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Protein

Interleukin-17 receptor E

Gene

Il17re

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
Gene namesi
Name:Il17re
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1889371. Il17re.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 414391ExtracellularSequence analysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Topological domaini436 – 637202CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mutant animals are born normally at the expected Mendelian frequency. They exhibit much lower expression of genes encoding antibacterial molecules, much greater bacterial burdens and total mortality after infection with Citrobacter rodentium.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 637614Interleukin-17 receptor EPRO_0000309468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BH06.
PaxDbiQ8BH06.
PRIDEiQ8BH06.

PTM databases

PhosphoSiteiQ8BH06.

Expressioni

Tissue specificityi

Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells.4 Publications

Developmental stagei

Expression starts at 10.5 dpc and reaches a plateau of expression at 12.5 dpc.1 Publication

Inductioni

Up-regulated by its own ligand IL17C. Also up-regulated by IL6 and TNF acting synergically. This induction can be further increased by IL23.1 Publication

Gene expression databases

BgeeiQ8BH06.
CleanExiMM_IL17RE.
ExpressionAtlasiQ8BH06. baseline and differential.
GenevisibleiQ8BH06. MM.

Interactioni

Subunit structurei

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Protein-protein interaction databases

IntActiQ8BH06. 2 interactions.
STRINGi10090.ENSMUSP00000062103.

Structurei

3D structure databases

ProteinModelPortaliQ8BH06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini447 – 583137SEFIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOGENOMiHOG000059623.
HOVERGENiHBG102913.
InParanoidiQ8BH06.
KOiK05168.
OMAiQFAWKHL.
OrthoDBiEOG78D7KB.
PhylomeDBiQ8BH06.
TreeFamiTF335690.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BH06-1) [UniParc]FASTAAdd to basket

Also known as: IL-17RE1, IL17RE-S

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPRLAALL LSLPLLLIGL AVSARVACPC LRSWTSHCLL AYRVDKRFAG
60 70 80 90 100
LQWGWFPLLV RKSKSPPKFE DYWRHRTPAS FQRKLLGSPS LSEESHRISI
110 120 130 140 150
PSSAISHRGQ RTKRAQPSAA EGREHLPEAG SQKCGGPEFS FDLLPEVQAV
160 170 180 190 200
RVTIPAGPKA SVRLCYQWAL ECEDLSSPFD TQKIVSGGHT VDLPYEFLLP
210 220 230 240 250
CMCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWQSIRFTD YSQHNQMVMA
260 270 280 290 300
LTLRCPLKLE ASLCWRQDPL TPCETLPNAT AQESEGWYIL ENVDLHPQLC
310 320 330 340 350
FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLTLHFSS RTYATFSAAW
360 370 380 390 400
SDPGLGPDTP MPPVYSISQT QGSVPVTLDL IIPFLRQENC ILVWRSDVHF
410 420 430 440 450
AWKHVLCPDV SHRHLGLLIL ALLALTALVG VVLVLLGRRL LPGSGRTRPV
460 470 480 490 500
LLLHAADSEA QRRLVGALAE LLRTALGGGR DVIVDLWEGT HVARIGPLPW
510 520 530 540 550
LWAARERVAR EQGTVLLLWN CAGPSTACSG DPQAASLRTL LCAAPRPLLL
560 570 580 590 600
AYFSRLCAKG DIPRPLRALP RYRLLRDLPR LLRALDAQPA TLASSWSHLG
610 620 630
AKRCLKNRLE QCHLLELEAA KDDYQGSTNS PCGFSCL
Length:637
Mass (Da):70,833
Last modified:March 1, 2003 - v1
Checksum:i5BFD2AB5128BB758
GO
Isoform 2 (identifier: Q8BH06-2) [UniParc]FASTAAdd to basket

Also known as: IL-17RE2

The sequence of this isoform differs from the canonical sequence as follows:
     410-442: VSHRHLGLLILALLALTALVGVVLVLLGRRLLP → DAPYPTQLLLRSL

Show »
Length:617
Mass (Da):68,809
Checksum:iD83A3D537FD27779
GO
Isoform 3 (identifier: Q8BH06-3) [UniParc]FASTAAdd to basket

Also known as: IL-17RE3

The sequence of this isoform differs from the canonical sequence as follows:
     410-455: Missing.

Show »
Length:591
Mass (Da):65,982
Checksum:i2D4B4980533FF756
GO
Isoform 4 (identifier: Q8BH06-4) [UniParc]FASTAAdd to basket

Also known as: IL-17RE4, IL-17RE5, IL17RE-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Show »
Length:436
Mass (Da):48,574
Checksum:iCAB5DA43BF6D2F56
GO
Isoform 5 (identifier: Q8BH06-5) [UniParc]FASTAAdd to basket

Also known as: IL-17RE6

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.

