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Q8BGW3 (BHE23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Class E basic helix-loop-helix protein 23

Short name=bHLHe23
Alternative name(s):
Class B basic helix-loop-helix protein 4
Short name=bHLHb4
Gene names
Name:Bhlhe23
Synonyms:Bhlhb4, H20
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation. Ref.1 Ref.4

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in brain and retina.

Developmental stage

Expression is confined to regions of the developing nervous system and pancreas. At E13 expressed at lower levels in the trigeminal ganglion, the ganglionic eminence, the ventral neural tube, and dorsal root ganglia. Expressed at moderate levels in the tectum of the embryonic midbrain. Most prominent expression is in the diencephalon, where it flanks either side of the roof of the third ventricle, dorsal/caudal to the dorsal thalamus. Detected in the pancreas during the time when most of the pancreatic endocrine cell types are beginning to differentiate and endocrine precursor cells remain loosely associated with the duct epithelium until they begin to form aggregates late in development. Ref.1

Disruption phenotype

Disrupted rod signaling and profound retinal dysfunction. Ref.4

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Class E basic helix-loop-helix protein 23
PRO_0000245527

Regions

Domain98 – 15255bHLH
Compositional bias76 – 11035Arg-rich

Experimental info

Sequence conflict871V → F in AAL51039. Ref.1
Sequence conflict1011L → F in AAL51039. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BGW3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 68DCD15E0D70C1FA

FASTA22323,701
        10         20         30         40         50         60 
MAELKSLSGD SYLALSHSYT ATGHAYAAAR GPETTRGFGA SGPGGDLPAA PASRVPAATV 

        70         80         90        100        110        120 
ESSGEQSGDE DEAFERRRRR RGSGVAVDAR RRPREQRSLR LSINARERRR MHDLNDALDG 

       130        140        150        160        170        180 
LRAVIPYAHS PSVRKLSKIA TLLLAKNYIL MQAQALEEMR RLVAYLNQGQ GLAAPVAAAP 

       190        200        210        220 
LTPFGQAAIY PFSAGTALGP CPDKCATFSG SPSALCKHCG EKP 

« Hide

References

« Hide 'large scale' references
[1]"BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary."
Bramblett D.E., Copeland N.G., Jenkins N.A., Tsai M.-J.
Genomics 79:402-412(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]"Mus musculus novel bHLH transcription factor mh20 gene, complete cds."
Takebayashi H., Nabeshima Y.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Retina and Spinal ganglion.
[4]"The transcription factor Bhlhb4 is required for rod bipolar cell maturation."
Bramblett D.E., Pennesi M.E., Wu S.M., Tsai M.-J.
Neuron 43:779-793(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF454760 mRNA. Translation: AAL51039.1.
AB053118 Genomic DNA. Translation: BAC81773.1.
AK044215 mRNA. Translation: BAC31821.1.
AK051155 mRNA. Translation: BAC34539.1.
RefSeqNP_542372.2. NM_080641.5.
UniGeneMm.134062.

3D structure databases

ProteinModelPortalQ8BGW3.
SMRQ8BGW3. Positions 100-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000104506.

PTM databases

PhosphoSiteQ8BGW3.

Proteomic databases

PRIDEQ8BGW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061098; ENSMUSP00000052737; ENSMUSG00000045493.
ENSMUST00000108878; ENSMUSP00000104506; ENSMUSG00000045493.
GeneID140489.
KEGGmmu:140489.
UCSCuc008okb.2. mouse.

Organism-specific databases

CTD128408.
MGIMGI:2153710. Bhlhe23.

Phylogenomic databases

eggNOGNOG308077.
GeneTreeENSGT00530000063239.
HOGENOMHOG000060094.
InParanoidQ8BGW3.
KOK09086.
OMALPGCPEK.
OrthoDBEOG7GQXWR.
PhylomeDBQ8BGW3.
TreeFamTF322733.

Gene expression databases

ArrayExpressQ8BGW3.
BgeeQ8BGW3.
GenevestigatorQ8BGW3.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369804.
PROQ8BGW3.
SOURCESearch...

Entry information

Entry nameBHE23_MOUSE
AccessionPrimary (citable) accession number: Q8BGW3
Secondary accession number(s): Q71MB7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot