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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

Ublcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:Ublcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1933105. Ublcp1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with nuclear proteasomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002426412 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGR9.
PaxDbiQ8BGR9.
PeptideAtlasiQ8BGR9.
PRIDEiQ8BGR9.

PTM databases

iPTMnetiQ8BGR9.
PhosphoSitePlusiQ8BGR9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041231.
GenevisibleiQ8BGR9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099859.

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi12 – 16Combined sources5
Beta strandi21 – 24Combined sources4
Helixi25 – 35Combined sources11
Turni40 – 42Combined sources3
Beta strandi44 – 47Combined sources4
Helixi61 – 64Combined sources4
Beta strandi70 – 75Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5TNMR-A3-79[»]
ProteinModelPortaliQ8BGR9.
SMRiQ8BGR9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BGR9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ8BGR9.
KOiK17618.
OMAiLFDHRSA.
OrthoDBiEOG091G0CRH.
PhylomeDBiQ8BGR9.
TreeFamiTF323786.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD
110 120 130 140 150
IEDEVVEVEN REENLLKVSR RVKEYKVEVL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF
310
LELNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,837
Last modified:March 1, 2003 - v1
Checksum:i77949D660DC7E3A4
GO
Isoform 2 (identifier: Q8BGR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):12,327
Checksum:iD9C96BCE5D4525E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194581 – 215Missing in isoform 2. 1 PublicationAdd BLAST215

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043952 mRNA. Translation: BAC31711.1.
AK050031 mRNA. Translation: BAC34039.1.
AK147744 mRNA. Translation: BAE28110.1.
AL669944 Genomic DNA. Translation: CAM22830.1.
BC002236 mRNA. Translation: AAH02236.1.
BC056652 mRNA. Translation: AAH56652.1.
BC083331 mRNA. Translation: AAH83331.1.
BC085111 mRNA. Translation: AAH85111.1.
BC106093 mRNA. Translation: AAI06094.1.
CCDSiCCDS24564.1. [Q8BGR9-1]
RefSeqiNP_077795.2. NM_024475.5. [Q8BGR9-1]
XP_006534585.1. XM_006534522.3. [Q8BGR9-1]
UniGeneiMm.338784.

Genome annotation databases

EnsembliENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231. [Q8BGR9-1]
GeneIDi79560.
KEGGimmu:79560.
UCSCiuc007ind.1. mouse. [Q8BGR9-2]
uc007ing.2. mouse. [Q8BGR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043952 mRNA. Translation: BAC31711.1.
AK050031 mRNA. Translation: BAC34039.1.
AK147744 mRNA. Translation: BAE28110.1.
AL669944 Genomic DNA. Translation: CAM22830.1.
BC002236 mRNA. Translation: AAH02236.1.
BC056652 mRNA. Translation: AAH56652.1.
BC083331 mRNA. Translation: AAH83331.1.
BC085111 mRNA. Translation: AAH85111.1.
BC106093 mRNA. Translation: AAI06094.1.
CCDSiCCDS24564.1. [Q8BGR9-1]
RefSeqiNP_077795.2. NM_024475.5. [Q8BGR9-1]
XP_006534585.1. XM_006534522.3. [Q8BGR9-1]
UniGeneiMm.338784.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5TNMR-A3-79[»]
ProteinModelPortaliQ8BGR9.
SMRiQ8BGR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099859.

PTM databases

iPTMnetiQ8BGR9.
PhosphoSitePlusiQ8BGR9.

Proteomic databases

EPDiQ8BGR9.
PaxDbiQ8BGR9.
PeptideAtlasiQ8BGR9.
PRIDEiQ8BGR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231. [Q8BGR9-1]
GeneIDi79560.
KEGGimmu:79560.
UCSCiuc007ind.1. mouse. [Q8BGR9-2]
uc007ing.2. mouse. [Q8BGR9-1]

Organism-specific databases

CTDi134510.
MGIiMGI:1933105. Ublcp1.

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ8BGR9.
KOiK17618.
OMAiLFDHRSA.
OrthoDBiEOG091G0CRH.
PhylomeDBiQ8BGR9.
TreeFamiTF323786.

Miscellaneous databases

EvolutionaryTraceiQ8BGR9.
PROiQ8BGR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041231.
GenevisibleiQ8BGR9. MM.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBCP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGR9
Secondary accession number(s): A2ACX3
, Q52L62, Q5XJH1, Q6PH96, Q99LT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.