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Q8BH34

- SEM3D_MOUSE

UniProt

Q8BH34 - SEM3D_MOUSE

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Protein
Semaphorin-3D
Gene
Sema3d
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3D
Gene namesi
Name:Sema3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1860118. Sema3d.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed prediction
Add
BLAST
Chaini38 – 777740Semaphorin-3D
PRO_0000042161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 128 By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi146 ↔ 155 By similarity
Disulfide bondi286 ↔ 398 By similarity
Disulfide bondi310 ↔ 358 By similarity
Disulfide bondi534 ↔ 552 By similarity
Glycosylationi607 – 6071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi665 ↔ 731 By similarity
Glycosylationi724 – 7241N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8BH34.

PTM databases

PhosphoSiteiQ8BH34.

Expressioni

Gene expression databases

ArrayExpressiQ8BH34.
BgeeiQ8BH34.
GenevestigatoriQ8BH34.

Structurei

3D structure databases

ProteinModelPortaliQ8BH34.
SMRiQ8BH34. Positions 39-683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 531488Sema
Add
BLAST
Domaini533 – 58553PSI
Add
BLAST
Domaini592 – 68089Ig-like C2-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi739 – 77335Arg/Lys-rich (basic)
Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG247995.
GeneTreeiENSGT00560000076660.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ8BH34.
KOiK06840.
OMAiKACADCC.
OrthoDBiEOG76QFGN.
PhylomeDBiQ8BH34.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01403. Sema. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH34-1 [UniParc]FASTAAdd to Basket

« Hide

MNVTKDENPR SRSQDLHLFH AWMMLIMTVL FLPVTETSKQ NIPRLKLTYK    50
DLLLSNTCIP FLGSSEGLDF QTLLLDEERG ILLLGAKDHV FLLSLVDLNK 100
NFKKIYWPAA KERVELCKLA GKDANAECAN FIRVLQPYNK THVYVCGTGA 150
FHPLCGYIDL GANKEELIFK LDTHNLESGR LKCPFDPQQP FASVMTDEHL 200
YSGTASDFLG KDTAFTRSLG LMQDHHSIRT DISEHHWLNG AKFIGTFPIP 250
DTYNPDDDKI YFFFRESSQE GSTSDRSILS RVGRVCKNDV GGQRSLINKW 300
TTFLKARLIC SIPGSDGADT HFDELQDIYL LPTRDERNPV VYGVFTTTSS 350
IFKGSAVCVY SMADIRAVFN GPYAHKESAD HRWVQYDGRI PYPRPGTCPS 400
KTYDPLIKST RDFPDDVISF IRRHPVMYKS VYPVAGAPTF KRINVDYRLT 450
QIVVDHVVAE DGQYDVMFLG TDIGTVLKVV SISKEKWNME EVVLEELQVF 500
KHPTAILNME LSLKQQQLYV GSWDGLVQLS LHRCDTYGKA CADCCLARDP 550
YCAWDGNACS RYAPTSKRRA RRQDVKYGDP ITQCWDIEDS ISHETADEKV 600
IFGIEFNSTF LECIPKSQQA SVEWYIQRSG DEHREELKPD ERIIKTDYGL 650
LIRSLQKKDS GMYYCKAQEH TFIHTIVKLT LNVIENEQME NTQRAEYQEG 700
QVKDLLAESR LRYKDYIQIL SSPNFSLDQY CEQMWYKEKR RQRNKGSPKW 750
KHMQEMKKKR NRRHHRDLDE LQRSVAT 777
Length:777
Mass (Da):89,549
Last modified:March 1, 2003 - v1
Checksum:i5450D8D45D1BDABF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028900 mRNA. Translation: BAC26185.1.
AK052671 mRNA. Translation: BAC35092.1.
CCDSiCCDS39013.1.
RefSeqiNP_083158.3. NM_028882.4.
XP_006503588.1. XM_006503525.1.
UniGeneiMm.89313.

Genome annotation databases

EnsembliENSMUST00000030868; ENSMUSP00000030868; ENSMUSG00000040254.
GeneIDi108151.
KEGGimmu:108151.
UCSCiuc008wlx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028900 mRNA. Translation: BAC26185.1 .
AK052671 mRNA. Translation: BAC35092.1 .
CCDSi CCDS39013.1.
RefSeqi NP_083158.3. NM_028882.4.
XP_006503588.1. XM_006503525.1.
UniGenei Mm.89313.

3D structure databases

ProteinModelPortali Q8BH34.
SMRi Q8BH34. Positions 39-683.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BH34.

Proteomic databases

PRIDEi Q8BH34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030868 ; ENSMUSP00000030868 ; ENSMUSG00000040254 .
GeneIDi 108151.
KEGGi mmu:108151.
UCSCi uc008wlx.2. mouse.

Organism-specific databases

CTDi 223117.
MGIi MGI:1860118. Sema3d.

Phylogenomic databases

eggNOGi NOG247995.
GeneTreei ENSGT00560000076660.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi Q8BH34.
KOi K06840.
OMAi KACADCC.
OrthoDBi EOG76QFGN.
PhylomeDBi Q8BH34.
TreeFami TF316102.

Miscellaneous databases

NextBioi 360170.
PROi Q8BH34.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BH34.
Bgeei Q8BH34.
Genevestigatori Q8BH34.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01403. Sema. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Skin.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 479-486, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSEM3D_MOUSE
AccessioniPrimary (citable) accession number: Q8BH34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi