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Q8BH10

- ORAI2_MOUSE

UniProt

Q8BH10 - ORAI2_MOUSE

Protein

Protein orai-2

Gene

Orai2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.By similarity

    Protein family/group databases

    TCDBi1.A.52.1.3. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein orai-2
    Alternative name(s):
    Transmembrane protein 142B
    Gene namesi
    Name:Orai2
    Synonyms:Tmem142b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2443195. Orai2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. growth cone Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Protein orai-2PRO_0000234392Add
    BLAST

    Proteomic databases

    PRIDEiQ8BH10.

    PTM databases

    PhosphoSiteiQ8BH10.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BH10.
    BgeeiQ8BH10.
    GenevestigatoriQ8BH10.

    Interactioni

    Subunit structurei

    Interacts with CRACR2A/EFCAB4B.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH10.
    SMRiQ8BH10. Positions 48-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Orai family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263788.
    GeneTreeiENSGT00390000015354.
    HOVERGENiHBG081343.
    InParanoidiQ8BH10.
    KOiK16057.
    OMAiPACSEPG.
    OrthoDBiEOG7G1V73.
    TreeFamiTF313576.

    Family and domain databases

    InterProiIPR012446. CRAC_channel.
    [Graphical view]
    PfamiPF07856. Orai-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BH10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW    50
    RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC 100
    TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW 150
    GFSTVLGILL FLAEVVLLCW IKFLPVDAKD QPGSHSHTGW QAALVSTIIM 200
    VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL DGHERSLQVV 250
    Length:250
    Mass (Da):28,199
    Last modified:March 1, 2003 - v1
    Checksum:i5B9F804800844911
    GO

    Sequence cautioni

    The sequence BAC31410.1 differs from that shown. Reason: Frameshift at position 9.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036013 mRNA. Translation: BAC29276.1.
    AK042940 mRNA. Translation: BAC31410.1. Frameshift.
    AK079619 mRNA. Translation: BAC37704.1.
    BC066070 mRNA. Translation: AAH66070.1.
    CCDSiCCDS39326.1.
    RefSeqiNP_848866.2. NM_178751.3.
    XP_006504493.1. XM_006504430.1.
    XP_006504494.1. XM_006504431.1.
    UniGeneiMm.308396.

    Genome annotation databases

    EnsembliENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747.
    GeneIDi269717.
    KEGGimmu:269717.
    UCSCiuc009aad.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036013 mRNA. Translation: BAC29276.1 .
    AK042940 mRNA. Translation: BAC31410.1 . Frameshift.
    AK079619 mRNA. Translation: BAC37704.1 .
    BC066070 mRNA. Translation: AAH66070.1 .
    CCDSi CCDS39326.1.
    RefSeqi NP_848866.2. NM_178751.3.
    XP_006504493.1. XM_006504430.1.
    XP_006504494.1. XM_006504431.1.
    UniGenei Mm.308396.

    3D structure databases

    ProteinModelPortali Q8BH10.
    SMRi Q8BH10. Positions 48-241.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.A.52.1.3. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    PTM databases

    PhosphoSitei Q8BH10.

    Proteomic databases

    PRIDEi Q8BH10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041048 ; ENSMUSP00000037137 ; ENSMUSG00000039747 .
    GeneIDi 269717.
    KEGGi mmu:269717.
    UCSCi uc009aad.2. mouse.

    Organism-specific databases

    CTDi 80228.
    MGIi MGI:2443195. Orai2.

    Phylogenomic databases

    eggNOGi NOG263788.
    GeneTreei ENSGT00390000015354.
    HOVERGENi HBG081343.
    InParanoidi Q8BH10.
    KOi K16057.
    OMAi PACSEPG.
    OrthoDBi EOG7G1V73.
    TreeFami TF313576.

    Miscellaneous databases

    NextBioi 393011.
    PROi Q8BH10.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BH10.
    Bgeei Q8BH10.
    Genevestigatori Q8BH10.

    Family and domain databases

    InterProi IPR012446. CRAC_channel.
    [Graphical view ]
    Pfami PF07856. Orai-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Spinal cord.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiORAI2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH10
    Secondary accession number(s): Q8C953
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3