Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-Y

Gene

Ccny

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin-dependent kinase CDK16.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-Y
Alternative name(s):
Cyclin fold protein 1
Gene namesi
Name:Ccny
Synonyms:Cfp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915224. Ccny.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000805152 – 341Cyclin-YAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei67Phosphothreonine; by CDK14By similarity1
Modified residuei71Phosphoserine; by CDK14By similarity1
Modified residuei73Phosphoserine; by CDK14By similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei83Phosphoserine; by CDK14By similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei288Phosphoserine; by CDK14By similarity1
Modified residuei295Phosphoserine; by CDK14By similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; leading to its degradation.By similarity
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BGU5.
PeptideAtlasiQ8BGU5.
PRIDEiQ8BGU5.

PTM databases

iPTMnetiQ8BGU5.
PhosphoSitePlusiQ8BGU5.
SwissPalmiQ8BGU5.

Expressioni

Tissue specificityi

Detected in brain, heart, lung, skeletal muscle, ovary, thymus and testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024286.
CleanExiMM_CCNY.
GenevisibleiQ8BGU5. MM.

Interactioni

Subunit structurei

Interacts with CDK14 and LRP6 (By similarity). Interacts with CDK16.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdk16Q047353EBI-772904,EBI-11615670

Protein-protein interaction databases

IntActiQ8BGU5. 4 interactors.
MINTiMINT-4125949.
STRINGi10090.ENSMUSP00000050001.

Structurei

3D structure databases

ProteinModelPortaliQ8BGU5.
SMRiQ8BGU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 265Cyclin N-terminalAdd BLAST123

Sequence similaritiesi

Belongs to the cyclin family. Cyclin Y subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1675. Eukaryota.
ENOG410XNQX. LUCA.
GeneTreeiENSGT00390000006626.
HOGENOMiHOG000021397.
HOVERGENiHBG058985.
InParanoidiQ8BGU5.
OMAiYDKHDPE.
OrthoDBiEOG091G0BM9.
PhylomeDBiQ8BGU5.
TreeFamiTF314464.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI
60 70 80 90 100
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQTSRKYSS
110 120 130 140 150
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH
160 170 180 190 200
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL
210 220 230 240 250
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN
260 270 280 290 300
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
310 320 330 340
KLEAISRLCE DKYKDLRKPM RKRSASADNL ILPRWSPAII S
Length:341
Mass (Da):39,395
Last modified:March 1, 2003 - v1
Checksum:i6F16CE5B14559FCB
GO
Isoform 2 (identifier: Q8BGU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,562
Checksum:i22558710C92190FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257L → P in BAB30772 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01483552 – 76Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017493 mRNA. Translation: BAB30772.1.
AK028696 mRNA. Translation: BAC26071.1.
AK076556 mRNA. Translation: BAC36391.1.
BC023321 mRNA. Translation: AAH23321.1.
BC035524 mRNA. Translation: AAH35524.1.
CCDSiCCDS29050.1. [Q8BGU5-1]
RefSeqiNP_080760.2. NM_026484.3. [Q8BGU5-1]
UniGeneiMm.376607.
Mm.86523.

Genome annotation databases

EnsembliENSMUST00000053917; ENSMUSP00000050001; ENSMUSG00000024286. [Q8BGU5-1]
GeneIDi67974.
KEGGimmu:67974.
UCSCiuc008eai.1. mouse. [Q8BGU5-1]
uc012azd.1. mouse. [Q8BGU5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017493 mRNA. Translation: BAB30772.1.
AK028696 mRNA. Translation: BAC26071.1.
AK076556 mRNA. Translation: BAC36391.1.
BC023321 mRNA. Translation: AAH23321.1.
BC035524 mRNA. Translation: AAH35524.1.
CCDSiCCDS29050.1. [Q8BGU5-1]
RefSeqiNP_080760.2. NM_026484.3. [Q8BGU5-1]
UniGeneiMm.376607.
Mm.86523.

3D structure databases

ProteinModelPortaliQ8BGU5.
SMRiQ8BGU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BGU5. 4 interactors.
MINTiMINT-4125949.
STRINGi10090.ENSMUSP00000050001.

PTM databases

iPTMnetiQ8BGU5.
PhosphoSitePlusiQ8BGU5.
SwissPalmiQ8BGU5.

Proteomic databases

PaxDbiQ8BGU5.
PeptideAtlasiQ8BGU5.
PRIDEiQ8BGU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053917; ENSMUSP00000050001; ENSMUSG00000024286. [Q8BGU5-1]
GeneIDi67974.
KEGGimmu:67974.
UCSCiuc008eai.1. mouse. [Q8BGU5-1]
uc012azd.1. mouse. [Q8BGU5-2]

Organism-specific databases

CTDi219771.
MGIiMGI:1915224. Ccny.

Phylogenomic databases

eggNOGiKOG1675. Eukaryota.
ENOG410XNQX. LUCA.
GeneTreeiENSGT00390000006626.
HOGENOMiHOG000021397.
HOVERGENiHBG058985.
InParanoidiQ8BGU5.
OMAiYDKHDPE.
OrthoDBiEOG091G0BM9.
PhylomeDBiQ8BGU5.
TreeFamiTF314464.

Miscellaneous databases

ChiTaRSiCcny. mouse.
PROiQ8BGU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024286.
CleanExiMM_CCNY.
GenevisibleiQ8BGU5. MM.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNY_MOUSE
AccessioniPrimary (citable) accession number: Q8BGU5
Secondary accession number(s): Q8CI87, Q9CYN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.