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Protein

Transmembrane protein 127

Gene

Tmem127

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.By similarity

GO - Molecular functioni

GO - Biological processi

  • endosome organization Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of TOR signaling Source: MGI
  • regulation of TOR signaling Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 127
Gene namesi
Name:Tmem127
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916720. Tmem127.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cytoplasm By similarity

  • Note: Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Transmembrane protein 127PRO_0000251719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei17 – 171PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BGP5.
PaxDbiQ8BGP5.
PRIDEiQ8BGP5.

PTM databases

iPTMnetiQ8BGP5.
PhosphoSiteiQ8BGP5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034850.
CleanExiMM_TMEM127.
ExpressionAtlasiQ8BGP5. baseline and differential.
GenevisibleiQ8BGP5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035434.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM127 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJHY. Eukaryota.
ENOG410XW58. LUCA.
GeneTreeiENSGT00390000005154.
HOGENOMiHOG000231823.
HOVERGENiHBG053128.
InParanoidiQ8BGP5.
OMAiMEETEPY.
OrthoDBiEOG091G0WXT.
PhylomeDBiQ8BGP5.
TreeFamiTF328671.

Family and domain databases

InterProiIPR033331. TMEM127.
[Graphical view]
PANTHERiPTHR28358. PTHR28358. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAPGGAGLP GGRRRRSPGS SALPKQPERS LASALPGALS ITALCTALAE
60 70 80 90 100
PAWLHIHGGT CSRQELGVSD VLGYVNPDLL KDFCMNPQTV LLLRVIAAFC
110 120 130 140 150
FLGILCSLSA FLLDVFGPKH PALKITRRYA FAHILTVLQC ATVIGFSYWA
160 170 180 190 200
SELILAQQQQ HKKYHGSQVY VTFAVSFYLV AGAGGASILA TAANLLRHYP
210 220 230
TEEEEQALEL LSEMEENDPY PAEYEVINQF QPPPAYTP
Length:238
Mass (Da):25,835
Last modified:March 1, 2003 - v1
Checksum:i80CB57F832B7C68D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030324 mRNA. Translation: BAC26902.1.
AK050216 mRNA. Translation: BAC34129.1.
AK165880 mRNA. Translation: BAE38434.1.
AL845368 Genomic DNA. Translation: CAM17442.1.
BC049832 mRNA. Translation: AAH49832.1.
CCDSiCCDS16697.1.
RefSeqiNP_780354.1. NM_175145.3.
UniGeneiMm.200889.

Genome annotation databases

EnsembliENSMUST00000035871; ENSMUSP00000035434; ENSMUSG00000034850.
GeneIDi69470.
KEGGimmu:69470.
UCSCiuc008mfc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030324 mRNA. Translation: BAC26902.1.
AK050216 mRNA. Translation: BAC34129.1.
AK165880 mRNA. Translation: BAE38434.1.
AL845368 Genomic DNA. Translation: CAM17442.1.
BC049832 mRNA. Translation: AAH49832.1.
CCDSiCCDS16697.1.
RefSeqiNP_780354.1. NM_175145.3.
UniGeneiMm.200889.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035434.

PTM databases

iPTMnetiQ8BGP5.
PhosphoSiteiQ8BGP5.

Proteomic databases

MaxQBiQ8BGP5.
PaxDbiQ8BGP5.
PRIDEiQ8BGP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035871; ENSMUSP00000035434; ENSMUSG00000034850.
GeneIDi69470.
KEGGimmu:69470.
UCSCiuc008mfc.1. mouse.

Organism-specific databases

CTDi55654.
MGIiMGI:1916720. Tmem127.

Phylogenomic databases

eggNOGiENOG410IJHY. Eukaryota.
ENOG410XW58. LUCA.
GeneTreeiENSGT00390000005154.
HOGENOMiHOG000231823.
HOVERGENiHBG053128.
InParanoidiQ8BGP5.
OMAiMEETEPY.
OrthoDBiEOG091G0WXT.
PhylomeDBiQ8BGP5.
TreeFamiTF328671.

Miscellaneous databases

ChiTaRSiTmem127. mouse.
PROiQ8BGP5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034850.
CleanExiMM_TMEM127.
ExpressionAtlasiQ8BGP5. baseline and differential.
GenevisibleiQ8BGP5. MM.

Family and domain databases

InterProiIPR033331. TMEM127.
[Graphical view]
PANTHERiPTHR28358. PTHR28358. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM127_MOUSE
AccessioniPrimary (citable) accession number: Q8BGP5
Secondary accession number(s): A2ARF9, Q3TMK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.