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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

Zkscan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri375 – 39723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Gene namesi
Name:Zkscan1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921820. Zkscan1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Zinc finger protein with KRAB and SCAN domains 1PRO_0000047754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Cross-linki277 – 277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336 – 336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki558 – 558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BGS3.
PaxDbiQ8BGS3.
PeptideAtlasiQ8BGS3.
PRIDEiQ8BGS3.

PTM databases

iPTMnetiQ8BGS3.
PhosphoSiteiQ8BGS3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029729.
CleanExiMM_ZKSCAN1.
GenevisibleiQ8BGS3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019660.

Structurei

3D structure databases

ProteinModelPortaliQ8BGS3.
SMRiQ8BGS3. Positions 50-138, 338-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 13883SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini225 – 30480KRABAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri375 – 39723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ8BGS3.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG091G046Q.
PhylomeDBiQ8BGS3.
TreeFamiTF350830.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTAESRETT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSSLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN SKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHETAQSHFK HSSRKPRLLS RALPATHVPA
210 220 230 240 250
PHHEGNPRDQ AMASALLTAD SQAMVKIEDM AVSLILEEWG CQNLARRNLN
260 270 280 290 300
RDSRQMNLGN VFSQGSENRN GNESTSKAEV KEDSTSHGEI AGRFQKEFGE
310 320 330 340 350
KREQQGRVVE RQQKNPEEKT GKEKKEPGPP TAKEKKPSTG ERGPREKGKG
360 370 380 390 400
LGRSFSLSAN FNNTPEEAPS GAKTHRCDEC GKCFTRSSSL IRHKIIHTGE
410 420 430 440 450
KPYECNECGK AFSLNSNLVL HQRIHTGEKP HECNECGKAF SHSSNLILHQ
460 470 480 490 500
RIHSGEKPYE CNECGKAFSQ SSDLTKHQRI HTGEKPYECS ECGKAFNRNS
510 520 530 540 550
YLILHRRIHT REKPYKCTKC GKAFTRSSTL TLHHRIHARE RTSEYSPASL
560
DAFGAFLKSC V
Length:561
Mass (Da):63,439
Last modified:March 1, 2003 - v1
Checksum:i757C4FD2CFB28DDB
GO
Isoform 2 (identifier: Q8BGS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-264: Missing.

Show »
Length:488
Mass (Da):55,419
Checksum:i27550A06A08F45B6
GO

Sequence cautioni

The sequence BAC27539 differs from that shown. Reason: Frameshift at position 479. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441L → M in BAC27539 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei192 – 26473Missing in isoform 2. 2 PublicationsVSP_016958Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131148 mRNA. Translation: BAD21398.1.
AK020039 mRNA. Translation: BAB31975.1.
AK028932 mRNA. Translation: BAC26200.1.
AK031759 mRNA. Translation: BAC27539.1. Frameshift.
AK036807 mRNA. Translation: BAC29584.1.
AK054323 mRNA. Translation: BAC35730.1.
AK135999 mRNA. Translation: BAE22767.1.
BC052441 mRNA. Translation: AAH52441.1.
CCDSiCCDS19788.1. [Q8BGS3-2]
CCDS19789.1. [Q8BGS3-1]
RefSeqiNP_084145.1. NM_029869.1. [Q8BGS3-2]
NP_598667.2. NM_133906.4. [Q8BGS3-1]
XP_006504691.1. XM_006504628.2. [Q8BGS3-2]
UniGeneiMm.213114.

Genome annotation databases

EnsembliENSMUST00000019660; ENSMUSP00000019660; ENSMUSG00000029729. [Q8BGS3-1]
ENSMUST00000066617; ENSMUSP00000068480; ENSMUSG00000029729. [Q8BGS3-2]
ENSMUST00000110962; ENSMUSP00000106587; ENSMUSG00000029729. [Q8BGS3-2]
ENSMUST00000110963; ENSMUSP00000106588; ENSMUSG00000029729. [Q8BGS3-2]
GeneIDi74570.
KEGGimmu:74570.
UCSCiuc009aej.1. mouse. [Q8BGS3-1]
uc009aek.1. mouse. [Q8BGS3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131148 mRNA. Translation: BAD21398.1.
AK020039 mRNA. Translation: BAB31975.1.
AK028932 mRNA. Translation: BAC26200.1.
AK031759 mRNA. Translation: BAC27539.1. Frameshift.
AK036807 mRNA. Translation: BAC29584.1.
AK054323 mRNA. Translation: BAC35730.1.
AK135999 mRNA. Translation: BAE22767.1.
BC052441 mRNA. Translation: AAH52441.1.
CCDSiCCDS19788.1. [Q8BGS3-2]
CCDS19789.1. [Q8BGS3-1]
RefSeqiNP_084145.1. NM_029869.1. [Q8BGS3-2]
NP_598667.2. NM_133906.4. [Q8BGS3-1]
XP_006504691.1. XM_006504628.2. [Q8BGS3-2]
UniGeneiMm.213114.

3D structure databases

ProteinModelPortaliQ8BGS3.
SMRiQ8BGS3. Positions 50-138, 338-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019660.

PTM databases

iPTMnetiQ8BGS3.
PhosphoSiteiQ8BGS3.

Proteomic databases

MaxQBiQ8BGS3.
PaxDbiQ8BGS3.
PeptideAtlasiQ8BGS3.
PRIDEiQ8BGS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019660; ENSMUSP00000019660; ENSMUSG00000029729. [Q8BGS3-1]
ENSMUST00000066617; ENSMUSP00000068480; ENSMUSG00000029729. [Q8BGS3-2]
ENSMUST00000110962; ENSMUSP00000106587; ENSMUSG00000029729. [Q8BGS3-2]
ENSMUST00000110963; ENSMUSP00000106588; ENSMUSG00000029729. [Q8BGS3-2]
GeneIDi74570.
KEGGimmu:74570.
UCSCiuc009aej.1. mouse. [Q8BGS3-1]
uc009aek.1. mouse. [Q8BGS3-2]

Organism-specific databases

CTDi7586.
MGIiMGI:1921820. Zkscan1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ8BGS3.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG091G046Q.
PhylomeDBiQ8BGS3.
TreeFamiTF350830.

Miscellaneous databases

PROiQ8BGS3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029729.
CleanExiMM_ZKSCAN1.
GenevisibleiQ8BGS3. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS3
Secondary accession number(s): Q7TS88, Q8BJ55, Q9CRN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.