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Q8BGL1 (PPM1N_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 1N

EC=3.1.3.16
Gene names
Name:Ppm1n
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Probable protein phosphatase 1N
PRO_0000349232

Regions

Domain58 – 312255PP2C-like
Compositional bias212 – 2154Poly-Arg

Sites

Metal binding961Manganese 1 By similarity
Metal binding961Manganese 2 By similarity
Metal binding971Manganese 1; via carbonyl oxygen By similarity
Metal binding2671Manganese 2 By similarity
Metal binding3101Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BGL1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8AC50F5AEF42F341

FASTA40443,201
        10         20         30         40         50         60 
MAAFVRLLER LGWAARAQQV VEQEVEEECS VPGASGSLLA APRCWQRLHR GAAATSGLRF 

        70         80         90        100        110        120 
GASAVQGWRA RMEDAHCARL ALPGLPSGWA FFAVLDGHGG ARAARFGARH LPGYVLGELG 

       130        140        150        160        170        180 
PAPQEPDGVR QALRSAFLQA DAQLSALWPR GDPGGSTAVA LLVSPRFLYL AHCGDSRALL 

       190        200        210        220        230        240 
SRSGSVAFCT EDHRPHRPRE RERIHDAGGT VRRRRVEGSL AVSRALGDFA YKQAPGRPPE 

       250        260        270        280        290        300 
LQLVSAEPEV AALARQDEDE FVLLASDGVW DALSGADLAG LVTSRLRLGL DLELLCAQLL 

       310        320        330        340        350        360 
DTCLCKGSLD NMTCMVVCFP GAPRPCEEAI SKEMALDEAL SHKVAELYAS AQEPPGLNTV 

       370        380        390        400 
FRTLASEDIP GLPPGGGLHS KAAVIAEAYS KLHQTPGECQ EEEW 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK044232 mRNA. Translation: BAC31831.1.
AK044334 mRNA. Translation: BAC31872.1.
BC096372 mRNA. Translation: AAH96372.1.
CCDSCCDS20895.1.
RefSeqNP_808359.1. NM_177691.3.
UniGeneMm.134068.

3D structure databases

ProteinModelPortalQ8BGL1.
SMRQ8BGL1. Positions 36-393.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8BGL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032560; ENSMUSP00000032560; ENSMUSG00000030402.
GeneID232941.
KEGGmmu:232941.
UCSCuc009flg.1. mouse.

Organism-specific databases

CTD147699.
MGIMGI:2142330. Ppm1n.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00740000115384.
HOGENOMHOG000233895.
HOVERGENHBG053647.
InParanoidQ8BGL1.
OMAHMEDAHC.
OrthoDBEOG7WMCJH.
PhylomeDBQ8BGL1.
TreeFamTF313590.

Gene expression databases

BgeeQ8BGL1.
GenevestigatorQ8BGL1.

Family and domain databases

Gene3D1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR012911. PP2C_C.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPPM1N. mouse.
NextBio381349.
PROQ8BGL1.
SOURCESearch...

Entry information

Entry namePPM1N_MOUSE
AccessionPrimary (citable) accession number: Q8BGL1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot