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Protein

Serine/threonine-protein kinase 32A

Gene

Stk32a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotationBy similarity1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32A (EC:2.7.11.1)
Gene namesi
Name:Stk32aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2442403. Stk32a.

Subcellular locationi

  • Cell membrane; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002324122 – 398Serine/threonine-protein kinase 32AAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8BGW6.
PeptideAtlasiQ8BGW6.
PRIDEiQ8BGW6.

PTM databases

iPTMnetiQ8BGW6.
PhosphoSitePlusiQ8BGW6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039954.
CleanExiMM_STK32A.
GenevisibleiQ8BGW6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038471.

Structurei

3D structure databases

ProteinModelPortaliQ8BGW6.
SMRiQ8BGW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133734.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8BGW6.
KOiK08793.
OMAiMLPRETQ.
OrthoDBiEOG091G0XV4.
PhylomeDBiQ8BGW6.
TreeFamiTF313395.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8BGW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANTSSKAP VFDENEDVNF DHFEILRAIG KGSFGKVCIV RKNDTKKMYA
60 70 80 90 100
MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV
110 120 130 140 150
DLLLGGDLRY HLQQNVHFQE DTVKLFICEL AMALDYLQSQ RIIHRDMKPD
160 170 180 190 200
NILLDEHGHV HITDFNIAAM LPKETRITTV AGTKPYMAPE MFTSRKETGY
210 220 230 240 250
SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVNMFET AIVTYPSAWS
260 270 280 290 300
QEMVSLLKKL LEPNPDQRFS HLTDIQNFPY MSDMNWDAVL QKRLIPGFIP
310 320 330 340 350
TKGRLNCDPT FELEEMILES KPLHKKKKRL AKREKEMKKS DSSQTCLLQE
360 370 380 390
HLDAVQKEFI IFNREKVKSD FNQRQANLAL EQTKNNTEEE EDGQNNNL
Note: No experimental confirmation available.Curated
Length:398
Mass (Da):46,509
Last modified:March 1, 2003 - v1
Checksum:i689BCA5B25CF18BB
GO
Isoform 21 Publication (identifier: Q8BGW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-187: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:368
Mass (Da):43,213
Checksum:i0DB7F6977C39BB56
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051996158 – 187Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036266 mRNA. Translation: BAC29366.1.
AK042599 mRNA. Translation: BAC31302.1.
AK044474 mRNA. Translation: BAC31941.1.
BC055002 mRNA. Translation: AAH55002.1.
CCDSiCCDS29218.1. [Q8BGW6-1]
RefSeqiNP_848864.1. NM_178749.3. [Q8BGW6-1]
UniGeneiMm.150401.

Genome annotation databases

EnsembliENSMUST00000045477; ENSMUSP00000038471; ENSMUSG00000039954. [Q8BGW6-1]
GeneIDi269019.
KEGGimmu:269019.
UCSCiuc008eue.1. mouse. [Q8BGW6-1]
uc012bcj.1. mouse. [Q8BGW6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036266 mRNA. Translation: BAC29366.1.
AK042599 mRNA. Translation: BAC31302.1.
AK044474 mRNA. Translation: BAC31941.1.
BC055002 mRNA. Translation: AAH55002.1.
CCDSiCCDS29218.1. [Q8BGW6-1]
RefSeqiNP_848864.1. NM_178749.3. [Q8BGW6-1]
UniGeneiMm.150401.

3D structure databases

ProteinModelPortaliQ8BGW6.
SMRiQ8BGW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038471.

PTM databases

iPTMnetiQ8BGW6.
PhosphoSitePlusiQ8BGW6.

Proteomic databases

PaxDbiQ8BGW6.
PeptideAtlasiQ8BGW6.
PRIDEiQ8BGW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045477; ENSMUSP00000038471; ENSMUSG00000039954. [Q8BGW6-1]
GeneIDi269019.
KEGGimmu:269019.
UCSCiuc008eue.1. mouse. [Q8BGW6-1]
uc012bcj.1. mouse. [Q8BGW6-2]

Organism-specific databases

CTDi202374.
MGIiMGI:2442403. Stk32a.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133734.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8BGW6.
KOiK08793.
OMAiMLPRETQ.
OrthoDBiEOG091G0XV4.
PhylomeDBiQ8BGW6.
TreeFamiTF313395.

Miscellaneous databases

ChiTaRSiStk32a. mouse.
PROiQ8BGW6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039954.
CleanExiMM_STK32A.
GenevisibleiQ8BGW6. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST32A_MOUSE
AccessioniPrimary (citable) accession number: Q8BGW6
Secondary accession number(s): Q7TPQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.