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Q8BGI5 (PEX26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisome assembly protein 26
Alternative name(s):
Peroxin-26
Gene names
Name:Pex26
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence By similarity.

Subunit structure

Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 By similarity.

Subcellular location

Peroxisome membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the peroxin-26 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BGI5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BGI5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     272-272: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Peroxisome assembly protein 26
PRO_0000058342

Regions

Topological domain1 – 246246Cytoplasmic Potential
Transmembrane247 – 26721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain268 – 30538Peroxisomal matrix Potential

Natural variations

Alternative sequence2721Missing in isoform 2.
VSP_010444

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 501128B88CE4DB36

FASTA30534,016
        10         20         30         40         50         60 
MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD FHAALETCER 

        70         80         90        100        110        120 
AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS WVLRYYQVPE KLPPKVLELC 

       130        140        150        160        170        180 
ILLYSKMKEP GAVLDVASAW LQDPDNQGLP DYGSLARLHV FRLLLPSGRL SEAEELAVRS 

       190        200        210        220        230        240 
AAFSEEQRVE ALQAIHLARQ QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW 

       250        260        270        280        290        300 
GSVVSHLLSQ PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP 


LALRD 

« Hide

Isoform 2 [UniParc].

Checksum: 957EBA701891D35B
Show »

FASTA30433,945

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Brain cortex, Cerebellum, Oviduct, Skin and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain and Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014598 mRNA. Translation: BAB29453.1.
AK040411 mRNA. Translation: BAC30589.1.
AK042663 mRNA. Translation: BAC31324.1.
AK044186 mRNA. Translation: BAC31808.1.
AK087637 mRNA. Translation: BAC39952.1.
AK147925 mRNA. Translation: BAE28233.1.
BC019144 mRNA. Translation: AAH19144.1.
BC058694 mRNA. Translation: AAH58694.1.
CCDSCCDS20488.1. [Q8BGI5-1]
RefSeqNP_083006.1. NM_028730.5. [Q8BGI5-1]
XP_006506765.1. XM_006506702.1. [Q8BGI5-2]
UniGeneMm.491240.

3D structure databases

ProteinModelPortalQ8BGI5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000117444.

PTM databases

PhosphoSiteQ8BGI5.

Proteomic databases

PaxDbQ8BGI5.
PRIDEQ8BGI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
GeneID74043.
KEGGmmu:74043.
UCSCuc009dod.1. mouse. [Q8BGI5-1]
uc009doe.1. mouse. [Q8BGI5-2]

Organism-specific databases

CTD55670.
MGIMGI:1921293. Pex26.

Phylogenomic databases

eggNOGNOG44501.
GeneTreeENSGT00510000049725.
HOGENOMHOG000294153.
HOVERGENHBG053574.
InParanoidQ8BGI5.
KOK13340.
OMALLYSKVG.
OrthoDBEOG712TWV.
PhylomeDBQ8BGI5.
TreeFamTF332318.

Gene expression databases

ArrayExpressQ8BGI5.
BgeeQ8BGI5.
CleanExMM_PEX26.
GenevestigatorQ8BGI5.

Family and domain databases

InterProIPR010797. Pex26.
[Graphical view]
PfamPF07163. Pex26. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio339614.
PROQ8BGI5.
SOURCESearch...

Entry information

Entry namePEX26_MOUSE
AccessionPrimary (citable) accession number: Q8BGI5
Secondary accession number(s): Q3UGH5, Q9D661
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot