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Protein

Band 4.1-like protein 5

Gene

Epb41l5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actomyosin structure organization Source: MGI
  • apical constriction Source: MGI
  • axial mesoderm development Source: MGI
  • axial mesoderm morphogenesis Source: MGI
  • cell morphogenesis involved in differentiation Source: MGI
  • cellular response to transforming growth factor beta stimulus Source: MGI
  • ectoderm development Source: MGI
  • embryonic foregut morphogenesis Source: MGI
  • endoderm development Source: MGI
  • epithelial cell morphogenesis Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • in utero embryonic development Source: MGI
  • left/right axis specification Source: MGI
  • mesoderm development Source: MGI
  • mesoderm migration involved in gastrulation Source: MGI
  • negative regulation of cell-cell adhesion Source: MGI
  • negative regulation of protein binding Source: MGI
  • neural plate morphogenesis Source: MGI
  • paraxial mesoderm development Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • positive regulation of epithelial cell migration Source: MGI
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of focal adhesion assembly Source: MGI
  • positive regulation of protein binding Source: MGI
  • posttranscriptional regulation of gene expression Source: MGI
  • regulation of establishment of protein localization Source: MGI
  • somite rostral/caudal axis specification Source: MGI
  • somitogenesis Source: MGI
  • substrate-dependent cell migration, cell attachment to substrate Source: MGI
  • unidimensional cell growth Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 5
Gene namesi
Name:Epb41l5
Synonyms:Epb4.1l5, Kiaa1548
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103006. Epb41l5.

Subcellular locationi

GO - Cellular componenti

  • cell leading edge Source: MGI
  • cytoplasm Source: MGI
  • cytoskeleton Source: InterPro
  • extrinsic component of membrane Source: InterPro
  • focal adhesion Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • ruffle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Band 4.1-like protein 5PRO_0000330355Add
BLAST

Proteomic databases

MaxQBiQ8BGS1.
PaxDbiQ8BGS1.
PRIDEiQ8BGS1.

PTM databases

iPTMnetiQ8BGS1.
PhosphoSiteiQ8BGS1.

Expressioni

Tissue specificityi

In the retina, expressed at the region of the outer limiting membrane, as well as in the retinal pigment epithelium, outer nuclear and outer plexiform layers. Also detected in the inner segments (at protein level). Expressed in the kidney (at protein level).1 Publication

Developmental stagei

At 10.5 dpc, strongly expressed in the developing neural tube and optic vesicle, as well as in the branchial arches and kidney. In the developing kidney, detected in the mesonephrotic tubules. At 11.5 dpc, expressed along the entire cranial-caudal length of the developing neural tube, including the anterior forebrain and the posterior spinal cord. Always restricted to the ventricular layer, where proliferative cells are located. Conversely, not detected in postmitotic neural compartments. In the developing lung, at 11.5 dpc, expressed in the internal endodermal layer and in particular in the nascent bronchial tips. At 12.5 dpc, in the optic vesicle, detected mainly in the retinal layer. The retinal pigment epithelium shows only background levels.1 Publication

Gene expression databases

BgeeiQ8BGS1.
ExpressionAtlasiQ8BGS1. baseline and differential.
GenevisibleiQ8BGS1. MM.

Interactioni

Subunit structurei

Interacts with MPP5, CRB2 and CRB3.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: MGI

Protein-protein interaction databases

BioGridi230501. 1 interaction.
IntActiQ8BGS1. 4 interactions.
MINTiMINT-4123950.
STRINGi10090.ENSMUSP00000058966.

