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Protein
Submitted name:

MCG13402, isoform CRA_a

Gene

Ptbp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: MGI
  3. pre-mRNA binding Source: MGI

GO - Biological processi

  1. mRNA processing Source: InterPro
  2. negative regulation of mRNA splicing, via spliceosome Source: MGI
  3. negative regulation of muscle cell differentiation Source: MGI
  4. negative regulation of RNA splicing Source: MGI
  5. regulation of alternative mRNA splicing, via spliceosome Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_260226. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG13402, isoform CRA_aImported
Submitted name:
Polypyrimidine tract-binding protein 1Imported
Gene namesi
Name:Ptbp1Imported
ORF Names:mCG_13402Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97791. Ptbp1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. membrane Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8BGJ5.

Structurei

3D structure databases

ProteinModelPortaliQ8BGJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074508.
HOVERGENiHBG069548.
KOiK13218.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L_PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 2 hits.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGIVPDIAV GTKRGSDELF STCVSNGPFI MSSSASAANG NDSKKFKGDN
60 70 80 90 100
RSAGVPSRVI HVRKLPSDVT EGEVISLGLP FGKVTNLLML KGKNQAFIEM
110 120 130 140 150
NTEEAANTMV NYYTSVAPVL RGQPIYIQFS NHKELKTDSS PNQARAQAAL
160 170 180 190 200
QAVNSVQSGN LALAASAAAV DAGMAMAGQS PVLRIIVENL FYPVTLDVLH
210 220 230 240 250
QIFSKFGTVL KIITFTKNNQ FQALLQYADP VSAQHAKLSL DGQNIYNACC
260 270 280 290 300
TLRIDFSKLT SLNVKYNNDK SRDYTRPDLP SGDSQPSLDQ TMAAAFGLSV
310 320 330 340 350
PNVHGALAPL AIPSAAAAAA ASRIAIPGLA GAGNSVLLVS NLNPERVTPQ
360 370 380 390 400
SLFILFGVYG DVQRVKILFN KKENALVQMA DGSQAQLAMS HLNGHKLHGK
410 420 430 440 450
SVRITLSKHQ SVQLPREGQE DQGLTKDYGS SPLHRFKKPG SKNFQNIFPP
460 470 480 490 500
SATLHLSNIP PSVSEDDLKS LFSSNGGVVK GFKFFQKDRK MALIQMGSVE
510 520
EAVQALIELH NHDLGENHHL RVSFSKSTI
Length:529
Mass (Da):56,892
Last modified:March 1, 2003 - v1
Checksum:i92244CDC02A415F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151846 Genomic DNA. No translation available.
AK044956 mRNA. Translation: BAC32158.1.
AK051669 mRNA. Translation: BAC34712.1.
AK082600 mRNA. Translation: BAC38544.1.
AK149941 mRNA. Translation: BAE29183.1.
AK168359 mRNA. Translation: BAE40295.1.
CH466553 Genomic DNA. Translation: EDL31643.1.
CH466553 Genomic DNA. Translation: EDL31645.1.
RefSeqiNP_032982.2. NM_008956.3.
UniGeneiMm.265610.

Genome annotation databases

EnsembliENSMUST00000165704; ENSMUSP00000127783; ENSMUSG00000006498.
GeneIDi19205.
KEGGimmu:19205.
UCSCiuc007gac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151846 Genomic DNA. No translation available.
AK044956 mRNA. Translation: BAC32158.1.
AK051669 mRNA. Translation: BAC34712.1.
AK082600 mRNA. Translation: BAC38544.1.
AK149941 mRNA. Translation: BAE29183.1.
AK168359 mRNA. Translation: BAE40295.1.
CH466553 Genomic DNA. Translation: EDL31643.1.
CH466553 Genomic DNA. Translation: EDL31645.1.
RefSeqiNP_032982.2. NM_008956.3.
UniGeneiMm.265610.

3D structure databases

ProteinModelPortaliQ8BGJ5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165704; ENSMUSP00000127783; ENSMUSG00000006498.
GeneIDi19205.
KEGGimmu:19205.
UCSCiuc007gac.1. mouse.

Organism-specific databases

CTDi5725.
MGIiMGI:97791. Ptbp1.

Phylogenomic databases

GeneTreeiENSGT00550000074508.
HOVERGENiHBG069548.
KOiK13218.

Enzyme and pathway databases

ReactomeiREACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_260226. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiPtbp1. mouse.
NextBioi295932.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8BGJ5.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L_PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 2 hits.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ParthenogenoteImported and Spinal ganglionImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DBA/2Imported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Bone marrowImported, CerebellumImported, ParthenogenoteImported and Spinal ganglionImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BGJ5_MOUSE
AccessioniPrimary (citable) accession number: Q8BGJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.