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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Gene

Kctd13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Alternative name(s):
BTB/POZ domain-containing protein KCTD13
Polymerase delta-interacting protein 1
Gene namesi
Name:Kctd13
Synonyms:Poldip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923739. Kctd13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912981 – 329BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1Add BLAST329

Proteomic databases

EPDiQ8BGV7.
MaxQBiQ8BGV7.
PaxDbiQ8BGV7.
PRIDEiQ8BGV7.

PTM databases

PhosphoSitePlusiQ8BGV7.

Expressioni

Inductioni

By TNF-alpha.1 Publication

Gene expression databases

BgeeiENSMUSG00000030685.
GenevisibleiQ8BGV7. MM.

Interactioni

Subunit structurei

Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA (By similarity).By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: UniProtKB
  • identical protein binding Source: MGI
  • protein domain specific binding Source: Ensembl

Protein-protein interaction databases

IntActiQ8BGV7. 1 interactor.
STRINGi10090.ENSMUSP00000032924.

Structurei

3D structure databases

ProteinModelPortaliQ8BGV7.
SMRiQ8BGV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 109BTBPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716. Eukaryota.
ENOG410XQYZ. LUCA.
GeneTreeiENSGT00900000140932.
HOGENOMiHOG000294088.
HOVERGENiHBG052219.
InParanoidiQ8BGV7.
KOiK15074.
OMAiHIMHDER.
OrthoDBiEOG091G0L1Y.
PhylomeDBiQ8BGV7.
TreeFamiTF315649.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEASGPAP AAAECLESPS PSSVEPGSPS YSLKPLTPNS KYVKLNVGGS
60 70 80 90 100
LHYTTLRTLT GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL
110 120 130 140 150
RDGSVPLPES ARELGELLGE ARYYLVQGLI EDCQLALQQK REKLSPLCLI
160 170 180 190 200
PTVTSPREEQ QLLASTSKPV VKLLHNRSNN KYSYTSTSDD NLLKNIELFD
210 220 230 240 250
KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT
260 270 280 290 300
KVEFPEARIF EETLNILIYE NSRGPDLALL EATGGAAGGG GAGRGDDEEN
310 320
REHRVRRIHV RRHITHDERP HGQQIVFKD
Length:329
Mass (Da):36,442
Last modified:March 1, 2003 - v1
Checksum:i6B312D8067060747
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF534881 mRNA. Translation: AAO16177.1.
AK075722 mRNA. Translation: BAC35910.1.
BC079607 mRNA. Translation: AAH79607.1.
CCDSiCCDS21851.1.
RefSeqiNP_766335.1. NM_172747.2.
UniGeneiMm.245897.

Genome annotation databases

EnsembliENSMUST00000032924; ENSMUSP00000032924; ENSMUSG00000030685.
GeneIDi233877.
KEGGimmu:233877.
UCSCiuc009jtm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiBACD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV7
Secondary accession number(s): Q6AXE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families