ID   ORAI2_MOUSE             Reviewed;         250 AA.
AC   Q8BH10; Q8C953;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Protein orai-2;
DE   AltName: Full=Transmembrane protein 142B;
GN   Name=Orai2; Synonyms=Tmem142b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC       subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC       current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CRACR2A/EFCAB4B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC31410.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK036013; BAC29276.1; -; mRNA.
DR   EMBL; AK042940; BAC31410.1; ALT_FRAME; mRNA.
DR   EMBL; AK079619; BAC37704.1; -; mRNA.
DR   EMBL; BC066070; AAH66070.1; -; mRNA.
DR   CCDS; CCDS39326.1; -.
DR   RefSeq; NP_848866.2; NM_178751.3.
DR   RefSeq; XP_006504493.1; XM_006504430.3.
DR   RefSeq; XP_006504494.1; XM_006504431.3.
DR   AlphaFoldDB; Q8BH10; -.
DR   SMR; Q8BH10; -.
DR   BioGRID; 234704; 1.
DR   STRING; 10090.ENSMUSP00000037137; -.
DR   TCDB; 1.A.52.1.3; the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.
DR   iPTMnet; Q8BH10; -.
DR   PhosphoSitePlus; Q8BH10; -.
DR   MaxQB; Q8BH10; -.
DR   PaxDb; 10090-ENSMUSP00000037137; -.
DR   ProteomicsDB; 293938; -.
DR   Antibodypedia; 31061; 194 antibodies from 28 providers.
DR   DNASU; 269717; -.
DR   Ensembl; ENSMUST00000041048.6; ENSMUSP00000037137.2; ENSMUSG00000039747.12.
DR   GeneID; 269717; -.
DR   KEGG; mmu:269717; -.
DR   UCSC; uc009aad.2; mouse.
DR   AGR; MGI:2443195; -.
DR   CTD; 80228; -.
DR   MGI; MGI:2443195; Orai2.
DR   VEuPathDB; HostDB:ENSMUSG00000039747; -.
DR   eggNOG; KOG4298; Eukaryota.
DR   GeneTree; ENSGT00390000015354; -.
DR   HOGENOM; CLU_062509_1_1_1; -.
DR   InParanoid; Q8BH10; -.
DR   OMA; SGHTGWQ; -.
DR   OrthoDB; 2905973at2759; -.
DR   PhylomeDB; Q8BH10; -.
DR   TreeFam; TF313576; -.
DR   BioGRID-ORCS; 269717; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Orai2; mouse.
DR   PRO; PR:Q8BH10; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q8BH10; Protein.
DR   Bgee; ENSMUSG00000039747; Expressed in granulocyte and 161 other cell types or tissues.
DR   ExpressionAtlas; Q8BH10; baseline and differential.
DR   GO; GO:0030426; C:growth cone; ISO:MGI.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0002115; P:store-operated calcium entry; IBA:GO_Central.
DR   Gene3D; 1.20.140.140; Calcium release-activated calcium channel protein Orai; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1; 1.
DR   PANTHER; PTHR31501:SF5; PROTEIN ORAI-2; 1.
DR   Pfam; PF07856; Orai-1; 1.
DR   Genevisible; Q8BH10; MM.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..250
FT                   /note="Protein orai-2"
FT                   /id="PRO_0000234392"
FT   TRANSMEM        66..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  28199 MW;  5B9F804800844911 CRC64;
     MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL
     KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC TTVLVAVHLF ALLISTCILP
     NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDAKD
     QPGSHSHTGW QAALVSTIIM VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL
     DGHERSLQVV
//