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Protein

CCR4-NOT transcription complex subunit 10

Gene

Cnot10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-MMU-429947. Deadenylation of mRNA.
R-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 10
Gene namesi
Name:Cnot10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926143. Cnot10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003145812 – 744CCR4-NOT transcription complex subunit 10Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BH15.
PaxDbiQ8BH15.
PeptideAtlasiQ8BH15.
PRIDEiQ8BH15.

PTM databases

iPTMnetiQ8BH15.
PhosphoSitePlusiQ8BH15.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056167.
CleanExiMM_CNOT10.
GenevisibleiQ8BH15. MM.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BH15. 1 interactor.
STRINGi10090.ENSMUSP00000064840.

Structurei

3D structure databases

ProteinModelPortaliQ8BH15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 107Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the CNOT10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
GeneTreeiENSGT00390000001827.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ8BH15.
KOiK12607.
OMAiSDQGAEK.
OrthoDBiEOG091G06Q4.
PhylomeDBiQ8BH15.
TreeFamiTF323368.

Family and domain databases

Gene3Di1.25.40.10. 7 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 5 hits.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BH15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADKPADQG AEKHEGAGQS SGVTDQEKEL SASALQAFTS GNYDACLQHL
60 70 80 90 100
ACLQDINKDD YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE
110 120 130 140 150
MDGLDDVENS MLYYNQAVIL YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA
160 170 180 190 200
VCFLLVDLYI LTHQAEKALH LLAVLEKMIS QGSGGKNGKN ETGNNSSKDG
210 220 230 240 250
SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK SVMNTAGNSA
260 270 280 290 300
PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
310 320 330 340 350
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGGTDPGKK FSGRPMCTLL
360 370 380 390 400
TNKRYELLYN CGIQLLHVGR PLAAFECLIE AVQVYHANPR LWLRLAECCI
410 420 430 440 450
AANKGTSEQE TKGLPTKKGI VQSIVGQGYH RKIVLASQSI QNTVYNDGQS
460 470 480 490 500
SAIPVASVEF AAICLRNALL LLPEEQQDPK QENGSKSSSQ LGGNTESSES
510 520 530 540 550
SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA YVALALGDNL
560 570 580 590 600
MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
610 620 630 640 650
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG
660 670 680 690 700
SAYCLRSEYD KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL
710 720 730 740
QMIKRNQLLP AVKAHSDVRK KTVFQPVHPI QPIQMPAFTT VQRK
Length:744
Mass (Da):81,818
Last modified:March 1, 2003 - v1
Checksum:i598C842BD70BC819
GO
Isoform 2 (identifier: Q8BH15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-505: Missing.

Show »
Length:743
Mass (Da):81,731
Checksum:iEB79A62718B62495
GO
Isoform 3 (identifier: Q8BH15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-744: Missing.

Show »
Length:614
Mass (Da):67,304
Checksum:iFC1C911C46F1AE46
GO
Isoform 4 (identifier: Q8BH15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-744: Missing.

Show »
Length:532
Mass (Da):58,644
Checksum:i59E44709A33F6AAD
GO
Isoform 5 (identifier: Q8BH15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-302: GECLRCMFWNNLGCI → AQFGDFLLQEGSAGK
     303-744: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,364
Checksum:i506FD31469030C18
GO
Isoform 6 (identifier: Q8BH15-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-644: Missing.

Show »
Length:100
Mass (Da):11,363
Checksum:i3FB6AD56E779B5C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0303151 – 644Missing in isoform 6. 1 PublicationAdd BLAST644
Alternative sequenceiVSP_030316288 – 302GECLR…NLGCI → AQFGDFLLQEGSAGK in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_030317303 – 744Missing in isoform 5. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_030318505Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_030319533 – 744Missing in isoform 4. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_030320615 – 744Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029103 mRNA. Translation: BAC26299.1.
AK149944 mRNA. Translation: BAE29186.1.
AK161842 mRNA. Translation: BAE36601.1.
BC025554 mRNA. Translation: AAH25554.1.
BC036179 mRNA. Translation: AAH36179.1.
BC039183 mRNA. Translation: AAH39183.1.
BC047204 mRNA. Translation: AAH47204.1.
CCDSiCCDS40794.1. [Q8BH15-1]
RefSeqiNP_705813.2. NM_153585.5. [Q8BH15-1]
XP_006512462.1. XM_006512399.3. [Q8BH15-2]
UniGeneiMm.283708.
Mm.486302.

Genome annotation databases

EnsembliENSMUST00000070117; ENSMUSP00000064840; ENSMUSG00000056167. [Q8BH15-1]
GeneIDi78893.
KEGGimmu:78893.
UCSCiuc009rxq.2. mouse. [Q8BH15-1]
uc009rxr.2. mouse. [Q8BH15-2]
uc009rxv.2. mouse. [Q8BH15-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029103 mRNA. Translation: BAC26299.1.
AK149944 mRNA. Translation: BAE29186.1.
AK161842 mRNA. Translation: BAE36601.1.
BC025554 mRNA. Translation: AAH25554.1.
BC036179 mRNA. Translation: AAH36179.1.
BC039183 mRNA. Translation: AAH39183.1.
BC047204 mRNA. Translation: AAH47204.1.
CCDSiCCDS40794.1. [Q8BH15-1]
RefSeqiNP_705813.2. NM_153585.5. [Q8BH15-1]
XP_006512462.1. XM_006512399.3. [Q8BH15-2]
UniGeneiMm.283708.
Mm.486302.

3D structure databases

ProteinModelPortaliQ8BH15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH15. 1 interactor.
STRINGi10090.ENSMUSP00000064840.

PTM databases

iPTMnetiQ8BH15.
PhosphoSitePlusiQ8BH15.

Proteomic databases

EPDiQ8BH15.
PaxDbiQ8BH15.
PeptideAtlasiQ8BH15.
PRIDEiQ8BH15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070117; ENSMUSP00000064840; ENSMUSG00000056167. [Q8BH15-1]
GeneIDi78893.
KEGGimmu:78893.
UCSCiuc009rxq.2. mouse. [Q8BH15-1]
uc009rxr.2. mouse. [Q8BH15-2]
uc009rxv.2. mouse. [Q8BH15-5]

Organism-specific databases

CTDi25904.
MGIiMGI:1926143. Cnot10.

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
GeneTreeiENSGT00390000001827.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ8BH15.
KOiK12607.
OMAiSDQGAEK.
OrthoDBiEOG091G06Q4.
PhylomeDBiQ8BH15.
TreeFamiTF323368.

Enzyme and pathway databases

ReactomeiR-MMU-429947. Deadenylation of mRNA.
R-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

PROiQ8BH15.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056167.
CleanExiMM_CNOT10.
GenevisibleiQ8BH15. MM.

Family and domain databases

Gene3Di1.25.40.10. 7 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCNO10_MOUSE
AccessioniPrimary (citable) accession number: Q8BH15
Secondary accession number(s): Q05CH8
, Q3TSS4, Q3UDS5, Q80VN2, Q8CI74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.