Q8BH34 (SEM3D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-3D

Gene names

Name:

Sema3d

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	777 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin By similarity.
Subcellular location	Secreted By similarity.
Domain	Strong binding to neuropilin is mediated by the carboxy third of the protein.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 PSI domain. Contains 1 Sema domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Secreted
Domain	Immunoglobulin domain Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 777	740	Semaphorin-3D		PRO_0000042161
Regions
	Domain	44 – 531	488	Sema
	Domain	533 – 585	53	PSI
	Domain	592 – 680	89	Ig-like C2-type
	Compositional bias	739 – 773	35	Arg/Lys-rich (basic)
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	607	1	N-linked (GlcNAc...) Potential
	Glycosylation	724	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 128		By similarity
	Disulfide bond	146 ↔ 155		By similarity
	Disulfide bond	286 ↔ 398		By similarity
	Disulfide bond	310 ↔ 358		By similarity
	Disulfide bond	534 ↔ 552		By similarity
	Disulfide bond	665 ↔ 731		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BH34 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5450D8D45D1BDABF	FASTA	777	89,549
	10 20 30 40 50 60 MNVTKDENPR SRSQDLHLFH AWMMLIMTVL FLPVTETSKQ NIPRLKLTYK DLLLSNTCIP 70 80 90 100 110 120 FLGSSEGLDF QTLLLDEERG ILLLGAKDHV FLLSLVDLNK NFKKIYWPAA KERVELCKLA 130 140 150 160 170 180 GKDANAECAN FIRVLQPYNK THVYVCGTGA FHPLCGYIDL GANKEELIFK LDTHNLESGR 190 200 210 220 230 240 LKCPFDPQQP FASVMTDEHL YSGTASDFLG KDTAFTRSLG LMQDHHSIRT DISEHHWLNG 250 260 270 280 290 300 AKFIGTFPIP DTYNPDDDKI YFFFRESSQE GSTSDRSILS RVGRVCKNDV GGQRSLINKW 310 320 330 340 350 360 TTFLKARLIC SIPGSDGADT HFDELQDIYL LPTRDERNPV VYGVFTTTSS IFKGSAVCVY 370 380 390 400 410 420 SMADIRAVFN GPYAHKESAD HRWVQYDGRI PYPRPGTCPS KTYDPLIKST RDFPDDVISF 430 440 450 460 470 480 IRRHPVMYKS VYPVAGAPTF KRINVDYRLT QIVVDHVVAE DGQYDVMFLG TDIGTVLKVV 490 500 510 520 530 540 SISKEKWNME EVVLEELQVF KHPTAILNME LSLKQQQLYV GSWDGLVQLS LHRCDTYGKA 550 560 570 580 590 600 CADCCLARDP YCAWDGNACS RYAPTSKRRA RRQDVKYGDP ITQCWDIEDS ISHETADEKV 610 620 630 640 650 660 IFGIEFNSTF LECIPKSQQA SVEWYIQRSG DEHREELKPD ERIIKTDYGL LIRSLQKKDS 670 680 690 700 710 720 GMYYCKAQEH TFIHTIVKLT LNVIENEQME NTQRAEYQEG QVKDLLAESR LRYKDYIQIL 730 740 750 760 770 SSPNFSLDQY CEQMWYKEKR RQRNKGSPKW KHMQEMKKKR NRRHHRDLDE LQRSVAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney and Skin.
[2]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 479-486, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK028900 mRNA. Translation: BAC26185.1. AK052671 mRNA. Translation: BAC35092.1.
IPI	IPI00221711.
RefSeq	NP_083158.3. NM_028882.4.
UniGene	Mm.89313.
3D structure databases
ProteinModelPortal	Q8BH34.
SMR	Q8BH34. Positions 39-683.
ModBase	Search...
PTM databases
PhosphoSite	Q8BH34.
Proteomic databases
PRIDE	Q8BH34.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030868; ENSMUSP00000030868; ENSMUSG00000040254.
GeneID	108151.
KEGG	mmu:108151.
UCSC	uc008wlx.2. mouse.
Organism-specific databases
CTD	223117.
MGI	MGI:1860118. Sema3d.
Phylogenomic databases
eggNOG	NOG247995.
GeneTree	ENSGT00560000076660.
HOGENOM	HOG000039964.
HOVERGEN	HBG055071.
InParanoid	Q8BH34.
KO	K06840.
OMA	ERVELCK.
OrthoDB	EOG4SQWW5.
Gene expression databases
ArrayExpress	Q8BH34.
Bgee	Q8BH34.
Genevestigator	Q8BH34.
GermOnline	ENSMUSG00000040254. Mus musculus.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01403. Sema. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	360170.
SOURCE	Search...

Entry information

Entry name

SEM3D_MOUSE

Accession

Primary (citable) accession number: Q8BH34

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program