Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor-associated calcium signal transducer 2

Gene

Tacstd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a growth factor receptor.By similarity

GO - Biological processi

  • cell-cell adhesion Source: GO_Central
  • negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • negative regulation of cell motility Source: UniProtKB
  • negative regulation of epithelial cell migration Source: UniProtKB
  • negative regulation of ruffle assembly Source: UniProtKB
  • negative regulation of stress fiber assembly Source: UniProtKB
  • negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • positive regulation of stem cell differentiation Source: MGI
  • regulation of epithelial cell proliferation Source: UniProtKB
  • ureteric bud morphogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Gene namesi
Name:Tacstd2
Synonyms:Trop2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1861606. Tacstd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 270ExtracellularSequence analysisAdd BLAST246
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 317CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • basal plasma membrane Source: UniProtKB
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • lateral plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000038018725 – 317Tumor-associated calcium signal transducer 2Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi67 ↔ 102PROSITE-ProRule annotation
Disulfide bondi113 ↔ 119PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BGV3.
PaxDbiQ8BGV3.
PeptideAtlasiQ8BGV3.
PRIDEiQ8BGV3.

PTM databases

iPTMnetiQ8BGV3.
PhosphoSitePlusiQ8BGV3.

Expressioni

Tissue specificityi

Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000051397.
GenevisibleiQ8BGV3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060099.

Structurei

3D structure databases

ProteinModelPortaliQ8BGV3.
SMRiQ8BGV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 139Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the EPCAM family.Curated
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6. Eukaryota.
ENOG4111M3B. LUCA.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
InParanoidiQ8BGV3.
KOiK17288.
OMAiRQCNQTS.
OrthoDBiEOG091G0G85.
PhylomeDBiQ8BGV3.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLDLAPL LLLLLAMATR FCTAQSNCTC PTNKMTVCDT NGPGGVCQCR
60 70 80 90 100
AMGSQVLVDC STLTSKCLLL KARMSARKSG RSLVMPSEHA ILDNDGLYDP
110 120 130 140 150
ECDDKGRFKA RQCNQTSVCW CVNSVGVRRT DKGDQSLRCD EVVRTHHILI
160 170 180 190 200
ELRHRPTDRA FNHSDLDSEL RRLFQERYKL HPSFLSAVHY EEPTIQIELR
210 220 230 240 250
QNASQKGLRD VDIADAAYYF ERDIKGESLF MGRRGLDVQV RGEPLHVERT
260 270 280 290 300
LIYYLDEKPP QFSMKRLTAG VIAVIAVVSV AVVAGVVVLV VTKRRKSGKY
310
KKVELKELGE MRSEPSL
Length:317
Mass (Da):35,574
Last modified:March 1, 2003 - v1
Checksum:i6C54185B96A4C640
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187A → V in CAA70063 (PubMed:9462726).Curated1
Sequence conflicti203A → V in CAA70063 (PubMed:9462726).Curated1
Sequence conflicti251L → V in CAA70063 (PubMed:9462726).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08830 Genomic DNA. Translation: CAA70063.1.
AK076410 mRNA. Translation: BAC36328.1.
AK077370 mRNA. Translation: BAC36773.1.
AK085753 mRNA. Translation: BAC39531.1.
CH466523 Genomic DNA. Translation: EDK98807.1.
BC117719 mRNA. Translation: AAI17720.1.
BC117720 mRNA. Translation: AAI17721.1.
CCDSiCCDS20221.1.
RefSeqiNP_064431.2. NM_020047.3.
UniGeneiMm.439913.

Genome annotation databases

EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397.
GeneIDi56753.
KEGGimmu:56753.
UCSCiuc009cfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08830 Genomic DNA. Translation: CAA70063.1.
AK076410 mRNA. Translation: BAC36328.1.
AK077370 mRNA. Translation: BAC36773.1.
AK085753 mRNA. Translation: BAC39531.1.
CH466523 Genomic DNA. Translation: EDK98807.1.
BC117719 mRNA. Translation: AAI17720.1.
BC117720 mRNA. Translation: AAI17721.1.
CCDSiCCDS20221.1.
RefSeqiNP_064431.2. NM_020047.3.
UniGeneiMm.439913.

3D structure databases

ProteinModelPortaliQ8BGV3.
SMRiQ8BGV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060099.

PTM databases

iPTMnetiQ8BGV3.
PhosphoSitePlusiQ8BGV3.

Proteomic databases

MaxQBiQ8BGV3.
PaxDbiQ8BGV3.
PeptideAtlasiQ8BGV3.
PRIDEiQ8BGV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397.
GeneIDi56753.
KEGGimmu:56753.
UCSCiuc009cfq.1. mouse.

Organism-specific databases

CTDi4070.
MGIiMGI:1861606. Tacstd2.

Phylogenomic databases

eggNOGiENOG410IFI6. Eukaryota.
ENOG4111M3B. LUCA.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
InParanoidiQ8BGV3.
KOiK17288.
OMAiRQCNQTS.
OrthoDBiEOG091G0G85.
PhylomeDBiQ8BGV3.
TreeFamiTF332767.

Miscellaneous databases

PROiQ8BGV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051397.
GenevisibleiQ8BGV3. MM.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV3
Secondary accession number(s): O55130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.