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Q8BH43 (WASF2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Wiskott-Aldrich syndrome protein family member 2
Short name=WASP family protein member 2
Alternative name(s):
Protein WAVE-2
Gene names
Name:Wasf2
Synonyms:Wave2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex By similarity.

Subunit structure

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Domain

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain By similarity.

Sequence similarities

Belongs to the SCAR/WAVE family.

Contains 1 WH2 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gcc2Q8CHG36EBI-643162,EBI-643470
SlmapQ3URD3-43EBI-643162,EBI-3294998
Smc2Q8CG484EBI-643162,EBI-643436

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Wiskott-Aldrich syndrome protein family member 2
PRO_0000188995

Regions

Domain435 – 45218WH2
Compositional bias247 – 2504Poly-Pro
Compositional bias268 – 2714Poly-Pro
Compositional bias318 – 32710Poly-Pro
Compositional bias345 – 3517Poly-Pro
Compositional bias362 – 3698Poly-Pro
Compositional bias374 – 3796Poly-Pro
Compositional bias388 – 40316Poly-Pro
Compositional bias414 – 4196Poly-Pro

Amino acid modifications

Modified residue4811Phosphoserine By similarity
Modified residue4831Phosphoserine By similarity
Modified residue4871Phosphoserine By similarity
Modified residue4881Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BH43 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 4F970D0577792503

FASTA49754,074
        10         20         30         40         50         60 
MPLVTRNIEP RHLCRQTLPS DTSELECRTN ITLANVIRQL GSLSKYAEDI FGEICTQASA 

        70         80         90        100        110        120 
FASRVNSLAE RVDRVQVKVT QLDPKEEEVS LQGINTRKAF RSSTTQDQKL FDRNSLPVPV 

       130        140        150        160        170        180 
LETYNSCDAP PPLNNLSPYR DDGKEALKFY TNPSYFFDLW KEKMLQDTKD IMKEKRKHRK 

       190        200        210        220        230        240 
EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKERLG PSGYSSTLVY QNGSIGSVEN 

       250        260        270        280        290        300 
VDAASYPPPP QSDSASSPSP SFSEDNLPPP PAEFSYPADN QRGSVLAGPK RTSMVSPSHP 

       310        320        330        340        350        360 
PPAPPLSSPP GPKPGFAPPP APPPPPPMSV PPPLPSMGFG SPGTPPPPSP PSFPPHPDFA 

       370        380        390        400        410        420 
APPPPPPPPA ADYPMPPPPL SQPSGGAPPP PPPPPPPGPP PLPFSGADGQ PAAPPPPPPS 

       430        440        450        460        470        480 
EATKPKSSLP AVSDARSDLL SAIRQGFQLR RVEEQREQEK RDVVGNDVAT ILSRRIAVEY 

       490 
SDSEDDSSEF DEDDWSD

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and expression profile of the human and mouse WAVE gene family."
Sossey-Alaoui K., Head K., Nowak N., Cowell J.K.
Mamm. Genome 14:314-322(2003) [PubMed: 12856283] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[3]"Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."
Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T.E.B.
EMBO J. 23:749-759(2004) [PubMed: 14765121] [Abstract]
Cited for: COMPONENT OF WAVE2 COMPLEX.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY135643 mRNA. Translation: AAN10152.1.
AK085458 mRNA. Translation: BAC39451.1.
IPIIPI00221723.
RefSeqNP_700472.1. NM_153423.6.
UniGeneMm.23566.

3D structure databases

ProteinModelPortalQ8BH43.
SMRQ8BH43. Positions 22-207, 434-481.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29535N.
IntActQ8BH43. 12 interactions.
MINTMINT-3390198.
STRINGQ8BH43.

PTM databases

PhosphoSiteQ8BH43.

Proteomic databases

PRIDEQ8BH43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084241; ENSMUSP00000081263; ENSMUSG00000028868.
ENSMUST00000105912; ENSMUSP00000101532; ENSMUSG00000028868.
GeneID242687.
KEGGmmu:242687.

Organism-specific databases

CTD10163.
MGIMGI:1098641. Wasf2.

Phylogenomic databases

HOGENOMHBG715875.
HOVERGENHBG058482.
InParanoidQ8BH43.
OMAIGSNESM.
OrthoDBEOG49W2GB.
PhylomeDBQ8BH43.

Gene expression databases

ArrayExpressQ8BH43.
BgeeQ8BH43.
CleanExMM_WASF2.
GenevestigatorQ8BH43.
GermOnlineENSMUSG00000028868. Mus musculus.

Family and domain databases

InterProIPR003124. WH2_actin-bd.
[Graphical view]
KOK05748.
PfamPF02205. WH2. 1 hit.
[Graphical view]
SMARTSM00246. WH2. 1 hit.
[Graphical view]
PROSITEPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385492.
SOURCESearch...

Entry information

Entry nameWASF2_MOUSE
AccessionPrimary (citable) accession number: Q8BH43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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