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Protein

Solute carrier family 25 member 40

Gene

Slc25a40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 40
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442486. Slc25a40.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei146 – 166Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei200 – 221Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei240 – 260Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918101 – 337Solute carrier family 25 member 40Add BLAST337

Proteomic databases

PaxDbiQ8BGP6.
PeptideAtlasiQ8BGP6.
PRIDEiQ8BGP6.

PTM databases

PhosphoSitePlusiQ8BGP6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054099.
CleanExiMM_SLC25A40.
ExpressionAtlasiQ8BGP6. baseline and differential.
GenevisibleiQ8BGP6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067611.

Structurei

3D structure databases

ProteinModelPortaliQ8BGP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 132Solcar 1Add BLAST119
Repeati140 – 224Solcar 2Add BLAST85
Repeati234 – 328Solcar 3Add BLAST95

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8BGP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG091G07QQ.
PhylomeDBiQ8BGP6.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPETEGPPP TIPVTPLQQM IASCTGAVLT SLMVTPLDVV KIRLQAQNNP
60 70 80 90 100
FPKGKCFLYS NGLMDHMCVC EEESKKAWYK KPGNFRGTLD AFLKILRNEG
110 120 130 140 150
IKSLWSGLPP TLVMAIPATV IYFTCYEQLS AFLKTKLGEN ETRIPIVAGV
160 170 180 190 200
VARFGAVTVI SPLELIRTKV QSKKFSYKEL YQFVSMRVSE DGWISLWKGW
210 220 230 240 250
APTILRDVPF SAMYWYNYEN LKRWLCEKSG LYEPTFMINF TSGALSGSFA
260 270 280 290 300
AVATLPFDVV KTQKQTQLWT NEYCKFPAPL DMSTWTIMKN IVADKGFSGL
310 320 330
FTGLIPRLVK IVPACAIMIS SYELGKSFFQ KQNVESR
Length:337
Mass (Da):37,964
Last modified:March 1, 2003 - v1
Checksum:i80554124DD995581
GO
Isoform 2 (identifier: Q8BGP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,198
Checksum:i875EE34823C66F31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24C → Y in BAC31842 (PubMed:16141072).Curated1
Sequence conflicti156A → G in BAE23124 (PubMed:16141072).Curated1
Sequence conflicti183F → L in BAE23124 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262431 – 63Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044260 mRNA. Translation: BAC31842.1.
AK045863 mRNA. Translation: BAC32513.1.
AK084797 mRNA. Translation: BAC39281.1.
AK088444 mRNA. Translation: BAC40356.1.
AK136770 mRNA. Translation: BAE23124.1.
BC083103 mRNA. Translation: AAH83103.1.
CCDSiCCDS39010.1. [Q8BGP6-1]
RefSeqiNP_001276524.1. NM_001289595.1. [Q8BGP6-1]
NP_001276525.1. NM_001289596.1. [Q8BGP6-2]
NP_848881.2. NM_178766.5. [Q8BGP6-1]
XP_006503654.1. XM_006503591.3. [Q8BGP6-1]
UniGeneiMm.146262.

Genome annotation databases

EnsembliENSMUST00000066921; ENSMUSP00000067611; ENSMUSG00000054099. [Q8BGP6-1]
ENSMUST00000170496; ENSMUSP00000130630; ENSMUSG00000054099. [Q8BGP6-1]
GeneIDi319653.
KEGGimmu:319653.
UCSCiuc008wkf.3. mouse. [Q8BGP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044260 mRNA. Translation: BAC31842.1.
AK045863 mRNA. Translation: BAC32513.1.
AK084797 mRNA. Translation: BAC39281.1.
AK088444 mRNA. Translation: BAC40356.1.
AK136770 mRNA. Translation: BAE23124.1.
BC083103 mRNA. Translation: AAH83103.1.
CCDSiCCDS39010.1. [Q8BGP6-1]
RefSeqiNP_001276524.1. NM_001289595.1. [Q8BGP6-1]
NP_001276525.1. NM_001289596.1. [Q8BGP6-2]
NP_848881.2. NM_178766.5. [Q8BGP6-1]
XP_006503654.1. XM_006503591.3. [Q8BGP6-1]
UniGeneiMm.146262.

3D structure databases

ProteinModelPortaliQ8BGP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067611.

PTM databases

PhosphoSitePlusiQ8BGP6.

Proteomic databases

PaxDbiQ8BGP6.
PeptideAtlasiQ8BGP6.
PRIDEiQ8BGP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066921; ENSMUSP00000067611; ENSMUSG00000054099. [Q8BGP6-1]
ENSMUST00000170496; ENSMUSP00000130630; ENSMUSG00000054099. [Q8BGP6-1]
GeneIDi319653.
KEGGimmu:319653.
UCSCiuc008wkf.3. mouse. [Q8BGP6-1]

Organism-specific databases

CTDi55972.
MGIiMGI:2442486. Slc25a40.

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8BGP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG091G07QQ.
PhylomeDBiQ8BGP6.
TreeFamiTF314720.

Miscellaneous databases

PROiQ8BGP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054099.
CleanExiMM_SLC25A40.
ExpressionAtlasiQ8BGP6. baseline and differential.
GenevisibleiQ8BGP6. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2540_MOUSE
AccessioniPrimary (citable) accession number: Q8BGP6
Secondary accession number(s): Q3UVZ5, Q8BXT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.