Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

Zkscan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri375 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Gene namesi
Name:Zkscan1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921820 Zkscan1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477541 – 561Zinc finger protein with KRAB and SCAN domains 1Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki301Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki373Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki476Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BGS3
PeptideAtlasiQ8BGS3
PRIDEiQ8BGS3

PTM databases

iPTMnetiQ8BGS3
PhosphoSitePlusiQ8BGS3

Expressioni

Gene expression databases

BgeeiENSMUSG00000029729
CleanExiMM_ZKSCAN1
GenevisibleiQ8BGS3 MM

Interactioni

Protein-protein interaction databases

BioGridi2168521 interactor.
IntActiQ8BGS3 1 interactor.
STRINGi10090.ENSMUSP00000019660

Structurei

3D structure databases

ProteinModelPortaliQ8BGS3
SMRiQ8BGS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 138SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini225 – 304KRABAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri375 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8BGS3
KOiK09229
OMAiQVHGPEM
OrthoDBiEOG091G046Q
PhylomeDBiQ8BGS3
TreeFamiTF350830

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.101 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTAESRETT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSSLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN SKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHETAQSHFK HSSRKPRLLS RALPATHVPA
210 220 230 240 250
PHHEGNPRDQ AMASALLTAD SQAMVKIEDM AVSLILEEWG CQNLARRNLN
260 270 280 290 300
RDSRQMNLGN VFSQGSENRN GNESTSKAEV KEDSTSHGEI AGRFQKEFGE
310 320 330 340 350
KREQQGRVVE RQQKNPEEKT GKEKKEPGPP TAKEKKPSTG ERGPREKGKG
360 370 380 390 400
LGRSFSLSAN FNNTPEEAPS GAKTHRCDEC GKCFTRSSSL IRHKIIHTGE
410 420 430 440 450
KPYECNECGK AFSLNSNLVL HQRIHTGEKP HECNECGKAF SHSSNLILHQ
460 470 480 490 500
RIHSGEKPYE CNECGKAFSQ SSDLTKHQRI HTGEKPYECS ECGKAFNRNS
510 520 530 540 550
YLILHRRIHT REKPYKCTKC GKAFTRSSTL TLHHRIHARE RTSEYSPASL
560
DAFGAFLKSC V
Length:561
Mass (Da):63,439
Last modified:March 1, 2003 - v1
Checksum:i757C4FD2CFB28DDB
GO
Isoform 2 (identifier: Q8BGS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-264: Missing.

Show »
Length:488
Mass (Da):55,419
Checksum:i27550A06A08F45B6
GO

Sequence cautioni

The sequence BAC27539 differs from that shown. Reason: Frameshift at position 479.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244L → M in BAC27539 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016958192 – 264Missing in isoform 2. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131148 mRNA Translation: BAD21398.1
AK020039 mRNA Translation: BAB31975.1
AK028932 mRNA Translation: BAC26200.1
AK031759 mRNA Translation: BAC27539.1 Frameshift.
AK036807 mRNA Translation: BAC29584.1
AK054323 mRNA Translation: BAC35730.1
AK135999 mRNA Translation: BAE22767.1
BC052441 mRNA Translation: AAH52441.1
CCDSiCCDS19788.1 [Q8BGS3-2]
CCDS19789.1 [Q8BGS3-1]
RefSeqiNP_084145.1, NM_029869.1 [Q8BGS3-2]
NP_598667.2, NM_133906.4 [Q8BGS3-1]
XP_006504691.1, XM_006504628.3 [Q8BGS3-2]
UniGeneiMm.213114

Genome annotation databases

EnsembliENSMUST00000019660; ENSMUSP00000019660; ENSMUSG00000029729 [Q8BGS3-1]
ENSMUST00000066617; ENSMUSP00000068480; ENSMUSG00000029729 [Q8BGS3-2]
ENSMUST00000110962; ENSMUSP00000106587; ENSMUSG00000029729 [Q8BGS3-2]
ENSMUST00000110963; ENSMUSP00000106588; ENSMUSG00000029729 [Q8BGS3-2]
GeneIDi74570
KEGGimmu:74570
UCSCiuc009aej.1 mouse [Q8BGS3-1]
uc009aek.1 mouse [Q8BGS3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZKSC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS3
Secondary accession number(s): Q7TS88, Q8BJ55, Q9CRN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome