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Q8BH10 (ORAI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein orai-2
Alternative name(s):
Transmembrane protein 142B
Gene names
Name:Orai2
Synonyms:Tmem142b
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1 By similarity.

Subunit structure

Interacts with EFCAB4B/CRACR2A By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Orai family.

Sequence caution

The sequence BAC31410.1 differs from that shown. Reason: Frameshift at position 9.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Protein orai-2
PRO_0000234392

Regions

Transmembrane66 – 8318Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane192 – 21221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8BH10 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5B9F804800844911

FASTA25028,199
        10         20         30         40         50         60 
MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL 

        70         80         90        100        110        120 
KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC TTVLVAVHLF ALLISTCILP 

       130        140        150        160        170        180 
NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDAKD 

       190        200        210        220        230        240 
QPGSHSHTGW QAALVSTIIM VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL 

       250 
DGHERSLQVV

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Spinal cord.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK036013 mRNA. Translation: BAC29276.1.
AK042940 mRNA. Translation: BAC31410.1. Frameshift.
AK079619 mRNA. Translation: BAC37704.1.
BC066070 mRNA. Translation: AAH66070.1.
IPIIPI00988532.
RefSeqNP_848866.2. NM_178751.3.
UniGeneMm.308396.

3D structure databases

ProteinModelPortalQ8BH10.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BH10.

Protein family/group databases

TCDB1.A.52.1.3. Ca2+ release-activated Ca2+ (CRAC) channel (CRAC-C) family.

Proteomic databases

PRIDEQ8BH10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747.
GeneID269717.
KEGGmmu:269717.

Organism-specific databases

CTD80228.
MGIMGI:2443195. Orai2.

Phylogenomic databases

GeneTreeENSGT00390000015354.
HOVERGENHBG081343.
InParanoidQ8BH10.
OMAPACSEPG.
OrthoDBEOG4DV5MR.
PhylomeDBQ8BH10.

Gene expression databases

ArrayExpressQ8BH10.
BgeeQ8BH10.
GenevestigatorQ8BH10.
GermOnlineENSMUSG00000039747. Mus musculus.

Family and domain databases

InterProIPR012446. CRAC_channel.
[Graphical view]
PfamPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio393011.
SOURCESearch...

Entry information

Entry nameORAI2_MOUSE
AccessionPrimary (citable) accession number: Q8BH10
Secondary accession number(s): Q8C953
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2003
Last modified: September 21, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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