Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Class E basic helix-loop-helix protein 23

Gene

Bhlhe23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of retinal cell programmed cell death Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • post-embryonic eye morphogenesis Source: MGI
  • retinal rod cell development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Class E basic helix-loop-helix protein 23
Short name:
bHLHe23
Alternative name(s):
Class B basic helix-loop-helix protein 4
Short name:
bHLHb4
Gene namesi
Name:Bhlhe23
Synonyms:Bhlhb4, H20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2153710 Bhlhe23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Disrupted rod signaling and profound retinal dysfunction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455271 – 223Class E basic helix-loop-helix protein 23Add BLAST223

Proteomic databases

PaxDbiQ8BGW3
PRIDEiQ8BGW3

PTM databases

iPTMnetiQ8BGW3
PhosphoSitePlusiQ8BGW3

Expressioni

Tissue specificityi

Expressed in brain and retina.

Developmental stagei

Expression is confined to regions of the developing nervous system and pancreas. At E13 expressed at lower levels in the trigeminal ganglion, the ganglionic eminence, the ventral neural tube, and dorsal root ganglia. Expressed at moderate levels in the tectum of the embryonic midbrain. Most prominent expression is in the diencephalon, where it flanks either side of the roof of the third ventricle, dorsal/caudal to the dorsal thalamus. Detected in the pancreas during the time when most of the pancreatic endocrine cell types are beginning to differentiate and endocrine precursor cells remain loosely associated with the duct epithelium until they begin to form aggregates late in development.1 Publication

Gene expression databases

BgeeiENSMUSG00000045493
ExpressionAtlasiQ8BGW3 baseline and differential
GenevisibleiQ8BGW3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052737

Structurei

3D structure databases

ProteinModelPortaliQ8BGW3
SMRiQ8BGW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 152bHLHPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 110Arg-richAdd BLAST35

Phylogenomic databases

eggNOGiENOG410IQ4C Eukaryota
ENOG4111Y1D LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000060094
InParanoidiQ8BGW3
KOiK09086
OMAiATCAEKC
OrthoDBiEOG091G129L
PhylomeDBiQ8BGW3
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032662 Bhlhe23
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF53 PTHR19290:SF53, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELKSLSGD SYLALSHSYT ATGHAYAAAR GPETTRGFGA SGPGGDLPAA
60 70 80 90 100
PASRVPAATV ESSGEQSGDE DEAFERRRRR RGSGVAVDAR RRPREQRSLR
110 120 130 140 150
LSINARERRR MHDLNDALDG LRAVIPYAHS PSVRKLSKIA TLLLAKNYIL
160 170 180 190 200
MQAQALEEMR RLVAYLNQGQ GLAAPVAAAP LTPFGQAAIY PFSAGTALGP
210 220
CPDKCATFSG SPSALCKHCG EKP
Length:223
Mass (Da):23,701
Last modified:March 1, 2003 - v1
Checksum:i68DCD15E0D70C1FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87V → F in AAL51039 (PubMed:11863370).Curated1
Sequence conflicti101L → F in AAL51039 (PubMed:11863370).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454760 mRNA Translation: AAL51039.1
AB053118 Genomic DNA Translation: BAC81773.1
AK044215 mRNA Translation: BAC31821.1
AK051155 mRNA Translation: BAC34539.1
CCDSiCCDS17187.1
RefSeqiNP_542372.2, NM_080641.5
UniGeneiMm.134062

Genome annotation databases

EnsembliENSMUST00000108878; ENSMUSP00000104506; ENSMUSG00000045493
GeneIDi140489
KEGGimmu:140489
UCSCiuc008okb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBHE23_MOUSE
AccessioniPrimary (citable) accession number: Q8BGW3
Secondary accession number(s): Q71MB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health