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Protein
Submitted name:

Alpha-galactosidase A

Gene

Gla

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiGH27. Glycoside Hydrolase Family 27.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-galactosidase AImported
Gene namesi
Name:GlaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1347344. Gla.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000031266.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 413Melibiase_2_CInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2366. Eukaryota.
ENOG410XPF1. LUCA.
GeneTreeiENSGT00390000008751.
HOVERGENiHBG001989.
KOiK01189.
OMAiLAMTPTM.
OrthoDBiEOG091G0BGV.
TreeFamiTF312909.

Family and domain databases

CDDicd14792. GH27. 1 hit.
Gene3Di3.20.20.70. 2 hits.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_27/36_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR035373. Melibiase/NAGA_C.
PfamiView protein in Pfam
PF16499. Melibiase_2. 1 hit.
PF17450. Melibiase_2_C. 1 hit.
PRINTSiPR00740. GLHYDRLASE27.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00512. ALPHA_GALACTOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMKLLSRDT RLVCELALCP LALVFWSILG VRALDNGLAR TPTMGWLHWE
60 70 80 90 100
RFMCNLDCQE EPDACISEQL FMQMAELMVS DGWRDAGYDY LCIDDCWMAP
110 120 130 140 150
ERDSKGRLQA DPQRFPSGIK HLANYVHSKG LKLGIYADVG NKTCAGFPGS
160 170 180 190 200
FGSYDIDAQT FADWGVDLLK FDGCHCDSVV SLENGYKYMA LALNRTGRSI
210 220 230 240 250
VYSCEWPLYL RPFHKPNYTD IQYYCNHWRN FDDVYDSWES IKNILSWTVV
260 270 280 290 300
YQKEIVEVAG PGSWNDPDML VIGNFGLSWD QQVTQMALWA IMAAPLLMSN
310 320 330 340 350
DLRQISSQAK ALLQNKDVIA INQDPLGKQG YCFRKENHIE VWERPLSNLA
360 370 380 390 400
WAVAVRNLQE IGGPCPYTIQ ISSLGRGLAC NPGCIITQLL PEKVHLGFYE
410 420
WTLTLKTRVN PSGTVLFRLE R
Length:421
Mass (Da):47,845
Last modified:March 1, 2003 - v1
Checksum:i5F66772334014B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004852 Genomic DNA. No translation available.
AK040081 mRNA. Translation: BAC30508.1.
AK054547 mRNA. Translation: BAC35819.1.
AK164231 mRNA. Translation: BAE37692.1.
RefSeqiNP_038491.2. NM_013463.2.
UniGeneiMm.1114.

Genome annotation databases

EnsembliENSMUST00000033621; ENSMUSP00000033621; ENSMUSG00000031266.
GeneIDi11605.
KEGGimmu:11605.
UCSCiuc009ugg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ8BGZ6_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported