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Protein

Y+L amino acid transporter 2

Gene

Slc7a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Transport

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_323105. Basigin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 2
Alternative name(s):
Solute carrier family 7 member 6
y(+)L-type amino acid transporter 2
Short name:
Y+LAT2
Short name:
y+LAT-2
Gene namesi
Name:Slc7a6Imported
Synonyms:Kiaa0245Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142598. Slc7a6.

Subcellular locationi

  • Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 7813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 11415CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 16732ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 1946CytoplasmicSequence Analysis
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 23520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 26610CytoplasmicSequence Analysis
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Topological domaini288 – 31124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence AnalysisAdd
BLAST
Topological domaini385 – 3851ExtracellularSequence Analysis
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Topological domaini407 – 42418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST
Topological domaini446 – 4516ExtracellularSequence Analysis
Transmembranei452 – 47221HelicalSequence AnalysisAdd
BLAST
Topological domaini473 – 51543CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Y+L amino acid transporter 2PRO_0000341478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8BGK6.
PaxDbiQ8BGK6.
PRIDEiQ8BGK6.

PTM databases

PhosphoSiteiQ8BGK6.

Expressioni

Tissue specificityi

Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver.1 Publication

Gene expression databases

BgeeiQ8BGK6.
GenevisibleiQ8BGK6. MM.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034378.

Structurei

3D structure databases

ProteinModelPortaliQ8BGK6.
SMRiQ8BGK6. Positions 53-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8BGK6.
KOiK13872.
OMAiELIMRDE.
OrthoDBiEOG73BVCR.
PhylomeDBiQ8BGK6.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q8BGK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAQELGSPT PTYHLLPKAN QHTVKEDAGS PSQGSPETMQ LKKEISLLNG
60 70 80 90 100
VSLVVGNMIG SGIFVSPKGV LKYTASYGLS LIVWAIGGLF SVVGALCYAE
110 120 130 140 150
LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLIVEPTSQ AIIAITFANY
160 170 180 190 200
IIKPSFPTCD PPYVACRLLA AACVCLLTFV NCAYVKWGTR VQDTFTYAKV
210 220 230 240 250
LALIAIIIMG LVKLCQGHTE HFQDAFKGSS WNVGDLSLAL YSALFSYSGW
260 270 280 290 300
DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNIQDVHK
310 320 330 340 350
SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG
360 370 380 390 400
HLPNLLSMIH IERFTPVPAL LFNCTMTLIY LVVKDVFLLI NYFSFSYWFF
410 420 430 440 450
VGLSVVGQLY LRWKEPDWPR PLKLSLFFPI VFCVCSLFLV AVPLFSDTIN
460 470 480 490 500
SLIGIGIALS GVPVYFLGVY LPESRRPLFI RNVLATVTRV TQKLCFCVLT
510
ELDVTEEKNV ERKTD
Length:515
Mass (Da):56,771
Last modified:March 1, 2003 - v1
Checksum:i8DF8352607228507
GO
Isoform 21 Publication (identifier: Q8BGK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     165-216: ACRLLAAACV...IIMGLVKLCQ → MFFFLPLPCF...AWSPTRLCPT

Note: No experimental confirmation available.Curated
Show »
Length:351
Mass (Da):39,901
Checksum:i755C17738F01F461
GO

Sequence cautioni

The sequence AAH38404.1 differs from that shown. Reason: Frameshift at position 345. Curated
The sequence BAC97909.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291W → R in BAE33971 (PubMed:16141072).Curated
Sequence conflicti132 – 1321L → P in BAE38304 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 164164Missing in isoform 2. 1 PublicationVSP_052833Add
BLAST
Alternative sequencei165 – 21652ACRLL…VKLCQ → MFFFLPLPCFLSLFFFLLLF HLFNSPSVFFLFFTFLLSPF SFAWSPTRLCPT in isoform 2. 1 PublicationVSP_052834Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129099 mRNA. Translation: BAC97909.1. Different initiation.
AK049478 mRNA. Translation: BAC33770.1.
AK053899 mRNA. Translation: BAC35581.1.
AK157127 mRNA. Translation: BAE33971.1.
AK164666 mRNA. Translation: BAE37866.1.
AK165629 mRNA. Translation: BAE38304.1.
AK165979 mRNA. Translation: BAE38497.1.
BC038404 mRNA. Translation: AAH38404.1. Frameshift.
CCDSiCCDS22631.1. [Q8BGK6-1]
RefSeqiNP_848913.1. NM_178798.3. [Q8BGK6-1]
XP_006531200.1. XM_006531137.2. [Q8BGK6-1]
XP_006531201.1. XM_006531138.2. [Q8BGK6-1]
UniGeneiMm.46749.

Genome annotation databases

EnsembliENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
GeneIDi330836.
KEGGimmu:330836.
UCSCiuc009nfl.1. mouse. [Q8BGK6-1]
uc009nfo.1. mouse. [Q8BGK6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129099 mRNA. Translation: BAC97909.1. Different initiation.
AK049478 mRNA. Translation: BAC33770.1.
AK053899 mRNA. Translation: BAC35581.1.
AK157127 mRNA. Translation: BAE33971.1.
AK164666 mRNA. Translation: BAE37866.1.
AK165629 mRNA. Translation: BAE38304.1.
AK165979 mRNA. Translation: BAE38497.1.
BC038404 mRNA. Translation: AAH38404.1. Frameshift.
CCDSiCCDS22631.1. [Q8BGK6-1]
RefSeqiNP_848913.1. NM_178798.3. [Q8BGK6-1]
XP_006531200.1. XM_006531137.2. [Q8BGK6-1]
XP_006531201.1. XM_006531138.2. [Q8BGK6-1]
UniGeneiMm.46749.

3D structure databases

ProteinModelPortaliQ8BGK6.
SMRiQ8BGK6. Positions 53-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034378.

PTM databases

PhosphoSiteiQ8BGK6.

Proteomic databases

MaxQBiQ8BGK6.
PaxDbiQ8BGK6.
PRIDEiQ8BGK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
GeneIDi330836.
KEGGimmu:330836.
UCSCiuc009nfl.1. mouse. [Q8BGK6-1]
uc009nfo.1. mouse. [Q8BGK6-2]

Organism-specific databases

CTDi9057.
MGIiMGI:2142598. Slc7a6.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8BGK6.
KOiK13872.
OMAiELIMRDE.
OrthoDBiEOG73BVCR.
PhylomeDBiQ8BGK6.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_323105. Basigin interactions.

Miscellaneous databases

ChiTaRSiSlc7a6. mouse.
NextBioi399586.
PROiQ8BGK6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGK6.
GenevisibleiQ8BGK6. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tailImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported and NODImported.
    Tissue: EmbryoImported, Embryonic stem cellImported, Embryonic stomachImported, EyeImported, LungImported and SpleenImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/NImported.
    Tissue: Mammary tumorImported.
  4. "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine."
    Broeer A., Wagner C.A., Lang F., Broeer S.
    Biochem. J. 349:787-795(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-293 (ISOFORM 1), TISSUE SPECIFICITY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYLAT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGK6
Secondary accession number(s): Q3TMY5
, Q3U084, Q6ZQF5, Q8CFY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.