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Protein

Splicing factor U2AF 26 kDa subunit

Gene

U2af1l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468). Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677).1 Publication3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 4029C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri149 – 17628C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms, mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor U2AF 26 kDa subunit
Alternative name(s):
U2 auxiliary factor 26
U2 small nuclear RNA auxiliary factor 1-like protein 4
Short name:
U2AF1-like 41 Publication
Gene namesi
Name:U2af1l4
Synonyms:U2af26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2678374. U2af1l4.

Subcellular locationi

Isoform 1 :
  • Nucleus 2 Publications
  • Nucleus speckle 1 Publication
  • Cytoplasm 3 Publications

  • Note: Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling.1 Publication
Isoform 3 :
Isoform 2 :
  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Disruption phenotypei

Mutant mice show defects in circadian gene expression and jet lag phenotype, but the master clock is not strongly affected. Per2 expression is rythmic, but Per1 expression becomes nearly arrythmic as well as Per1 target genes, such as Dbp. No splicing alteration was observed in the brain. Mutant mice show a faster adaptation to experimental jet lag, which is consistent with the circadian splicing switch providing a buffering system against sudden light changes.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi190 – 1901P → A: Does not impair nuclear localization. 1 Publication
Mutagenesisi195 – 1951P → A: Does not impair nuclear localization. 1 Publication
Mutagenesisi196 – 1961P → A: Does not impair nuclear localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 220219Splicing factor U2AF 26 kDa subunitPRO_0000309741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Post-translational modificationi

Isoform 3 is rapidly degraded by a proteasome-mediated degradation pathway.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGJ9.
MaxQBiQ8BGJ9.
PaxDbiQ8BGJ9.
PRIDEiQ8BGJ9.

PTM databases

iPTMnetiQ8BGJ9.
PhosphoSiteiQ8BGJ9.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in the brain.1 Publication

Inductioni

Up-regulated in response to T-cell activation (at protein level) (PubMed:16819553). Circadian alternative splicing switch accounts for rhythmic isoform expression. A circadian splicing switch produces isoform 3 in the brain cerebellum and liver (at protein level). Isoform 3 expression is regulated with the circadian rhythm but is also quickly increased upon light exposure (4-8 hours after light exposure). Expression of isoform 3 changes approximately 5-fold across a period of 24 hours, with concomitant changes in isoform 1, resulting in total U2af1l4 remaining constant (PubMed:24837677).2 Publications

Gene expression databases

BgeeiQ8BGJ9.
CleanExiMM_U2AF1L4.
ExpressionAtlasiQ8BGJ9. baseline.
GenevisibleiQ8BGJ9. MM.

Interactioni

Subunit structurei

Interacts with GFI1, U2AF2 and C1QBP. Isoform 3 interacts with PER1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C1qbpO356584EBI-4288480,EBI-642072
Gfi1P703385EBI-4288480,EBI-3954754

Protein-protein interaction databases

IntActiQ8BGJ9. 2 interactions.
STRINGi10090.ENSMUSP00000039406.

Structurei

3D structure databases

ProteinModelPortaliQ8BGJ9.
SMRiQ8BGJ9. Positions 15-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 14783RRMPROSITE-ProRule annotationAdd
BLAST

Domaini

The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling.1 Publication
Isoform 3 contains a C-terminus domain with homology to Drosophila TIM (THD domain). Isoform 3 interacts with Per1 and specifically down-regulates its expression, probably by facilitating its recruitment to the proteasome. The interaction with PER1 depends on the presence of the THD domain, but the THD domain is not directly involved in the interaction.1 Publication

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 4029C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri149 – 17628C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2202. Eukaryota.
ENOG410Z5PX. LUCA.
GeneTreeiENSGT00530000063193.
HOGENOMiHOG000178619.
HOVERGENiHBG054605.
InParanoidiQ8BGJ9.
KOiK12836.
OMAiDDYHHRD.
TreeFamiTF300143.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR009145. U2AF_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Circadian and light-inducible alternative splicing, which occurs at least in brain and liver.

