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Q8BGV3

- TACD2_MOUSE

UniProt

Q8BGV3 - TACD2_MOUSE

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Protein

Tumor-associated calcium signal transducer 2

Gene

Tacstd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May function as a growth factor receptor.By similarity

GO - Biological processi

  1. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  2. negative regulation of cell motility Source: UniProtKB
  3. negative regulation of epithelial cell migration Source: UniProtKB
  4. negative regulation of ruffle assembly Source: UniProtKB
  5. negative regulation of stress fiber assembly Source: UniProtKB
  6. negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  7. positive regulation of stem cell differentiation Source: MGI
  8. regulation of epithelial cell proliferation Source: UniProtKB
  9. ureteric bud morphogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Gene namesi
Name:Tacstd2
Synonyms:Trop2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1861606. Tacstd2.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. basal plasma membrane Source: UniProtKB
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lateral plasma membrane Source: UniProtKB
  6. membrane Source: MGI
  7. nucleus Source: MGI
  8. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 317293Tumor-associated calcium signal transducer 2PRO_0000380187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi67 ↔ 102PROSITE-ProRule annotation
Disulfide bondi113 ↔ 119PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BGV3.
PRIDEiQ8BGV3.

PTM databases

PhosphoSiteiQ8BGV3.

Expressioni

Tissue specificityi

Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes.1 Publication

Gene expression databases

BgeeiQ8BGV3.
GenevestigatoriQ8BGV3.

Structurei

3D structure databases

ProteinModelPortaliQ8BGV3.
SMRiQ8BGV3. Positions 95-141.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 270246ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31726CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 13976Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EPCAM family.Curated
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46689.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
InParanoidiQ8BGV3.
KOiK17288.
OMAiRQCNQTS.
OrthoDBiEOG7HQN8S.
PhylomeDBiQ8BGV3.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGLDLAPL LLLLLAMATR FCTAQSNCTC PTNKMTVCDT NGPGGVCQCR
60 70 80 90 100
AMGSQVLVDC STLTSKCLLL KARMSARKSG RSLVMPSEHA ILDNDGLYDP
110 120 130 140 150
ECDDKGRFKA RQCNQTSVCW CVNSVGVRRT DKGDQSLRCD EVVRTHHILI
160 170 180 190 200
ELRHRPTDRA FNHSDLDSEL RRLFQERYKL HPSFLSAVHY EEPTIQIELR
210 220 230 240 250
QNASQKGLRD VDIADAAYYF ERDIKGESLF MGRRGLDVQV RGEPLHVERT
260 270 280 290 300
LIYYLDEKPP QFSMKRLTAG VIAVIAVVSV AVVAGVVVLV VTKRRKSGKY
310
KKVELKELGE MRSEPSL
Length:317
Mass (Da):35,574
Last modified:March 1, 2003 - v1
Checksum:i6C54185B96A4C640
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871A → V in CAA70063. (PubMed:9462726)Curated
Sequence conflicti203 – 2031A → V in CAA70063. (PubMed:9462726)Curated
Sequence conflicti251 – 2511L → V in CAA70063. (PubMed:9462726)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08830 Genomic DNA. Translation: CAA70063.1.
AK076410 mRNA. Translation: BAC36328.1.
AK077370 mRNA. Translation: BAC36773.1.
AK085753 mRNA. Translation: BAC39531.1.
CH466523 Genomic DNA. Translation: EDK98807.1.
BC117719 mRNA. Translation: AAI17720.1.
BC117720 mRNA. Translation: AAI17721.1.
CCDSiCCDS20221.1.
RefSeqiNP_064431.2. NM_020047.3.
UniGeneiMm.439913.

Genome annotation databases

EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397.
GeneIDi56753.
KEGGimmu:56753.
UCSCiuc009cfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08830 Genomic DNA. Translation: CAA70063.1 .
AK076410 mRNA. Translation: BAC36328.1 .
AK077370 mRNA. Translation: BAC36773.1 .
AK085753 mRNA. Translation: BAC39531.1 .
CH466523 Genomic DNA. Translation: EDK98807.1 .
BC117719 mRNA. Translation: AAI17720.1 .
BC117720 mRNA. Translation: AAI17721.1 .
CCDSi CCDS20221.1.
RefSeqi NP_064431.2. NM_020047.3.
UniGenei Mm.439913.

3D structure databases

ProteinModelPortali Q8BGV3.
SMRi Q8BGV3. Positions 95-141.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGV3.

Proteomic databases

PaxDbi Q8BGV3.
PRIDEi Q8BGV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058178 ; ENSMUSP00000060099 ; ENSMUSG00000051397 .
GeneIDi 56753.
KEGGi mmu:56753.
UCSCi uc009cfq.1. mouse.

Organism-specific databases

CTDi 4070.
MGIi MGI:1861606. Tacstd2.

Phylogenomic databases

eggNOGi NOG46689.
GeneTreei ENSGT00390000018245.
HOGENOMi HOG000074086.
InParanoidi Q8BGV3.
KOi K17288.
OMAi RQCNQTS.
OrthoDBi EOG7HQN8S.
PhylomeDBi Q8BGV3.
TreeFami TF332767.

Miscellaneous databases

NextBioi 313282.
PROi Q8BGV3.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGV3.
Genevestigatori Q8BGV3.

Family and domain databases

Gene3Di 4.10.800.10. 1 hit.
InterProi IPR000716. Thyroglobulin_1.
[Graphical view ]
Pfami PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
SMARTi SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57610. SSF57610. 1 hit.
PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2."
    El Sewedy T., Fornaro M., Alberti S.
    Int. J. Cancer 75:324-330(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Mammary gland and Skin.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTACD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV3
Secondary accession number(s): O55130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3