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Protein

BolA-like protein 2

Gene

Bola2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 2
Gene namesi
Name:Bola2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913412. Bola2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8686BolA-like protein 2PRO_0000201237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGS2.
MaxQBiQ8BGS2.
PaxDbiQ8BGS2.
PeptideAtlasiQ8BGS2.
PRIDEiQ8BGS2.

PTM databases

PhosphoSiteiQ8BGS2.

Expressioni

Gene expression databases

BgeeiQ8BGS2.
CleanExiMM_BOLA2.
GenevisibleiQ8BGS2. MM.

Interactioni

Protein-protein interaction databases

BioGridi211260. 1 interaction.
IntActiQ8BGS2. 1 interaction.
MINTiMINT-4102637.
STRINGi10090.ENSMUSP00000114873.

Structurei

Secondary structure

86
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 33Combined sources
Helixi5 – 1612Combined sources
Beta strandi19 – 257Combined sources
Beta strandi28 – 314Combined sources
Beta strandi35 – 406Combined sources
Helixi43 – 464Combined sources
Helixi49 – 5911Combined sources
Turni60 – 634Combined sources
Helixi64 – 663Combined sources
Beta strandi68 – 758Combined sources
Helixi77 – 826Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V9JNMR-A1-86[»]
ProteinModelPortaliQ8BGS2.
SMRiQ8BGS2. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BGS2.

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

eggNOGiKOG3348. Eukaryota.
COG0271. LUCA.
GeneTreeiENSGT00510000047760.
HOGENOMiHOG000255170.
HOVERGENiHBG080902.
InParanoidiQ8BGS2.
OMAiNACLEEE.
OrthoDBiEOG7HTHKJ.
PhylomeDBiQ8BGS2.
TreeFamiTF313141.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
PIRSFiPIRSF003113. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSADYLRE KLRQDLEAEH VEVEDTTLNR CATSFRVLVV SAKFEGKPLL
60 70 80
QRHRLVNECL AEELPHIHAF EQKTLTPEQW TRQRRE
Note: No experimental confirmation available.
Length:86
Mass (Da):10,215
Last modified:March 1, 2003 - v1
Checksum:i76E2ADCAF3B6FAD2
GO
Isoform 2 (identifier: Q8BGS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Note: No experimental confirmation available.
Show »
Length:54
Mass (Da):6,329
Checksum:iB203A712221B2D51
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 8632Missing in isoform 2. 1 PublicationVSP_010094Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002662 mRNA. Translation: BAC25001.1.
AK003922 mRNA. Translation: BAC25060.1.
CH466531 Genomic DNA. Translation: EDL17416.1.
BC045523 mRNA. Translation: AAH45523.1.
BC061197 mRNA. Translation: AAH61197.1.
CCDSiCCDS40129.1. [Q8BGS2-1]
RefSeqiNP_780312.1. NM_175103.3. [Q8BGS2-1]
UniGeneiMm.358692.

Genome annotation databases

EnsembliENSMUST00000106369; ENSMUSP00000101977; ENSMUSG00000047721. [Q8BGS2-2]
ENSMUST00000130498; ENSMUSP00000114873; ENSMUSG00000047721. [Q8BGS2-1]
GeneIDi66162.
KEGGimmu:66162.
UCSCiuc009jsj.1. mouse. [Q8BGS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002662 mRNA. Translation: BAC25001.1.
AK003922 mRNA. Translation: BAC25060.1.
CH466531 Genomic DNA. Translation: EDL17416.1.
BC045523 mRNA. Translation: AAH45523.1.
BC061197 mRNA. Translation: AAH61197.1.
CCDSiCCDS40129.1. [Q8BGS2-1]
RefSeqiNP_780312.1. NM_175103.3. [Q8BGS2-1]
UniGeneiMm.358692.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V9JNMR-A1-86[»]
ProteinModelPortaliQ8BGS2.
SMRiQ8BGS2. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211260. 1 interaction.
IntActiQ8BGS2. 1 interaction.
MINTiMINT-4102637.
STRINGi10090.ENSMUSP00000114873.

PTM databases

PhosphoSiteiQ8BGS2.

Proteomic databases

EPDiQ8BGS2.
MaxQBiQ8BGS2.
PaxDbiQ8BGS2.
PeptideAtlasiQ8BGS2.
PRIDEiQ8BGS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106369; ENSMUSP00000101977; ENSMUSG00000047721. [Q8BGS2-2]
ENSMUST00000130498; ENSMUSP00000114873; ENSMUSG00000047721. [Q8BGS2-1]
GeneIDi66162.
KEGGimmu:66162.
UCSCiuc009jsj.1. mouse. [Q8BGS2-1]

Organism-specific databases

CTDi552900.
MGIiMGI:1913412. Bola2.

Phylogenomic databases

eggNOGiKOG3348. Eukaryota.
COG0271. LUCA.
GeneTreeiENSGT00510000047760.
HOGENOMiHOG000255170.
HOVERGENiHBG080902.
InParanoidiQ8BGS2.
OMAiNACLEEE.
OrthoDBiEOG7HTHKJ.
PhylomeDBiQ8BGS2.
TreeFamiTF313141.

Miscellaneous databases

EvolutionaryTraceiQ8BGS2.
PROiQ8BGS2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGS2.
CleanExiMM_BOLA2.
GenevisibleiQ8BGS2. MM.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
PIRSFiPIRSF003113. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Colon and Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Pancreas, Spleen and Testis.
  5. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiBOLA2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS2
Secondary accession number(s): Q0P601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.