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Protein

Probable asparagine--tRNA ligase, mitochondrial

Gene

Nars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable asparagine--tRNA ligase, mitochondrial (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:Nars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142075. Nars2.

Subcellular locationi

  • Mitochondrion matrix By similarity
  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionSequence analysisAdd
BLAST
Chaini15 – 477463Probable asparagine--tRNA ligase, mitochondrialPRO_0000250723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei353 – 3531N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGV0.
MaxQBiQ8BGV0.
PaxDbiQ8BGV0.
PeptideAtlasiQ8BGV0.
PRIDEiQ8BGV0.

PTM databases

iPTMnetiQ8BGV0.
PhosphoSiteiQ8BGV0.

Expressioni

Tissue specificityi

Expressed in brain and inner ear, including the cochlear epithelium and organ of Corti.1 Publication

Gene expression databases

BgeeiENSMUSG00000018995.
ExpressionAtlasiQ8BGV0. baseline and differential.
GenevisibleiQ8BGV0. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044937.

Structurei

3D structure databases

ProteinModelPortaliQ8BGV0.
SMRiQ8BGV0. Positions 41-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0554. Eukaryota.
COG0017. LUCA.
GeneTreeiENSGT00550000074970.
HOGENOMiHOG000226033.
HOVERGENiHBG067799.
InParanoidiQ8BGV0.
KOiK01893.
OMAiPEDMEFF.
OrthoDBiEOG091G07DH.
PhylomeDBiQ8BGV0.
TreeFamiTF315088.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGARRLLGA LRLCSSVSCP RPRASAKMRV RDALRVQDAR GECVTVQGWI
60 70 80 90 100
RSVRSQKEVL FLHVNDGSSL ESLQIVADSS FDSRELTFGS SVQVQGQLVK
110 120 130 140 150
SQSKRQNVEL KAEKIEVIGD CEAKAFPIKY KERHPLEYLR QYPHLRCRTN
160 170 180 190 200
ALGSILRVRS EATAAIHSYF KDNGFVHIHT PVLTSNDCEG AGELFQVEPS
210 220 230 240 250
SKIKGPKESF FDVPAFLTVS GQLHLEVMSG AFTQVFTFGP TFRAENSQSR
260 270 280 290 300
RHLAEFYMVE AEISFVESLQ DLMQVMEELF KATTEMVLSH CPEDVELCHQ
310 320 330 340 350
FIAAGQKGRL EHMLKNNFLI ISYTEAIEIL KQASQNFAFT PKWGVDLQTE
360 370 380 390 400
HEKYLVRHCG NIPVFVINYP SELKPFYMRE NEDGPQNTVA AVDLLVPGVG
410 420 430 440 450
ELFGGSLREE RYHVLEQRLA RSGLTKAYQW YLDLRKFGSV PHGGFGMGFE
460 470
RYLQCILGVD NIKDVIPFPR FTHSCLL
Length:477
Mass (Da):53,962
Last modified:March 1, 2003 - v1
Checksum:i6CCBAC318E7830DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046799 mRNA. Translation: BAC32875.1.
AK047091 mRNA. Translation: BAC32958.1.
AK050718 mRNA. Translation: BAC34391.1.
AK138260 mRNA. Translation: BAE23597.1.
AK164179 mRNA. Translation: BAE37666.1.
CCDSiCCDS21454.1.
RefSeqiNP_705819.3. NM_153591.4.
UniGeneiMm.274864.

Genome annotation databases

EnsembliENSMUST00000044466; ENSMUSP00000044937; ENSMUSG00000018995.
GeneIDi244141.
KEGGimmu:244141.
UCSCiuc009iiw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046799 mRNA. Translation: BAC32875.1.
AK047091 mRNA. Translation: BAC32958.1.
AK050718 mRNA. Translation: BAC34391.1.
AK138260 mRNA. Translation: BAE23597.1.
AK164179 mRNA. Translation: BAE37666.1.
CCDSiCCDS21454.1.
RefSeqiNP_705819.3. NM_153591.4.
UniGeneiMm.274864.

3D structure databases

ProteinModelPortaliQ8BGV0.
SMRiQ8BGV0. Positions 41-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044937.

PTM databases

iPTMnetiQ8BGV0.
PhosphoSiteiQ8BGV0.

Proteomic databases

EPDiQ8BGV0.
MaxQBiQ8BGV0.
PaxDbiQ8BGV0.
PeptideAtlasiQ8BGV0.
PRIDEiQ8BGV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044466; ENSMUSP00000044937; ENSMUSG00000018995.
GeneIDi244141.
KEGGimmu:244141.
UCSCiuc009iiw.2. mouse.

Organism-specific databases

CTDi79731.
MGIiMGI:2142075. Nars2.

Phylogenomic databases

eggNOGiKOG0554. Eukaryota.
COG0017. LUCA.
GeneTreeiENSGT00550000074970.
HOGENOMiHOG000226033.
HOVERGENiHBG067799.
InParanoidiQ8BGV0.
KOiK01893.
OMAiPEDMEFF.
OrthoDBiEOG091G07DH.
PhylomeDBiQ8BGV0.
TreeFamiTF315088.

Miscellaneous databases

ChiTaRSiNars2. mouse.
PROiQ8BGV0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018995.
ExpressionAtlasiQ8BGV0. baseline and differential.
GenevisibleiQ8BGV0. MM.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNM_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.