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Protein

E3 ubiquitin-protein ligase TRIM23

Gene

Trim23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an E3 ubiquitin-protein ligase. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 76RING-type; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri122 – 168B box-type; degeneratePROSITE-ProRule annotationAdd BLAST47
Nucleotide bindingi411 – 418GTPBy similarity8
Nucleotide bindingi454 – 458GTPBy similarity5
Nucleotide bindingi513 – 516GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM23 (EC:6.3.2.-)
Alternative name(s):
ADP-ribosylation factor domain-containing protein 1
GTP-binding protein ARD-1
Tripartite motif-containing protein 23
Gene namesi
Name:Trim23
Synonyms:Arfd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1933161. Trim23.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • Golgi membrane Source: HGNC
  • lysosomal membrane Source: HGNC
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074841 – 574E3 ubiquitin-protein ligase TRIM23Add BLAST574

Proteomic databases

PaxDbiQ8BGX0.
PeptideAtlasiQ8BGX0.
PRIDEiQ8BGX0.

PTM databases

iPTMnetiQ8BGX0.
PhosphoSitePlusiQ8BGX0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021712.
CleanExiMM_TRIM23.
ExpressionAtlasiQ8BGX0. baseline and differential.
GenevisibleiQ8BGX0. MM.

Interactioni

Subunit structurei

Interacts with PSCD1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069371.

Structurei

3D structure databases

ProteinModelPortaliQ8BGX0.
SMRiQ8BGX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 574ARF-likeAdd BLAST185

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 379Sequence analysisAdd BLAST28

Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.By similarity

Sequence similaritiesi

In the C-terminal section; belongs to the small GTPase superfamily. Arf family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 76RING-type; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri122 – 168B box-type; degeneratePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
KOG4185. Eukaryota.
ENOG410ZGPK. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000008208.
HOVERGENiHBG000551.
InParanoidiQ8BGX0.
KOiK07963.
OMAiRAVRCPF.
OrthoDBiEOG091G05L6.
PhylomeDBiQ8BGX0.
TreeFamiTF320703.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAVNKPG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL
60 70 80 90 100
CGHTVCHDCL TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE
110 120 130 140 150
RLQNGHIGQY GAAEEAIGTS GESIIRCDED EAHVASVYCT VCATHLCSDC
160 170 180 190 200
SQVTHSTKTL AKHRRVPLAD KPHEKTMCCQ HQVHAIEFVC LEEGCQTSPL
210 220 230 240 250
MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF TEEISDYSRK
260 270 280 290 300
LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCVRA YFSDLHETLC
310 320 330 340 350
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSQVSTACL HCEKTLQQDD
360 370 380 390 400
CRVVLAKQEI TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG
410 420 430 440 450
PKMEIRVVTL GLDGAGKTTI LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF
460 470 480 490 500
TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD SSHRDRISEA HSELAKLLTE
510 520 530 540 550
KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS WYIQGCDARS
560 570
GMGLYEGLDW LSRQLVAAGV LDVA
Length:574
Mass (Da):63,931
Last modified:March 1, 2003 - v1
Checksum:i678D7BDA937E16F2
GO
Isoform 2 (identifier: Q8BGX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAALAVNKPGAGVDSGRQGSRGTAVVK → MFLFYIQ

Note: No experimental confirmation available.
Show »
Length:554
Mass (Da):62,295
Checksum:iF9EBFBD66733E9B1
GO
Isoform 3 (identifier: Q8BGX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: Missing.

Note: No experimental confirmation available.
Show »
Length:513
Mass (Da):57,137
Checksum:i8419B4F21A09DC84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371Q → K in BAC27156 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0108141 – 27MAALA…TAVVK → MFLFYIQ in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_010815216 – 276Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030843 mRNA. Translation: BAC27156.1.
AK030862 mRNA. Translation: BAC27160.1.
AK039280 mRNA. Translation: BAC30304.1.
AK042070 mRNA. Translation: BAC31152.1.
AK088922 mRNA. Translation: BAC40654.1.
BC056390 mRNA. Translation: AAH56390.1.
BC059017 mRNA. Translation: AAH59017.1.
CCDSiCCDS26747.1. [Q8BGX0-2]
RefSeqiNP_109656.1. NM_030731.3. [Q8BGX0-2]
UniGeneiMm.244190.

Genome annotation databases

EnsembliENSMUST00000022225; ENSMUSP00000022225; ENSMUSG00000021712. [Q8BGX0-1]
ENSMUST00000069174; ENSMUSP00000069371; ENSMUSG00000021712. [Q8BGX0-2]
ENSMUST00000069187; ENSMUSP00000070767; ENSMUSG00000021712. [Q8BGX0-3]
GeneIDi81003.
KEGGimmu:81003.
UCSCiuc007rsx.1. mouse. [Q8BGX0-1]
uc007rsy.1. mouse. [Q8BGX0-2]
uc011zeg.1. mouse. [Q8BGX0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030843 mRNA. Translation: BAC27156.1.
AK030862 mRNA. Translation: BAC27160.1.
AK039280 mRNA. Translation: BAC30304.1.
AK042070 mRNA. Translation: BAC31152.1.
AK088922 mRNA. Translation: BAC40654.1.
BC056390 mRNA. Translation: AAH56390.1.
BC059017 mRNA. Translation: AAH59017.1.
CCDSiCCDS26747.1. [Q8BGX0-2]
RefSeqiNP_109656.1. NM_030731.3. [Q8BGX0-2]
UniGeneiMm.244190.

3D structure databases

ProteinModelPortaliQ8BGX0.
SMRiQ8BGX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069371.

PTM databases

iPTMnetiQ8BGX0.
PhosphoSitePlusiQ8BGX0.

Proteomic databases

PaxDbiQ8BGX0.
PeptideAtlasiQ8BGX0.
PRIDEiQ8BGX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022225; ENSMUSP00000022225; ENSMUSG00000021712. [Q8BGX0-1]
ENSMUST00000069174; ENSMUSP00000069371; ENSMUSG00000021712. [Q8BGX0-2]
ENSMUST00000069187; ENSMUSP00000070767; ENSMUSG00000021712. [Q8BGX0-3]
GeneIDi81003.
KEGGimmu:81003.
UCSCiuc007rsx.1. mouse. [Q8BGX0-1]
uc007rsy.1. mouse. [Q8BGX0-2]
uc011zeg.1. mouse. [Q8BGX0-3]

Organism-specific databases

CTDi373.
MGIiMGI:1933161. Trim23.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
KOG4185. Eukaryota.
ENOG410ZGPK. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000008208.
HOVERGENiHBG000551.
InParanoidiQ8BGX0.
KOiK07963.
OMAiRAVRCPF.
OrthoDBiEOG091G05L6.
PhylomeDBiQ8BGX0.
TreeFamiTF320703.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8BGX0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021712.
CleanExiMM_TRIM23.
ExpressionAtlasiQ8BGX0. baseline and differential.
GenevisibleiQ8BGX0. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI23_MOUSE
AccessioniPrimary (citable) accession number: Q8BGX0
Secondary accession number(s): Q8C2B6, Q8CDA4, Q8CDA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.