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Protein

Transcription cofactor vestigial-like protein 2

Gene

Vgll2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: MGI
  • transcription coactivator activity Source: MGI

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • skeletal muscle tissue development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 2
Short name:
Vgl-2
Alternative name(s):
Protein VITO1
Gene namesi
Name:Vgll2
Synonyms:Vgl2, Vito1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2447460. Vgll2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Transcription cofactor vestigial-like protein 2PRO_0000191350Add
BLAST

Proteomic databases

PaxDbiQ8BGW8.
PRIDEiQ8BGW8.

PTM databases

PhosphoSiteiQ8BGW8.

Expressioni

Tissue specificityi

Skeletal muscle specific.1 Publication

Developmental stagei

Expressed in the somitic myotome from E8.75 mouse embryos onwards and later on in skeletal muscle but not in the heart. Additional expression domains during development are detected in the pharyngeal pouches and clefts starting at E8.0 as well as in the cranial pharynx and in Rathkes pouch.1 Publication

Gene expression databases

BgeeiENSMUSG00000049641.
CleanExiMM_VGLL2.
GenevisibleiQ8BGW8. MM.

Interactioni

Subunit structurei

Interacts with TEFs. Binds to TEAD1/TEF1.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

BioGridi229591. 2 interactions.
STRINGi10090.ENSMUSP00000124091.

Structurei

3D structure databases

ProteinModelPortaliQ8BGW8.
SMRiQ8BGW8. Positions 75-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IJDA. Eukaryota.
ENOG410Y23M. LUCA.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiQ8BGW8.
OMAiTEPWHHA.
OrthoDBiEOG091G0GKN.
PhylomeDBiQ8BGW8.
TreeFamiTF326340.

Family and domain databases

InterProiIPR011520. Vg_fam.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CASPGSSASG
60 70 80 90 100
SSSFSNPTPA SVKEEEGSPE KERPPEAEYI NSRCVLFTYF QGDISSVVDE
110 120 130 140 150
HFSRALSHPS SYTPSCTSSK AHRSSGPWRA EGTFPMSQRS FPASFWNSAY
160 170 180 190 200
QAPVPAPLGS PLAAAHSELP FATDPYSPAT LHGHLHQGAA DWHHAHPHHA
210 220 230 240 250
HPHHPYALGG ALGAQASAYP RPAVHEVYAP HFDPRYGPLL MPAATGRPGR
260 270 280 290 300
LAPASAPAPG SPPCELAAKG EPAGSAWAAP GGPFVSPTGD VAQSLGLSVD
310 320
SGKRRRECSL PSAPPALYPT LG
Length:322
Mass (Da):34,064
Last modified:March 1, 2003 - v1
Checksum:i6869E34EC6AEAFD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301Missing in BAC35232 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542181 mRNA. Translation: AAN37898.1.
AJ578054 mRNA. Translation: CAE17332.1.
AK048390 mRNA. Translation: BAC33319.1.
AK052987 mRNA. Translation: BAC35232.1.
CCDSiCCDS23837.1.
RefSeqiNP_001287886.1. NM_001300957.1.
NP_722481.1. NM_153786.2.
UniGeneiMm.87237.

Genome annotation databases

EnsembliENSMUST00000163017; ENSMUSP00000124091; ENSMUSG00000049641.
GeneIDi215031.
KEGGimmu:215031.
UCSCiuc007faz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542181 mRNA. Translation: AAN37898.1.
AJ578054 mRNA. Translation: CAE17332.1.
AK048390 mRNA. Translation: BAC33319.1.
AK052987 mRNA. Translation: BAC35232.1.
CCDSiCCDS23837.1.
RefSeqiNP_001287886.1. NM_001300957.1.
NP_722481.1. NM_153786.2.
UniGeneiMm.87237.

3D structure databases

ProteinModelPortaliQ8BGW8.
SMRiQ8BGW8. Positions 75-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229591. 2 interactions.
STRINGi10090.ENSMUSP00000124091.

PTM databases

PhosphoSiteiQ8BGW8.

Proteomic databases

PaxDbiQ8BGW8.
PRIDEiQ8BGW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163017; ENSMUSP00000124091; ENSMUSG00000049641.
GeneIDi215031.
KEGGimmu:215031.
UCSCiuc007faz.2. mouse.

Organism-specific databases

CTDi245806.
MGIiMGI:2447460. Vgll2.

Phylogenomic databases

eggNOGiENOG410IJDA. Eukaryota.
ENOG410Y23M. LUCA.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiQ8BGW8.
OMAiTEPWHHA.
OrthoDBiEOG091G0GKN.
PhylomeDBiQ8BGW8.
TreeFamiTF326340.

Miscellaneous databases

PROiQ8BGW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049641.
CleanExiMM_VGLL2.
GenevisibleiQ8BGW8. MM.

Family and domain databases

InterProiIPR011520. Vg_fam.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGW8
Secondary accession number(s): Q8BWB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.