ID   PEX26_MOUSE             Reviewed;         305 AA.
AC   Q8BGI5; Q3UGH5; Q9D661;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 2.
DT   24-JAN-2024, entry version 140.
DE   RecName: Full=Peroxisome assembly protein 26 {ECO:0000305};
DE   AltName: Full=Peroxin-26 {ECO:0000305};
GN   Name=Pex26 {ECO:0000312|MGI:MGI:1921293};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J;
RC   TISSUE=Brain cortex, Cerebellum, Oviduct, Skin, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Peroxisomal docking factor that anchors PEX1 and PEX6 to
CC       peroxisome membranes. PEX26 is therefore required for the formation of
CC       the PEX1-PEX6 AAA ATPase complex, a complex that mediates the
CC       extraction of the PEX5 receptor from peroxisomal membrane.
CC       {ECO:0000250|UniProtKB:Q7Z412}.
CC   -!- SUBUNIT: Interacts (via its cytoplasmic domain) with PEX6; interaction
CC       is direct and is ATP-dependent. Interacts with PEX1; interaction is
CC       indirect and is mediated via interaction with PEX6.
CC       {ECO:0000250|UniProtKB:Q7Z412}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q7Z412}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q7Z412}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BGI5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BGI5-2; Sequence=VSP_010444;
CC   -!- SIMILARITY: Belongs to the peroxin-26 family. {ECO:0000305}.
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DR   EMBL; AK014598; BAB29453.1; -; mRNA.
DR   EMBL; AK040411; BAC30589.1; -; mRNA.
DR   EMBL; AK042663; BAC31324.1; -; mRNA.
DR   EMBL; AK044186; BAC31808.1; -; mRNA.
DR   EMBL; AK087637; BAC39952.1; -; mRNA.
DR   EMBL; AK147925; BAE28233.1; -; mRNA.
DR   EMBL; BC019144; AAH19144.1; -; mRNA.
DR   EMBL; BC058694; AAH58694.1; -; mRNA.
DR   CCDS; CCDS20488.1; -. [Q8BGI5-1]
DR   CCDS; CCDS80603.1; -. [Q8BGI5-2]
DR   RefSeq; NP_001291702.1; NM_001304773.1. [Q8BGI5-2]
DR   RefSeq; NP_001291703.1; NM_001304774.1.
DR   RefSeq; NP_083006.1; NM_028730.6. [Q8BGI5-1]
DR   AlphaFoldDB; Q8BGI5; -.
DR   SMR; Q8BGI5; -.
DR   STRING; 10090.ENSMUSP00000085921; -.
DR   iPTMnet; Q8BGI5; -.
DR   PhosphoSitePlus; Q8BGI5; -.
DR   EPD; Q8BGI5; -.
DR   MaxQB; Q8BGI5; -.
DR   PaxDb; 10090-ENSMUSP00000085921; -.
DR   ProteomicsDB; 289471; -. [Q8BGI5-1]
DR   ProteomicsDB; 289472; -. [Q8BGI5-2]
DR   Pumba; Q8BGI5; -.
DR   Ensembl; ENSMUST00000088561.10; ENSMUSP00000085921.4; ENSMUSG00000067825.12. [Q8BGI5-1]
DR   Ensembl; ENSMUST00000120066.8; ENSMUSP00000113233.2; ENSMUSG00000067825.12. [Q8BGI5-2]
DR   Ensembl; ENSMUST00000125633.2; ENSMUSP00000117444.2; ENSMUSG00000067825.12. [Q8BGI5-1]
DR   GeneID; 74043; -.
DR   KEGG; mmu:74043; -.
DR   UCSC; uc009dod.2; mouse. [Q8BGI5-1]
DR   UCSC; uc009doe.2; mouse. [Q8BGI5-2]
DR   AGR; MGI:1921293; -.
DR   CTD; 55670; -.
DR   MGI; MGI:1921293; Pex26.
DR   VEuPathDB; HostDB:ENSMUSG00000067825; -.
DR   eggNOG; ENOG502RXMN; Eukaryota.
DR   GeneTree; ENSGT00510000049725; -.
DR   InParanoid; Q8BGI5; -.
DR   OMA; QTCERAW; -.
DR   OrthoDB; 5388243at2759; -.
DR   PhylomeDB; Q8BGI5; -.
DR   TreeFam; TF332318; -.
DR   Reactome; R-MMU-9033241; Peroxisomal protein import.
DR   Reactome; R-MMU-9603798; Class I peroxisomal membrane protein import.
DR   BioGRID-ORCS; 74043; 3 hits in 60 CRISPR screens.
DR   ChiTaRS; Pex26; mouse.
DR   PRO; PR:Q8BGI5; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q8BGI5; Protein.
DR   Bgee; ENSMUSG00000067825; Expressed in secondary oocyte and 247 other cell types or tissues.
DR   ExpressionAtlas; Q8BGI5; baseline and differential.
DR   GO; GO:0005778; C:peroxisomal membrane; ISS:UniProtKB.
DR   GO; GO:0005777; C:peroxisome; ISO:MGI.
DR   GO; GO:0051117; F:ATPase binding; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; ISS:UniProtKB.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; ISS:UniProtKB.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; IEA:InterPro.
DR   GO; GO:0022615; P:protein to membrane docking; ISS:UniProtKB.
DR   InterPro; IPR010797; Pex26.
DR   PANTHER; PTHR16262; PEROXISOME ASSEMBLY PROTEIN 26; 1.
DR   PANTHER; PTHR16262:SF2; PEROXISOME ASSEMBLY PROTEIN 26; 1.
DR   Pfam; PF07163; Pex26; 1.
DR   Genevisible; Q8BGI5; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Peroxisome; Protein transport;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..305
FT                   /note="Peroxisome assembly protein 26"
FT                   /id="PRO_0000058342"
FT   TOPO_DOM        1..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z412"
FT   TRANSMEM        247..267
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..305
FT                   /note="Peroxisomal matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z412"
FT   VAR_SEQ         272
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_010444"
SQ   SEQUENCE   305 AA;  34016 MW;  501128B88CE4DB36 CRC64;
     MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD FHAALETCER
     AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS WVLRYYQVPE KLPPKVLELC
     ILLYSKMKEP GAVLDVASAW LQDPDNQGLP DYGSLARLHV FRLLLPSGRL SEAEELAVRS
     AAFSEEQRVE ALQAIHLARQ QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW
     GSVVSHLLSQ PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP
     LALRD
//