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Protein

Solute carrier family 25 member 40

Gene

Slc25a40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 40
Gene namesi
Name:Slc25a40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442486. Slc25a40.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei200 – 22122Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Solute carrier family 25 member 40PRO_0000291810Add
BLAST

Proteomic databases

MaxQBiQ8BGP6.
PaxDbiQ8BGP6.
PRIDEiQ8BGP6.

Expressioni

Gene expression databases

BgeeiQ8BGP6.
CleanExiMM_SLC25A40.
ExpressionAtlasiQ8BGP6. baseline and differential.
GenevisibleiQ8BGP6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067611.

Structurei

3D structure databases

ProteinModelPortaliQ8BGP6.
SMRiQ8BGP6. Positions 19-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 132119Solcar 1Add
BLAST
Repeati140 – 22485Solcar 2Add
BLAST
Repeati234 – 32895Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8BGP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG79KPFV.
PhylomeDBiQ8BGP6.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPETEGPPP TIPVTPLQQM IASCTGAVLT SLMVTPLDVV KIRLQAQNNP
60 70 80 90 100
FPKGKCFLYS NGLMDHMCVC EEESKKAWYK KPGNFRGTLD AFLKILRNEG
110 120 130 140 150
IKSLWSGLPP TLVMAIPATV IYFTCYEQLS AFLKTKLGEN ETRIPIVAGV
160 170 180 190 200
VARFGAVTVI SPLELIRTKV QSKKFSYKEL YQFVSMRVSE DGWISLWKGW
210 220 230 240 250
APTILRDVPF SAMYWYNYEN LKRWLCEKSG LYEPTFMINF TSGALSGSFA
260 270 280 290 300
AVATLPFDVV KTQKQTQLWT NEYCKFPAPL DMSTWTIMKN IVADKGFSGL
310 320 330
FTGLIPRLVK IVPACAIMIS SYELGKSFFQ KQNVESR
Length:337
Mass (Da):37,964
Last modified:March 1, 2003 - v1
Checksum:i80554124DD995581
GO
Isoform 2 (identifier: Q8BGP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,198
Checksum:i875EE34823C66F31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241C → Y in BAC31842 (PubMed:16141072).Curated
Sequence conflicti156 – 1561A → G in BAE23124 (PubMed:16141072).Curated
Sequence conflicti183 – 1831F → L in BAE23124 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. 1 PublicationVSP_026243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044260 mRNA. Translation: BAC31842.1.
AK045863 mRNA. Translation: BAC32513.1.
AK084797 mRNA. Translation: BAC39281.1.
AK088444 mRNA. Translation: BAC40356.1.
AK136770 mRNA. Translation: BAE23124.1.
BC083103 mRNA. Translation: AAH83103.1.
CCDSiCCDS39010.1. [Q8BGP6-1]
RefSeqiNP_001276524.1. NM_001289595.1. [Q8BGP6-1]
NP_001276525.1. NM_001289596.1. [Q8BGP6-2]
NP_848881.2. NM_178766.5. [Q8BGP6-1]
XP_006503654.1. XM_006503591.2. [Q8BGP6-1]
UniGeneiMm.146262.

Genome annotation databases

EnsembliENSMUST00000066921; ENSMUSP00000067611; ENSMUSG00000054099. [Q8BGP6-1]
ENSMUST00000170496; ENSMUSP00000130630; ENSMUSG00000054099. [Q8BGP6-1]
GeneIDi319653.
KEGGimmu:319653.
UCSCiuc008wkf.3. mouse. [Q8BGP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044260 mRNA. Translation: BAC31842.1.
AK045863 mRNA. Translation: BAC32513.1.
AK084797 mRNA. Translation: BAC39281.1.
AK088444 mRNA. Translation: BAC40356.1.
AK136770 mRNA. Translation: BAE23124.1.
BC083103 mRNA. Translation: AAH83103.1.
CCDSiCCDS39010.1. [Q8BGP6-1]
RefSeqiNP_001276524.1. NM_001289595.1. [Q8BGP6-1]
NP_001276525.1. NM_001289596.1. [Q8BGP6-2]
NP_848881.2. NM_178766.5. [Q8BGP6-1]
XP_006503654.1. XM_006503591.2. [Q8BGP6-1]
UniGeneiMm.146262.

3D structure databases

ProteinModelPortaliQ8BGP6.
SMRiQ8BGP6. Positions 19-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067611.

Proteomic databases

MaxQBiQ8BGP6.
PaxDbiQ8BGP6.
PRIDEiQ8BGP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066921; ENSMUSP00000067611; ENSMUSG00000054099. [Q8BGP6-1]
ENSMUST00000170496; ENSMUSP00000130630; ENSMUSG00000054099. [Q8BGP6-1]
GeneIDi319653.
KEGGimmu:319653.
UCSCiuc008wkf.3. mouse. [Q8BGP6-1]

Organism-specific databases

CTDi55972.
MGIiMGI:2442486. Slc25a40.

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8BGP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG79KPFV.
PhylomeDBiQ8BGP6.
TreeFamiTF314720.

Miscellaneous databases

PROiQ8BGP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGP6.
CleanExiMM_SLC25A40.
ExpressionAtlasiQ8BGP6. baseline and differential.
GenevisibleiQ8BGP6. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina, Diencephalon, Heart, Retina and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic stem cell.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Lung, Spleen and Testis.

Entry informationi

Entry nameiS2540_MOUSE
AccessioniPrimary (citable) accession number: Q8BGP6
Secondary accession number(s): Q3UVZ5, Q8BXT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.