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Protein

Peroxisome assembly protein 26

Gene

Pex26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (By similarity).By similarity

GO - Molecular functioni

  1. ATPase binding Source: MGI
  2. protein complex binding Source: MGI
  3. protein C-terminus binding Source: MGI

GO - Biological processi

  1. protein import into peroxisome matrix Source: MGI
  2. protein import into peroxisome membrane Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 26
Alternative name(s):
Peroxin-26
Gene namesi
Name:Pex26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921293. Pex26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 246246CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini268 – 30538Peroxisomal matrixSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: InterPro
  2. peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Peroxisome assembly protein 26PRO_0000058342Add
BLAST

Proteomic databases

PaxDbiQ8BGI5.
PRIDEiQ8BGI5.

PTM databases

PhosphoSiteiQ8BGI5.

Expressioni

Gene expression databases

BgeeiQ8BGI5.
CleanExiMM_PEX26.
ExpressionAtlasiQ8BGI5. baseline and differential.
GenevestigatoriQ8BGI5.

Interactioni

Subunit structurei

Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117444.

Structurei

3D structure databases

ProteinModelPortaliQ8BGI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-26 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44501.
GeneTreeiENSGT00510000049725.
HOGENOMiHOG000294153.
HOVERGENiHBG053574.
InParanoidiQ8BGI5.
KOiK13340.
OMAiQMCILLY.
OrthoDBiEOG712TWV.
PhylomeDBiQ8BGI5.
TreeFamiTF332318.

Family and domain databases

InterProiIPR010797. Pex26.
[Graphical view]
PfamiPF07163. Pex26. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD
60 70 80 90 100
FHAALETCER AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS
110 120 130 140 150
WVLRYYQVPE KLPPKVLELC ILLYSKMKEP GAVLDVASAW LQDPDNQGLP
160 170 180 190 200
DYGSLARLHV FRLLLPSGRL SEAEELAVRS AAFSEEQRVE ALQAIHLARQ
210 220 230 240 250
QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW GSVVSHLLSQ
260 270 280 290 300
PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP

LALRD
Length:305
Mass (Da):34,016
Last modified:May 24, 2004 - v2
Checksum:i501128B88CE4DB36
GO
Isoform 2 (identifier: Q8BGI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-272: Missing.

Show »
Length:304
Mass (Da):33,945
Checksum:i957EBA701891D35B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei272 – 2721Missing in isoform 2. 1 PublicationVSP_010444

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014598 mRNA. Translation: BAB29453.1.
AK040411 mRNA. Translation: BAC30589.1.
AK042663 mRNA. Translation: BAC31324.1.
AK044186 mRNA. Translation: BAC31808.1.
AK087637 mRNA. Translation: BAC39952.1.
AK147925 mRNA. Translation: BAE28233.1.
BC019144 mRNA. Translation: AAH19144.1.
BC058694 mRNA. Translation: AAH58694.1.
CCDSiCCDS20488.1. [Q8BGI5-1]
RefSeqiNP_083006.1. NM_028730.6. [Q8BGI5-1]
UniGeneiMm.491240.

Genome annotation databases

EnsembliENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
GeneIDi74043.
KEGGimmu:74043.
UCSCiuc009dod.1. mouse. [Q8BGI5-1]
uc009doe.1. mouse. [Q8BGI5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014598 mRNA. Translation: BAB29453.1.
AK040411 mRNA. Translation: BAC30589.1.
AK042663 mRNA. Translation: BAC31324.1.
AK044186 mRNA. Translation: BAC31808.1.
AK087637 mRNA. Translation: BAC39952.1.
AK147925 mRNA. Translation: BAE28233.1.
BC019144 mRNA. Translation: AAH19144.1.
BC058694 mRNA. Translation: AAH58694.1.
CCDSiCCDS20488.1. [Q8BGI5-1]
RefSeqiNP_083006.1. NM_028730.6. [Q8BGI5-1]
UniGeneiMm.491240.

3D structure databases

ProteinModelPortaliQ8BGI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117444.

PTM databases

PhosphoSiteiQ8BGI5.

Proteomic databases

PaxDbiQ8BGI5.
PRIDEiQ8BGI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
GeneIDi74043.
KEGGimmu:74043.
UCSCiuc009dod.1. mouse. [Q8BGI5-1]
uc009doe.1. mouse. [Q8BGI5-2]

Organism-specific databases

CTDi55670.
MGIiMGI:1921293. Pex26.

Phylogenomic databases

eggNOGiNOG44501.
GeneTreeiENSGT00510000049725.
HOGENOMiHOG000294153.
HOVERGENiHBG053574.
InParanoidiQ8BGI5.
KOiK13340.
OMAiQMCILLY.
OrthoDBiEOG712TWV.
PhylomeDBiQ8BGI5.
TreeFamiTF332318.

Miscellaneous databases

NextBioi339614.
PROiQ8BGI5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGI5.
CleanExiMM_PEX26.
ExpressionAtlasiQ8BGI5. baseline and differential.
GenevestigatoriQ8BGI5.

Family and domain databases

InterProiIPR010797. Pex26.
[Graphical view]
PfamiPF07163. Pex26. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum, Oviduct, Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain and Liver.

Entry informationi

Entry nameiPEX26_MOUSE
AccessioniPrimary (citable) accession number: Q8BGI5
Secondary accession number(s): Q3UGH5, Q9D661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 29, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.