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Protein

Keratin, type II cytoskeletal 75

Gene

Krt75

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei401 – 4011Stutter

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 75
Alternative name(s):
Cytokeratin-75
Short name:
CK-75
Keratin-6 hair follicle
Short name:
mK6hf
Keratin-75
Short name:
K75
Type II keratin-K6hf
Type-II keratin Kb18
Gene namesi
Name:Krt75
Synonyms:Kb18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1923500. Krt75.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • intermediate filament Source: MGI
  • intracellular Source: MGI
  • keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi159 – 1591Missing : Mice develop hair and nail defects resembling pachyonychia congenita. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Keratin, type II cytoskeletal 75PRO_0000314888Add
BLAST

Proteomic databases

MaxQBiQ8BGZ7.
PaxDbiQ8BGZ7.
PRIDEiQ8BGZ7.

PTM databases

iPTMnetiQ8BGZ7.
PhosphoSiteiQ8BGZ7.

Expressioni

Tissue specificityi

Expressed in the companion layer and upper germinative matrix region of the hair follicle and the medulla of the hair shaft. Also expressed in epithelia of the nail bed and fungiform papillae of dorsal tongue epithelium (at protein level).3 Publications

Gene expression databases

BgeeiQ8BGZ7.
CleanExiMM_KRT75.
GenevisibleiQ8BGZ7. MM.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17.By similarity

Protein-protein interaction databases

IntActiQ8BGZ7. 1 interaction.
STRINGi10090.ENSMUSP00000036246.

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ7.
SMRiQ8BGZ7. Positions 147-289, 316-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 149149HeadAdd
BLAST
Regioni150 – 459310RodAdd
BLAST
Regioni150 – 18536Coil 1AAdd
BLAST
Regioni186 – 20419Linker 1Add
BLAST
Regioni205 – 29793Coil 1BAdd
BLAST
Regioni298 – 32023Linker 12Add
BLAST
Regioni321 – 459139Coil 2Add
BLAST
Regioni460 – 55192TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 12183Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ8BGZ7.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8BGZ7.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSTITFH SGSRRGFSTA SATTPTAGRS RFSSVSVARS SGNSGGLGRI
60 70 80 90 100
SGIGSGFGSR SLYNLGGTRR VSIGGCAGSG FRGGFGGRTS SGFGGSSGFA
110 120 130 140 150
YGGGIGGGFG GPGFSVCPSG GIQEVTVNQS LLTPLNLQID PTIQRVRKEE
160 170 180 190 200
REQIKTLNNK FASFIDKVRF LEQQNKVLET KWNLLQEQGS RTVRQNLEPF
210 220 230 240 250
FDTYVNDLRR QLDGITAERG RLDAELRNMQ EVVEDFKVRY EDEINKRAAA
260 270 280 290 300
ENEFVGLKKD VDSAYMNKVE LEAKVDSLTD QINFYRMIYE AELSQMQNQV
310 320 330 340 350
SDTSVVLSMD NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYEEL
360 370 380 390 400
QVTAGRHGDD LRNTKQEISE MNRMIQRLRS EIDAVKKQCS SLQTAISDAE
410 420 430 440 450
QRGELALKDA RAKLMELEDA LQKAKQDMAR LLREYQELMN VKLALDVEIA
460 470 480 490 500
TYRKLLEGEE CRLSGEGVSP VNISVVTSTV SSGYGGGANI GGGSLGLGGN
510 520 530 540 550
SGYSFTTSGG HSLGTGLGGS GFTTTSSRGP VGSGSSIKFV SSTSSRKSYK

H
Length:551
Mass (Da):59,741
Last modified:March 1, 2003 - v1
Checksum:i5EFF6DE17985D4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028972 mRNA. Translation: BAC26221.1.
AK037233 mRNA. Translation: BAC29769.1.
AK076367 mRNA. Translation: BAC36315.1.
BC137935 mRNA. Translation: AAI37936.1.
BC137936 mRNA. Translation: AAI37937.1.
CCDSiCCDS27856.1.
RefSeqiNP_579935.1. NM_133357.3.
UniGeneiMm.106868.

Genome annotation databases

EnsembliENSMUST00000042957; ENSMUSP00000036246; ENSMUSG00000022986.
GeneIDi109052.
KEGGimmu:109052.
UCSCiuc007xtp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028972 mRNA. Translation: BAC26221.1.
AK037233 mRNA. Translation: BAC29769.1.
AK076367 mRNA. Translation: BAC36315.1.
BC137935 mRNA. Translation: AAI37936.1.
BC137936 mRNA. Translation: AAI37937.1.
CCDSiCCDS27856.1.
RefSeqiNP_579935.1. NM_133357.3.
UniGeneiMm.106868.

3D structure databases

ProteinModelPortaliQ8BGZ7.
SMRiQ8BGZ7. Positions 147-289, 316-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BGZ7. 1 interaction.
STRINGi10090.ENSMUSP00000036246.

PTM databases

iPTMnetiQ8BGZ7.
PhosphoSiteiQ8BGZ7.

Proteomic databases

MaxQBiQ8BGZ7.
PaxDbiQ8BGZ7.
PRIDEiQ8BGZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042957; ENSMUSP00000036246; ENSMUSG00000022986.
GeneIDi109052.
KEGGimmu:109052.
UCSCiuc007xtp.1. mouse.

Organism-specific databases

CTDi9119.
MGIiMGI:1923500. Krt75.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ8BGZ7.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8BGZ7.
TreeFamiTF317854.

Miscellaneous databases

NextBioi361608.
PROiQ8BGZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGZ7.
CleanExiMM_KRT75.
GenevisibleiQ8BGZ7. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b."
    Wojcik S.M., Longley M.A., Roop D.R.
    J. Cell Biol. 154:619-630(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles."
    Wang Z., Wong P., Langbein L., Schweizer J., Coulombe P.A.
    J. Invest. Dermatol. 121:1276-1282(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita."
    Chen J., Jaeger K., Den Z., Koch P.J., Sundberg J.P., Roop D.R.
    J. Invest. Dermatol. 128:270-279(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ASN-159.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK2C75_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ7
Secondary accession number(s): B2RQH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Its presence in surviving mice lacking Krt6a and Krt6b, may explain the absence of hair and nail defects in such mice.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.