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Protein

Cyclin-Y

Gene

Ccny

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin-dependent kinase CDK16.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-Y
Alternative name(s):
Cyclin fold protein 1
Gene namesi
Name:Ccny
Synonyms:Cfp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915224. Ccny.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000805152 – 341Cyclin-YAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei67Phosphothreonine; by CDK14By similarity1
Modified residuei71Phosphoserine; by CDK14By similarity1
Modified residuei73Phosphoserine; by CDK14By similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei83Phosphoserine; by CDK14By similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei288Phosphoserine; by CDK14By similarity1
Modified residuei295Phosphoserine; by CDK14By similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; leading to its degradation.By similarity
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BGU5.
PeptideAtlasiQ8BGU5.
PRIDEiQ8BGU5.

PTM databases

iPTMnetiQ8BGU5.
PhosphoSitePlusiQ8BGU5.
SwissPalmiQ8BGU5.

Expressioni

Tissue specificityi

Detected in brain, heart, lung, skeletal muscle, ovary, thymus and testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024286.
CleanExiMM_CCNY.
GenevisibleiQ8BGU5. MM.

Interactioni

Subunit structurei

Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (By similarity). Interacts with CDK14 (By similarity). Interacts with CDK16 (PubMed:22184064). Interacts with LRP6 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdk16Q047353EBI-772904,EBI-11615670

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BGU5. 4 interactors.
MINTiMINT-4125949.
STRINGi10090.ENSMUSP00000050001.

Structurei

3D structure databases

ProteinModelPortaliQ8BGU5.
SMRiQ8BGU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 265Cyclin N-terminalAdd BLAST123

Sequence similaritiesi

Belongs to the cyclin family. Cyclin Y subfamily.Curated

Phylogenomic databases

eggNOGiKOG1675. Eukaryota.
ENOG410XNQX. LUCA.
GeneTreeiENSGT00390000006626.
HOGENOMiHOG000021397.
HOVERGENiHBG058985.
InParanoidiQ8BGU5.
OMAiYDKHDPE.
OrthoDBiEOG091G0BM9.
PhylomeDBiQ8BGU5.
TreeFamiTF314464.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 1 hit.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
PfamiView protein in Pfam
PF00134. Cyclin_N. 1 hit.
PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI
60 70 80 90 100
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQTSRKYSS
110 120 130 140 150
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH
160 170 180 190 200
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL
210 220 230 240 250
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN
260 270 280 290 300
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
310 320 330 340
KLEAISRLCE DKYKDLRKPM RKRSASADNL ILPRWSPAII S
Length:341
Mass (Da):39,395
Last modified:March 1, 2003 - v1
Checksum:i6F16CE5B14559FCB
GO
Isoform 2 (identifier: Q8BGU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,562
Checksum:i22558710C92190FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257L → P in BAB30772 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01483552 – 76Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017493 mRNA. Translation: BAB30772.1.
AK028696 mRNA. Translation: BAC26071.1.
AK076556 mRNA. Translation: BAC36391.1.
BC023321 mRNA. Translation: AAH23321.1.
BC035524 mRNA. Translation: AAH35524.1.
CCDSiCCDS29050.1. [Q8BGU5-1]
RefSeqiNP_080760.2. NM_026484.3. [Q8BGU5-1]
UniGeneiMm.376607.
Mm.86523.

Genome annotation databases

EnsembliENSMUST00000053917; ENSMUSP00000050001; ENSMUSG00000024286. [Q8BGU5-1]
GeneIDi67974.
KEGGimmu:67974.
UCSCiuc008eai.1. mouse. [Q8BGU5-1]
uc012azd.1. mouse. [Q8BGU5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNY_MOUSE
AccessioniPrimary (citable) accession number: Q8BGU5
Secondary accession number(s): Q8CI87, Q9CYN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families