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Protein

Eukaryotic translation initiation factor 5A-2

Gene

Eif5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

mRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-204626. Hypusine synthesis from eIF5A-lysine.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-2
Short name:
eIF-5A-2
Short name:
eIF-5A2
Alternative name(s):
Eukaryotic initiation factor 5A isoform 2
Gene namesi
Name:Eif5a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933735. Eif5a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 153152Eukaryotic translation initiation factor 5A-2PRO_0000229765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei50 – 501HypusineBy similarity

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

MaxQBiQ8BGY2.
PaxDbiQ8BGY2.
PeptideAtlasiQ8BGY2.
PRIDEiQ8BGY2.

PTM databases

iPTMnetiQ8BGY2.
PhosphoSiteiQ8BGY2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050192.
CleanExiMM_EIF5A2.
GenevisibleiQ8BGY2. MM.

Interactioni

Protein-protein interaction databases

BioGridi229006. 1 interaction.
STRINGi10090.ENSMUSP00000050289.

Structurei

3D structure databases

ProteinModelPortaliQ8BGY2.
SMRiQ8BGY2. Positions 15-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271. Eukaryota.
COG0231. LUCA.
GeneTreeiENSGT00390000003738.
HOGENOMiHOG000106270.
HOVERGENiHBG001104.
InParanoidiQ8BGY2.
KOiK03263.
OMAiASETYPM.
OrthoDBiEOG091G0P2P.
PhylomeDBiQ8BGY2.
TreeFamiTF101534.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS
110 120 130 140 150
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK

PCK
Length:153
Mass (Da):16,793
Last modified:January 23, 2007 - v3
Checksum:i632BFE7F6DB073BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205262 mRNA. Translation: AAO18680.1.
AY205263 mRNA. Translation: AAO18681.1.
AY205264 mRNA. Translation: AAO18682.1.
AY205265 mRNA. Translation: AAO18683.1.
AK052412 mRNA. Translation: BAC34978.1.
AK082214 mRNA. Translation: BAC38441.1.
BC106843 mRNA. Translation: AAI06844.1.
BC106844 mRNA. Translation: AAI06845.1.
CCDSiCCDS17277.1.
RefSeqiNP_808254.1. NM_177586.5.
UniGeneiMm.193670.

Genome annotation databases

EnsembliENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192.
GeneIDi208691.
KEGGimmu:208691.
UCSCiuc008oud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205262 mRNA. Translation: AAO18680.1.
AY205263 mRNA. Translation: AAO18681.1.
AY205264 mRNA. Translation: AAO18682.1.
AY205265 mRNA. Translation: AAO18683.1.
AK052412 mRNA. Translation: BAC34978.1.
AK082214 mRNA. Translation: BAC38441.1.
BC106843 mRNA. Translation: AAI06844.1.
BC106844 mRNA. Translation: AAI06845.1.
CCDSiCCDS17277.1.
RefSeqiNP_808254.1. NM_177586.5.
UniGeneiMm.193670.

3D structure databases

ProteinModelPortaliQ8BGY2.
SMRiQ8BGY2. Positions 15-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229006. 1 interaction.
STRINGi10090.ENSMUSP00000050289.

PTM databases

iPTMnetiQ8BGY2.
PhosphoSiteiQ8BGY2.

Proteomic databases

MaxQBiQ8BGY2.
PaxDbiQ8BGY2.
PeptideAtlasiQ8BGY2.
PRIDEiQ8BGY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192.
GeneIDi208691.
KEGGimmu:208691.
UCSCiuc008oud.1. mouse.

Organism-specific databases

CTDi56648.
MGIiMGI:1933735. Eif5a2.

Phylogenomic databases

eggNOGiKOG3271. Eukaryota.
COG0231. LUCA.
GeneTreeiENSGT00390000003738.
HOGENOMiHOG000106270.
HOVERGENiHBG001104.
InParanoidiQ8BGY2.
KOiK03263.
OMAiASETYPM.
OrthoDBiEOG091G0P2P.
PhylomeDBiQ8BGY2.
TreeFamiTF101534.

Enzyme and pathway databases

ReactomeiR-MMU-204626. Hypusine synthesis from eIF5A-lysine.

Miscellaneous databases

ChiTaRSiEif5a2. mouse.
PROiQ8BGY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050192.
CleanExiMM_EIF5A2.
GenevisibleiQ8BGY2. MM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF5A2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.