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Q8BGV3 (TACD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Gene names
Name:Tacstd2
Synonyms:Trop2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a growth factor receptor By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes. Ref.1

Sequence similarities

Belongs to the EPCAM family.

Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of branching involved in ureteric bud morphogenesis

Inferred from direct assay PubMed 22194864. Source: UniProtKB

negative regulation of cell motility

Inferred from direct assay PubMed 22194864. Source: UniProtKB

negative regulation of epithelial cell migration

Inferred from direct assay PubMed 22194864. Source: UniProtKB

negative regulation of ruffle assembly

Inferred from direct assay PubMed 22194864. Source: UniProtKB

negative regulation of stress fiber assembly

Inferred from direct assay PubMed 22194864. Source: UniProtKB

negative regulation of substrate adhesion-dependent cell spreading

Inferred from direct assay PubMed 22194864. Source: UniProtKB

positive regulation of stem cell differentiation

Inferred from direct assay PubMed 23070813. Source: MGI

regulation of epithelial cell proliferation

Inferred from expression pattern PubMed 22194864. Source: UniProtKB

ureteric bud morphogenesis

Inferred from expression pattern PubMed 22194864. Source: UniProtKB

   Cellular_componentbasal plasma membrane

Inferred from direct assay PubMed 22194864. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 23070813. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lateral plasma membrane

Inferred from direct assay PubMed 22194864. Source: UniProtKB

membrane

Inferred from direct assay PubMed 23070813. Source: MGI

nucleus

Inferred from direct assay PubMed 23070813. Source: MGI

plasma membrane

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 317293Tumor-associated calcium signal transducer 2
PRO_0000380187

Regions

Topological domain25 – 270246Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 31726Cytoplasmic Potential
Domain64 – 13976Thyroglobulin type-1

Amino acid modifications

Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 102 By similarity
Disulfide bond113 ↔ 119 By similarity
Disulfide bond121 ↔ 139 By similarity

Experimental info

Sequence conflict1871A → V in CAA70063. Ref.1
Sequence conflict2031A → V in CAA70063. Ref.1
Sequence conflict2511L → V in CAA70063. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BGV3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6C54185B96A4C640

FASTA31735,574
        10         20         30         40         50         60 
MARGLDLAPL LLLLLAMATR FCTAQSNCTC PTNKMTVCDT NGPGGVCQCR AMGSQVLVDC 

        70         80         90        100        110        120 
STLTSKCLLL KARMSARKSG RSLVMPSEHA ILDNDGLYDP ECDDKGRFKA RQCNQTSVCW 

       130        140        150        160        170        180 
CVNSVGVRRT DKGDQSLRCD EVVRTHHILI ELRHRPTDRA FNHSDLDSEL RRLFQERYKL 

       190        200        210        220        230        240 
HPSFLSAVHY EEPTIQIELR QNASQKGLRD VDIADAAYYF ERDIKGESLF MGRRGLDVQV 

       250        260        270        280        290        300 
RGEPLHVERT LIYYLDEKPP QFSMKRLTAG VIAVIAVVSV AVVAGVVVLV VTKRRKSGKY 

       310 
KKVELKELGE MRSEPSL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2."
El Sewedy T., Fornaro M., Alberti S.
Int. J. Cancer 75:324-330(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head, Mammary gland and Skin.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08830 Genomic DNA. Translation: CAA70063.1.
AK076410 mRNA. Translation: BAC36328.1.
AK077370 mRNA. Translation: BAC36773.1.
AK085753 mRNA. Translation: BAC39531.1.
CH466523 Genomic DNA. Translation: EDK98807.1.
BC117719 mRNA. Translation: AAI17720.1.
BC117720 mRNA. Translation: AAI17721.1.
RefSeqNP_064431.2. NM_020047.3.
UniGeneMm.439913.

3D structure databases

ProteinModelPortalQ8BGV3.
SMRQ8BGV3. Positions 95-141.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BGV3.

Proteomic databases

PaxDbQ8BGV3.
PRIDEQ8BGV3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397.
GeneID56753.
KEGGmmu:56753.
UCSCuc009cfq.1. mouse.

Organism-specific databases

CTD4070.
MGIMGI:1861606. Tacstd2.

Phylogenomic databases

eggNOGNOG46689.
GeneTreeENSGT00390000018245.
HOGENOMHOG000074086.
InParanoidQ8BGV3.
KOK17288.
OMARQCNQTS.
OrthoDBEOG7HQN8S.
PhylomeDBQ8BGV3.
TreeFamTF332767.

Gene expression databases

BgeeQ8BGV3.
GenevestigatorQ8BGV3.

Family and domain databases

Gene3D4.10.800.10. 1 hit.
InterProIPR000716. Thyroglobulin_1.
[Graphical view]
PfamPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTSM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57610. SSF57610. 1 hit.
PROSITEPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313282.
PROQ8BGV3.
SOURCESearch...

Entry information

Entry nameTACD2_MOUSE
AccessionPrimary (citable) accession number: Q8BGV3
Secondary accession number(s): O55130
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot