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Q8BGL1

- PPM1N_MOUSE

UniProt

Q8BGL1 - PPM1N_MOUSE

Protein

Probable protein phosphatase 1N

Gene

Ppm1n

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi96 – 961Manganese 1By similarity
    Metal bindingi96 – 961Manganese 2By similarity
    Metal bindingi97 – 971Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi267 – 2671Manganese 2By similarity
    Metal bindingi310 – 3101Manganese 2By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. manganese ion binding Source: InterPro
    3. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 1N (EC:3.1.3.16)
    Gene namesi
    Name:Ppm1n
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2142330. Ppm1n.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Probable protein phosphatase 1NPRO_0000349232Add
    BLAST

    Proteomic databases

    PRIDEiQ8BGL1.

    Expressioni

    Gene expression databases

    BgeeiQ8BGL1.
    GenevestigatoriQ8BGL1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGL1.
    SMRiQ8BGL1. Positions 36-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 312255PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi212 – 2154Poly-Arg

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000115384.
    HOGENOMiHOG000233895.
    HOVERGENiHBG053647.
    InParanoidiQ8BGL1.
    OMAiHMEDAHC.
    OrthoDBiEOG7WMCJH.
    PhylomeDBiQ8BGL1.
    TreeFamiTF313590.

    Family and domain databases

    Gene3Di1.10.10.430. 1 hit.
    3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR012911. PP2C_C.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    PF07830. PP2C_C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81601. SSF81601. 1 hit.
    SSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BGL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFVRLLER LGWAARAQQV VEQEVEEECS VPGASGSLLA APRCWQRLHR    50
    GAAATSGLRF GASAVQGWRA RMEDAHCARL ALPGLPSGWA FFAVLDGHGG 100
    ARAARFGARH LPGYVLGELG PAPQEPDGVR QALRSAFLQA DAQLSALWPR 150
    GDPGGSTAVA LLVSPRFLYL AHCGDSRALL SRSGSVAFCT EDHRPHRPRE 200
    RERIHDAGGT VRRRRVEGSL AVSRALGDFA YKQAPGRPPE LQLVSAEPEV 250
    AALARQDEDE FVLLASDGVW DALSGADLAG LVTSRLRLGL DLELLCAQLL 300
    DTCLCKGSLD NMTCMVVCFP GAPRPCEEAI SKEMALDEAL SHKVAELYAS 350
    AQEPPGLNTV FRTLASEDIP GLPPGGGLHS KAAVIAEAYS KLHQTPGECQ 400
    EEEW 404
    Length:404
    Mass (Da):43,201
    Last modified:March 1, 2003 - v1
    Checksum:i8AC50F5AEF42F341
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044232 mRNA. Translation: BAC31831.1.
    AK044334 mRNA. Translation: BAC31872.1.
    BC096372 mRNA. Translation: AAH96372.1.
    CCDSiCCDS20895.1.
    RefSeqiNP_808359.1. NM_177691.3.
    UniGeneiMm.134068.

    Genome annotation databases

    EnsembliENSMUST00000032560; ENSMUSP00000032560; ENSMUSG00000030402.
    GeneIDi232941.
    KEGGimmu:232941.
    UCSCiuc009flg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044232 mRNA. Translation: BAC31831.1 .
    AK044334 mRNA. Translation: BAC31872.1 .
    BC096372 mRNA. Translation: AAH96372.1 .
    CCDSi CCDS20895.1.
    RefSeqi NP_808359.1. NM_177691.3.
    UniGenei Mm.134068.

    3D structure databases

    ProteinModelPortali Q8BGL1.
    SMRi Q8BGL1. Positions 36-393.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8BGL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032560 ; ENSMUSP00000032560 ; ENSMUSG00000030402 .
    GeneIDi 232941.
    KEGGi mmu:232941.
    UCSCi uc009flg.1. mouse.

    Organism-specific databases

    CTDi 147699.
    MGIi MGI:2142330. Ppm1n.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000115384.
    HOGENOMi HOG000233895.
    HOVERGENi HBG053647.
    InParanoidi Q8BGL1.
    OMAi HMEDAHC.
    OrthoDBi EOG7WMCJH.
    PhylomeDBi Q8BGL1.
    TreeFami TF313590.

    Miscellaneous databases

    ChiTaRSi PPM1N. mouse.
    NextBioi 381349.
    PROi Q8BGL1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGL1.
    Genevestigatori Q8BGL1.

    Family and domain databases

    Gene3Di 1.10.10.430. 1 hit.
    3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR012911. PP2C_C.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    PF07830. PP2C_C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81601. SSF81601. 1 hit.
    SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiPPM1N_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3