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Protein

Hippocalcin-like protein 4

Gene

Hpcal4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.By similarity

Miscellaneous

Probably binds two or three calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi159 – 1703PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 4
Alternative name(s):
Neural visinin-like protein 2
Short name:
NVP-2
Gene namesi
Name:Hpcal4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2157521 Hpcal4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737782 – 191Hippocalcin-like protein 4Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ8BGZ1
PaxDbiQ8BGZ1
PRIDEiQ8BGZ1

PTM databases

iPTMnetiQ8BGZ1
PhosphoSitePlusiQ8BGZ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000046093
CleanExiMM_HPCAL4
ExpressionAtlasiQ8BGZ1 baseline and differential
GenevisibleiQ8BGZ1 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BGZ1, 1 interactor
MINTiQ8BGZ1
STRINGi10090.ENSMUSP00000051487

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ1
SMRiQ8BGZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 59EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini146 – 181EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiQ8BGZ1
OMAiCDIDLYK
OrthoDBiEOG091G11T4
PhylomeDBiQ8BGZ1
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029534 VILIP-2
PANTHERiPTHR23055:SF84 PTHR23055:SF84, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKNNSKLAP EVLEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ
60 70 80 90 100
LYIKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK
110 120 130 140 150
LNWAFEMYDL DGDGRITRLE MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR
160 170 180 190
VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS IVLLLQCDMQ K
Length:191
Mass (Da):22,215
Last modified:January 23, 2007 - v3
Checksum:i60E513B9FEA75662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079893 mRNA Translation: BAC16230.1
AK032591 mRNA Translation: BAC27938.1
CCDSiCCDS18611.1
RefSeqiNP_778163.1, NM_174998.4
UniGeneiMm.270641

Genome annotation databases

EnsembliENSMUST00000059667; ENSMUSP00000051487; ENSMUSG00000046093
ENSMUST00000106246; ENSMUSP00000101853; ENSMUSG00000046093
GeneIDi170638
KEGGimmu:170638
UCSCiuc008uox.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHPCL4_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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