Q8BGR9 (UBCP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Name:

Ublcp1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: Compara
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BGR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BGR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 318

318

Ubiquitin-like domain-containing CTD phosphatase 1

PRO_0000242641

Regions

Domain

3 – 81

79

Ubiquitin-like

Domain

133 – 294

162

FCP1 homology

Region

133 – 294

162

Phosphatase By similarity

Amino acid modifications

Modified residue

117

1

N6-acetyllysine By similarity

Natural variations

Alternative sequence

1 – 215

215

Missing in isoform 2.

VSP_019458

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

318

Helix Strand Turn

Details...

Beta strand

5 – 9

5

Beta strand

12 – 16

5

Beta strand

21 – 24

4

Helix

25 – 35

11

Turn

40 – 42

3

Beta strand

44 – 47

4

Helix

61 – 64

4

Beta strand

70 – 75

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 77949D660DC7E3A4	FASTA	318	36,837
	10 20 30 40 50 60 MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK 70 80 90 100 110 120 LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD IEDEVVEVEN REENLLKVSR 130 140 150 160 170 180 RVKEYKVEVL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV 190 200 210 220 230 240 IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS 250 260 270 280 290 300 EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF 310 LELNHKYWER YLSKKQGQ
	Isoform 2 [UniParc]. Checksum: D9C96BCE5D4525E6	FASTA	103	12,327
	10 20 30 40 50 60 MITVHTPRRG LIDVKPLGVI WGKFSEFYSK KNTIMFDDIG RNFLMNPQNG LKIRPFMKAH 70 80 90 100 LNRDKDKELV KLTQYLKEIA KLDDFLELNH KYWERYLSKK QGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Brain cortex and Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6, Czech II, FVB/N and ICR. Tissue: Brain, Liver, Mammary tumor and Trophoblast stem cell.
[4]	"Solution structure of the ubiquitin-like domain from mouse hypothetical 8430435i17RIK protein." RIKEN structural genomics initiative (RSGI) Submitted (MAY-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 3-79.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK043952 mRNA. Translation: BAC31711.1.
AK050031 mRNA. Translation: BAC34039.1.
AK147744 mRNA. Translation: BAE28110.1.
AL669944 Genomic DNA. Translation: CAM22830.1.
BC002236 mRNA. Translation: AAH02236.1.
BC056652 mRNA. Translation: AAH56652.1.
BC083331 mRNA. Translation: AAH83331.1.
BC085111 mRNA. Translation: AAH85111.1.
BC106093 mRNA. Translation: AAI06094.1.

IPI

IPI00221688.
IPI00761674.

RefSeq

NP_077795.2. NM_024475.5.

UniGene

Mm.338784.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V5T	NMR	-	A	3-79	[»]

ProteinModelPortal

Q8BGR9.

SMR

Q8BGR9. Positions 1-311.

ModBase

Search...

Protein-protein interaction databases

STRING

10090.ENSMUSP00000099859.

PTM databases

PhosphoSite

Q8BGR9.

Proteomic databases

PaxDb

Q8BGR9.

PRIDE

Q8BGR9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231.

GeneID

79560.

KEGG

mmu:79560.

UCSC

uc007ind.1. mouse.
uc007ing.2. mouse.

Organism-specific databases

CTD

134510.

MGI

MGI:1933105. Ublcp1.

Phylogenomic databases

eggNOG

NOG310886.

GeneTree

ENSGT00390000010107.

HOGENOM

HOG000231279.

HOVERGEN

HBG080207.

InParanoid

A2ACX3.

KO

K01090.

OMA

KWIDAKM.

OrthoDB

EOG476K0P.

Gene expression databases

Bgee

Q8BGR9.

Genevestigator

Q8BGR9.

GermOnline

ENSMUSG00000041231. Mus musculus.

Family and domain databases

Gene3D

3.40.50.1000. 1 hit.

InterPro

IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin.
IPR019955. Ubiquitin_supergroup.
[Graphical view]

Pfam

PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]

SMART

SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]

SUPFAM

SSF56784. HAD-like_dom. 1 hit.

TIGRFAMs

TIGR02245. HAD_IIID1. 1 hit.

PROSITE

PS50969. FCP1. 1 hit.
PS00299. UBIQUITIN_1. False negative.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8BGR9.

NextBio

349947.

SOURCE

Search...

Entry information

Entry name

UBCP1_MOUSE

Accession

Primary (citable) accession number: Q8BGR9
Secondary accession number(s): A2ACX3 , Q52L62, Q5XJH1, Q6PH96, Q99LT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program