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Protein

Zinc finger protein 750

Gene

Znf750

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 46C2H2-type; degenerateAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 750
Gene namesi
Name:Znf750
Synonyms:Zfp750
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442210 Zfp750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470711 – 703Zinc finger protein 750Add BLAST703

Proteomic databases

PaxDbiQ8BH05
PRIDEiQ8BH05

PTM databases

PhosphoSitePlusiQ8BH05

Expressioni

Gene expression databases

BgeeiENSMUSG00000039238
CleanExiMM_ZFP750
GenevisibleiQ8BH05 MM

Structurei

3D structure databases

ProteinModelPortaliQ8BH05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 46C2H2-type; degenerateAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF50 Eukaryota
ENOG410ZK89 LUCA
GeneTreeiENSGT00530000063870
HOGENOMiHOG000049178
HOVERGENiHBG080198
InParanoidiQ8BH05
OMAiHYRFFQQ
OrthoDBiEOG091G036R
PhylomeDBiQ8BH05
TreeFamiTF331381

Sequencei

Sequence statusi: Complete.

Q8BH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK
60 70 80 90 100
NSITLVSEQD RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP
110 120 130 140 150
KSQQGSAKED AKENLEMQAR GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG
160 170 180 190 200
VRHSAFVPVG EHRLRGPEDT EATEVLANST TKASSFHAKS AFHTPGYPWK
210 220 230 240 250
AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA EHGLAAIYSP
260 270 280 290 300
YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
310 320 330 340 350
QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP
360 370 380 390 400
ASSPSELNLS SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS
410 420 430 440 450
AATGSPGRPS PTNFTQTSQT FEGLCDLSNK AASSGTLERL QQAEQSPTAF
460 470 480 490 500
KPVQRGSESP HSQPPANRTE SPKSLQAMNG DPPAQTGSSN SFITEAPPSS
510 520 530 540 550
PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL PLNLSVKDLC
560 570 580 590 600
NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
610 620 630 640 650
VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS
660 670 680 690 700
ATENLEAQCD LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT

RVS
Length:703
Mass (Da):76,645
Last modified:March 1, 2003 - v1
Checksum:i5C93367C6595BD8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131L → Q in BAC27080 (PubMed:16141072).Curated1
Sequence conflicti421F → L in BAC27080 (PubMed:16141072).Curated1
Sequence conflicti638V → A in AAI50906 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030690 mRNA Translation: BAC27080.1
AK037185 mRNA Translation: BAC29743.1
AK037240 mRNA Translation: BAC29771.1
AL663088 Genomic DNA No translation available.
BC150905 mRNA Translation: AAI50906.1
CCDSiCCDS25779.1
RefSeqiNP_848878.1, NM_178763.4
UniGeneiMm.11395

Genome annotation databases

EnsembliENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238
GeneIDi319530
KEGGimmu:319530
UCSCiuc007mvz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZN750_MOUSE
AccessioniPrimary (citable) accession number: Q8BH05
Secondary accession number(s): B1ATU1
, B9EKG8, Q66JP3, Q8C0L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health