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Q8BGK6

- YLAT2_MOUSE

UniProt

Q8BGK6 - YLAT2_MOUSE

Protein

Y+L amino acid transporter 2

Gene

Slc7a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells By similarity.By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro
    2. antiporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Antiport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Y+L amino acid transporter 2
    Alternative name(s):
    Solute carrier family 7 member 6
    y(+)L-type amino acid transporter 2
    Short name:
    Y+LAT2
    Short name:
    y+LAT-2
    Gene namesi
    Name:Slc7a6Imported
    Synonyms:Kiaa0245Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2142598. Slc7a6.

    Subcellular locationi

    Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Y+L amino acid transporter 2PRO_0000341478Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BGK6.
    PaxDbiQ8BGK6.
    PRIDEiQ8BGK6.

    PTM databases

    PhosphoSiteiQ8BGK6.

    Expressioni

    Tissue specificityi

    Strongest expression in brain but also detected in testis, parotis, small intestine, heart and kidney. Weakly expressed in spleen, lung and liver.1 Publication

    Gene expression databases

    BgeeiQ8BGK6.
    GenevestigatoriQ8BGK6.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGK6.
    SMRiQ8BGK6. Positions 53-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini136 – 16732ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 1946CytoplasmicSequence Analysis
    Topological domaini216 – 23520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26610CytoplasmicSequence Analysis
    Topological domaini288 – 31124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini385 – 3851ExtracellularSequence Analysis
    Topological domaini407 – 42418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini446 – 4516ExtracellularSequence Analysis
    Topological domaini473 – 51543CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110280.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ8BGK6.
    KOiK13872.
    OMAiLEELIMR.
    OrthoDBiEOG73BVCR.
    PhylomeDBiQ8BGK6.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 12 Publications (identifier: Q8BGK6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAQELGSPT PTYHLLPKAN QHTVKEDAGS PSQGSPETMQ LKKEISLLNG    50
    VSLVVGNMIG SGIFVSPKGV LKYTASYGLS LIVWAIGGLF SVVGALCYAE 100
    LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLIVEPTSQ AIIAITFANY 150
    IIKPSFPTCD PPYVACRLLA AACVCLLTFV NCAYVKWGTR VQDTFTYAKV 200
    LALIAIIIMG LVKLCQGHTE HFQDAFKGSS WNVGDLSLAL YSALFSYSGW 250
    DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNIQDVHK 300
    SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG 350
    HLPNLLSMIH IERFTPVPAL LFNCTMTLIY LVVKDVFLLI NYFSFSYWFF 400
    VGLSVVGQLY LRWKEPDWPR PLKLSLFFPI VFCVCSLFLV AVPLFSDTIN 450
    SLIGIGIALS GVPVYFLGVY LPESRRPLFI RNVLATVTRV TQKLCFCVLT 500
    ELDVTEEKNV ERKTD 515
    Length:515
    Mass (Da):56,771
    Last modified:March 1, 2003 - v1
    Checksum:i8DF8352607228507
    GO
    Isoform 21 Publication (identifier: Q8BGK6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-164: Missing.
         165-216: ACRLLAAACV...IIMGLVKLCQ → MFFFLPLPCF...AWSPTRLCPT

