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Protein

Synaptoporin

Gene

Synpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

TCDBi9.B.130.1.1. the tetraspan vesicle membrane protein (tvp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptoporin
Gene namesi
Name:Synpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919253. Synpr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 8156VesicularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11412CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 17742VesicularSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 26567CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of synaptic vesicle membrane Source: MGI
  • neuron projection Source: UniProtKB-SubCell
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265SynaptoporinPRO_0000179158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Modified residuei212 – 2121PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BGN8.
PaxDbiQ8BGN8.
PeptideAtlasiQ8BGN8.
PRIDEiQ8BGN8.

PTM databases

iPTMnetiQ8BGN8.
PhosphoSiteiQ8BGN8.

Expressioni

Gene expression databases

BgeeiQ8BGN8.
CleanExiMM_SYNPR.
ExpressionAtlasiQ8BGN8. baseline and differential.
GenevisibleiQ8BGN8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064986.

Structurei

3D structure databases

ProteinModelPortaliQ8BGN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 202202MARVELPROSITE-ProRule annotationAdd
BLAST
Repeati210 – 21451
Repeati222 – 22652
Repeati227 – 23153
Repeati232 – 23654
Repeati238 – 24255

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 242335 X approximate repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ8BGN8.
OMAiDEFGQQS.
OrthoDBiEOG7WT43S.
PhylomeDBiQ8BGN8.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCMVIFAPLF AMFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR
60 70 80 90 100
LQQVTFEVPT CEGKEQQKLA LVGDSSSSAE FFVTVAVFAF LYSLAATVVY
110 120 130 140 150
IFFQNKYREN NRGPLIDFIV TVVFSFLWLV GSSAWAKGLS DVKVATDPKE
160 170 180 190 200
VLLLMSACKQ PSNKCMAVHS PVMSSLNTSV VFGFLNFILW AGNIWFVFKE
210 220 230 240 250
TGWHSSGQRY LSDPMEKHSS SYNQGRYNQE SYGSSGGYSQ QANLGPTSDE
260
FGQQPSGPTS FNNQI
Length:265
Mass (Da):29,228
Last modified:March 1, 2003 - v1
Checksum:i81DD473A422815E5
GO
Isoform 2 (identifier: Q8BGN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MCMVIFAP → MDPVSQVASAGTFRALKEPLAFLRALEL

Show »
Length:285
Mass (Da):31,349
Checksum:iF3A7B5DE24A3B739
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301E → K in BAC37181 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MCMVIFAP → MDPVSQVASAGTFRALKEPL AFLRALEL in isoform 2. 2 PublicationsVSP_008550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005132 mRNA. Translation: BAB23831.1.
AK032442 mRNA. Translation: BAC27871.1.
AK049661 mRNA. Translation: BAC33864.1.
AK078223 mRNA. Translation: BAC37181.1.
BC026512 mRNA. Translation: AAH26512.1.
CCDSiCCDS26821.1. [Q8BGN8-2]
CCDS49402.1. [Q8BGN8-1]
RefSeqiNP_001156504.1. NM_001163032.1. [Q8BGN8-1]
NP_082328.3. NM_028052.4. [Q8BGN8-2]
UniGeneiMm.317515.

Genome annotation databases

EnsembliENSMUST00000070323; ENSMUSP00000064986; ENSMUSG00000056296. [Q8BGN8-2]
ENSMUST00000112656; ENSMUSP00000108275; ENSMUSG00000056296. [Q8BGN8-1]
GeneIDi72003.
KEGGimmu:72003.
UCSCiuc007sfy.2. mouse. [Q8BGN8-2]
uc007sga.2. mouse. [Q8BGN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005132 mRNA. Translation: BAB23831.1.
AK032442 mRNA. Translation: BAC27871.1.
AK049661 mRNA. Translation: BAC33864.1.
AK078223 mRNA. Translation: BAC37181.1.
BC026512 mRNA. Translation: AAH26512.1.
CCDSiCCDS26821.1. [Q8BGN8-2]
CCDS49402.1. [Q8BGN8-1]
RefSeqiNP_001156504.1. NM_001163032.1. [Q8BGN8-1]
NP_082328.3. NM_028052.4. [Q8BGN8-2]
UniGeneiMm.317515.

3D structure databases

ProteinModelPortaliQ8BGN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064986.

Protein family/group databases

TCDBi9.B.130.1.1. the tetraspan vesicle membrane protein (tvp) family.

PTM databases

iPTMnetiQ8BGN8.
PhosphoSiteiQ8BGN8.

Proteomic databases

MaxQBiQ8BGN8.
PaxDbiQ8BGN8.
PeptideAtlasiQ8BGN8.
PRIDEiQ8BGN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070323; ENSMUSP00000064986; ENSMUSG00000056296. [Q8BGN8-2]
ENSMUST00000112656; ENSMUSP00000108275; ENSMUSG00000056296. [Q8BGN8-1]
GeneIDi72003.
KEGGimmu:72003.
UCSCiuc007sfy.2. mouse. [Q8BGN8-2]
uc007sga.2. mouse. [Q8BGN8-1]

Organism-specific databases

CTDi132204.
MGIiMGI:1919253. Synpr.

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ8BGN8.
OMAiDEFGQQS.
OrthoDBiEOG7WT43S.
PhylomeDBiQ8BGN8.
TreeFamiTF315804.

Miscellaneous databases

ChiTaRSiSynpr. mouse.
PROiQ8BGN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGN8.
CleanExiMM_SYNPR.
ExpressionAtlasiQ8BGN8. baseline and differential.
GenevisibleiQ8BGN8. MM.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Olfactory bulb and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 150-159 AND 210-217, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSYNPR_MOUSE
AccessioniPrimary (citable) accession number: Q8BGN8
Secondary accession number(s): Q8C5J4, Q9DB89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.