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Protein

Y+L amino acid transporter 2

Gene

Slc7a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 2
Alternative name(s):
Solute carrier family 7 member 6
y(+)L-type amino acid transporter 2
Short name:
Y+LAT2
Short name:
y+LAT-2
Gene namesi
Name:Slc7a6Imported
Synonyms:Kiaa0245Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142598. Slc7a6.

Subcellular locationi

  • Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 78ExtracellularSequence analysisAdd BLAST13
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 114CytoplasmicSequence analysisAdd BLAST15
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 167ExtracellularSequence analysisAdd BLAST32
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 194CytoplasmicSequence analysis6
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 235ExtracellularSequence analysisAdd BLAST20
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 266CytoplasmicSequence analysis10
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 311ExtracellularSequence analysisAdd BLAST24
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 363CytoplasmicSequence analysisAdd BLAST31
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385ExtracellularSequence analysis1
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 424CytoplasmicSequence analysisAdd BLAST18
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 451ExtracellularSequence analysis6
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 515CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003414781 – 515Y+L amino acid transporter 2Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8BGK6.
PeptideAtlasiQ8BGK6.
PRIDEiQ8BGK6.

PTM databases

iPTMnetiQ8BGK6.
PhosphoSitePlusiQ8BGK6.

Expressioni

Tissue specificityi

Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000031904.
GenevisibleiQ8BGK6. MM.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034378.

Structurei

3D structure databases

ProteinModelPortaliQ8BGK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8BGK6.
KOiK13872.
OMAiGSSWDVG.
OrthoDBiEOG091G07EM.
PhylomeDBiQ8BGK6.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q8BGK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAQELGSPT PTYHLLPKAN QHTVKEDAGS PSQGSPETMQ LKKEISLLNG
60 70 80 90 100
VSLVVGNMIG SGIFVSPKGV LKYTASYGLS LIVWAIGGLF SVVGALCYAE
110 120 130 140 150
LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLIVEPTSQ AIIAITFANY
160 170 180 190 200
IIKPSFPTCD PPYVACRLLA AACVCLLTFV NCAYVKWGTR VQDTFTYAKV
210 220 230 240 250
LALIAIIIMG LVKLCQGHTE HFQDAFKGSS WNVGDLSLAL YSALFSYSGW
260 270 280 290 300
DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNIQDVHK
310 320 330 340 350
SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG
360 370 380 390 400
HLPNLLSMIH IERFTPVPAL LFNCTMTLIY LVVKDVFLLI NYFSFSYWFF
410 420 430 440 450
VGLSVVGQLY LRWKEPDWPR PLKLSLFFPI VFCVCSLFLV AVPLFSDTIN
460 470 480 490 500
SLIGIGIALS GVPVYFLGVY LPESRRPLFI RNVLATVTRV TQKLCFCVLT
510
ELDVTEEKNV ERKTD
Length:515
Mass (Da):56,771
Last modified:March 1, 2003 - v1
Checksum:i8DF8352607228507
GO
Isoform 21 Publication (identifier: Q8BGK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     165-216: ACRLLAAACV...IIMGLVKLCQ → MFFFLPLPCF...AWSPTRLCPT

Note: No experimental confirmation available.Curated
Show »
Length:351
Mass (Da):39,901
Checksum:i755C17738F01F461
GO

Sequence cautioni

The sequence AAH38404 differs from that shown. Reason: Frameshift at position 345.Curated
The sequence BAC97909 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129W → R in BAE33971 (PubMed:16141072).Curated1
Sequence conflicti132L → P in BAE38304 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0528331 – 164Missing in isoform 2. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_052834165 – 216ACRLL…VKLCQ → MFFFLPLPCFLSLFFFLLLF HLFNSPSVFFLFFTFLLSPF SFAWSPTRLCPT in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129099 mRNA. Translation: BAC97909.1. Different initiation.
AK049478 mRNA. Translation: BAC33770.1.
AK053899 mRNA. Translation: BAC35581.1.
AK157127 mRNA. Translation: BAE33971.1.
AK164666 mRNA. Translation: BAE37866.1.
AK165629 mRNA. Translation: BAE38304.1.
AK165979 mRNA. Translation: BAE38497.1.
BC038404 mRNA. Translation: AAH38404.1. Frameshift.
CCDSiCCDS22631.1. [Q8BGK6-1]
RefSeqiNP_848913.1. NM_178798.3. [Q8BGK6-1]
XP_006531200.1. XM_006531137.3. [Q8BGK6-1]
XP_006531201.1. XM_006531138.3. [Q8BGK6-1]
XP_017168357.1. XM_017312868.1. [Q8BGK6-1]
UniGeneiMm.46749.

Genome annotation databases

EnsembliENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
GeneIDi330836.
KEGGimmu:330836.
UCSCiuc009nfl.1. mouse. [Q8BGK6-1]
uc009nfo.1. mouse. [Q8BGK6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129099 mRNA. Translation: BAC97909.1. Different initiation.
AK049478 mRNA. Translation: BAC33770.1.
AK053899 mRNA. Translation: BAC35581.1.
AK157127 mRNA. Translation: BAE33971.1.
AK164666 mRNA. Translation: BAE37866.1.
AK165629 mRNA. Translation: BAE38304.1.
AK165979 mRNA. Translation: BAE38497.1.
BC038404 mRNA. Translation: AAH38404.1. Frameshift.
CCDSiCCDS22631.1. [Q8BGK6-1]
RefSeqiNP_848913.1. NM_178798.3. [Q8BGK6-1]
XP_006531200.1. XM_006531137.3. [Q8BGK6-1]
XP_006531201.1. XM_006531138.3. [Q8BGK6-1]
XP_017168357.1. XM_017312868.1. [Q8BGK6-1]
UniGeneiMm.46749.

3D structure databases

ProteinModelPortaliQ8BGK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034378.

PTM databases

iPTMnetiQ8BGK6.
PhosphoSitePlusiQ8BGK6.

Proteomic databases

PaxDbiQ8BGK6.
PeptideAtlasiQ8BGK6.
PRIDEiQ8BGK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
GeneIDi330836.
KEGGimmu:330836.
UCSCiuc009nfl.1. mouse. [Q8BGK6-1]
uc009nfo.1. mouse. [Q8BGK6-2]

Organism-specific databases

CTDi9057.
MGIiMGI:2142598. Slc7a6.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8BGK6.
KOiK13872.
OMAiGSSWDVG.
OrthoDBiEOG091G07EM.
PhylomeDBiQ8BGK6.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc7a6. mouse.
PROiQ8BGK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031904.
GenevisibleiQ8BGK6. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYLAT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGK6
Secondary accession number(s): Q3TMY5
, Q3U084, Q6ZQF5, Q8CFY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.