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Q8BGW3

- BHE23_MOUSE

UniProt

Q8BGW3 - BHE23_MOUSE

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Protein

Class E basic helix-loop-helix protein 23

Gene

Bhlhe23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of retinal cell programmed cell death Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. post-embryonic eye morphogenesis Source: MGI
  4. retinal rod cell development Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Class E basic helix-loop-helix protein 23
Short name:
bHLHe23
Alternative name(s):
Class B basic helix-loop-helix protein 4
Short name:
bHLHb4
Gene namesi
Name:Bhlhe23
Synonyms:Bhlhb4, H20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2153710. Bhlhe23.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Disrupted rod signaling and profound retinal dysfunction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Class E basic helix-loop-helix protein 23PRO_0000245527Add
BLAST

Proteomic databases

PRIDEiQ8BGW3.

PTM databases

PhosphoSiteiQ8BGW3.

Expressioni

Tissue specificityi

Expressed in brain and retina.

Developmental stagei

Expression is confined to regions of the developing nervous system and pancreas. At E13 expressed at lower levels in the trigeminal ganglion, the ganglionic eminence, the ventral neural tube, and dorsal root ganglia. Expressed at moderate levels in the tectum of the embryonic midbrain. Most prominent expression is in the diencephalon, where it flanks either side of the roof of the third ventricle, dorsal/caudal to the dorsal thalamus. Detected in the pancreas during the time when most of the pancreatic endocrine cell types are beginning to differentiate and endocrine precursor cells remain loosely associated with the duct epithelium until they begin to form aggregates late in development.1 Publication

Gene expression databases

BgeeiQ8BGW3.
GenevestigatoriQ8BGW3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104506.

Structurei

3D structure databases

ProteinModelPortaliQ8BGW3.
SMRiQ8BGW3. Positions 100-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 15255bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 11035Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG308077.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000060094.
InParanoidiQ8BGW3.
KOiK09086.
OMAiLPGCPEK.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ8BGW3.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELKSLSGD SYLALSHSYT ATGHAYAAAR GPETTRGFGA SGPGGDLPAA
60 70 80 90 100
PASRVPAATV ESSGEQSGDE DEAFERRRRR RGSGVAVDAR RRPREQRSLR
110 120 130 140 150
LSINARERRR MHDLNDALDG LRAVIPYAHS PSVRKLSKIA TLLLAKNYIL
160 170 180 190 200
MQAQALEEMR RLVAYLNQGQ GLAAPVAAAP LTPFGQAAIY PFSAGTALGP
210 220
CPDKCATFSG SPSALCKHCG EKP
Length:223
Mass (Da):23,701
Last modified:March 1, 2003 - v1
Checksum:i68DCD15E0D70C1FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871V → F in AAL51039. (PubMed:11863370)Curated
Sequence conflicti101 – 1011L → F in AAL51039. (PubMed:11863370)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454760 mRNA. Translation: AAL51039.1.
AB053118 Genomic DNA. Translation: BAC81773.1.
AK044215 mRNA. Translation: BAC31821.1.
AK051155 mRNA. Translation: BAC34539.1.
CCDSiCCDS17187.1.
RefSeqiNP_542372.2. NM_080641.5.
UniGeneiMm.134062.

Genome annotation databases

EnsembliENSMUST00000108878; ENSMUSP00000104506; ENSMUSG00000045493.
GeneIDi140489.
KEGGimmu:140489.
UCSCiuc008okb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454760 mRNA. Translation: AAL51039.1 .
AB053118 Genomic DNA. Translation: BAC81773.1 .
AK044215 mRNA. Translation: BAC31821.1 .
AK051155 mRNA. Translation: BAC34539.1 .
CCDSi CCDS17187.1.
RefSeqi NP_542372.2. NM_080641.5.
UniGenei Mm.134062.

3D structure databases

ProteinModelPortali Q8BGW3.
SMRi Q8BGW3. Positions 100-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000104506.

PTM databases

PhosphoSitei Q8BGW3.

Proteomic databases

PRIDEi Q8BGW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108878 ; ENSMUSP00000104506 ; ENSMUSG00000045493 .
GeneIDi 140489.
KEGGi mmu:140489.
UCSCi uc008okb.2. mouse.

Organism-specific databases

CTDi 128408.
MGIi MGI:2153710. Bhlhe23.

Phylogenomic databases

eggNOGi NOG308077.
GeneTreei ENSGT00530000063239.
HOGENOMi HOG000060094.
InParanoidi Q8BGW3.
KOi K09086.
OMAi LPGCPEK.
OrthoDBi EOG7GQXWR.
PhylomeDBi Q8BGW3.
TreeFami TF322733.

Miscellaneous databases

NextBioi 369804.
PROi Q8BGW3.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGW3.
Genevestigatori Q8BGW3.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary."
    Bramblett D.E., Copeland N.G., Jenkins N.A., Tsai M.-J.
    Genomics 79:402-412(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "Mus musculus novel bHLH transcription factor mh20 gene, complete cds."
    Takebayashi H., Nabeshima Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina and Spinal ganglion.
  4. "The transcription factor Bhlhb4 is required for rod bipolar cell maturation."
    Bramblett D.E., Pennesi M.E., Wu S.M., Tsai M.-J.
    Neuron 43:779-793(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiBHE23_MOUSE
AccessioniPrimary (citable) accession number: Q8BGW3
Secondary accession number(s): Q71MB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3