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Q8BH34 (SEM3D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Semaphorin-3D
Gene names
Name:Sema3d
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length777 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin By similarity.

Subcellular location

Secreted By similarity.

Domain

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   DomainImmunoglobulin domain
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

nervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 777740Semaphorin-3D
PRO_0000042161

Regions

Domain44 – 531488Sema
Domain533 – 58553PSI
Domain592 – 68089Ig-like C2-type
Compositional bias739 – 77335Arg/Lys-rich (basic)

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation6071N-linked (GlcNAc...) Potential
Glycosylation7241N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 128 By similarity
Disulfide bond146 ↔ 155 By similarity
Disulfide bond286 ↔ 398 By similarity
Disulfide bond310 ↔ 358 By similarity
Disulfide bond534 ↔ 552 By similarity
Disulfide bond665 ↔ 731 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BH34 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5450D8D45D1BDABF

FASTA77789,549
        10         20         30         40         50         60 
MNVTKDENPR SRSQDLHLFH AWMMLIMTVL FLPVTETSKQ NIPRLKLTYK DLLLSNTCIP 

        70         80         90        100        110        120 
FLGSSEGLDF QTLLLDEERG ILLLGAKDHV FLLSLVDLNK NFKKIYWPAA KERVELCKLA 

       130        140        150        160        170        180 
GKDANAECAN FIRVLQPYNK THVYVCGTGA FHPLCGYIDL GANKEELIFK LDTHNLESGR 

       190        200        210        220        230        240 
LKCPFDPQQP FASVMTDEHL YSGTASDFLG KDTAFTRSLG LMQDHHSIRT DISEHHWLNG 

       250        260        270        280        290        300 
AKFIGTFPIP DTYNPDDDKI YFFFRESSQE GSTSDRSILS RVGRVCKNDV GGQRSLINKW 

       310        320        330        340        350        360 
TTFLKARLIC SIPGSDGADT HFDELQDIYL LPTRDERNPV VYGVFTTTSS IFKGSAVCVY 

       370        380        390        400        410        420 
SMADIRAVFN GPYAHKESAD HRWVQYDGRI PYPRPGTCPS KTYDPLIKST RDFPDDVISF 

       430        440        450        460        470        480 
IRRHPVMYKS VYPVAGAPTF KRINVDYRLT QIVVDHVVAE DGQYDVMFLG TDIGTVLKVV 

       490        500        510        520        530        540 
SISKEKWNME EVVLEELQVF KHPTAILNME LSLKQQQLYV GSWDGLVQLS LHRCDTYGKA 

       550        560        570        580        590        600 
CADCCLARDP YCAWDGNACS RYAPTSKRRA RRQDVKYGDP ITQCWDIEDS ISHETADEKV 

       610        620        630        640        650        660 
IFGIEFNSTF LECIPKSQQA SVEWYIQRSG DEHREELKPD ERIIKTDYGL LIRSLQKKDS 

       670        680        690        700        710        720 
GMYYCKAQEH TFIHTIVKLT LNVIENEQME NTQRAEYQEG QVKDLLAESR LRYKDYIQIL 

       730        740        750        760        770 
SSPNFSLDQY CEQMWYKEKR RQRNKGSPKW KHMQEMKKKR NRRHHRDLDE LQRSVAT 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney and Skin.
[2]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 479-486, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028900 mRNA. Translation: BAC26185.1.
AK052671 mRNA. Translation: BAC35092.1.
CCDSCCDS39013.1.
RefSeqNP_083158.3. NM_028882.4.
XP_006503588.1. XM_006503525.1.
UniGeneMm.89313.

3D structure databases

ProteinModelPortalQ8BH34.
SMRQ8BH34. Positions 39-683.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BH34.

Proteomic databases

PRIDEQ8BH34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030868; ENSMUSP00000030868; ENSMUSG00000040254.
GeneID108151.
KEGGmmu:108151.
UCSCuc008wlx.2. mouse.

Organism-specific databases

CTD223117.
MGIMGI:1860118. Sema3d.

Phylogenomic databases

eggNOGNOG247995.
GeneTreeENSGT00560000076660.
HOGENOMHOG000039964.
HOVERGENHBG055071.
InParanoidQ8BH34.
KOK06840.
OMAKACADCC.
OrthoDBEOG76QFGN.
PhylomeDBQ8BH34.
TreeFamTF316102.

Gene expression databases

ArrayExpressQ8BH34.
BgeeQ8BH34.
GenevestigatorQ8BH34.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PfamPF01403. Sema. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio360170.
PROQ8BH34.
SOURCESearch...

Entry information

Entry nameSEM3D_MOUSE
AccessionPrimary (citable) accession number: Q8BH34
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot