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Q8BGX0

- TRI23_MOUSE

UniProt

Q8BGX0 - TRI23_MOUSE

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Protein

E3 ubiquitin-protein ligase TRIM23

Gene

Trim23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as an E3 ubiquitin-protein ligase. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 7646RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 16847B box-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi411 – 4188GTPBy similarity
Nucleotide bindingi454 – 4585GTPBy similarity
Nucleotide bindingi513 – 5164GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: HGNC
  2. GTPase activity Source: HGNC
  3. GTP binding Source: HGNC
  4. ligase activity Source: UniProtKB-KW
  5. ubiquitin-protein transferase activity Source: HGNC
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. protein ubiquitination Source: HGNC
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM23 (EC:6.3.2.-)
Alternative name(s):
ADP-ribosylation factor domain-containing protein 1
GTP-binding protein ARD-1
Tripartite motif-containing protein 23
Gene namesi
Name:Trim23
Synonyms:Arfd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1933161. Trim23.

Subcellular locationi

Endomembrane system By similarity. Golgi apparatus membrane By similarity. Lysosome membrane By similarity
Note: Membrane-associated with the Golgi complex and lysosomal structures.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi membrane Source: HGNC
  4. lysosomal membrane Source: HGNC
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574E3 ubiquitin-protein ligase TRIM23PRO_0000207484Add
BLAST

Proteomic databases

MaxQBiQ8BGX0.
PaxDbiQ8BGX0.
PRIDEiQ8BGX0.

PTM databases

PhosphoSiteiQ8BGX0.

Expressioni

Gene expression databases

BgeeiQ8BGX0.
CleanExiMM_TRIM23.
ExpressionAtlasiQ8BGX0. baseline and differential.
GenevestigatoriQ8BGX0.

Interactioni

Subunit structurei

Interacts with PSCD1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BGX0.
SMRiQ8BGX0. Positions 16-106, 127-219, 371-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni390 – 574185ARF-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili352 – 37928Sequence AnalysisAdd
BLAST

Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.By similarity

Sequence similaritiesi

In the C-terminal section; belongs to the small GTPase superfamily. Arf family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 7646RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 16847B box-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118835.
HOGENOMiHOG000008208.
HOVERGENiHBG000551.
InParanoidiQ8BGX0.
KOiK07963.
OMAiRAVRCPF.
OrthoDBiEOG76DTS0.
PhylomeDBiQ8BGX0.
TreeFamiTF320703.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BGX0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAVNKPG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL
60 70 80 90 100
CGHTVCHDCL TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE
110 120 130 140 150
RLQNGHIGQY GAAEEAIGTS GESIIRCDED EAHVASVYCT VCATHLCSDC
160 170 180 190 200
SQVTHSTKTL AKHRRVPLAD KPHEKTMCCQ HQVHAIEFVC LEEGCQTSPL
210 220 230 240 250
MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF TEEISDYSRK
260 270 280 290 300
LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCVRA YFSDLHETLC
310 320 330 340 350
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSQVSTACL HCEKTLQQDD
360 370 380 390 400
CRVVLAKQEI TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG
410 420 430 440 450
PKMEIRVVTL GLDGAGKTTI LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF
460 470 480 490 500
TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD SSHRDRISEA HSELAKLLTE
510 520 530 540 550
KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS WYIQGCDARS
560 570
GMGLYEGLDW LSRQLVAAGV LDVA
Length:574
Mass (Da):63,931
Last modified:March 1, 2003 - v1
Checksum:i678D7BDA937E16F2
GO
Isoform 2 (identifier: Q8BGX0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAALAVNKPGAGVDSGRQGSRGTAVVK → MFLFYIQ

Note: No experimental confirmation available.

Show »
Length:554
Mass (Da):62,295
Checksum:iF9EBFBD66733E9B1
GO
Isoform 3 (identifier: Q8BGX0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: Missing.

Note: No experimental confirmation available.

Show »
Length:513
Mass (Da):57,137
Checksum:i8419B4F21A09DC84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti371 – 3711Q → K in BAC27156. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MAALA…TAVVK → MFLFYIQ in isoform 2. 1 PublicationVSP_010814Add
BLAST
Alternative sequencei216 – 27661Missing in isoform 3. 1 PublicationVSP_010815Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030843 mRNA. Translation: BAC27156.1.
AK030862 mRNA. Translation: BAC27160.1.
AK039280 mRNA. Translation: BAC30304.1.
AK042070 mRNA. Translation: BAC31152.1.
AK088922 mRNA. Translation: BAC40654.1.
BC056390 mRNA. Translation: AAH56390.1.
BC059017 mRNA. Translation: AAH59017.1.
CCDSiCCDS26747.1. [Q8BGX0-2]
RefSeqiNP_109656.1. NM_030731.3. [Q8BGX0-2]
UniGeneiMm.244190.

Genome annotation databases

EnsembliENSMUST00000022225; ENSMUSP00000022225; ENSMUSG00000021712. [Q8BGX0-1]
ENSMUST00000069174; ENSMUSP00000069371; ENSMUSG00000021712. [Q8BGX0-2]
ENSMUST00000069187; ENSMUSP00000070767; ENSMUSG00000021712. [Q8BGX0-3]
GeneIDi81003.
KEGGimmu:81003.
UCSCiuc007rsx.1. mouse. [Q8BGX0-1]
uc007rsy.1. mouse. [Q8BGX0-2]
uc011zeg.1. mouse. [Q8BGX0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030843 mRNA. Translation: BAC27156.1 .
AK030862 mRNA. Translation: BAC27160.1 .
AK039280 mRNA. Translation: BAC30304.1 .
AK042070 mRNA. Translation: BAC31152.1 .
AK088922 mRNA. Translation: BAC40654.1 .
BC056390 mRNA. Translation: AAH56390.1 .
BC059017 mRNA. Translation: AAH59017.1 .
CCDSi CCDS26747.1. [Q8BGX0-2 ]
RefSeqi NP_109656.1. NM_030731.3. [Q8BGX0-2 ]
UniGenei Mm.244190.

3D structure databases

ProteinModelPortali Q8BGX0.
SMRi Q8BGX0. Positions 16-106, 127-219, 371-565.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGX0.

Proteomic databases

MaxQBi Q8BGX0.
PaxDbi Q8BGX0.
PRIDEi Q8BGX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022225 ; ENSMUSP00000022225 ; ENSMUSG00000021712 . [Q8BGX0-1 ]
ENSMUST00000069174 ; ENSMUSP00000069371 ; ENSMUSG00000021712 . [Q8BGX0-2 ]
ENSMUST00000069187 ; ENSMUSP00000070767 ; ENSMUSG00000021712 . [Q8BGX0-3 ]
GeneIDi 81003.
KEGGi mmu:81003.
UCSCi uc007rsx.1. mouse. [Q8BGX0-1 ]
uc007rsy.1. mouse. [Q8BGX0-2 ]
uc011zeg.1. mouse. [Q8BGX0-3 ]

Organism-specific databases

CTDi 373.
MGIi MGI:1933161. Trim23.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118835.
HOGENOMi HOG000008208.
HOVERGENi HBG000551.
InParanoidi Q8BGX0.
KOi K07963.
OMAi RAVRCPF.
OrthoDBi EOG76DTS0.
PhylomeDBi Q8BGX0.
TreeFami TF320703.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 350338.
PROi Q8BGX0.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGX0.
CleanExi MM_TRIM23.
ExpressionAtlasi Q8BGX0. baseline and differential.
Genevestigatori Q8BGX0.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SMARTi SM00177. ARF. 1 hit.
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Spinal cord and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiTRI23_MOUSE
AccessioniPrimary (citable) accession number: Q8BGX0
Secondary accession number(s): Q8C2B6, Q8CDA4, Q8CDA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3