Reviewed,
UniProtKB/Swiss-Prot Q8BH43 (WASF2_MOUSE)
Last modified
June 16, 2009.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Wiskott-Aldrich syndrome protein family member 2 Short name=WASP family protein member 2 Alternative name(s): Protein WAVE-2 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 497 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton By similarity. |
| Subunit structure | Binds actin and the Arp2/3 complex. Interacts with BAIAP2 By similarity. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300 By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Domain | Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. |
| Sequence similarities | Belongs to the SCAR/WAVE family. Contains 1 WH2 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Ligand | Actin-binding |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | Rac protein signal transduction Inferred from mutant phenotype. Source: MGI actin cytoskeleton organizationInferred from mutant phenotype. Source: MGI actin filament-based movementInferred from mutant phenotype. Source: MGI ameboidal cell migrationInferred from mutant phenotype. Source: MGI angiogenesisInferred from mutant phenotype. Source: MGI endocytosisInferred from direct assay. Source: MGI lamellipodium assemblyInferred from mutant phenotype. Source: MGI |
| Cellular component | cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell early endosomeInferred from direct assay. Source: MGI ruffleInferred from direct assay. Source: MGI |
| Molecular function | actin binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Q91VR8 | 2 | EBI-643162,EBI-643491 | ||
| Gcc2 | Q8CHG3 | 2 | EBI-643162,EBI-643470 | |
| Slmap | Q9EQ03 | 2 | EBI-643162,EBI-643207 | |
| Smc2 | Q8CG48 | 2 | EBI-643162,EBI-643436 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 497 | 497 | Wiskott-Aldrich syndrome protein family member 2 | PRO_0000188995 | |||||
Regions | |||||||||
| Domain | 435 – 452 | 18 | WH2 | ||||||
| Compositional bias | 247 – 250 | 4 | Poly-Pro | ||||||
| Compositional bias | 268 – 271 | 4 | Poly-Pro | ||||||
| Compositional bias | 318 – 327 | 10 | Poly-Pro | ||||||
| Compositional bias | 345 – 351 | 7 | Poly-Pro | ||||||
| Compositional bias | 362 – 369 | 8 | Poly-Pro | ||||||
| Compositional bias | 374 – 379 | 6 | Poly-Pro | ||||||
| Compositional bias | 388 – 403 | 16 | Poly-Pro | ||||||
| Compositional bias | 414 – 419 | 6 | Poly-Pro | ||||||
Amino acid modifications | |||||||||
| Modified residue | 481 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 483 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 487 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 488 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AY135643 mRNA. Translation: AAN10152.1. AK085458 mRNA. Translation: BAC39451.1. | |
| IPI | IPI00221723. |
| RefSeq | NP_700472.1. |
| UniGene | Mm.23566 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8BH43. 12 interactions. |
PTM databases | |
| PhosphoSite | Q8BH43. |
Proteomic databases | |
| PRIDE | Q8BH43. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000028868. Mus musculus. [Contig view] |
| GeneID | 242687. |
| KEGG | mmu:242687. |
Organism-specific databases | |
| MGI | MGI:1098641. Wasf2. |
Phylogenomic databases | |
| HOGENOM | Q8BH43. |
| HOVERGEN | Q8BH43. |
| OMA | Q8BH43. PFSGADG. |
Gene expression databases | |
| ArrayExpress | Q8BH43. |
| Bgee | Q8BH43. |
| CleanEx | MM_WASF2. |
| GermOnline | ENSMUSG00000028868. Mus musculus. |
Family and domain databases | |
| InterPro | IPR003124. WH2_actin_bd. [Graphical view] |
| Pfam | PF02205. WH2. 1 hit. [Graphical view] |
| SMART | SM00246. WH2. 1 hit. [Graphical view] |
| PROSITE | PS51082. WH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 385492. |
| SOURCE | Search... |
Entry information
| Entry name | WASF2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BH43 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


