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Q8BGX0 (TRI23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase TRIM23

EC=6.3.2.-
Alternative name(s):
ADP-ribosylation factor domain-containing protein 1
GTP-binding protein ARD-1
Tripartite motif-containing protein 23
Gene names
Name:Trim23
Synonyms:Arfd1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an E3 ubiquitin-protein ligase By similarity. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with PSCD1 By similarity.

Subcellular location

Endomembrane system By similarity. Golgi apparatus membrane By similarity. Lysosome membrane By similarity. Note: Membrane-associated with the Golgi complex and lysosomal structures By similarity.

Domain

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity By similarity.

Sequence similarities

In the C-terminal section; belongs to the small GTPase superfamily. Arf family.

Contains 1 B box-type zinc finger.

Contains 1 RING-type zinc finger.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BGX0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BGX0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAALAVNKPGAGVDSGRQGSRGTAVVK → MFLFYIQ
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8BGX0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 574574E3 ubiquitin-protein ligase TRIM23
PRO_0000207484

Regions

Zinc finger31 – 7646RING-type; degenerate
Zinc finger122 – 16847B box-type; degenerate
Nucleotide binding411 – 4188GTP By similarity
Nucleotide binding454 – 4585GTP By similarity
Nucleotide binding513 – 5164GTP By similarity
Region390 – 574185ARF-like
Coiled coil352 – 37928 Potential

Natural variations

Alternative sequence1 – 2727MAALA…TAVVK → MFLFYIQ in isoform 2.
VSP_010814
Alternative sequence216 – 27661Missing in isoform 3.
VSP_010815

Experimental info

Sequence conflict3711Q → K in BAC27156. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 678D7BDA937E16F2

FASTA57463,931
        10         20         30         40         50         60 
MAALAVNKPG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL 

        70         80         90        100        110        120 
TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGHIGQY GAAEEAIGTS 

       130        140        150        160        170        180 
GESIIRCDED EAHVASVYCT VCATHLCSDC SQVTHSTKTL AKHRRVPLAD KPHEKTMCCQ 

       190        200        210        220        230        240 
HQVHAIEFVC LEEGCQTSPL MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF 

       250        260        270        280        290        300 
TEEISDYSRK LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCVRA YFSDLHETLC 

       310        320        330        340        350        360 
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSQVSTACL HCEKTLQQDD CRVVLAKQEI 

       370        380        390        400        410        420 
TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG PKMEIRVVTL GLDGAGKTTI 

       430        440        450        460        470        480 
LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD 

       490        500        510        520        530        540 
SSHRDRISEA HSELAKLLTE KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS 

       550        560        570 
WYIQGCDARS GMGLYEGLDW LSRQLVAAGV LDVA 

« Hide

Isoform 2 [UniParc].

Checksum: F9EBFBD66733E9B1
Show »

FASTA55462,295
Isoform 3 [UniParc].

Checksum: 8419B4F21A09DC84
Show »

FASTA51357,137

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: C57BL/6J.
Tissue: Spinal cord and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030843 mRNA. Translation: BAC27156.1.
AK030862 mRNA. Translation: BAC27160.1.
AK039280 mRNA. Translation: BAC30304.1.
AK042070 mRNA. Translation: BAC31152.1.
AK088922 mRNA. Translation: BAC40654.1.
BC056390 mRNA. Translation: AAH56390.1.
BC059017 mRNA. Translation: AAH59017.1.
RefSeqNP_109656.1. NM_030731.3.
UniGeneMm.244190.

3D structure databases

ProteinModelPortalQ8BGX0.
SMRQ8BGX0. Positions 16-79, 127-219, 371-565.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BGX0.

Proteomic databases

PaxDbQ8BGX0.
PRIDEQ8BGX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022225; ENSMUSP00000022225; ENSMUSG00000021712. [Q8BGX0-1]
ENSMUST00000069174; ENSMUSP00000069371; ENSMUSG00000021712. [Q8BGX0-2]
ENSMUST00000069187; ENSMUSP00000070767; ENSMUSG00000021712. [Q8BGX0-3]
GeneID81003.
KEGGmmu:81003.
UCSCuc007rsx.1. mouse. [Q8BGX0-1]
uc007rsy.1. mouse. [Q8BGX0-2]
uc011zeg.1. mouse. [Q8BGX0-3]

Organism-specific databases

CTD373.
MGIMGI:1933161. Trim23.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00750000117257.
HOGENOMHOG000008208.
HOVERGENHBG000551.
InParanoidQ8BGX0.
KOK07963.
OMARAVRCPF.
OrthoDBEOG76DTS0.
PhylomeDBQ8BGX0.
TreeFamTF320703.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8BGX0.
BgeeQ8BGX0.
CleanExMM_TRIM23.
GenevestigatorQ8BGX0.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR00328. SAR1GTPBP.
SMARTSM00177. ARF. 1 hit.
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350338.
PROQ8BGX0.
SOURCESearch...

Entry information

Entry nameTRI23_MOUSE
AccessionPrimary (citable) accession number: Q8BGX0
Secondary accession number(s): Q8C2B6, Q8CDA4, Q8CDA7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot