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Protein

DDB1- and CUL4-associated factor 12

Gene

Dcaf12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 12
Alternative name(s):
WD repeat-containing protein 40A
Gene namesi
Name:Dcaf12
Synonyms:Kiaa1892, Wdr40a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916220. Dcaf12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068421 – 453DDB1- and CUL4-associated factor 12Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BGZ3.
PaxDbiQ8BGZ3.
PeptideAtlasiQ8BGZ3.
PRIDEiQ8BGZ3.

PTM databases

iPTMnetiQ8BGZ3.
PhosphoSitePlusiQ8BGZ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028436.
CleanExiMM_WDR40A.
GenevisibleiQ8BGZ3. MM.

Interactioni

Subunit structurei

Interacts with DDB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030145.

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 178WD 1Add BLAST41
Repeati182 – 220WD 2Add BLAST39
Repeati250 – 289WD 3Add BLAST40
Repeati338 – 375WD 4Add BLAST38

Sequence similaritiesi

Belongs to the WD repeat DCAF12 family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IGRG. Eukaryota.
ENOG410XTH6. LUCA.
GeneTreeiENSGT00390000001132.
HOGENOMiHOG000047356.
HOVERGENiHBG055605.
InParanoidiQ8BGZ3.
KOiK11803.
OMAiYNCKVRA.
OrthoDBiEOG091G05P2.
PhylomeDBiQ8BGZ3.
TreeFamiTF323731.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKAVSRKR KASASPGAGS DAQGPQFGWD HSLHKRKRLP PVKRSLVYYL
60 70 80 90 100
KNREVRLQNE TSYSRLLHGY AAQQLPSLLK EREFHLGTLN KVFASQWLNH
110 120 130 140 150
RQVVCGTKCN TLFVVDVQTG QITKIPILKD REPGGVTQQG CGIHAIELNP
160 170 180 190 200
SRTLLATGGD NPNSLAIYRL PTLDPVCVGD DGHKDWIFSI AWINDTMAVS
210 220 230 240 250
GSRDGSMGLW EVTDDVLTKS DARHNVSPVP VYAHITHKAL KDIPKEDTNP
260 270 280 290 300
DNCKVRALAF NNKNKELGAV SLDGYFHLWK AENTLSKLLS TKLPYCRENV
310 320 330 340 350
CLAYGSEWSV YAVGSQAHVS FLDPRQPSYN VKSVCSRERG SGIRSVSFYE
360 370 380 390 400
HIITVGTGQG SLLFYDIRAQ RFLEERLSAC YGSKPRLAGE NLKLTTGRGW
410 420 430 440 450
LNHDETWRNY FSDIDFFPNA VYTHCYDSSG TKLFVAGGPL PSGLHGNYAG

LWS
Length:453
Mass (Da):50,459
Last modified:March 1, 2003 - v1
Checksum:i60212662F05FAB7A
GO

Sequence cautioni

The sequence BAC39908 differs from that shown. Reason: Frameshift at position 116.Curated
The sequence BAD32567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44R → S in BAD32567 (PubMed:15368895).Curated1
Sequence conflicti294P → A in BAC39908 (PubMed:16141072).Curated1
Sequence conflicti375E → G in BAC41053 (PubMed:16141072).Curated1
Sequence conflicti438G → P in BAB23817 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173289 mRNA. Translation: BAD32567.1. Different initiation.
AK005099 mRNA. Translation: BAB23817.2.
AK030173 mRNA. Translation: BAC26822.1.
AK031089 mRNA. Translation: BAC27247.1.
AK087517 mRNA. Translation: BAC39908.1. Frameshift.
AK090028 mRNA. Translation: BAC41053.1.
AL807823 Genomic DNA. Translation: CAM20984.1.
BC023852 mRNA. Translation: AAH23852.1.
CCDSiCCDS18059.1.
RefSeqiNP_081169.2. NM_026893.3.
UniGeneiMm.28891.

Genome annotation databases

EnsembliENSMUST00000030145; ENSMUSP00000030145; ENSMUSG00000028436.
GeneIDi68970.
KEGGimmu:68970.
UCSCiuc008sil.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173289 mRNA. Translation: BAD32567.1. Different initiation.
AK005099 mRNA. Translation: BAB23817.2.
AK030173 mRNA. Translation: BAC26822.1.
AK031089 mRNA. Translation: BAC27247.1.
AK087517 mRNA. Translation: BAC39908.1. Frameshift.
AK090028 mRNA. Translation: BAC41053.1.
AL807823 Genomic DNA. Translation: CAM20984.1.
BC023852 mRNA. Translation: AAH23852.1.
CCDSiCCDS18059.1.
RefSeqiNP_081169.2. NM_026893.3.
UniGeneiMm.28891.

3D structure databases

ProteinModelPortaliQ8BGZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030145.

PTM databases

iPTMnetiQ8BGZ3.
PhosphoSitePlusiQ8BGZ3.

Proteomic databases

EPDiQ8BGZ3.
PaxDbiQ8BGZ3.
PeptideAtlasiQ8BGZ3.
PRIDEiQ8BGZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030145; ENSMUSP00000030145; ENSMUSG00000028436.
GeneIDi68970.
KEGGimmu:68970.
UCSCiuc008sil.2. mouse.

Organism-specific databases

CTDi25853.
MGIiMGI:1916220. Dcaf12.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGRG. Eukaryota.
ENOG410XTH6. LUCA.
GeneTreeiENSGT00390000001132.
HOGENOMiHOG000047356.
HOVERGENiHBG055605.
InParanoidiQ8BGZ3.
KOiK11803.
OMAiYNCKVRA.
OrthoDBiEOG091G05P2.
PhylomeDBiQ8BGZ3.
TreeFamiTF323731.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiDcaf12. mouse.
PROiQ8BGZ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028436.
CleanExiMM_WDR40A.
GenevisibleiQ8BGZ3. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCA12_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ3
Secondary accession number(s): Q69Z77
, Q8BN60, Q8C1Y4, Q9DB95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.