    Note: No experimental confirmation available.Curated

    Show »
    Length:351
    Mass (Da):39,901
    Checksum:i755C17738F01F461
    GO

    Sequence cautioni

    The sequence AAH38404.1 differs from that shown. Reason: Frameshift at position 345.
    The sequence BAC97909.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti129 – 1291W → R in BAE33971. (PubMed:16141072)Curated
    Sequence conflicti132 – 1321L → P in BAE38304. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 164164Missing in isoform 2. 1 PublicationVSP_052833Add
    BLAST
    Alternative sequencei165 – 21652ACRLL…VKLCQ → MFFFLPLPCFLSLFFFLLLF HLFNSPSVFFLFFTFLLSPF SFAWSPTRLCPT in isoform 2. 1 PublicationVSP_052834Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129099 mRNA. Translation: BAC97909.1. Different initiation.
    AK049478 mRNA. Translation: BAC33770.1.
    AK053899 mRNA. Translation: BAC35581.1.
    AK157127 mRNA. Translation: BAE33971.1.
    AK164666 mRNA. Translation: BAE37866.1.
    AK165629 mRNA. Translation: BAE38304.1.
    AK165979 mRNA. Translation: BAE38497.1.
    BC038404 mRNA. Translation: AAH38404.1. Frameshift.
    CCDSiCCDS22631.1. [Q8BGK6-1]
    RefSeqiNP_848913.1. NM_178798.3. [Q8BGK6-1]
    XP_006531200.1. XM_006531137.1. [Q8BGK6-1]
    XP_006531201.1. XM_006531138.1. [Q8BGK6-1]
    UniGeneiMm.46749.

    Genome annotation databases

    EnsembliENSMUST00000034378; ENSMUSP00000034378; ENSMUSG00000031904. [Q8BGK6-1]
    GeneIDi330836.
    KEGGimmu:330836.
    UCSCiuc009nfl.1. mouse. [Q8BGK6-1]
    uc009nfo.1. mouse. [Q8BGK6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129099 mRNA. Translation: BAC97909.1 . Different initiation.
    AK049478 mRNA. Translation: BAC33770.1 .
    AK053899 mRNA. Translation: BAC35581.1 .
    AK157127 mRNA. Translation: BAE33971.1 .
    AK164666 mRNA. Translation: BAE37866.1 .
    AK165629 mRNA. Translation: BAE38304.1 .
    AK165979 mRNA. Translation: BAE38497.1 .
    BC038404 mRNA. Translation: AAH38404.1 . Frameshift.
    CCDSi CCDS22631.1. [Q8BGK6-1 ]
    RefSeqi NP_848913.1. NM_178798.3. [Q8BGK6-1 ]
    XP_006531200.1. XM_006531137.1. [Q8BGK6-1 ]
    XP_006531201.1. XM_006531138.1. [Q8BGK6-1 ]
    UniGenei Mm.46749.

    3D structure databases

    ProteinModelPortali Q8BGK6.
    SMRi Q8BGK6. Positions 53-360.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BGK6.

    Proteomic databases

    MaxQBi Q8BGK6.
    PaxDbi Q8BGK6.
    PRIDEi Q8BGK6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034378 ; ENSMUSP00000034378 ; ENSMUSG00000031904 . [Q8BGK6-1 ]
    GeneIDi 330836.
    KEGGi mmu:330836.
    UCSCi uc009nfl.1. mouse. [Q8BGK6-1 ]
    uc009nfo.1. mouse. [Q8BGK6-2 ]

    Organism-specific databases

    CTDi 9057.
    MGIi MGI:2142598. Slc7a6.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110280.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q8BGK6.
    KOi K13872.
    OMAi LEELIMR.
    OrthoDBi EOG73BVCR.
    PhylomeDBi Q8BGK6.
    TreeFami TF313355.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    ChiTaRSi SLC7A6. mouse.
    NextBioi 399586.
    PROi Q8BGK6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGK6.
    Genevestigatori Q8BGK6.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryonic tailImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6JImported and NODImported.
      Tissue: EmbryoImported, Embryonic stem cellImported, Embryonic stomachImported, EyeImported, LungImported and SpleenImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/NImported.
      Tissue: Mammary tumorImported.
    4. "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine."
      Broeer A., Wagner C.A., Lang F., Broeer S.
      Biochem. J. 349:787-795(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-293 (ISOFORM 1), TISSUE SPECIFICITY.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYLAT2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGK6
    Secondary accession number(s): Q3TMY5
    , Q3U084, Q6ZQF5, Q8CFY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3