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Q8BGL1

- PPM1N_MOUSE

UniProt

Q8BGL1 - PPM1N_MOUSE

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Protein

Probable protein phosphatase 1N

Gene

Ppm1n

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Manganese 1By similarity
Metal bindingi96 – 961Manganese 2By similarity
Metal bindingi97 – 971Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi267 – 2671Manganese 2By similarity
Metal bindingi310 – 3101Manganese 2By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. manganese ion binding Source: InterPro
  3. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 1N (EC:3.1.3.16)
Gene namesi
Name:Ppm1n
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2142330. Ppm1n.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Probable protein phosphatase 1NPRO_0000349232Add
BLAST

Proteomic databases

PRIDEiQ8BGL1.

Expressioni

Gene expression databases

BgeeiQ8BGL1.
GenevestigatoriQ8BGL1.

Structurei

3D structure databases

ProteinModelPortaliQ8BGL1.
SMRiQ8BGL1. Positions 36-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 312255PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 2154Poly-Arg

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233895.
HOVERGENiHBG053647.
InParanoidiQ8BGL1.
OMAiHMEDAHC.
OrthoDBiEOG7WMCJH.
PhylomeDBiQ8BGL1.
TreeFamiTF313590.

Family and domain databases

Gene3Di1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR012911. PP2C_C.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFVRLLER LGWAARAQQV VEQEVEEECS VPGASGSLLA APRCWQRLHR
60 70 80 90 100
GAAATSGLRF GASAVQGWRA RMEDAHCARL ALPGLPSGWA FFAVLDGHGG
110 120 130 140 150
ARAARFGARH LPGYVLGELG PAPQEPDGVR QALRSAFLQA DAQLSALWPR
160 170 180 190 200
GDPGGSTAVA LLVSPRFLYL AHCGDSRALL SRSGSVAFCT EDHRPHRPRE
210 220 230 240 250
RERIHDAGGT VRRRRVEGSL AVSRALGDFA YKQAPGRPPE LQLVSAEPEV
260 270 280 290 300
AALARQDEDE FVLLASDGVW DALSGADLAG LVTSRLRLGL DLELLCAQLL
310 320 330 340 350
DTCLCKGSLD NMTCMVVCFP GAPRPCEEAI SKEMALDEAL SHKVAELYAS
360 370 380 390 400
AQEPPGLNTV FRTLASEDIP GLPPGGGLHS KAAVIAEAYS KLHQTPGECQ

EEEW
Length:404
Mass (Da):43,201
Last modified:March 1, 2003 - v1
Checksum:i8AC50F5AEF42F341
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044232 mRNA. Translation: BAC31831.1.
AK044334 mRNA. Translation: BAC31872.1.
BC096372 mRNA. Translation: AAH96372.1.
CCDSiCCDS20895.1.
RefSeqiNP_808359.1. NM_177691.3.
UniGeneiMm.134068.

Genome annotation databases

EnsembliENSMUST00000032560; ENSMUSP00000032560; ENSMUSG00000030402.
GeneIDi232941.
KEGGimmu:232941.
UCSCiuc009flg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044232 mRNA. Translation: BAC31831.1 .
AK044334 mRNA. Translation: BAC31872.1 .
BC096372 mRNA. Translation: AAH96372.1 .
CCDSi CCDS20895.1.
RefSeqi NP_808359.1. NM_177691.3.
UniGenei Mm.134068.

3D structure databases

ProteinModelPortali Q8BGL1.
SMRi Q8BGL1. Positions 36-393.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BGL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032560 ; ENSMUSP00000032560 ; ENSMUSG00000030402 .
GeneIDi 232941.
KEGGi mmu:232941.
UCSCi uc009flg.1. mouse.

Organism-specific databases

CTDi 147699.
MGIi MGI:2142330. Ppm1n.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000115384.
HOGENOMi HOG000233895.
HOVERGENi HBG053647.
InParanoidi Q8BGL1.
OMAi HMEDAHC.
OrthoDBi EOG7WMCJH.
PhylomeDBi Q8BGL1.
TreeFami TF313590.

Miscellaneous databases

ChiTaRSi PPM1N. mouse.
NextBioi 381349.
PROi Q8BGL1.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGL1.
Genevestigatori Q8BGL1.

Family and domain databases

Gene3Di 1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR012911. PP2C_C.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiPPM1N_MOUSE
AccessioniPrimary (citable) accession number: Q8BGL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3