Show »
Length:311
Mass (Da):34,082
Checksum:iD58E7260BF96BE1F
GO

Sequence cautioni

The sequence BAC37436.1 differs from that shown. Reason: Frameshift at positions 541 and 582. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771T → M in AAH26737 (PubMed:15489334).Curated
Sequence conflicti399 – 3991H → Q in AAH26737 (PubMed:15489334).Curated
Sequence conflicti543 – 5431A → P in BAC37436 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 326326Missing in isoform 5. 2 PublicationsVSP_029197Add
BLAST
Alternative sequencei1 – 201201Missing in isoform 4. 1 PublicationVSP_029198Add
BLAST
Alternative sequencei410 – 45546Missing in isoform 3. 1 PublicationVSP_029199Add
BLAST
Alternative sequencei410 – 44233VSHRH…RRLLP → DAPYPTQLLLRSL in isoform 2. 1 PublicationVSP_029200Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ092339 mRNA. Translation: AAZ85958.1.
DQ092340 mRNA. Translation: AAZ85959.1.
DQ092341 mRNA. Translation: AAZ85960.1.
AF458068 mRNA. Translation: AAM77572.1.
AK046302 mRNA. Translation: BAC32678.1.
AK046713 mRNA. Translation: BAC32842.1.
AK078876 mRNA. Translation: BAC37436.1. Frameshift.
AK169498 mRNA. Translation: BAE41201.1.
BC026737 mRNA. Translation: AAH26737.1.
BC069861 mRNA. Translation: AAH69861.1.
CCDSiCCDS20420.1. [Q8BH06-1]
CCDS20421.1. [Q8BH06-4]
RefSeqiNP_001029201.1. NM_001034029.1. [Q8BH06-4]
NP_001029203.1. NM_001034031.1. [Q8BH06-4]
NP_665825.2. NM_145826.5. [Q8BH06-1]
UniGeneiMm.131781.

Genome annotation databases

EnsembliENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088. [Q8BH06-4]
ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088. [Q8BH06-1]
ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088. [Q8BH06-4]
ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088. [Q8BH06-3]
ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088. [Q8BH06-2]
GeneIDi57890.
KEGGimmu:57890.
UCSCiuc009dgg.1. mouse. [Q8BH06-1]
uc009dgj.1. mouse. [Q8BH06-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ092339 mRNA. Translation: AAZ85958.1.
DQ092340 mRNA. Translation: AAZ85959.1.
DQ092341 mRNA. Translation: AAZ85960.1.
AF458068 mRNA. Translation: AAM77572.1.
AK046302 mRNA. Translation: BAC32678.1.
AK046713 mRNA. Translation: BAC32842.1.
AK078876 mRNA. Translation: BAC37436.1. Frameshift.
AK169498 mRNA. Translation: BAE41201.1.
BC026737 mRNA. Translation: AAH26737.1.
BC069861 mRNA. Translation: AAH69861.1.
CCDSiCCDS20420.1. [Q8BH06-1]
CCDS20421.1. [Q8BH06-4]
RefSeqiNP_001029201.1. NM_001034029.1. [Q8BH06-4]
NP_001029203.1. NM_001034031.1. [Q8BH06-4]
NP_665825.2. NM_145826.5. [Q8BH06-1]
UniGeneiMm.131781.

3D structure databases

ProteinModelPortaliQ8BH06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH06. 2 interactions.
STRINGi10090.ENSMUSP00000062103.

PTM databases

PhosphoSiteiQ8BH06.

Proteomic databases

MaxQBiQ8BH06.
PaxDbiQ8BH06.
PRIDEiQ8BH06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088. [Q8BH06-4]
ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088. [Q8BH06-1]
ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088. [Q8BH06-4]
ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088. [Q8BH06-3]
ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088. [Q8BH06-2]
GeneIDi57890.
KEGGimmu:57890.
UCSCiuc009dgg.1. mouse. [Q8BH06-1]
uc009dgj.1. mouse. [Q8BH06-5]

Organism-specific databases

CTDi132014.
MGIiMGI:1889371. Il17re.

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOGENOMiHOG000059623.
HOVERGENiHBG102913.
InParanoidiQ8BH06.
KOiK05168.
OMAiQFAWKHL.
OrthoDBiEOG78D7KB.
PhylomeDBiQ8BH06.
TreeFamiTF335690.

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Miscellaneous databases

PROiQ8BH06.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BH06.
CleanExiMM_IL17RE.
ExpressionAtlasiQ8BH06. baseline and differential.
GenevisibleiQ8BH06. MM.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway."
    Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.
    Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Identification of novel IL-17 related receptors."
    Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Colon, Corpora quadrigemina and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Strain: C57BL/6J and Czech II.
    Tissue: Mammary tumor and Olfactory epithelium.
  5. "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E."
    Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C.
    Immunity 35:611-621(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY, INDUCTION.
  6. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
    Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
    Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  7. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiI17RE_MOUSE
AccessioniPrimary (citable) accession number: Q8BH06
Secondary accession number(s): Q3I5F0
, Q6NSU9, Q8C5D0, Q8K4C1, Q8R335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.