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Q8BH31

- MFSD8_MOUSE

UniProt

Q8BH31 - MFSD8_MOUSE

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Protein

Major facilitator superfamily domain-containing protein 8

Gene
Mfsd8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a carrier that transport small solutes by using chemiosmotic ion gradients Reviewed prediction.

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 8
Gene namesi
Name:Mfsd8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1919425. Mfsd8.

Subcellular locationi

Lysosome membrane; Multi-pass membrane protein By similarity
Note: Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Reviewed predictionAdd
BLAST
Topological domaini63 – 7513Extracellular Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Topological domaini97 – 10610Cytoplasmic Reviewed prediction
Transmembranei107 – 12721Helical; Reviewed predictionAdd
BLAST
Topological domaini128 – 14013Extracellular Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Reviewed predictionAdd
BLAST
Topological domaini162 – 17413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Reviewed predictionAdd
BLAST
Topological domaini196 – 21217Extracellular Reviewed predictionAdd
BLAST
Transmembranei213 – 23321Helical; Reviewed predictionAdd
BLAST
Topological domaini234 – 26734Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei268 – 28821Helical; Reviewed predictionAdd
BLAST
Topological domaini289 – 31022Extracellular Reviewed predictionAdd
BLAST
Transmembranei311 – 33121Helical; Reviewed predictionAdd
BLAST
Topological domaini332 – 3387Cytoplasmic Reviewed prediction
Transmembranei339 – 35921Helical; Reviewed predictionAdd
BLAST
Topological domaini360 – 41657Extracellular Reviewed predictionAdd
BLAST
Transmembranei417 – 43923Helical; Reviewed predictionAdd
BLAST
Topological domaini440 – 45213Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei453 – 47321Helical; Reviewed predictionAdd
BLAST
Topological domaini474 – 48310Extracellular Reviewed prediction
Transmembranei484 – 50421Helical; Reviewed predictionAdd
BLAST
Topological domaini505 – 51915Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProtKB-SubCell
  3. lysosome Source: MGI
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Major facilitator superfamily domain-containing protein 8PRO_0000311233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BH31.

PTM databases

PhosphoSiteiQ8BH31.

Expressioni

Gene expression databases

BgeeiQ8BH31.
CleanExiMM_MFSD8.
GenevestigatoriQ8BH31.

Structurei

3D structure databases

ProteinModelPortaliQ8BH31.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi13 – 142Dileucine internalization motif By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294425.
GeneTreeiENSGT00530000063854.
HOGENOMiHOG000047970.
HOVERGENiHBG061584.
InParanoidiQ8BH31.
KOiK12307.
OMAiFEEASTD.
OrthoDBiEOG7M3J04.
PhylomeDBiQ8BH31.
TreeFamiTF316590.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH31-1 [UniParc]FASTAAdd to Basket

« Hide

MANLGSEAER EPLLGPGSPG SREWSEIETQ EHYKSRWKSV RILYLTMFLS    50
SVGFSIVIMS IWPYLQKIDQ TADASFLGWV IASYSLGQMV ASPLFGLWSN 100
YRPRKEPLIV SISISVAANC LYAYVHVPAA HNKYYMLIAR GLVGFGAGNV 150
AVVRSYIAGA TSLQERTNAM ANTSTCQALG FILGPVFQTC FALIGEKGVT 200
WDIIKLQVNM YTAPVLLAAF LGILNIILIL FILREHRVDD LGRQCKSVNF 250
QEENTDEPQI PEGSIDQVAV VATNIVFFVV LFIFAVYETI LTPLTLDMYA 300
WTQEQAVLYD GILLVAFGVE AVLVFMGVKL LSKKIGERAI LLGGFVVVWV 350
GFFILLPWGN QFPKIQWEDL HNSSTPNTTF GEIIIGLWNS SREDHSEQPT 400
GCPIEQTWCL YTPVIHLAQF LTAAVLIGTG YPACSVMSYT LYSKVLGPKP 450
QGIYMGWLTT SGSAARILGP VFISHVYTYL GPRWAFSLVC GIVVLTILLI 500
GAVYKRLVAF SVRYMRIQE 519
Length:519
Mass (Da):57,569
Last modified:March 1, 2003 - v1
Checksum:i552FF574371BE4FE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → G in AAH10483. 1 Publication
Sequence conflicti39 – 391S → F in BAB28676. 1 Publication
Sequence conflicti50 – 501S → N in BAB28676. 1 Publication
Sequence conflicti116 – 1161V → G in BAB28676. 1 Publication
Sequence conflicti129 – 1291A → T in BAB28676. 1 Publication
Sequence conflicti313 – 3131L → F in AAH10483. 1 Publication
Sequence conflicti391 – 3911S → P in AAH10483. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013144 mRNA. Translation: BAB28676.1.
AK032080 mRNA. Translation: BAC27687.1.
AK077957 mRNA. Translation: BAC37083.1.
BC010483 mRNA. Translation: AAH10483.1.
BC113183 mRNA. Translation: AAI13184.1.
BC113790 mRNA. Translation: AAI13791.1.
CCDSiCCDS17329.1.
RefSeqiNP_082416.2. NM_028140.4.
UniGeneiMm.130610.

Genome annotation databases

EnsembliENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759.
GeneIDi72175.
KEGGimmu:72175.
UCSCiuc008pbp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013144 mRNA. Translation: BAB28676.1 .
AK032080 mRNA. Translation: BAC27687.1 .
AK077957 mRNA. Translation: BAC37083.1 .
BC010483 mRNA. Translation: AAH10483.1 .
BC113183 mRNA. Translation: AAI13184.1 .
BC113790 mRNA. Translation: AAI13791.1 .
CCDSi CCDS17329.1.
RefSeqi NP_082416.2. NM_028140.4.
UniGenei Mm.130610.

3D structure databases

ProteinModelPortali Q8BH31.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BH31.

Proteomic databases

PRIDEi Q8BH31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026859 ; ENSMUSP00000026859 ; ENSMUSG00000025759 .
GeneIDi 72175.
KEGGi mmu:72175.
UCSCi uc008pbp.1. mouse.

Organism-specific databases

CTDi 256471.
MGIi MGI:1919425. Mfsd8.

Phylogenomic databases

eggNOGi NOG294425.
GeneTreei ENSGT00530000063854.
HOGENOMi HOG000047970.
HOVERGENi HBG061584.
InParanoidi Q8BH31.
KOi K12307.
OMAi FEEASTD.
OrthoDBi EOG7M3J04.
PhylomeDBi Q8BH31.
TreeFami TF316590.

Miscellaneous databases

NextBioi 335627.
PROi Q8BH31.
SOURCEi Search...

Gene expression databases

Bgeei Q8BH31.
CleanExi MM_MFSD8.
Genevestigatori Q8BH31.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-519.

Entry informationi

Entry nameiMFSD8_MOUSE
AccessioniPrimary (citable) accession number: Q8BH31
Secondary accession number(s): Q91VS1, Q9CZ06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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