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Protein

Protein FAM168A

Gene

Fam168a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM168A
Gene namesi
Name:Fam168a
Synonyms:Kiaa0280
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442372. Fam168a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507431 – 244Protein FAM168AAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei102Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ8BGZ2.
PRIDEiQ8BGZ2.

PTM databases

iPTMnetiQ8BGZ2.
PhosphoSitePlusiQ8BGZ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029461.
ExpressionAtlasiQ8BGZ2. baseline and differential.
GenevisibleiQ8BGZ2. MM.

Interactioni

Subunit structurei

Interacts with POLB. Interacts with AKT1 and MT1X. May interact with FAM168B.By similarity

Protein-protein interaction databases

IntActiQ8BGZ2. 1 interactor.
STRINGi10090.ENSMUSP00000038233.

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ2.
SMRiQ8BGZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Phylogenomic databases

eggNOGiENOG410IHUV. Eukaryota.
ENOG410XR79. LUCA.
GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ8BGZ2.
PhylomeDBiQ8BGZ2.
TreeFamiTF331128.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP
60 70 80 90 100
EFQFLHSAYA TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA
110 120 130 140 150
FRYTAGTPYK VPPTQSNTAP PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG
160 170 180 190 200
AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI YPAPVAAPRT NGVAMGMVAG
210 220 230 240
TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV PPHW
Length:244
Mass (Da):26,184
Last modified:March 1, 2003 - v1
Checksum:i60E3E9621665D30C
GO
Isoform 2 (identifier: Q8BGZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.

Show »
Length:235
Mass (Da):25,061
Checksum:i8236A41DEBEAC93D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79 – 83GTFHL → RHLPP in BAC65517 (PubMed:12693553).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01009651 – 59Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043083 mRNA. Translation: BAC31453.1.
AK047153 mRNA. Translation: BAC32972.1.
AK048559 mRNA. Translation: BAC33374.1.
AK051453 mRNA. Translation: BAC34646.1.
AK137424 mRNA. Translation: BAE23348.1.
BC076580 mRNA. Translation: AAH76580.1.
AK122235 mRNA. Translation: BAC65517.1.
CCDSiCCDS21505.1. [Q8BGZ2-2]
RefSeqiNP_848879.1. NM_178764.3. [Q8BGZ2-2]
XP_006507982.1. XM_006507919.2. [Q8BGZ2-1]
XP_006507983.1. XM_006507920.2. [Q8BGZ2-1]
XP_006507985.1. XM_006507922.2. [Q8BGZ2-2]
UniGeneiMm.260362.

Genome annotation databases

EnsembliENSMUST00000049053; ENSMUSP00000038233; ENSMUSG00000029461. [Q8BGZ2-2]
ENSMUST00000107042; ENSMUSP00000102657; ENSMUSG00000029461. [Q8BGZ2-1]
ENSMUST00000207875; ENSMUSP00000146851; ENSMUSG00000029461. [Q8BGZ2-2]
GeneIDi319604.
KEGGimmu:319604.
UCSCiuc009inr.1. mouse. [Q8BGZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043083 mRNA. Translation: BAC31453.1.
AK047153 mRNA. Translation: BAC32972.1.
AK048559 mRNA. Translation: BAC33374.1.
AK051453 mRNA. Translation: BAC34646.1.
AK137424 mRNA. Translation: BAE23348.1.
BC076580 mRNA. Translation: AAH76580.1.
AK122235 mRNA. Translation: BAC65517.1.
CCDSiCCDS21505.1. [Q8BGZ2-2]
RefSeqiNP_848879.1. NM_178764.3. [Q8BGZ2-2]
XP_006507982.1. XM_006507919.2. [Q8BGZ2-1]
XP_006507983.1. XM_006507920.2. [Q8BGZ2-1]
XP_006507985.1. XM_006507922.2. [Q8BGZ2-2]
UniGeneiMm.260362.

3D structure databases

ProteinModelPortaliQ8BGZ2.
SMRiQ8BGZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BGZ2. 1 interactor.
STRINGi10090.ENSMUSP00000038233.

PTM databases

iPTMnetiQ8BGZ2.
PhosphoSitePlusiQ8BGZ2.

Proteomic databases

PaxDbiQ8BGZ2.
PRIDEiQ8BGZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049053; ENSMUSP00000038233; ENSMUSG00000029461. [Q8BGZ2-2]
ENSMUST00000107042; ENSMUSP00000102657; ENSMUSG00000029461. [Q8BGZ2-1]
ENSMUST00000207875; ENSMUSP00000146851; ENSMUSG00000029461. [Q8BGZ2-2]
GeneIDi319604.
KEGGimmu:319604.
UCSCiuc009inr.1. mouse. [Q8BGZ2-1]

Organism-specific databases

CTDi23201.
MGIiMGI:2442372. Fam168a.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHUV. Eukaryota.
ENOG410XR79. LUCA.
GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ8BGZ2.
PhylomeDBiQ8BGZ2.
TreeFamiTF331128.

Miscellaneous databases

ChiTaRSiFam168a. mouse.
PROiQ8BGZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029461.
ExpressionAtlasiQ8BGZ2. baseline and differential.
GenevisibleiQ8BGZ2. MM.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF168A_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ2
Secondary accession number(s): Q3UVC2, Q80U50, Q8BGN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.