Structurei

3D structure databases

ProteinModelPortaliQ8BGS1.
SMRiQ8BGS1. Positions 45-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 327285FERMPROSITE-ProRule annotationAdd
BLAST

Domaini

The FERM domain binds to CRB1.By similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ60. Eukaryota.
ENOG410XRFC. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231632.
HOVERGENiHBG051434.
InParanoidiQ8BGS1.
OMAiTDFVHEH.
OrthoDBiEOG73FQM2.
PhylomeDBiQ8BGS1.
TreeFamiTF319780.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR030694. Band4.1-like5.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23280:SF15. PTHR23280:SF15. 1 hit.
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSFLRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDAK SIITCRVSLL
60 70 80 90 100
DGTDVSVDLP KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG
110 120 130 140 150
TKSIKKQVKI GSPYCLHLRV KFYSSEPNNL REELTRYLFV LQLKQDILSG
160 170 180 190 200
KLECPFDTAV QLAAYNLQAE LGDYDLAEHS PELVSEFRFV PIQTEEMELA
210 220 230 240 250
IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR DGNDYSLGLT
260 270 280 290 300
PTGVLVFEGE TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV
310 320 330 340 350
FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK
360 370 380 390 400
TEYQTTKTNK ARRSTSFERR PSKRYSRRTL QMKASTTQPE DLGVLNASAQ
410 420 430 440 450
KSDSQQAWGV MSPVPVTSSS SCGAVQVEIE NLPQTSATEQ HDRKCLPLSV
460 470 480 490 500
DLLNSPDLLE TTIGDVTRTS ETSAPFPAPD TINVATRSNE LEEFKAECET
510 520 530 540 550
LKDDTEKLKQ LETEQTILPS LRPTIDINVN SQEEVVKLTE KCLNNAIENP
560 570 580 590 600
ALNAVKVPPD FKSNILKAQV EAVHKVTRED SLLTHKNASV QDAATNSTAF
610 620 630 640 650
NENDVPVCKD SLTPVHGTAA DSASVLKDAT DELDALLLSL TENLMDHTVT
660 670 680 690 700
PQVSSPSMIT PRWIIPQSAT ISNGLAGYGA SLAGTDECSQ KDGFSLISPP
710 720 730
APFLVDAVTS SAPPLPEDST LKQKCLLTTE L
Length:731
Mass (Da):81,636
Last modified:March 1, 2003 - v1
Checksum:i77348A1F68EF596A
GO
Isoform 2 (identifier: Q8BGS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-504: CLPLSVDLLN...KAECETLKDD → WLSATSDRCQ...LSGRAAMTEI
     505-731: Missing.

Show »
Length:504
Mass (Da):57,633
Checksum:iFC03EB20078B6891
GO
Isoform 3 (identifier: Q8BGS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-393: G → GRFSSLLYS

Note: No experimental confirmation available.
Show »
Length:739
Mass (Da):82,590
Checksum:iE74E687E891EBCF5
GO

Sequence cautioni

The sequence BAD32476.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131P → H in BAE39535 (PubMed:16141072).Curated
Sequence conflicti173 – 1731D → Y in BAC28794 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei393 – 3931G → GRFSSLLYS in isoform 3. 1 PublicationVSP_033039
Alternative sequencei445 – 50460CLPLS…TLKDD → WLSATSDRCQRGGNQWNPRA LPPPQTAYRNYTDFVHEHNV KNAGAHHDAQLSGRAAMTEI in isoform 2. 2 PublicationsVSP_033040Add
BLAST
Alternative sequencei505 – 731227Missing in isoform 2. 2 PublicationsVSP_033041Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173198 mRNA. Translation: BAD32476.1. Different initiation.
AK034676 mRNA. Translation: BAC28794.1.
AK044959 mRNA. Translation: BAC32159.1.
AK044996 mRNA. Translation: BAC32177.1.
AK079301 mRNA. Translation: BAC37601.1.
AK136125 mRNA. Translation: BAE22832.1.
AK161141 mRNA. Translation: BAE36211.1.
AK167449 mRNA. Translation: BAE39535.1.
BC003937 mRNA. Translation: AAH03937.1.
BC011476 mRNA. Translation: AAH11476.1.
CCDSiCCDS15226.1. [Q8BGS1-1]
CCDS48339.1. [Q8BGS1-2]
RefSeqiNP_001106887.1. NM_001113416.1. [Q8BGS1-2]
NP_663481.2. NM_145506.4. [Q8BGS1-1]
XP_006529460.1. XM_006529397.1. [Q8BGS1-1]
XP_006529461.1. XM_006529398.1. [Q8BGS1-1]
XP_006529463.1. XM_006529400.1. [Q8BGS1-2]
UniGeneiMm.253156.
Mm.442310.