Isoform 1 (identifier: Q8BGJ9-1) [UniParc]FASTAAdd to basket

Also known as: fl1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIVLLN
60 70 80 90 100
LYRNPQNTAQ TADGSHCHVS DVEVQEHYDN FFEEVFTELQ EKYGEIEEMN
110 120 130 140 150
VCDNLGDHLV GNVYVKFRRE EDAERAVAEL NNRWFNGQAV HAELSPVTDF
160 170 180 190 200
RESCCRQYEM GECTRGGFCN FMHLRPISRN LRRQLYGRGP RHRSPPRSHT
210 220
GHRPRERNRR RSPDHRHGRF
Note: Cytoplasmic and nuclear. Displays active nucleo-cytoplasmic shuttling. Shows a circadian expression at the mRNA level.3 Publications
Length:220
Mass (Da):25,836
Last modified:March 1, 2003 - v1
Checksum:i90AC4B4126060169
GO
Isoform 2 (identifier: Q8BGJ9-2) [UniParc]FASTAAdd to basket

Also known as: U2AF26DeltaE7, DE72 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     162-193: Missing.

Note: Produced by exon 7 skipping. Cytoplasm (Ref.4). Shows a circadian expression at the mRNA level.2 Publications
Show »
Length:188
Mass (Da):21,968
Checksum:i06D1165548E5398F
GO
Isoform 3 (identifier: Q8BGJ9-3) [UniParc]FASTAAdd to basket

Also known as: U2AF26DeltaE67, DE672 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     117-220: FRREEDAERA...RSPDHRHGRF → VTSKVPHRSP...NLRLSILGAF

Note: Produced by exons 6 and 7 skipping. Produced by a circadian splicing switch in brain and liver. Contains a C-terminus domain with homology to Drosophila TIM (THD). Cytoplasmic. Shows a circadian expression at the mRNA and protein levels. Expression is quickly increased upon light exposure. Has a strongly reduced half-life compared to other isoforms.1 Publication
Show »
Length:259
Mass (Da):28,785
Checksum:iF89C265FF89C1D0B
GO
Isoform 4 (identifier: Q8BGJ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-143: TADGSHCHVS...WFNGQAVHAE → ASELHNIICS...NLRLSILGAF
     144-220: Missing.

Note: Produced by usage of an alternative 3' splice site in exon 8.1 Publication
Show »
Length:143
Mass (Da):15,600
Checksum:i3AB71D76F82CA757
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 14383TADGS…AVHAE → ASELHNIICSTQEPPPPVPP PIKVKKFVNQGLWFPSTPTP KKGCKPTTVSAEELGASLGS GSALVSRGCFNTCNLRLSIL GAF in isoform 4. 1 PublicationVSP_056874Add
BLAST
Alternative sequencei117 – 220104FRREE…RHGRF → VTSKVPHRSPSPRKEPTSFP RPPAWSLLRRVPLLSTQGHR CSCPASLFKVPFTLQSQHPQ ASELHNIICSTQEPPPPVPP PIKVKKFVNQGLWFPSTPTP KKGCKPTTVSAEELGASLGS GSALVSRGCFNTCNLRLSIL GAF in isoform 3. 1 PublicationVSP_056875Add
BLAST
Alternative sequencei144 – 22077Missing in isoform 4. VSP_056876Add
BLAST
Alternative sequencei162 – 19332Missing in isoform 2. VSP_056877Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419339 mRNA. Translation: AAN63524.1.
AF419340 Genomic DNA. Translation: AAN63525.1.
AK160974 mRNA. Translation: BAE36125.1.
BC060972 mRNA. Translation: AAH60972.1.
CCDSiCCDS21100.1. [Q8BGJ9-1]
RefSeqiNP_739566.1. NM_170760.3. [Q8BGJ9-1]
UniGeneiMm.34790.

