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Protein

Zinc finger protein 750

Gene

Znf750

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4622C2H2-type; degenerateAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 750
Gene namesi
Name:Znf750
Synonyms:Zfp750
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442210. Zfp750.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Zinc finger protein 750PRO_0000247071Add
BLAST

Proteomic databases

PaxDbiQ8BH05.
PRIDEiQ8BH05.

PTM databases

PhosphoSiteiQ8BH05.

Expressioni

Gene expression databases

BgeeiQ8BH05.
CleanExiMM_ZFP750.
GenevisibleiQ8BH05. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089951.

Structurei

3D structure databases

ProteinModelPortaliQ8BH05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4622C2H2-type; degenerateAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF50. Eukaryota.
ENOG410ZK89. LUCA.
GeneTreeiENSGT00530000063870.
HOGENOMiHOG000049178.
HOVERGENiHBG080198.
InParanoidiQ8BH05.
OMAiHYRFFQQ.
OrthoDBiEOG7G1V5J.
PhylomeDBiQ8BH05.
TreeFamiTF331381.

Sequencei

Sequence statusi: Complete.

Q8BH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK
60 70 80 90 100
NSITLVSEQD RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP
110 120 130 140 150
KSQQGSAKED AKENLEMQAR GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG
160 170 180 190 200
VRHSAFVPVG EHRLRGPEDT EATEVLANST TKASSFHAKS AFHTPGYPWK
210 220 230 240 250
AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA EHGLAAIYSP
260 270 280 290 300
YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
310 320 330 340 350
QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP
360 370 380 390 400
ASSPSELNLS SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS
410 420 430 440 450
AATGSPGRPS PTNFTQTSQT FEGLCDLSNK AASSGTLERL QQAEQSPTAF
460 470 480 490 500
KPVQRGSESP HSQPPANRTE SPKSLQAMNG DPPAQTGSSN SFITEAPPSS
510 520 530 540 550
PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL PLNLSVKDLC
560 570 580 590 600
NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
610 620 630 640 650
VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS
660 670 680 690 700
ATENLEAQCD LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT

RVS
Length:703
Mass (Da):76,645
Last modified:March 1, 2003 - v1
Checksum:i5C93367C6595BD8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311L → Q in BAC27080 (PubMed:16141072).Curated
Sequence conflicti421 – 4211F → L in BAC27080 (PubMed:16141072).Curated
Sequence conflicti638 – 6381V → A in AAI50906 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030690 mRNA. Translation: BAC27080.1.
AK037185 mRNA. Translation: BAC29743.1.
AK037240 mRNA. Translation: BAC29771.1.
AL663088 Genomic DNA. Translation: CAM19958.1.
BC150905 mRNA. Translation: AAI50906.1.
CCDSiCCDS25779.1.
RefSeqiNP_848878.1. NM_178763.4.
UniGeneiMm.11395.

Genome annotation databases

EnsembliENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238.
GeneIDi319530.
KEGGimmu:319530.
UCSCiuc007mvz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030690 mRNA. Translation: BAC27080.1.
AK037185 mRNA. Translation: BAC29743.1.
AK037240 mRNA. Translation: BAC29771.1.
AL663088 Genomic DNA. Translation: CAM19958.1.
BC150905 mRNA. Translation: AAI50906.1.
CCDSiCCDS25779.1.
RefSeqiNP_848878.1. NM_178763.4.
UniGeneiMm.11395.

3D structure databases

ProteinModelPortaliQ8BH05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089951.

PTM databases

PhosphoSiteiQ8BH05.

Proteomic databases

PaxDbiQ8BH05.
PRIDEiQ8BH05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238.
GeneIDi319530.
KEGGimmu:319530.
UCSCiuc007mvz.2. mouse.

Organism-specific databases

CTDi319530.
MGIiMGI:2442210. Zfp750.

Phylogenomic databases

eggNOGiENOG410IF50. Eukaryota.
ENOG410ZK89. LUCA.
GeneTreeiENSGT00530000063870.
HOGENOMiHOG000049178.
HOVERGENiHBG080198.
InParanoidiQ8BH05.
OMAiHYRFFQQ.
OrthoDBiEOG7G1V5J.
PhylomeDBiQ8BH05.
TreeFamiTF331381.

Miscellaneous databases

NextBioi394924.
PROiQ8BH05.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BH05.
CleanExiMM_ZFP750.
GenevisibleiQ8BH05. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN750_MOUSE
AccessioniPrimary (citable) accession number: Q8BH05
Secondary accession number(s): B1ATU1
, B9EKG8, Q66JP3, Q8C0L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.