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Q8BGR9

- UBCP1_MOUSE

UniProt

Q8BGR9 - UBCP1_MOUSE

Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

Ublcp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Name:Ublcp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1933105. Ublcp1.

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes.By similarity

    GO - Cellular componenti

    1. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 318317Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei117 – 1171N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8BGR9.
    PaxDbiQ8BGR9.
    PRIDEiQ8BGR9.

    PTM databases

    PhosphoSiteiQ8BGR9.

    Expressioni

    Gene expression databases

    BgeeiQ8BGR9.
    GenevestigatoriQ8BGR9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000099859.

    Structurei

    Secondary structure

    1
    318
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 95
    Beta strandi12 – 165
    Beta strandi21 – 244
    Helixi25 – 3511
    Turni40 – 423
    Beta strandi44 – 474
    Helixi61 – 644
    Beta strandi70 – 756

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V5TNMR-A3-79[»]
    ProteinModelPortaliQ8BGR9.
    SMRiQ8BGR9. Positions 1-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8BGR9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 294162PhosphataseBy similarityAdd
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG310886.
    GeneTreeiENSGT00390000010107.
    HOGENOMiHOG000231279.
    HOVERGENiHBG080207.
    InParanoidiA2ACX3.
    KOiK17618.
    OMAiELNPPRE.
    OrthoDBiEOG74TX01.
    PhylomeDBiQ8BGR9.
    TreeFamiTF323786.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BGR9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV    50
    KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD 100
    IEDEVVEVEN REENLLKVSR RVKEYKVEVL NPPREGKKLL VLDVDYTLFD 150
    HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS 200
    TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM 250
    FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF 300
    LELNHKYWER YLSKKQGQ 318
    Length:318
    Mass (Da):36,837
    Last modified:March 1, 2003 - v1
    Checksum:i77949D660DC7E3A4
    GO
    Isoform 2 (identifier: Q8BGR9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-215: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:104
    Mass (Da):12,459
    Checksum:i4C3AA4F2AED08C86
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 215214Missing in isoform 2. 1 PublicationVSP_019458Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043952 mRNA. Translation: BAC31711.1.
    AK050031 mRNA. Translation: BAC34039.1.
    AK147744 mRNA. Translation: BAE28110.1.
    AL669944 Genomic DNA. Translation: CAM22830.1.
    BC002236 mRNA. Translation: AAH02236.1.
    BC056652 mRNA. Translation: AAH56652.1.
    BC083331 mRNA. Translation: AAH83331.1.
    BC085111 mRNA. Translation: AAH85111.1.
    BC106093 mRNA. Translation: AAI06094.1.
    CCDSiCCDS24564.1. [Q8BGR9-1]
    RefSeqiNP_077795.2. NM_024475.5. [Q8BGR9-1]
    XP_006534585.1. XM_006534522.1. [Q8BGR9-1]
    UniGeneiMm.338784.

    Genome annotation databases

    EnsembliENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231. [Q8BGR9-1]
    GeneIDi79560.
    KEGGimmu:79560.
    UCSCiuc007ind.1. mouse. [Q8BGR9-2]
    uc007ing.2. mouse. [Q8BGR9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043952 mRNA. Translation: BAC31711.1 .
    AK050031 mRNA. Translation: BAC34039.1 .
    AK147744 mRNA. Translation: BAE28110.1 .
    AL669944 Genomic DNA. Translation: CAM22830.1 .
    BC002236 mRNA. Translation: AAH02236.1 .
    BC056652 mRNA. Translation: AAH56652.1 .
    BC083331 mRNA. Translation: AAH83331.1 .
    BC085111 mRNA. Translation: AAH85111.1 .
    BC106093 mRNA. Translation: AAI06094.1 .
    CCDSi CCDS24564.1. [Q8BGR9-1 ]
    RefSeqi NP_077795.2. NM_024475.5. [Q8BGR9-1 ]
    XP_006534585.1. XM_006534522.1. [Q8BGR9-1 ]
    UniGenei Mm.338784.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V5T NMR - A 3-79 [» ]
    ProteinModelPortali Q8BGR9.
    SMRi Q8BGR9. Positions 1-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000099859.

    PTM databases

    PhosphoSitei Q8BGR9.

    Proteomic databases

    MaxQBi Q8BGR9.
    PaxDbi Q8BGR9.
    PRIDEi Q8BGR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102795 ; ENSMUSP00000099859 ; ENSMUSG00000041231 . [Q8BGR9-1 ]
    GeneIDi 79560.
    KEGGi mmu:79560.
    UCSCi uc007ind.1. mouse. [Q8BGR9-2 ]
    uc007ing.2. mouse. [Q8BGR9-1 ]

    Organism-specific databases

    CTDi 134510.
    MGIi MGI:1933105. Ublcp1.

    Phylogenomic databases

    eggNOGi NOG310886.
    GeneTreei ENSGT00390000010107.
    HOGENOMi HOG000231279.
    HOVERGENi HBG080207.
    InParanoidi A2ACX3.
    KOi K17618.
    OMAi ELNPPRE.
    OrthoDBi EOG74TX01.
    PhylomeDBi Q8BGR9.
    TreeFami TF323786.

    Miscellaneous databases

    EvolutionaryTracei Q8BGR9.
    NextBioi 349947.
    PROi Q8BGR9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGR9.
    Genevestigatori Q8BGR9.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Brain cortex and Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6, Czech II, FVB/N and ICR.
      Tissue: Brain, Liver, Mammary tumor and Trophoblast stem cell.
    4. "Solution structure of the ubiquitin-like domain from mouse hypothetical 8430435i17RIK protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAY-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 3-79.

    Entry informationi

    Entry nameiUBCP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGR9
    Secondary accession number(s): A2ACX3
    , Q52L62, Q5XJH1, Q6PH96, Q99LT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3