak N., Cowell J.K.
      Mamm. Genome 14:314-322(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."
      Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T.E.B.
      EMBO J. 23:749-759(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF WAVE2 COMPLEX.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiWASF2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3