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Q8BGX0

- TRI23_MOUSE

UniProt

Q8BGX0 - TRI23_MOUSE

Protein

E3 ubiquitin-protein ligase TRIM23

Gene

Trim23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Acts as an E3 ubiquitin-protein ligase. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 7646RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri122 – 16847B box-type; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi411 – 4188GTPBy similarity
    Nucleotide bindingi454 – 4585GTPBy similarity
    Nucleotide bindingi513 – 5164GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: HGNC
    2. GTPase activity Source: HGNC
    3. GTP binding Source: HGNC
    4. ligase activity Source: UniProtKB-KW
    5. ubiquitin-protein transferase activity Source: HGNC
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. protein ubiquitination Source: HGNC
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM23 (EC:6.3.2.-)
    Alternative name(s):
    ADP-ribosylation factor domain-containing protein 1
    GTP-binding protein ARD-1
    Tripartite motif-containing protein 23
    Gene namesi
    Name:Trim23
    Synonyms:Arfd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1933161. Trim23.

    Subcellular locationi

    Endomembrane system By similarity. Golgi apparatus membrane By similarity. Lysosome membrane By similarity
    Note: Membrane-associated with the Golgi complex and lysosomal structures.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. Golgi membrane Source: HGNC
    3. lysosomal membrane Source: HGNC
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574E3 ubiquitin-protein ligase TRIM23PRO_0000207484Add
    BLAST

    Proteomic databases

    PaxDbiQ8BGX0.
    PRIDEiQ8BGX0.

    PTM databases

    PhosphoSiteiQ8BGX0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BGX0.
    BgeeiQ8BGX0.
    CleanExiMM_TRIM23.
    GenevestigatoriQ8BGX0.

    Interactioni

    Subunit structurei

    Interacts with PSCD1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGX0.
    SMRiQ8BGX0. Positions 16-79, 127-219, 371-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni390 – 574185ARF-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili352 – 37928Sequence AnalysisAdd
    BLAST

    Domaini

    The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.By similarity

    Sequence similaritiesi

    In the C-terminal section; belongs to the small GTPase superfamily. Arf family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 7646RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri122 – 16847B box-type; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117257.
    HOGENOMiHOG000008208.
    HOVERGENiHBG000551.
    InParanoidiQ8BGX0.
    KOiK07963.
    OMAiRAVRCPF.
    OrthoDBiEOG76DTS0.
    PhylomeDBiQ8BGX0.
    TreeFamiTF320703.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003649. Bbox_C.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    IPR000315. Znf_B-box.
    IPR007087. Znf_C2H2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    SM00502. BBC. 1 hit.
    SM00336. BBOX. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BGX0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALAVNKPG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL    50
    CGHTVCHDCL TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE 100
    RLQNGHIGQY GAAEEAIGTS GESIIRCDED EAHVASVYCT VCATHLCSDC 150
    SQVTHSTKTL AKHRRVPLAD KPHEKTMCCQ HQVHAIEFVC LEEGCQTSPL 200
    MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF TEEISDYSRK 250
    LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCVRA YFSDLHETLC 300
    RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSQVSTACL HCEKTLQQDD 350
    CRVVLAKQEI TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG 400
    PKMEIRVVTL GLDGAGKTTI LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF 450
    TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD SSHRDRISEA HSELAKLLTE 500
    KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS WYIQGCDARS 550
    GMGLYEGLDW LSRQLVAAGV LDVA 574
    Length:574
    Mass (Da):63,931
    Last modified:March 1, 2003 - v1
    Checksum:i678D7BDA937E16F2
    GO
    Isoform 2 (identifier: Q8BGX0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MAALAVNKPGAGVDSGRQGSRGTAVVK → MFLFYIQ

    Note: No experimental confirmation available.

    Show »
    Length:554
    Mass (Da):62,295
    Checksum:iF9EBFBD66733E9B1
    GO
    Isoform 3 (identifier: Q8BGX0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-276: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:513
    Mass (Da):57,137
    Checksum:i8419B4F21A09DC84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti371 – 3711Q → K in BAC27156. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727MAALA…TAVVK → MFLFYIQ in isoform 2. 1 PublicationVSP_010814Add
    BLAST
    Alternative sequencei216 – 27661Missing in isoform 3. 1 PublicationVSP_010815Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030843 mRNA. Translation: BAC27156.1.
    AK030862 mRNA. Translation: BAC27160.1.
    AK039280 mRNA. Translation: BAC30304.1.
    AK042070 mRNA. Translation: BAC31152.1.
    AK088922 mRNA. Translation: BAC40654.1.
    BC056390 mRNA. Translation: AAH56390.1.
    BC059017 mRNA. Translation: AAH59017.1.
    CCDSiCCDS26747.1. [Q8BGX0-2]
    RefSeqiNP_109656.1. NM_030731.3. [Q8BGX0-2]
    UniGeneiMm.244190.

    Genome annotation databases

    EnsembliENSMUST00000022225; ENSMUSP00000022225; ENSMUSG00000021712. [Q8BGX0-1]
    ENSMUST00000069174; ENSMUSP00000069371; ENSMUSG00000021712. [Q8BGX0-2]
    ENSMUST00000069187; ENSMUSP00000070767; ENSMUSG00000021712. [Q8BGX0-3]
    GeneIDi81003.
    KEGGimmu:81003.
    UCSCiuc007rsx.1. mouse. [Q8BGX0-1]
    uc007rsy.1. mouse. [Q8BGX0-2]
    uc011zeg.1. mouse. [Q8BGX0-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030843 mRNA. Translation: BAC27156.1 .
    AK030862 mRNA. Translation: BAC27160.1 .
    AK039280 mRNA. Translation: BAC30304.1 .
    AK042070 mRNA. Translation: BAC31152.1 .
    AK088922 mRNA. Translation: BAC40654.1 .
    BC056390 mRNA. Translation: AAH56390.1 .
    BC059017 mRNA. Translation: AAH59017.1 .
    CCDSi CCDS26747.1. [Q8BGX0-2 ]
    RefSeqi NP_109656.1. NM_030731.3. [Q8BGX0-2 ]
    UniGenei Mm.244190.

    3D structure databases

    ProteinModelPortali Q8BGX0.
    SMRi Q8BGX0. Positions 16-79, 127-219, 371-565.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BGX0.

    Proteomic databases

    PaxDbi Q8BGX0.
    PRIDEi Q8BGX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022225 ; ENSMUSP00000022225 ; ENSMUSG00000021712 . [Q8BGX0-1 ]
    ENSMUST00000069174 ; ENSMUSP00000069371 ; ENSMUSG00000021712 . [Q8BGX0-2 ]
    ENSMUST00000069187 ; ENSMUSP00000070767 ; ENSMUSG00000021712 . [Q8BGX0-3 ]
    GeneIDi 81003.
    KEGGi mmu:81003.
    UCSCi uc007rsx.1. mouse. [Q8BGX0-1 ]
    uc007rsy.1. mouse. [Q8BGX0-2 ]
    uc011zeg.1. mouse. [Q8BGX0-3 ]

    Organism-specific databases

    CTDi 373.
    MGIi MGI:1933161. Trim23.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117257.
    HOGENOMi HOG000008208.
    HOVERGENi HBG000551.
    InParanoidi Q8BGX0.
    KOi K07963.
    OMAi RAVRCPF.
    OrthoDBi EOG76DTS0.
    PhylomeDBi Q8BGX0.
    TreeFami TF320703.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 350338.
    PROi Q8BGX0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BGX0.
    Bgeei Q8BGX0.
    CleanExi MM_TRIM23.
    Genevestigatori Q8BGX0.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003649. Bbox_C.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    IPR000315. Znf_B-box.
    IPR007087. Znf_C2H2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    SM00502. BBC. 1 hit.
    SM00336. BBOX. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Spinal cord and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiTRI23_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGX0
    Secondary accession number(s): Q8C2B6, Q8CDA4, Q8CDA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3