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Protein
Submitted name:

Lef1 protein

Gene

Lef1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi269 – 337HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Lef1 proteinImported
Submitted name:
Lymphoid enhancer binding factor 1, isoform CRA_cImported
Submitted name:
Lymphoid enhancer-binding factor 1Imported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lef1Imported
ORF Names:mCG_10208Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96770. Lef1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ8BGZ9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027985.
ExpressionAtlasiQ8BGZ9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ9.
SMRiQ8BGZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 337HMG box DNA-bindingInterPro annotationAdd BLAST69

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.
KOiK04492.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR028769. LEF1.
IPR024940. TCF/LEF.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF43. PTHR10373:SF43. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLSGGGGG GDPELCATDE MIPFKDEGDP QKEKIFAEIS HPEEEGDLAD
60 70 80 90 100
IKSSLVNESE IIPASNGHEV VRQAPSSQEP YHDKAREHPD EGKHPDGGLY
110 120 130 140 150
NKGPSYSSYS GYIMMPNMNS DPYMSNGSLS PPIPRTSNKV PVVQPSHAVH
160 170 180 190 200
PLTPLITYSD EHFSPGSHPS HIPSDVNSKQ GMSRHPPAPE IPTFYPLSPG
210 220 230 240 250
GVGQITPPIG WFSHHMIPGP PGPHTTGIPH PAIVTPQVKQ EHPHTDSDLM
260 270 280 290 300
HVKPQHEQRK EQEPKRPHIK KPLNAFMLYM KEMRANVVAE CTLKESAAIN
310 320 330 340 350
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKKRKR
360 370 380
EKLQESTSGG KRSSFPTCKA KAATPGPLLE MEAC
Length:384
Mass (Da):42,576
Last modified:March 1, 2003 - v1
Checksum:i5E9313F72287ECCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
BC057543 mRNA. Translation: AAH57543.1.
AK028246 mRNA. Translation: BAC25837.1.
AK034819 mRNA. Translation: BAC28841.1.
CH466532 Genomic DNA. Translation: EDL12206.1.
RefSeqiNP_001263331.1. NM_001276402.1.
NP_001263332.1. NM_001276403.1.
NP_034833.2. NM_010703.4.
UniGeneiMm.255219.

Genome annotation databases

EnsembliENSMUST00000106341; ENSMUSP00000101948; ENSMUSG00000027985.
GeneIDi16842.
KEGGimmu:16842.
UCSCiuc008rjg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114668 Genomic DNA. No translation available.
AC123634 Genomic DNA. No translation available.
BC057543 mRNA. Translation: AAH57543.1.
AK028246 mRNA. Translation: BAC25837.1.
AK034819 mRNA. Translation: BAC28841.1.
CH466532 Genomic DNA. Translation: EDL12206.1.
RefSeqiNP_001263331.1. NM_001276402.1.
NP_001263332.1. NM_001276403.1.
NP_034833.2. NM_010703.4.
UniGeneiMm.255219.

3D structure databases

ProteinModelPortaliQ8BGZ9.
SMRiQ8BGZ9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ8BGZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106341; ENSMUSP00000101948; ENSMUSG00000027985.
GeneIDi16842.
KEGGimmu:16842.
UCSCiuc008rjg.2. mouse.

Organism-specific databases

CTDi51176.
MGIiMGI:96770. Lef1.

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.
KOiK04492.

Miscellaneous databases

ChiTaRSiLef1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027985.
ExpressionAtlasiQ8BGZ9. baseline and differential.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR028769. LEF1.
IPR024940. TCF/LEF.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF43. PTHR10373:SF43. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8BGZ9_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 12, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.