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Q8BH31 (MFSD8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major facilitator superfamily domain-containing protein 8
Gene names
Name:Mfsd8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a carrier that transport small solutes by using chemiosmotic ion gradients Potential.

Subcellular location

Lysosome membrane; Multi-pass membrane protein By similarity. Note: Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs By similarity.

Sequence similarities

Belongs to the major facilitator superfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Major facilitator superfamily domain-containing protein 8
PRO_0000311233

Regions

Topological domain1 – 4141Cytoplasmic Potential
Transmembrane42 – 6221Helical; Potential
Topological domain63 – 7513Extracellular Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 10610Cytoplasmic Potential
Transmembrane107 – 12721Helical; Potential
Topological domain128 – 14013Extracellular Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 17413Cytoplasmic Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 21217Extracellular Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 26734Cytoplasmic Potential
Transmembrane268 – 28821Helical; Potential
Topological domain289 – 31022Extracellular Potential
Transmembrane311 – 33121Helical; Potential
Topological domain332 – 3387Cytoplasmic Potential
Transmembrane339 – 35921Helical; Potential
Topological domain360 – 41657Extracellular Potential
Transmembrane417 – 43923Helical; Potential
Topological domain440 – 45213Cytoplasmic Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 48310Extracellular Potential
Transmembrane484 – 50421Helical; Potential
Topological domain505 – 51915Cytoplasmic Potential
Motif13 – 142Dileucine internalization motif By similarity

Amino acid modifications

Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict251S → G in AAH10483. Ref.2
Sequence conflict391S → F in BAB28676. Ref.1
Sequence conflict501S → N in BAB28676. Ref.1
Sequence conflict1161V → G in BAB28676. Ref.1
Sequence conflict1291A → T in BAB28676. Ref.1
Sequence conflict3131L → F in AAH10483. Ref.2
Sequence conflict3911S → P in AAH10483. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BH31 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 552FF574371BE4FE

FASTA51957,569
        10         20         30         40         50         60 
MANLGSEAER EPLLGPGSPG SREWSEIETQ EHYKSRWKSV RILYLTMFLS SVGFSIVIMS 

        70         80         90        100        110        120 
IWPYLQKIDQ TADASFLGWV IASYSLGQMV ASPLFGLWSN YRPRKEPLIV SISISVAANC 

       130        140        150        160        170        180 
LYAYVHVPAA HNKYYMLIAR GLVGFGAGNV AVVRSYIAGA TSLQERTNAM ANTSTCQALG 

       190        200        210        220        230        240 
FILGPVFQTC FALIGEKGVT WDIIKLQVNM YTAPVLLAAF LGILNIILIL FILREHRVDD 

       250        260        270        280        290        300 
LGRQCKSVNF QEENTDEPQI PEGSIDQVAV VATNIVFFVV LFIFAVYETI LTPLTLDMYA 

       310        320        330        340        350        360 
WTQEQAVLYD GILLVAFGVE AVLVFMGVKL LSKKIGERAI LLGGFVVVWV GFFILLPWGN 

       370        380        390        400        410        420 
QFPKIQWEDL HNSSTPNTTF GEIIIGLWNS SREDHSEQPT GCPIEQTWCL YTPVIHLAQF 

       430        440        450        460        470        480 
LTAAVLIGTG YPACSVMSYT LYSKVLGPKP QGIYMGWLTT SGSAARILGP VFISHVYTYL 

       490        500        510 
GPRWAFSLVC GIVVLTILLI GAVYKRLVAF SVRYMRIQE 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Medulla oblongata and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-519.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK013144 mRNA. Translation: BAB28676.1.
AK032080 mRNA. Translation: BAC27687.1.
AK077957 mRNA. Translation: BAC37083.1.
BC010483 mRNA. Translation: AAH10483.1.
BC113183 mRNA. Translation: AAI13184.1.
BC113790 mRNA. Translation: AAI13791.1.
RefSeqNP_082416.2. NM_028140.4.
UniGeneMm.130610.

3D structure databases

ProteinModelPortalQ8BH31.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BH31.

Proteomic databases

PRIDEQ8BH31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759.
GeneID72175.
KEGGmmu:72175.
UCSCuc008pbp.1. mouse.

Organism-specific databases

CTD256471.
MGIMGI:1919425. Mfsd8.

Phylogenomic databases

eggNOGNOG294425.
GeneTreeENSGT00530000063854.
HOGENOMHOG000047970.
HOVERGENHBG061584.
InParanoidQ8BH31.
KOK12307.
OMALQINMYT.
OrthoDBEOG7M3J04.
TreeFamTF316590.

Gene expression databases

BgeeQ8BH31.
CleanExMM_MFSD8.
GenevestigatorQ8BH31.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335627.
PROQ8BH31.
SOURCESearch...

Entry information

Entry nameMFSD8_MOUSE
AccessionPrimary (citable) accession number: Q8BH31
Secondary accession number(s): Q91VS1, Q9CZ06
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot