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Q8BH43

- WASF2_MOUSE

UniProt

Q8BH43 - WASF2_MOUSE

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Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

Wasf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. actin filament-based movement Source: MGI
  3. ameboidal cell migration Source: MGI
  4. angiogenesis Source: MGI
  5. cellular component movement Source: MGI
  6. endocytosis Source: MGI
  7. lamellipodium assembly Source: MGI
  8. lamellipodium morphogenesis Source: MGI
  9. megakaryocyte development Source: MGI
  10. negative regulation of stress fiber assembly Source: Ensembl
  11. positive regulation of lamellipodium assembly Source: Ensembl
  12. Rac protein signal transduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_198374. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 2
Short name:
WASP family protein member 2
Alternative name(s):
Protein WAVE-2
Gene namesi
Name:Wasf2
Synonyms:Wave2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1098641. Wasf2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cytoskeleton Source: UniProtKB-KW
  3. early endosome Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. intracellular Source: MGI
  6. lamellipodium Source: MGI
  7. ruffle Source: MGI
  8. SCAR complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Wiskott-Aldrich syndrome protein family member 2PRO_0000188995Add
BLAST

Proteomic databases

MaxQBiQ8BH43.
PaxDbiQ8BH43.
PRIDEiQ8BH43.

PTM databases

PhosphoSiteiQ8BH43.

Expressioni

Gene expression databases

BgeeiQ8BH43.
CleanExiMM_WASF2.
ExpressionAtlasiQ8BH43. baseline and differential.
GenevestigatoriQ8BH43.

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Gcc2Q8CHG36EBI-643162,EBI-643470
SlmapQ3URD3-43EBI-643162,EBI-3294998
Smc2Q8CG484EBI-643162,EBI-643436

Protein-protein interaction databases

BioGridi232443. 2 interactions.
DIPiDIP-29535N.
IntActiQ8BH43. 17 interactions.
MINTiMINT-3390198.

Structurei

3D structure databases

ProteinModelPortaliQ8BH43.
SMRiQ8BH43. Positions 23-197, 434-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini435 – 45218WH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi247 – 2504Poly-Pro
Compositional biasi268 – 2714Poly-Pro
Compositional biasi318 – 32710Poly-Pro
Compositional biasi345 – 3517Poly-Pro
Compositional biasi362 – 3698Poly-Pro
Compositional biasi374 – 3796Poly-Pro
Compositional biasi388 – 40316Poly-ProAdd
BLAST
Compositional biasi414 – 4196Poly-Pro

Domaini

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain (By similarity).By similarity

Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG299696.
GeneTreeiENSGT00730000110593.
HOGENOMiHOG000214057.
HOVERGENiHBG058482.
InParanoidiQ8BH43.
KOiK05748.
OMAiDTSELEC.
OrthoDBiEOG7VHSXK.
PhylomeDBiQ8BH43.
TreeFamiTF315031.

Family and domain databases

InterProiIPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR12902. PTHR12902. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLVTRNIEP RHLCRQTLPS DTSELECRTN ITLANVIRQL GSLSKYAEDI
60 70 80 90 100
FGEICTQASA FASRVNSLAE RVDRVQVKVT QLDPKEEEVS LQGINTRKAF
110 120 130 140 150
RSSTTQDQKL FDRNSLPVPV LETYNSCDAP PPLNNLSPYR DDGKEALKFY
160 170 180 190 200
TNPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK
210 220 230 240 250
EEWEKMKMGQ EFVESKERLG PSGYSSTLVY QNGSIGSVEN VDAASYPPPP
260 270 280 290 300
QSDSASSPSP SFSEDNLPPP PAEFSYPADN QRGSVLAGPK RTSMVSPSHP
310 320 330 340 350
PPAPPLSSPP GPKPGFAPPP APPPPPPMSV PPPLPSMGFG SPGTPPPPSP
360 370 380 390 400
PSFPPHPDFA APPPPPPPPA ADYPMPPPPL SQPSGGAPPP PPPPPPPGPP
410 420 430 440 450
PLPFSGADGQ PAAPPPPPPS EATKPKSSLP AVSDARSDLL SAIRQGFQLR
460 470 480 490
RVEEQREQEK RDVVGNDVAT ILSRRIAVEY SDSEDDSSEF DEDDWSD
Length:497
Mass (Da):54,074
Last modified:March 1, 2003 - v1
Checksum:i4F970D0577792503
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135643 mRNA. Translation: AAN10152.1.
AK085458 mRNA. Translation: BAC39451.1.
CCDSiCCDS18742.1.
RefSeqiNP_700472.1. NM_153423.6.
XP_006538911.1. XM_006538848.1.
XP_006538912.1. XM_006538849.1.
XP_006538913.1. XM_006538850.1.
UniGeneiMm.23566.

Genome annotation databases

EnsembliENSMUST00000084241; ENSMUSP00000081263; ENSMUSG00000028868.
ENSMUST00000105912; ENSMUSP00000101532; ENSMUSG00000028868.
GeneIDi242687.
KEGGimmu:242687.
UCSCiuc008vcf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135643 mRNA. Translation: AAN10152.1 .
AK085458 mRNA. Translation: BAC39451.1 .
CCDSi CCDS18742.1.
RefSeqi NP_700472.1. NM_153423.6.
XP_006538911.1. XM_006538848.1.
XP_006538912.1. XM_006538849.1.
XP_006538913.1. XM_006538850.1.
UniGenei Mm.23566.

3D structure databases

ProteinModelPortali Q8BH43.
SMRi Q8BH43. Positions 23-197, 434-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232443. 2 interactions.
DIPi DIP-29535N.
IntActi Q8BH43. 17 interactions.
MINTi MINT-3390198.

PTM databases

PhosphoSitei Q8BH43.

Proteomic databases

MaxQBi Q8BH43.
PaxDbi Q8BH43.
PRIDEi Q8BH43.

Protocols and materials databases

DNASUi 242687.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084241 ; ENSMUSP00000081263 ; ENSMUSG00000028868 .
ENSMUST00000105912 ; ENSMUSP00000101532 ; ENSMUSG00000028868 .
GeneIDi 242687.
KEGGi mmu:242687.
UCSCi uc008vcf.1. mouse.

Organism-specific databases

CTDi 10163.
MGIi MGI:1098641. Wasf2.

Phylogenomic databases

eggNOGi NOG299696.
GeneTreei ENSGT00730000110593.
HOGENOMi HOG000214057.
HOVERGENi HBG058482.
InParanoidi Q8BH43.
KOi K05748.
OMAi DTSELEC.
OrthoDBi EOG7VHSXK.
PhylomeDBi Q8BH43.
TreeFami TF315031.

Enzyme and pathway databases

Reactomei REACT_198374. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

NextBioi 385492.
PROi Q8BH43.
SOURCEi Search...

Gene expression databases

Bgeei Q8BH43.
CleanExi MM_WASF2.
ExpressionAtlasi Q8BH43. baseline and differential.
Genevestigatori Q8BH43.

Family and domain databases

InterProi IPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view ]
PANTHERi PTHR12902. PTHR12902. 1 hit.
Pfami PF02205. WH2. 1 hit.
[Graphical view ]
SMARTi SM00246. WH2. 1 hit.
[Graphical view ]
PROSITEi PS51082. WH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the human and mouse WAVE gene family."
    Sossey-Alaoui K., Head K., Nowak N., Cowell J.K.
    Mamm. Genome 14:314-322(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."
    Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T.E.B.
    EMBO J. 23:749-759(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF WAVE2 COMPLEX.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiWASF2_MOUSE
AccessioniPrimary (citable) accession number: Q8BH43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3