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Protein

CCR4-NOT transcription complex subunit 10

Gene

Cnot10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-MMU-429947 Deadenylation of mRNA
R-MMU-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 10
Gene namesi
Name:Cnot10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926143 Cnot10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003145812 – 744CCR4-NOT transcription complex subunit 10Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BH15
PaxDbiQ8BH15
PeptideAtlasiQ8BH15
PRIDEiQ8BH15

PTM databases

iPTMnetiQ8BH15
PhosphoSitePlusiQ8BH15

Expressioni

Gene expression databases

BgeeiENSMUSG00000056167
CleanExiMM_CNOT10
ExpressionAtlasiQ8BH15 baseline and differential
GenevisibleiQ8BH15 MM

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BH15, 1 interactor
STRINGi10090.ENSMUSP00000064840

Structurei

3D structure databases

ProteinModelPortaliQ8BH15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 107Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the CNOT10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2471 Eukaryota
ENOG410XQQJ LUCA
GeneTreeiENSGT00390000001827
HOGENOMiHOG000111843
HOVERGENiHBG077464
InParanoidiQ8BH15
KOiK12607
OMAiGKHNLGI
OrthoDBiEOG091G06Q4
PhylomeDBiQ8BH15
TreeFamiTF323368

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 5 hits

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BH15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADKPADQG AEKHEGAGQS SGVTDQEKEL SASALQAFTS GNYDACLQHL
60 70 80 90 100
ACLQDINKDD YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE
110 120 130 140 150
MDGLDDVENS MLYYNQAVIL YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA
160 170 180 190 200
VCFLLVDLYI LTHQAEKALH LLAVLEKMIS QGSGGKNGKN ETGNNSSKDG
210 220 230 240 250
SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK SVMNTAGNSA
260 270 280 290 300
PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
310 320 330 340 350
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGGTDPGKK FSGRPMCTLL
360 370 380 390 400
TNKRYELLYN CGIQLLHVGR PLAAFECLIE AVQVYHANPR LWLRLAECCI
410 420 430 440 450
AANKGTSEQE TKGLPTKKGI VQSIVGQGYH RKIVLASQSI QNTVYNDGQS
460 470 480 490 500
SAIPVASVEF AAICLRNALL LLPEEQQDPK QENGSKSSSQ LGGNTESSES
510 520 530 540 550
SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA YVALALGDNL
560 570 580 590 600
MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
610 620 630 640 650
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG
660 670 680 690 700
SAYCLRSEYD KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL
710 720 730 740
QMIKRNQLLP AVKAHSDVRK KTVFQPVHPI QPIQMPAFTT VQRK
Length:744
Mass (Da):81,818
Last modified:March 1, 2003 - v1
Checksum:i598C842BD70BC819
GO
Isoform 2 (identifier: Q8BH15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-505: Missing.

Show »
Length:743
Mass (Da):81,731
Checksum:iEB79A62718B62495
GO
Isoform 3 (identifier: Q8BH15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-744: Missing.

Show »
Length:614
Mass (Da):67,304
Checksum:iFC1C911C46F1AE46
GO
Isoform 4 (identifier: Q8BH15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-744: Missing.

Show »
Length:532
Mass (Da):58,644
Checksum:i59E44709A33F6AAD
GO
Isoform 5 (identifier: Q8BH15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-302: GECLRCMFWNNLGCI → AQFGDFLLQEGSAGK
     303-744: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,364
Checksum:i506FD31469030C18
GO
Isoform 6 (identifier: Q8BH15-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-644: Missing.

Show »
Length:100
Mass (Da):11,363
Checksum:i3FB6AD56E779B5C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0303151 – 644Missing in isoform 6. 1 PublicationAdd BLAST644
Alternative sequenceiVSP_030316288 – 302GECLR…NLGCI → AQFGDFLLQEGSAGK in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_030317303 – 744Missing in isoform 5. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_030318505Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_030319533 – 744Missing in isoform 4. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_030320615 – 744Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029103 mRNA Translation: BAC26299.1
AK149944 mRNA Translation: BAE29186.1
AK161842 mRNA Translation: BAE36601.1
BC025554 mRNA Translation: AAH25554.1
BC036179 mRNA Translation: AAH36179.1
BC039183 mRNA Translation: AAH39183.1
BC047204 mRNA Translation: AAH47204.1
CCDSiCCDS40794.1 [Q8BH15-1]
RefSeqiNP_705813.2, NM_153585.5 [Q8BH15-1]
XP_006512462.1, XM_006512399.3 [Q8BH15-2]
UniGeneiMm.283708
Mm.486302

Genome annotation databases

EnsembliENSMUST00000070117; ENSMUSP00000064840; ENSMUSG00000056167 [Q8BH15-1]
GeneIDi78893
KEGGimmu:78893
UCSCiuc009rxq.2 mouse [Q8BH15-1]
uc009rxr.2 mouse [Q8BH15-2]
uc009rxv.2 mouse [Q8BH15-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNO10_MOUSE
AccessioniPrimary (citable) accession number: Q8BH15
Secondary accession number(s): Q05CH8
, Q3TSS4, Q3UDS5, Q80VN2, Q8CI74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health