Q8BGT7 (SPF30_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Survival of motor neuron-related-splicing factor 30

Alternative name(s):
30 kDa splicing factor SMNrp
SMN-related protein
Survival motor neuron domain-containing protein 1

Gene names

Name:	Smndc1
Synonyms:	Smnr, Spf30

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Necessary for spliceosome assembly. Overexpression causes apoptosis By similarity.
Subunit structure	Associates with spliceosomes. Associates with U4/U5/U6 tri-snRNP and with U2 snRNP By similarity.
Subcellular location	Nucleus speckle By similarity. Nucleus › Cajal body By similarity. Note: Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies By similarity.
Sequence similarities	Belongs to the SMN family. Contains 1 Tudor domain.

Ontologies

Keywords
Biological process	Apoptosis mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Cajal body Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: InterPro nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Survival of motor neuron-related-splicing factor 30		PRO_0000218909
Regions
	Domain	72 – 132	61	Tudor
	Motif	142 – 160	19	Nuclear localization signal Potential
Amino acid modifications
	Modified residue	201	1	Phosphoserine By similarity
	Modified residue	219	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BGT7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 70C59F9AD4D1EF8A	FASTA	238	26,753
	10 20 30 40 50 60 MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS 70 80 90 100 110 120 SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAV YGNAEVTPLL 130 140 150 160 170 180 NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ 190 200 210 220 230 FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Clee S.M., Klass D.M., Attie A.D. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Colon and Submandibular gland.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Olfactory epithelium and Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ479929 Genomic DNA. Translation: ABF48508.1. AK078834 mRNA. Translation: BAC37414.1. AK090047 mRNA. Translation: BAC41064.1. BC058779 mRNA. Translation: AAH58779.1. BC098223 mRNA. Translation: AAH98223.1.
IPI	IPI00221714.
RefSeq	NP_766017.1. NM_172429.2.
UniGene	Mm.313687.
3D structure databases
ProteinModelPortal	Q8BGT7.
SMR	Q8BGT7. Positions 71-126.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BGT7.
PTM databases
PhosphoSite	Q8BGT7.
Proteomic databases
PRIDE	Q8BGT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025997; ENSMUSP00000025997; ENSMUSG00000025024.
GeneID	76479.
KEGG	mmu:76479.
UCSC	uc008hws.1. mouse.
Organism-specific databases
CTD	10285.
MGI	MGI:1923729. Smndc1.
Phylogenomic databases
GeneTree	ENSGT00560000077236.
HOGENOM	HBG280247.
HOVERGEN	HBG057021.
InParanoid	Q8BGT7.
OMA	GQYYDAT.
OrthoDB	EOG4H464Q.
PhylomeDB	Q8BGT7.
Gene expression databases
ArrayExpress	Q8BGT7.
Bgee	Q8BGT7.
CleanEx	MM_SMNDC1.
Genevestigator	Q8BGT7.
GermOnline	ENSMUSG00000025024. Mus musculus.
Family and domain databases
InterPro	IPR010304. Survival_motor_neuron. IPR002999. Tudor. IPR018351. Tudor_subgr. [Graphical view]
KO	K12839.
Pfam	PF06003. SMN. 1 hit. [Graphical view]
SMART	SM00333. TUDOR. 1 hit. [Graphical view]
PROSITE	PS50304. TUDOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	345220.
SOURCE	Search...

Entry information

Entry name

SPF30_MOUSE

Accession

Primary (citable) accession number: Q8BGT7
Secondary accession number(s): Q4QQL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program