Genome annotation databases

EnsembliENSMUST00000043273; ENSMUSP00000039406; ENSMUSG00000078765. [Q8BGJ9-1]
ENSMUST00000163654; ENSMUSP00000131048; ENSMUSG00000078765. [Q8BGJ9-2]
ENSMUST00000167042; ENSMUSP00000128886; ENSMUSG00000109378. [Q8BGJ9-1]
ENSMUST00000171912; ENSMUSP00000130983; ENSMUSG00000109378. [Q8BGJ9-1]
GeneIDi233073.
KEGGimmu:233073.
UCSCiuc009gfa.1. mouse. [Q8BGJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419339 mRNA. Translation: AAN63524.1.
AF419340 Genomic DNA. Translation: AAN63525.1.
AK160974 mRNA. Translation: BAE36125.1.
BC060972 mRNA. Translation: AAH60972.1.
CCDSiCCDS21100.1. [Q8BGJ9-1]
RefSeqiNP_739566.1. NM_170760.3. [Q8BGJ9-1]
UniGeneiMm.34790.

3D structure databases

ProteinModelPortaliQ8BGJ9.
SMRiQ8BGJ9. Positions 15-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BGJ9. 2 interactions.
STRINGi10090.ENSMUSP00000039406.

PTM databases

iPTMnetiQ8BGJ9.
PhosphoSiteiQ8BGJ9.

Proteomic databases

EPDiQ8BGJ9.
MaxQBiQ8BGJ9.
PaxDbiQ8BGJ9.
PRIDEiQ8BGJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043273; ENSMUSP00000039406; ENSMUSG00000078765. [Q8BGJ9-1]
ENSMUST00000163654; ENSMUSP00000131048; ENSMUSG00000078765. [Q8BGJ9-2]
ENSMUST00000167042; ENSMUSP00000128886; ENSMUSG00000109378. [Q8BGJ9-1]
ENSMUST00000171912; ENSMUSP00000130983; ENSMUSG00000109378. [Q8BGJ9-1]
GeneIDi233073.
KEGGimmu:233073.
UCSCiuc009gfa.1. mouse. [Q8BGJ9-1]

Organism-specific databases

CTDi199746.
MGIiMGI:2678374. U2af1l4.

Phylogenomic databases

eggNOGiKOG2202. Eukaryota.
ENOG410Z5PX. LUCA.
GeneTreeiENSGT00530000063193.
HOGENOMiHOG000178619.
HOVERGENiHBG054605.
InParanoidiQ8BGJ9.
KOiK12836.
OMAiDDYHHRD.
TreeFamiTF300143.

Miscellaneous databases

PROiQ8BGJ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGJ9.
CleanExiMM_U2AF1L4.
ExpressionAtlasiQ8BGJ9. baseline.
GenevisibleiQ8BGJ9. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR009145. U2AF_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of U2AF(6), a splicing factor related to U2AF(35)."
    Shepard J., Reick M., Olson S., Graveley B.R.
    Mol. Cell. Biol. 22:221-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION, RNA-BINDING, INTERACTION WITH U2AF2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: 129/SvEvTacfBr and C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing."
    Heyd F., ten Dam G., Moeroey T.
    Nat. Immunol. 7:859-867(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GFI1 AND U2AF2, INDUCTION, SUBCELLULAR LOCATION (ISOFORM 1).
  5. "Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26."
    Heyd F., Carmo-Fonseca M., Moroy T.
    J. Biol. Chem. 283:19636-19645(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, ALTERNATIVE SPLICING (ISOFORMS 2 AND 3), INTERACTION WITH C1QBP, MUTAGENESIS OF PRO-190; PRO-195 AND PRO-196.
  6. "Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice."
    Preussner M., Wilhelmi I., Schultz A.S., Finkernagel F., Michel M., Moeroey T., Heyd F.
    Mol. Cell 54:651-662(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3 AND 4), INDUCTION BY CIRCADIAN RYTHM (ISOFORM 3), INTERACTION WITH PER1 (ISOFORM 3), DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION (ISOFORMS 1 AND 3).

Entry informationi

Entry nameiU2AF4_MOUSE
AccessioniPrimary (citable) accession number: Q8BGJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Orthologs of U2af1l4 do not appear to exist in lower eukaryotes, Drosophila, C. elegans, plants, or vertebrates such as Xenopus or zebrafish (PubMed:11739736). Existence of splicing isoforms of U2af1l4 in human and rat is not yet proven.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.