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Q8BGK6 (YLAT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Y+L amino acid transporter 2
Alternative name(s):
Solute carrier family 7 member 6
y(+)L-type amino acid transporter 2
Short name=Y+LAT2
Short name=y+LAT-2
Gene names
Name:Slc7a6
Synonyms:Kiaa0245
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells By similarity. UniProtKB Q92536

Subunit structure

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc By similarity. UniProtKB Q92536

Subcellular location

Basolateral cell membrane; Multi-pass membrane protein By similarity UniProtKB Q92536.

Tissue specificity

Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver. Ref.4

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]

Sequence caution

The sequence AAH38404.1 differs from that shown. Reason: Frameshift at position 345.

The sequence BAC97909.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 Ref.3 (identifier: Q8BGK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q8BGK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     165-216: ACRLLAAACV...IIMGLVKLCQ → MFFFLPLPCF...AWSPTRLCPT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Y+L amino acid transporter 2
PRO_0000341478

Regions

Topological domain1 – 4444Cytoplasmic Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 7813Extracellular Potential
Transmembrane79 – 9921Helical; Potential
Topological domain100 – 11415Cytoplasmic Potential
Transmembrane115 – 13521Helical; Potential
Topological domain136 – 16732Extracellular Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 1946Cytoplasmic Potential
Transmembrane195 – 21521Helical; Potential
Topological domain216 – 23520Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 26610Cytoplasmic Potential
Transmembrane267 – 28721Helical; Potential
Topological domain288 – 31124Extracellular Potential
Transmembrane312 – 33221Helical; Potential
Topological domain333 – 36331Cytoplasmic Potential
Transmembrane364 – 38421Helical; Potential
Topological domain3851Extracellular Potential
Transmembrane386 – 40621Helical; Potential
Topological domain407 – 42418Cytoplasmic Potential
Transmembrane425 – 44521Helical; Potential
Topological domain446 – 4516Extracellular Potential
Transmembrane452 – 47221Helical; Potential
Topological domain473 – 51543Cytoplasmic Potential

Amino acid modifications

Modified residue301Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 164164Missing in isoform 2. Ref.1
VSP_052833
Alternative sequence165 – 21652ACRLL…VKLCQ → MFFFLPLPCFLSLFFFLLLF HLFNSPSVFFLFFTFLLSPF SFAWSPTRLCPT in isoform 2. Ref.1
VSP_052834

Experimental info

Sequence conflict1291W → R in BAE33971. Ref.2
Sequence conflict1321L → P in BAE38304. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8DF8352607228507

FASTA51556,771
        10         20         30         40         50         60 
MEAQELGSPT PTYHLLPKAN QHTVKEDAGS PSQGSPETMQ LKKEISLLNG VSLVVGNMIG 

        70         80         90        100        110        120 
SGIFVSPKGV LKYTASYGLS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG 

       130        140        150        160        170        180 
GFIAFIRLWV SLLIVEPTSQ AIIAITFANY IIKPSFPTCD PPYVACRLLA AACVCLLTFV 

       190        200        210        220        230        240 
NCAYVKWGTR VQDTFTYAKV LALIAIIIMG LVKLCQGHTE HFQDAFKGSS WNVGDLSLAL 

       250        260        270        280        290        300 
YSALFSYSGW DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNIQDVHK 

       310        320        330        340        350        360 
SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG HLPNLLSMIH 

       370        380        390        400        410        420 
IERFTPVPAL LFNCTMTLIY LVVKDVFLLI NYFSFSYWFF VGLSVVGQLY LRWKEPDWPR 

       430        440        450        460        470        480 
PLKLSLFFPI VFCVCSLFLV AVPLFSDTIN SLIGIGIALS GVPVYFLGVY LPESRRPLFI 

       490        500        510 
RNVLATVTRV TQKLCFCVLT ELDVTEEKNV ERKTD 

« Hide

Isoform 2 [UniParc].

Checksum: 755C17738F01F461
Show »

FASTA35139,901

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryonic tail.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Embryo, Embryonic stem cell, Embryonic stomach, Eye, Lung and Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine."
Broeer A., Wagner C.A., Lang F., Broeer S.
Biochem. J. 349:787-795(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-293 (ISOFORM 1), TISSUE SPECIFICITY.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129099 mRNA. Translation: BAC97909.1. Different initiation.
AK049478 mRNA. Translation: BAC33770.1.
AK053899 mRNA. Translation: BAC35581.1.
AK157127 mRNA. Translation: BAE33971.1.
AK164666 mRNA. Translation: BAE37866.1.
AK165629 mRNA. Translation: BAE38304.1.
AK165979 mRNA. Translation: BAE38497.1.
BC038404 mRNA. Translation: AAH38404.1. Frameshift.
RefSeqNP_848913.1. NM_178798.3.
XP_006531200.1. XM_006531137.1.
XP_006531201.1. XM_006531138.1.
UniGeneMm.46749.

3D structure databases

ProteinModelPortalQ8BGK6.
SMRQ8BGK6. Positions 44-380.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BGK6.

Proteomic databases

PaxDbQ8BGK6.
PRIDEQ8BGK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
GeneID330836.
KEGGmmu:330836.
UCSCuc009nfl.1. mouse. [Q8BGK6-1]
uc009nfo.1. mouse. [Q8BGK6-2]

Organism-specific databases

CTD9057.
MGIMGI:2142598. Slc7a6.
RougeSearch...

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00730000110280.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidQ8BGK6.
KOK13872.
OMAFCICSLF.
OrthoDBEOG73BVCR.
PhylomeDBQ8BGK6.
TreeFamTF313355.

Gene expression databases

BgeeQ8BGK6.
GenevestigatorQ8BGK6.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC7A6. mouse.
NextBio399586.
PROQ8BGK6.
SOURCESearch...

Entry information

Entry nameYLAT2_MOUSE
AccessionPrimary (citable) accession number: Q8BGK6
Secondary accession number(s): Q3TMY5 expand/collapse secondary AC list , Q3U084, Q6ZQF5, Q8CFY3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot