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Protein

Palmitoyltransferase ZDHHC15

Gene

Zdhhc15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Enzyme regulationi

Inhibited by 2-bromopalmitate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Zinc 1By similarity1
Metal bindingi134Zinc 1By similarity1
Metal bindingi144Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi148Zinc 2By similarity1
Metal bindingi151Zinc 1By similarity1
Metal bindingi158Zinc 2By similarity1
Active sitei159S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1 Publication1
Metal bindingi165Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • establishment of protein localization Source: MGI
  • protein palmitoylation Source: MGI
  • synaptic vesicle maturation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15 (EC:2.3.1.2251 Publication)
Alternative name(s):
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
Gene namesi
Name:Zdhhc15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1915336 Zdhhc15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalBy similarityAdd BLAST20
Transmembranei21 – 41HelicalBy similarityAdd BLAST21
Topological domaini42 – 56CytoplasmicBy similarityAdd BLAST15
Transmembranei57 – 77HelicalBy similarityAdd BLAST21
Topological domaini78 – 172LumenalBy similarityAdd BLAST95
Transmembranei173 – 193HelicalBy similarityAdd BLAST21
Topological domaini194 – 210CytoplasmicBy similarityAdd BLAST17
Transmembranei211 – 234HelicalBy similarityAdd BLAST24
Topological domaini235 – 337LumenalBy similarityAdd BLAST103

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi156 – 157DH → AA: Fails to enhance DLG4 palmitoylation. 1 Publication2
Mutagenesisi159C → S: Fails to enhance DLG4 palmitoylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128941 – 337Palmitoyltransferase ZDHHC15Add BLAST337

Post-translational modificationi

Autopalmitoylated (in vitro).1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ8BGJ0
MaxQBiQ8BGJ0
PaxDbiQ8BGJ0
PeptideAtlasiQ8BGJ0
PRIDEiQ8BGJ0

PTM databases

PhosphoSitePlusiQ8BGJ0
SwissPalmiQ8BGJ0

Expressioni

Tissue specificityi

Expressed mainly in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000033906
CleanExiMM_ZDHHC15
GenevisibleiQ8BGJ0 MM

Interactioni

Protein-protein interaction databases

BioGridi224365, 3 interactors
STRINGi10090.ENSMUSP00000047615

Structurei

3D structure databases

SMRiQ8BGJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 179DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.1 Publication

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000234777
HOVERGENiHBG055108
InParanoidiQ8BGJ0
KOiK20028
OMAiGLRCCQR
OrthoDBiEOG091G0AXR
PhylomeDBiQ8BGJ0
TreeFamiTF316044

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFAW TYWKSIFTLP QQPNQKFHLS YTDKERYKNE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGSGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDNKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EEPWEDNEDD SRDYPEGSSS LAVESET
Length:337
Mass (Da):39,269
Last modified:March 1, 2003 - v1
Checksum:i93FFBDB720B09421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029137 mRNA Translation: BAC26317.1
AK032922 mRNA Translation: BAC28087.1
AK077949 mRNA Translation: BAC37081.1
AK160360 mRNA Translation: BAE35757.1
CCDSiCCDS30332.1
RefSeqiNP_780567.1, NM_175358.4
UniGeneiMm.30574

Genome annotation databases

EnsembliENSMUST00000042070; ENSMUSP00000047615; ENSMUSG00000033906
GeneIDi108672
KEGGimmu:108672
UCSCiuc009uaj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZDH15_MOUSE
AccessioniPrimary (citable) accession number: Q8BGJ0
Secondary accession number(s): Q3TV63, Q8BMB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health