Q8BGL1 (PPM1N_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 1N
EC=3.1.3.16

Gene names

Name:

Ppm1n

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: InterPro phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Probable protein phosphatase 1N		PRO_0000349232
Regions
	Domain	58 – 312	255	PP2C-like
	Compositional bias	212 – 215	4	Poly-Arg
Sites
	Metal binding	96	1	Manganese 1 By similarity
	Metal binding	96	1	Manganese 2 By similarity
	Metal binding	97	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	267	1	Manganese 2 By similarity
	Metal binding	310	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BGL1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8AC50F5AEF42F341	FASTA	404	43,201
	10 20 30 40 50 60 MAAFVRLLER LGWAARAQQV VEQEVEEECS VPGASGSLLA APRCWQRLHR GAAATSGLRF 70 80 90 100 110 120 GASAVQGWRA RMEDAHCARL ALPGLPSGWA FFAVLDGHGG ARAARFGARH LPGYVLGELG 130 140 150 160 170 180 PAPQEPDGVR QALRSAFLQA DAQLSALWPR GDPGGSTAVA LLVSPRFLYL AHCGDSRALL 190 200 210 220 230 240 SRSGSVAFCT EDHRPHRPRE RERIHDAGGT VRRRRVEGSL AVSRALGDFA YKQAPGRPPE 250 260 270 280 290 300 LQLVSAEPEV AALARQDEDE FVLLASDGVW DALSGADLAG LVTSRLRLGL DLELLCAQLL 310 320 330 340 350 360 DTCLCKGSLD NMTCMVVCFP GAPRPCEEAI SKEMALDEAL SHKVAELYAS AQEPPGLNTV 370 380 390 400 FRTLASEDIP GLPPGGGLHS KAAVIAEAYS KLHQTPGECQ EEEW

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Retina.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK044232 mRNA. Translation: BAC31831.1. AK044334 mRNA. Translation: BAC31872.1. BC096372 mRNA. Translation: AAH96372.1.
IPI	IPI00221634.
RefSeq	NP_808359.1. NM_177691.3.
UniGene	Mm.134068.
3D structure databases
HSSP	HSSP built from PDB template 1A6Q based on UniProtKB P35813.
ProteinModelPortal	Q8BGL1.
SMR	Q8BGL1. Positions 36-393.
ModBase	Search...
Proteomic databases
PRIDE	Q8BGL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032560; ENSMUSP00000032560; ENSMUSG00000030402.
GeneID	232941.
KEGG	mmu:232941.
UCSC	uc009flg.1. mouse.
Organism-specific databases
CTD	147699.
MGI	MGI:2142330. Ppm1n.
Phylogenomic databases
eggNOG	COG0631.
GeneTree	ENSGT00650000093052.
HOGENOM	HOG000233895.
HOVERGEN	HBG053647.
InParanoid	Q8BGL1.
OMA	HMEDAHC.
OrthoDB	EOG4H4645.
Gene expression databases
Bgee	Q8BGL1.
Genevestigator	Q8BGL1.
Family and domain databases
Gene3D	1.10.10.430. 1 hit. 3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR012911. PP2C_C. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. PF07830. PP2C_C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit. SSF81601. PP2C_C. 1 hit.
PROSITE	PS01032. PP2C. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPM1N. mouse.
NextBio	381349.
SOURCE	Search...

Entry information

Entry name

PPM1N_MOUSE

Accession

Primary (citable) accession number: Q8BGL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program