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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

Ublcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:Ublcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1933105 Ublcp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002426412 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGR9
PaxDbiQ8BGR9
PeptideAtlasiQ8BGR9
PRIDEiQ8BGR9

PTM databases

iPTMnetiQ8BGR9
PhosphoSitePlusiQ8BGR9

Expressioni

Gene expression databases

BgeeiENSMUSG00000041231
GenevisibleiQ8BGR9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099859

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi12 – 16Combined sources5
Beta strandi21 – 24Combined sources4
Helixi25 – 35Combined sources11
Turni40 – 42Combined sources3
Beta strandi44 – 47Combined sources4
Helixi61 – 64Combined sources4
Beta strandi70 – 75Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5TNMR-A3-79[»]
ProteinModelPortaliQ8BGR9
SMRiQ8BGR9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BGR9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
KOG1872 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000010107
HOGENOMiHOG000231279
HOVERGENiHBG080207
InParanoidiQ8BGR9
KOiK17618
OMAiFKLMMVG
OrthoDBiEOG091G0CRH
PhylomeDBiQ8BGR9
TreeFamiTF323786

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR011943 HAD-SF_hydro_IIID
IPR023214 HAD_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF03031 NIF, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02245 HAD_IIID1, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD
110 120 130 140 150
IEDEVVEVEN REENLLKVSR RVKEYKVEVL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF
310
LELNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,837
Last modified:March 1, 2003 - v1
Checksum:i77949D660DC7E3A4
GO
Isoform 2 (identifier: Q8BGR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):12,327
Checksum:iD9C96BCE5D4525E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194581 – 215Missing in isoform 2. 1 PublicationAdd BLAST215

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043952 mRNA Translation: BAC31711.1
AK050031 mRNA Translation: BAC34039.1
AK147744 mRNA Translation: BAE28110.1
AL669944 Genomic DNA No translation available.
BC002236 mRNA Translation: AAH02236.1
BC056652 mRNA Translation: AAH56652.1
BC083331 mRNA Translation: AAH83331.1
BC085111 mRNA Translation: AAH85111.1
BC106093 mRNA Translation: AAI06094.1
CCDSiCCDS24564.1 [Q8BGR9-1]
RefSeqiNP_077795.2, NM_024475.5 [Q8BGR9-1]
XP_006534585.1, XM_006534522.3 [Q8BGR9-1]
UniGeneiMm.338784

Genome annotation databases

EnsembliENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231 [Q8BGR9-1]
GeneIDi79560
KEGGimmu:79560
UCSCiuc007ind.1 mouse [Q8BGR9-2]
uc007ing.2 mouse [Q8BGR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiUBCP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGR9
Secondary accession number(s): A2ACX3
, Q52L62, Q5XJH1, Q6PH96, Q99LT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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