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Q8BGV3

- TACD2_MOUSE

UniProt

Q8BGV3 - TACD2_MOUSE

Protein

Tumor-associated calcium signal transducer 2

Gene

Tacstd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May function as a growth factor receptor.By similarity

    GO - Biological processi

    1. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    2. negative regulation of cell motility Source: UniProtKB
    3. negative regulation of epithelial cell migration Source: UniProtKB
    4. negative regulation of ruffle assembly Source: UniProtKB
    5. negative regulation of stress fiber assembly Source: UniProtKB
    6. negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
    7. positive regulation of stem cell differentiation Source: MGI
    8. regulation of epithelial cell proliferation Source: UniProtKB
    9. ureteric bud morphogenesis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor-associated calcium signal transducer 2
    Alternative name(s):
    Cell surface glycoprotein Trop-2
    Gene namesi
    Name:Tacstd2
    Synonyms:Trop2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1861606. Tacstd2.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. basal plasma membrane Source: UniProtKB
    2. extracellular space Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. lateral plasma membrane Source: UniProtKB
    5. membrane Source: MGI
    6. nucleus Source: MGI
    7. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 317293Tumor-associated calcium signal transducer 2PRO_0000380187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi67 ↔ 102PROSITE-ProRule annotation
    Disulfide bondi113 ↔ 119PROSITE-ProRule annotation
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8BGV3.
    PRIDEiQ8BGV3.

    PTM databases

    PhosphoSiteiQ8BGV3.

    Expressioni

    Tissue specificityi

    Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes.1 Publication

    Gene expression databases

    BgeeiQ8BGV3.
    GenevestigatoriQ8BGV3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGV3.
    SMRiQ8BGV3. Positions 95-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 270246ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31726CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 13976Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPCAM family.Curated
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46689.
    GeneTreeiENSGT00390000018245.
    HOGENOMiHOG000074086.
    InParanoidiQ8BGV3.
    KOiK17288.
    OMAiRQCNQTS.
    OrthoDBiEOG7HQN8S.
    PhylomeDBiQ8BGV3.
    TreeFamiTF332767.

    Family and domain databases

    Gene3Di4.10.800.10. 1 hit.
    InterProiIPR000716. Thyroglobulin_1.
    [Graphical view]
    PfamiPF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BGV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGLDLAPL LLLLLAMATR FCTAQSNCTC PTNKMTVCDT NGPGGVCQCR    50
    AMGSQVLVDC STLTSKCLLL KARMSARKSG RSLVMPSEHA ILDNDGLYDP 100
    ECDDKGRFKA RQCNQTSVCW CVNSVGVRRT DKGDQSLRCD EVVRTHHILI 150
    ELRHRPTDRA FNHSDLDSEL RRLFQERYKL HPSFLSAVHY EEPTIQIELR 200
    QNASQKGLRD VDIADAAYYF ERDIKGESLF MGRRGLDVQV RGEPLHVERT 250
    LIYYLDEKPP QFSMKRLTAG VIAVIAVVSV AVVAGVVVLV VTKRRKSGKY 300
    KKVELKELGE MRSEPSL 317
    Length:317
    Mass (Da):35,574
    Last modified:March 1, 2003 - v1
    Checksum:i6C54185B96A4C640
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti187 – 1871A → V in CAA70063. (PubMed:9462726)Curated
    Sequence conflicti203 – 2031A → V in CAA70063. (PubMed:9462726)Curated
    Sequence conflicti251 – 2511L → V in CAA70063. (PubMed:9462726)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08830 Genomic DNA. Translation: CAA70063.1.
    AK076410 mRNA. Translation: BAC36328.1.
    AK077370 mRNA. Translation: BAC36773.1.
    AK085753 mRNA. Translation: BAC39531.1.
    CH466523 Genomic DNA. Translation: EDK98807.1.
    BC117719 mRNA. Translation: AAI17720.1.
    BC117720 mRNA. Translation: AAI17721.1.
    CCDSiCCDS20221.1.
    RefSeqiNP_064431.2. NM_020047.3.
    UniGeneiMm.439913.

    Genome annotation databases

    EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397.
    GeneIDi56753.
    KEGGimmu:56753.
    UCSCiuc009cfq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08830 Genomic DNA. Translation: CAA70063.1 .
    AK076410 mRNA. Translation: BAC36328.1 .
    AK077370 mRNA. Translation: BAC36773.1 .
    AK085753 mRNA. Translation: BAC39531.1 .
    CH466523 Genomic DNA. Translation: EDK98807.1 .
    BC117719 mRNA. Translation: AAI17720.1 .
    BC117720 mRNA. Translation: AAI17721.1 .
    CCDSi CCDS20221.1.
    RefSeqi NP_064431.2. NM_020047.3.
    UniGenei Mm.439913.

    3D structure databases

    ProteinModelPortali Q8BGV3.
    SMRi Q8BGV3. Positions 95-141.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BGV3.

    Proteomic databases

    PaxDbi Q8BGV3.
    PRIDEi Q8BGV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058178 ; ENSMUSP00000060099 ; ENSMUSG00000051397 .
    GeneIDi 56753.
    KEGGi mmu:56753.
    UCSCi uc009cfq.1. mouse.

    Organism-specific databases

    CTDi 4070.
    MGIi MGI:1861606. Tacstd2.

    Phylogenomic databases

    eggNOGi NOG46689.
    GeneTreei ENSGT00390000018245.
    HOGENOMi HOG000074086.
    InParanoidi Q8BGV3.
    KOi K17288.
    OMAi RQCNQTS.
    OrthoDBi EOG7HQN8S.
    PhylomeDBi Q8BGV3.
    TreeFami TF332767.

    Miscellaneous databases

    NextBioi 313282.
    PROi Q8BGV3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGV3.
    Genevestigatori Q8BGV3.

    Family and domain databases

    Gene3Di 4.10.800.10. 1 hit.
    InterProi IPR000716. Thyroglobulin_1.
    [Graphical view ]
    Pfami PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2."
      El Sewedy T., Fornaro M., Alberti S.
      Int. J. Cancer 75:324-330(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Mammary gland and Skin.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTACD2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGV3
    Secondary accession number(s): O55130
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3