Reviewed, UniProtKB/Swiss-Prot Q8BGW1 (FTO_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein fto
Alternative name(s):
    Fat mass and obesity-associated protein
    Protein fatso

Gene names

Name:	Fto
Synonyms:	Kiaa1752

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the fto family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Disease	Obesity
PTM	Acetylation
Gene Ontology (GO)
Biological process	determination of left/right symmetry Inferred from expression pattern. Source: HGNC embryonic limb morphogenesis Inferred from expression pattern. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BGW1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BGW1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     453-502: CQSRVVRTLP...LRGQLLEARS → FVLLRGGVWCPCPSSARPAQRTKVEDILS

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8BGW1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     411-413: TNA → VSA
     414-502: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8BGW1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     296-316: DDLNATHQHCVLAGSQPRFSS → GNVGSLRVGHLWGFEIHFWIL
     317-502: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Protein fto		PRO_0000286164
Amino acid modifications
	Modified residue	213	1	N6-acetyllysine By similarity
Natural variations
	Alternative sequence	296 – 316	21	DDLNA…PRFSS → GNVGSLRVGHLWGFEIHFWI L in isoform 4.		VSP_025007
	Alternative sequence	317 – 502	186	Missing in isoform 4.		VSP_025008
	Alternative sequence	411 – 413	3	TNA → VSA in isoform 3.		VSP_025009
	Alternative sequence	414 – 502	89	Missing in isoform 3.		VSP_025010
	Alternative sequence	453 – 502	50	CQSRV…LEARS → FVLLRGGVWCPCPSSARPAQ RTKVEDILS in isoform 2.		VSP_025011
Experimental info
	Sequence conflict	181	1	G → R in BAC32382. Ref.3
	Sequence conflict	384	1	N → S in CAB59324. Ref.1
	Sequence conflict	384	1	N → S in BAC98247. Ref.2
	Sequence conflict	384	1	N → S in BAC40629. Ref.3
	Sequence conflict	384	1	N → S in AAH22222. Ref.4
	Sequence conflict	410	1	M → V in BAC98247. Ref.2
	Sequence conflict	410	1	M → V in BAC40629. Ref.3
	Sequence conflict	410	1	M → V in AAH22222. Ref.4
	Sequence conflict	463	1	V → A in BAC40629. Ref.3
	Sequence conflict	463	1	V → A in AAH22222. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 69223B824028D872	FASTA	502	58,007
	10 20 30 40 50 60 MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 70 80 90 100 110 120 LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 130 140 150 160 170 180 KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 190 200 210 220 230 240 GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 250 260 270 280 290 300 VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 310 320 330 340 350 360 THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 370 380 390 400 410 420 LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 430 440 450 460 470 480 EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 490 500 PLPFDLTDVV SELRGQLLEA RS
	Isoform 2. Checksum: D79A1C3143BEF2D9	FASTA	481	55,393
	10 20 30 40 50 60 MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 70 80 90 100 110 120 LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 130 140 150 160 170 180 KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 190 200 210 220 230 240 GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 250 260 270 280 290 300 VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 310 320 330 340 350 360 THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 370 380 390 400 410 420 LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 430 440 450 460 470 480 EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARFVLLRGGV WCPCPSSARP AQRTKVEDIL S
	Isoform 3. Checksum: A3E62B85C8133963	FASTA	413	47,593
	10 20 30 40 50 60 MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 70 80 90 100 110 120 LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 130 140 150 160 170 180 KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 190 200 210 220 230 240 GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 250 260 270 280 290 300 VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 310 320 330 340 350 360 THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 370 380 390 400 410 LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM VSA
	Isoform 4. Checksum: C6C1B6EB7E895140	FASTA	316	36,366
	10 20 30 40 50 60 MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 70 80 90 100 110 120 LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 130 140 150 160 170 180 KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 190 200 210 220 230 240 GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 250 260 270 280 290 300 VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLGNVGS 310 LRVGHLWGFE IHFWIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation." Peters T., Ausmeier K., Ruether U. Mamm. Genome 10:983-986(1999) [PubMed: 10501967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Strain: C57BL/6J and NOD. Tissue: Aorta, Bone, Corpora quadrigemina, Skin, Thymus and Vein.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6 and FVB/N. Tissue: Brain and Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ237917 mRNA. Translation: CAB59324.1. AK129437 mRNA. Translation: BAC98247.1. Different initiation. AK036677 mRNA. Translation: BAC29533.1. AK040866 mRNA. Translation: BAC30724.1. AK045465 mRNA. Translation: BAC32382.1. AK049502 mRNA. Translation: BAC33780.1. AK088881 mRNA. Translation: BAC40629.1. AK161060 mRNA. Translation: BAE36177.1. BC022222 mRNA. Translation: AAH22222.1. BC057008 mRNA. Translation: AAH57008.1.
IPI	IPI00280462. IPI00845534. IPI00845571. IPI00845590.
RefSeq	NP_036066.2.
UniGene	Mm.4375
3D structure databases
SMR	Q8BGW1. Positions 83-320.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BGW1.
Proteomic databases
PRIDE	Q8BGW1.
Genome annotation databases
Ensembl	ENSMUST00000069718; ENSMUSP00000068380; ENSMUSG00000055932; Mus musculus. [Genome view]
GeneID	26383.
KEGG	mmu:26383.
UCSC	uc009mst.1. mouse.
Organism-specific databases
CTD	26383.
MGI	MGI:1347093. Fto.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG09408.
HOVERGEN	Q8BGW1.
InParanoid	Q8BGW1.
OMA	HGCLFRD.
OrthoDB	EOG94TRV4.
PhylomeDB	Q8BGW1.
Gene expression databases
ArrayExpress	Q8BGW1.
Bgee	Q8BGW1.
CleanEx	MM_FTO.
Genevestigator	Q8BGW1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	304305.
SOURCE	Search...

Entry information

Entry name

FTO_MOUSE

Accession

Primary (citable) accession number: Q8BGW1
Secondary accession number(s): Q3TTZ5 , Q6ZPI7, Q8BR68, Q8CB66, Q8R250, Q9QZ13

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 1, 2003
Last modified:	January 19, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)