ID   FTO_MOUSE               Reviewed;         502 AA.
AC   Q8BGW1; Q3TTZ5; Q6ZPI7; Q8BR68; Q8CB66; Q8R250; Q9QZ13;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Protein fto;
DE   AltName: Full=Fat mass and obesity-associated protein;
DE   AltName: Full=Protein fatso;
GN   Name=Fto; Synonyms=Kiaa1752;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   MEDLINE=99431665; PubMed=10501967; DOI=10.1007/s003359901144;
RA   Peters T., Ausmeier K., Ruether U.;
RT   "Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft)
RT   mouse mutation.";
RL   Mamm. Genome 10:983-986(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   MEDLINE=22977043; PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   III. The complete nucleotide sequences of 500 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC   STRAIN=C57BL/6J, and NOD;
RC   TISSUE=Aorta, Bone, Corpora quadrigemina, Skin, Thymus, and Vein;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6, and FVB/N; TISSUE=Brain, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8BGW1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BGW1-2; Sequence=VSP_025011;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q8BGW1-3; Sequence=VSP_025009, VSP_025010;
CC         Note=No experimental confirmation available;
CC       Name=4;
CC         IsoId=Q8BGW1-4; Sequence=VSP_025007, VSP_025008;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the fto family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AJ237917; CAB59324.1; -; mRNA.
DR   EMBL; AK129437; BAC98247.1; ALT_INIT; mRNA.
DR   EMBL; AK036677; BAC29533.1; -; mRNA.
DR   EMBL; AK040866; BAC30724.1; -; mRNA.
DR   EMBL; AK045465; BAC32382.1; -; mRNA.
DR   EMBL; AK049502; BAC33780.1; -; mRNA.
DR   EMBL; AK088881; BAC40629.1; -; mRNA.
DR   EMBL; AK161060; BAE36177.1; -; mRNA.
DR   EMBL; BC022222; AAH22222.1; -; mRNA.
DR   EMBL; BC057008; AAH57008.1; -; mRNA.
DR   IPI; IPI00280462; -.
DR   IPI; IPI00845534; -.
DR   IPI; IPI00845571; -.
DR   IPI; IPI00845590; -.
DR   RefSeq; NP_036066.2; -.
DR   UniGene; Mm.4375; -.
DR   Ensembl; ENSMUSG00000055932; Mus musculus.
DR   GeneID; 26383; -.
DR   KEGG; mmu:26383; -.
DR   MGI; MGI:1347093; Fto.
DR   HOVERGEN; Q8BGW1; -.
DR   OMA; Q8BGW1; TPVSRIL.
DR   NextBio; 304305; -.
DR   ArrayExpress; Q8BGW1; -.
DR   Bgee; Q8BGW1; -.
DR   CleanEx; MM_FTO; -.
DR   GO; GO:0007368; P:determination of left/right symmetry; IEP:HGNC.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IEP:HGNC.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Obesity.
FT   CHAIN         1    502       Protein fto.
FT                                /FTId=PRO_0000286164.
FT   VAR_SEQ     296    316       DDLNATHQHCVLAGSQPRFSS -> GNVGSLRVGHLWGFEI
FT                                HFWIL (in isoform 4).
FT                                /FTId=VSP_025007.
FT   VAR_SEQ     317    502       Missing (in isoform 4).
FT                                /FTId=VSP_025008.
FT   VAR_SEQ     411    413       TNA -> VSA (in isoform 3).
FT                                /FTId=VSP_025009.
FT   VAR_SEQ     414    502       Missing (in isoform 3).
FT                                /FTId=VSP_025010.
FT   VAR_SEQ     453    502       CQSRVVRTLPVQQKPDCRPYWEKDDPSMPLPFDLTDVVSEL
FT                                RGQLLEARS -> FVLLRGGVWCPCPSSARPAQRTKVEDIL
FT                                S (in isoform 2).
FT                                /FTId=VSP_025011.
FT   CONFLICT    181    181       G -> R (in Ref. 3; BAC32382).
FT   CONFLICT    384    384       N -> S (in Ref. 1; CAB59324, 2; BAC98247,
FT                                3; BAC40629 and 4; AAH22222).
FT   CONFLICT    410    410       M -> V (in Ref. 2; BAC98247, 3; BAC40629
FT                                and 4; AAH22222).
FT   CONFLICT    463    463       V -> A (in Ref. 3; BAC40629 and 4;
FT                                AAH22222).
SQ   SEQUENCE   502 AA;  58007 MW;  69223B824028D872 CRC64;
     MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE
     LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV
     KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV
     GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA
     VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA
     THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV
     LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR
     EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM
     PLPFDLTDVV SELRGQLLEA RS
//