Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8BH43 (WASF2_MOUSE)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Wiskott-Aldrich syndrome protein family member 2
      Short name=WASP family protein member 2
Alternative name(s):
    Protein WAVE-2
Gene names
Name: Wasf2
Synonyms: Wave2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton By similarity.

Subunit structure

Binds actin and the Arp2/3 complex. Interacts with BAIAP2 By similarity. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300 By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Domain

Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.

Sequence similarities

Belongs to the SCAR/WAVE family.

Contains 1 WH2 domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Wiskott-Aldrich syndrome protein family member 2
PRO_0000188995

Regions

Domain435 – 45218WH2
Compositional bias247 – 2504Poly-Pro
Compositional bias268 – 2714Poly-Pro
Compositional bias318 – 32710Poly-Pro
Compositional bias345 – 3517Poly-Pro
Compositional bias362 – 3698Poly-Pro
Compositional bias374 – 3796Poly-Pro
Compositional bias388 – 40316Poly-Pro
Compositional bias414 – 4196Poly-Pro

Amino acid modifications

Modified residue4811Phosphoserine By similarity
Modified residue4831Phosphoserine By similarity
Modified residue4871Phosphoserine By similarity
Modified residue4881Phosphoserine By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8BH43-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 4F970D0577792503

FASTA49754,074
        10         20         30         40         50         60 
MPLVTRNIEP RHLCRQTLPS DTSELECRTN ITLANVIRQL GSLSKYAEDI FGEICTQASA 

        70         80         90        100        110        120 
FASRVNSLAE RVDRVQVKVT QLDPKEEEVS LQGINTRKAF RSSTTQDQKL FDRNSLPVPV 

       130        140        150        160        170        180 
LETYNSCDAP PPLNNLSPYR DDGKEALKFY TNPSYFFDLW KEKMLQDTKD IMKEKRKHRK 

       190        200        210        220        230        240 
EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKERLG PSGYSSTLVY QNGSIGSVEN 

       250        260        270        280        290        300 
VDAASYPPPP QSDSASSPSP SFSEDNLPPP PAEFSYPADN QRGSVLAGPK RTSMVSPSHP 

       310        320        330        340        350        360 
PPAPPLSSPP GPKPGFAPPP APPPPPPMSV PPPLPSMGFG SPGTPPPPSP PSFPPHPDFA 

       370        380        390        400        410        420 
APPPPPPPPA ADYPMPPPPL SQPSGGAPPP PPPPPPPGPP PLPFSGADGQ PAAPPPPPPS 

       430        440        450        460        470        480 
EATKPKSSLP AVSDARSDLL SAIRQGFQLR RVEEQREQEK RDVVGNDVAT ILSRRIAVEY 

       490 
SDSEDDSSEF DEDDWSD

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Genomic organization and expression profile of the human and mouse WAVE gene family."
Sossey-Alaoui K., Head K., Nowak N., Cowell J.K.
Mamm. Genome 14:314-322(2003) [PubMed: 12856283] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[3]"Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."
Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T.E.B.
EMBO J. 23:749-759(2004) [PubMed: 14765121] [Abstract]
Cited for: COMPONENT OF WAVE2 COMPLEX.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AY135643 mRNA. Translation: AAN10152.1.
AK085458 mRNA. Translation: BAC39451.1.
IPIIPI00221723.
RefSeqNP_700472.1.
UniGeneMm.23566

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ8BH43. 12 interactions.

PTM databases

PhosphoSiteQ8BH43.

Proteomic databases

PRIDEQ8BH43.

Genome annotation databases

EnsemblENSMUSG00000028868. Mus musculus. [Contig view]
GeneID242687.
KEGGmmu:242687.

Organism-specific databases

MGIMGI:1098641. Wasf2.

Phylogenomic databases

HOGENOMQ8BH43.
HOVERGENQ8BH43.
OMAQ8BH43. PFSGADG.

Gene expression databases

ArrayExpressQ8BH43.
BgeeQ8BH43.
CleanExMM_WASF2.
GermOnlineENSMUSG00000028868. Mus musculus.

Family and domain databases

InterProIPR003124. WH2_actin_bd.
[Graphical view]
PfamPF02205. WH2. 1 hit.
[Graphical view]
SMARTSM00246. WH2. 1 hit.
[Graphical view]
PROSITEPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio385492.
SOURCESearch...

Hide | Top

Entry information

Entry nameWASF2_MOUSE
AccessionPrimary (citable) accession number: Q8BH43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents