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Q8BGI5

- PEX26_MOUSE

UniProt

Q8BGI5 - PEX26_MOUSE

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Protein

Peroxisome assembly protein 26

Gene
Pex26
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence By similarity.

GO - Biological processi

  1. protein import into peroxisome matrix Source: Ensembl
  2. protein import into peroxisome membrane Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 26
Alternative name(s):
Peroxin-26
Gene namesi
Name:Pex26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1921293. Pex26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 246246Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini268 – 30538Peroxisomal matrix Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Peroxisome assembly protein 26PRO_0000058342Add
BLAST

Proteomic databases

PaxDbiQ8BGI5.
PRIDEiQ8BGI5.

PTM databases

PhosphoSiteiQ8BGI5.

Expressioni

Gene expression databases

ArrayExpressiQ8BGI5.
BgeeiQ8BGI5.
CleanExiMM_PEX26.
GenevestigatoriQ8BGI5.

Interactioni

Subunit structurei

Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117444.

Structurei

3D structure databases

ProteinModelPortaliQ8BGI5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-26 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44501.
GeneTreeiENSGT00510000049725.
HOGENOMiHOG000294153.
HOVERGENiHBG053574.
InParanoidiQ8BGI5.
KOiK13340.
OMAiLLYSKVG.
OrthoDBiEOG712TWV.
PhylomeDBiQ8BGI5.
TreeFamiTF332318.

Family and domain databases

InterProiIPR010797. Pex26.
[Graphical view]
PfamiPF07163. Pex26. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BGI5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD    50
FHAALETCER AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS 100
WVLRYYQVPE KLPPKVLELC ILLYSKMKEP GAVLDVASAW LQDPDNQGLP 150
DYGSLARLHV FRLLLPSGRL SEAEELAVRS AAFSEEQRVE ALQAIHLARQ 200
QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW GSVVSHLLSQ 250
PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP 300
LALRD 305
Length:305
Mass (Da):34,016
Last modified:May 24, 2004 - v2
Checksum:i501128B88CE4DB36
GO
Isoform 2 (identifier: Q8BGI5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-272: Missing.

Show »
Length:304
Mass (Da):33,945
Checksum:i957EBA701891D35B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei272 – 2721Missing in isoform 2. VSP_010444

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014598 mRNA. Translation: BAB29453.1.
AK040411 mRNA. Translation: BAC30589.1.
AK042663 mRNA. Translation: BAC31324.1.
AK044186 mRNA. Translation: BAC31808.1.
AK087637 mRNA. Translation: BAC39952.1.
AK147925 mRNA. Translation: BAE28233.1.
BC019144 mRNA. Translation: AAH19144.1.
BC058694 mRNA. Translation: AAH58694.1.
CCDSiCCDS20488.1. [Q8BGI5-1]
RefSeqiNP_083006.1. NM_028730.5. [Q8BGI5-1]
XP_006506765.1. XM_006506702.1. [Q8BGI5-2]
UniGeneiMm.491240.

Genome annotation databases

EnsembliENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
GeneIDi74043.
KEGGimmu:74043.
UCSCiuc009dod.1. mouse. [Q8BGI5-1]
uc009doe.1. mouse. [Q8BGI5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014598 mRNA. Translation: BAB29453.1 .
AK040411 mRNA. Translation: BAC30589.1 .
AK042663 mRNA. Translation: BAC31324.1 .
AK044186 mRNA. Translation: BAC31808.1 .
AK087637 mRNA. Translation: BAC39952.1 .
AK147925 mRNA. Translation: BAE28233.1 .
BC019144 mRNA. Translation: AAH19144.1 .
BC058694 mRNA. Translation: AAH58694.1 .
CCDSi CCDS20488.1. [Q8BGI5-1 ]
RefSeqi NP_083006.1. NM_028730.5. [Q8BGI5-1 ]
XP_006506765.1. XM_006506702.1. [Q8BGI5-2 ]
UniGenei Mm.491240.

3D structure databases

ProteinModelPortali Q8BGI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000117444.

PTM databases

PhosphoSitei Q8BGI5.

Proteomic databases

PaxDbi Q8BGI5.
PRIDEi Q8BGI5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088561 ; ENSMUSP00000085921 ; ENSMUSG00000067825 . [Q8BGI5-1 ]
ENSMUST00000120066 ; ENSMUSP00000113233 ; ENSMUSG00000067825 . [Q8BGI5-2 ]
ENSMUST00000125633 ; ENSMUSP00000117444 ; ENSMUSG00000067825 . [Q8BGI5-1 ]
GeneIDi 74043.
KEGGi mmu:74043.
UCSCi uc009dod.1. mouse. [Q8BGI5-1 ]
uc009doe.1. mouse. [Q8BGI5-2 ]

Organism-specific databases

CTDi 55670.
MGIi MGI:1921293. Pex26.

Phylogenomic databases

eggNOGi NOG44501.
GeneTreei ENSGT00510000049725.
HOGENOMi HOG000294153.
HOVERGENi HBG053574.
InParanoidi Q8BGI5.
KOi K13340.
OMAi LLYSKVG.
OrthoDBi EOG712TWV.
PhylomeDBi Q8BGI5.
TreeFami TF332318.

Miscellaneous databases

NextBioi 339614.
PROi Q8BGI5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BGI5.
Bgeei Q8BGI5.
CleanExi MM_PEX26.
Genevestigatori Q8BGI5.

Family and domain databases

InterProi IPR010797. Pex26.
[Graphical view ]
Pfami PF07163. Pex26. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum, Oviduct, Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain and Liver.

Entry informationi

Entry nameiPEX26_MOUSE
AccessioniPrimary (citable) accession number: Q8BGI5
Secondary accession number(s): Q3UGH5, Q9D661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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