Genome annotation databases

EnsembliENSMUST00000027632; ENSMUSP00000027632; ENSMUSG00000026383. [Q8BGS1-2]
ENSMUST00000052404; ENSMUSP00000058966; ENSMUSG00000026383. [Q8BGS1-1]
ENSMUST00000163147; ENSMUSP00000128374; ENSMUSG00000026383. [Q8BGS1-3]
ENSMUST00000191046; ENSMUSP00000140227; ENSMUSG00000026383. [Q8BGS1-2]
GeneIDi226352.
KEGGimmu:226352.
UCSCiuc007ciw.2. mouse. [Q8BGS1-1]
uc007cix.2. mouse. [Q8BGS1-2]
uc011wqs.1. mouse. [Q8BGS1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173198 mRNA. Translation: BAD32476.1. Different initiation.
AK034676 mRNA. Translation: BAC28794.1.
AK044959 mRNA. Translation: BAC32159.1.
AK044996 mRNA. Translation: BAC32177.1.
AK079301 mRNA. Translation: BAC37601.1.
AK136125 mRNA. Translation: BAE22832.1.
AK161141 mRNA. Translation: BAE36211.1.
AK167449 mRNA. Translation: BAE39535.1.
BC003937 mRNA. Translation: AAH03937.1.
BC011476 mRNA. Translation: AAH11476.1.
CCDSiCCDS15226.1. [Q8BGS1-1]
CCDS48339.1. [Q8BGS1-2]
RefSeqiNP_001106887.1. NM_001113416.1. [Q8BGS1-2]
NP_663481.2. NM_145506.4. [Q8BGS1-1]
XP_006529460.1. XM_006529397.1. [Q8BGS1-1]
XP_006529461.1. XM_006529398.1. [Q8BGS1-1]
XP_006529463.1. XM_006529400.1. [Q8BGS1-2]
UniGeneiMm.253156.
Mm.442310.

3D structure databases

ProteinModelPortaliQ8BGS1.
SMRiQ8BGS1. Positions 45-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230501. 1 interaction.
IntActiQ8BGS1. 4 interactions.
MINTiMINT-4123950.
STRINGi10090.ENSMUSP00000058966.

PTM databases

iPTMnetiQ8BGS1.
PhosphoSiteiQ8BGS1.

Proteomic databases

MaxQBiQ8BGS1.
PaxDbiQ8BGS1.
PRIDEiQ8BGS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027632; ENSMUSP00000027632; ENSMUSG00000026383. [Q8BGS1-2]
ENSMUST00000052404; ENSMUSP00000058966; ENSMUSG00000026383. [Q8BGS1-1]
ENSMUST00000163147; ENSMUSP00000128374; ENSMUSG00000026383. [Q8BGS1-3]
ENSMUST00000191046; ENSMUSP00000140227; ENSMUSG00000026383. [Q8BGS1-2]
GeneIDi226352.
KEGGimmu:226352.
UCSCiuc007ciw.2. mouse. [Q8BGS1-1]
uc007cix.2. mouse. [Q8BGS1-2]
uc011wqs.1. mouse. [Q8BGS1-3]

Organism-specific databases

CTDi57669.
MGIiMGI:103006. Epb41l5.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQ60. Eukaryota.
ENOG410XRFC. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231632.
HOVERGENiHBG051434.
InParanoidiQ8BGS1.
OMAiTDFVHEH.
OrthoDBiEOG73FQM2.
PhylomeDBiQ8BGS1.
TreeFamiTF319780.

Miscellaneous databases

NextBioi378110.
PROiQ8BGS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGS1.
ExpressionAtlasiQ8BGS1. baseline and differential.
GenevisibleiQ8BGS1. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR030694. Band4.1-like5.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23280:SF15. PTHR23280:SF15. 1 hit.
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Skin and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Pancreas and Testis.

Entry informationi

Entry nameiE41L5_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS1
Secondary accession number(s): Q3TJG0
, Q69ZG8, Q8BSC9, Q99KZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.