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Protein

Zona pellucida-like domain-containing protein 1

Gene

Zpld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-like domain-containing protein 1
Short name:
ZP domain-containing protein 1
Alternative name(s):
CupulinBy similarity
Cleaved into the following chain:
Zona pellucida-like domain-containing protein 1, secreted formBy similarity
Gene namesi
Name:Zpld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443415. Zpld1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 373ExtracellularSequence analysisAdd BLAST354
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 415CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030728620 – 415Zona pellucida-like domain-containing protein 1Add BLAST396
ChainiPRO_000044181620 – 319Zona pellucida-like domain-containing protein 1, secreted formCuratedAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 155By similarity
Disulfide bondi79 ↔ 104By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 296By similarity
Disulfide bondi255 ↔ 313By similarity

Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted form found in the extracellular matrix of the cupula.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei319 – 320CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BGZ8.
PRIDEiQ8BGZ8.

PTM databases

iPTMnetiQ8BGZ8.
PhosphoSitePlusiQ8BGZ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064310.
CleanExiMM_ZPLD1.

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 320ZPPROSITE-ProRule annotationAdd BLAST278

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGW3. Eukaryota.
ENOG411153Y. LUCA.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000136343.
HOVERGENiHBG108778.
InParanoidiQ8BGZ8.
OMAiRDINVYC.
OrthoDBiEOG091G06ZH.
PhylomeDBiQ8BGZ8.
TreeFamiTF330284.

Family and domain databases

InterProiView protein in InterPro
IPR001507. ZP_dom.
PfamiView protein in Pfam
PF00100. Zona_pellucida. 1 hit.
SMARTiView protein in SMART
SM00241. ZP. 1 hit.
PROSITEiView protein in PROSITE
PS51034. ZP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVWLLFLL AIRVSPGSAQ FNSYNCDANL HSRFPAERDI SVYCGVQAIT
60 70 80 90 100
MKINFCTVLF SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST
110 120 130 140 150
LEGCGNNLVV STIPGVGASG NATTVQIGNI SGYIDTPDPP AVISYLPGLL
160 170 180 190 200
YKFSCSYPLE YLVNNTQLAS SSAAISVREN NGTFVSTLNL LLYNDSTYRE
210 220 230 240 250
QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS GNPNDDTRYD
260 270 280 290 300
LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCLTKL
310 320 330 340 350
CRADDCPLLM PICGNRKRRD AQSWTTWAPQ STSGNAVLSA GPIITRSDET
360 370 380 390 400
PTNNSQLGSL SVPPFQLNAV TSSLISGMVI LGVLCFSLLL CSLALLHRKG
410
STSLVLNGVR NPVFE
Length:415
Mass (Da):45,448
Last modified:March 1, 2003 - v1
Checksum:i5ED1871A4E257CA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358G → V in AAI16255 (PubMed:15489334).Curated1
Sequence conflicti408G → A in AAI16255 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034628 mRNA. Translation: BAC28777.1.
AK047981 mRNA. Translation: BAC33205.1.
AK052599 mRNA. Translation: BAC35056.1.
BC116254 mRNA. Translation: AAI16255.1.
BC116255 mRNA. Translation: AAI16256.1.
CCDSiCCDS28215.1.
RefSeqiNP_848835.1. NM_178720.4.
XP_006522195.1. XM_006522132.2.
UniGeneiMm.245045.

Genome annotation databases

EnsembliENSMUST00000036412; ENSMUSP00000049012; ENSMUSG00000064310.
ENSMUST00000143914; ENSMUSP00000119774; ENSMUSG00000064310.
GeneIDi239852.
KEGGimmu:239852.
UCSCiuc007zlk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZPLD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ8
Secondary accession number(s): Q14BA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot