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Protein

Protein orai-2

Gene

Orai2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.By similarity

Protein family/group databases

TCDBi1.A.52.1.3. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
Transmembrane protein 142B
Gene namesi
Name:Orai2
Synonyms:Tmem142b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2443195. Orai2.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8318HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. growth cone Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Protein orai-2PRO_0000234392Add
BLAST

Proteomic databases

MaxQBiQ8BH10.
PRIDEiQ8BH10.

PTM databases

PhosphoSiteiQ8BH10.

Expressioni

Gene expression databases

BgeeiQ8BH10.
ExpressionAtlasiQ8BH10. baseline and differential.
GenevestigatoriQ8BH10.

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BH10.
SMRiQ8BH10. Positions 48-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOVERGENiHBG081343.
InParanoidiQ8BH10.
KOiK16057.
OMAiPACSEPG.
OrthoDBiEOG7G1V73.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030034. Orai-2.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF5. PTHR31501:SF5. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW
60 70 80 90 100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC
110 120 130 140 150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW
160 170 180 190 200
GFSTVLGILL FLAEVVLLCW IKFLPVDAKD QPGSHSHTGW QAALVSTIIM
210 220 230 240 250
VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL DGHERSLQVV
Length:250
Mass (Da):28,199
Last modified:March 1, 2003 - v1
Checksum:i5B9F804800844911
GO

Sequence cautioni

The sequence BAC31410.1 differs from that shown. Reason: Frameshift at position 9. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036013 mRNA. Translation: BAC29276.1.
AK042940 mRNA. Translation: BAC31410.1. Frameshift.
AK079619 mRNA. Translation: BAC37704.1.
BC066070 mRNA. Translation: AAH66070.1.
CCDSiCCDS39326.1.
RefSeqiNP_848866.2. NM_178751.3.
XP_006504493.1. XM_006504430.1.
XP_006504494.1. XM_006504431.1.
UniGeneiMm.308396.

Genome annotation databases

EnsembliENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747.
GeneIDi269717.
KEGGimmu:269717.
UCSCiuc009aad.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036013 mRNA. Translation: BAC29276.1.
AK042940 mRNA. Translation: BAC31410.1. Frameshift.
AK079619 mRNA. Translation: BAC37704.1.
BC066070 mRNA. Translation: AAH66070.1.
CCDSiCCDS39326.1.
RefSeqiNP_848866.2. NM_178751.3.
XP_006504493.1. XM_006504430.1.
XP_006504494.1. XM_006504431.1.
UniGeneiMm.308396.

3D structure databases

ProteinModelPortaliQ8BH10.
SMRiQ8BH10. Positions 48-241.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.A.52.1.3. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

PTM databases

PhosphoSiteiQ8BH10.

Proteomic databases

MaxQBiQ8BH10.
PRIDEiQ8BH10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747.
GeneIDi269717.
KEGGimmu:269717.
UCSCiuc009aad.2. mouse.

Organism-specific databases

CTDi80228.
MGIiMGI:2443195. Orai2.

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOVERGENiHBG081343.
InParanoidiQ8BH10.
KOiK16057.
OMAiPACSEPG.
OrthoDBiEOG7G1V73.
TreeFamiTF313576.

Miscellaneous databases

NextBioi393011.
PROiQ8BH10.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BH10.
ExpressionAtlasiQ8BH10. baseline and differential.
GenevestigatoriQ8BH10.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030034. Orai-2.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF5. PTHR31501:SF5. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiORAI2_MOUSE
AccessioniPrimary (citable) accession number: Q8BH10
Secondary accession number(s): Q8C953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.