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Protein

Peroxisome assembly protein 26

Gene

Pex26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 26
Alternative name(s):
Peroxin-26
Gene namesi
Name:Pex26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1921293 Pex26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 246CytoplasmicSequence analysisAdd BLAST246
Transmembranei247 – 267Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini268 – 305Peroxisomal matrixSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583421 – 305Peroxisome assembly protein 26Add BLAST305

Proteomic databases

PaxDbiQ8BGI5
PRIDEiQ8BGI5

PTM databases

iPTMnetiQ8BGI5
PhosphoSitePlusiQ8BGI5

Expressioni

Gene expression databases

BgeeiENSMUSG00000067825
CleanExiMM_PEX26
ExpressionAtlasiQ8BGI5 baseline and differential
GenevisibleiQ8BGI5 MM

Interactioni

Subunit structurei

Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085921

Structurei

3D structure databases

ProteinModelPortaliQ8BGI5
SMRiQ8BGI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-26 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEAS Eukaryota
ENOG4111ZGY LUCA
GeneTreeiENSGT00510000049725
HOGENOMiHOG000294153
HOVERGENiHBG053574
InParanoidiQ8BGI5
KOiK13340
OMAiLAEMNRW
OrthoDBiEOG091G0KX2
PhylomeDBiQ8BGI5
TreeFamiTF332318

Family and domain databases

InterProiView protein in InterPro
IPR010797 Pex26
PANTHERiPTHR16262 PTHR16262, 1 hit
PfamiView protein in Pfam
PF07163 Pex26, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD
60 70 80 90 100
FHAALETCER AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS
110 120 130 140 150
WVLRYYQVPE KLPPKVLELC ILLYSKMKEP GAVLDVASAW LQDPDNQGLP
160 170 180 190 200
DYGSLARLHV FRLLLPSGRL SEAEELAVRS AAFSEEQRVE ALQAIHLARQ
210 220 230 240 250
QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW GSVVSHLLSQ
260 270 280 290 300
PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP

LALRD
Length:305
Mass (Da):34,016
Last modified:May 24, 2004 - v2
Checksum:i501128B88CE4DB36
GO
Isoform 2 (identifier: Q8BGI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-272: Missing.

Show »
Length:304
Mass (Da):33,945
Checksum:i957EBA701891D35B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010444272Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014598 mRNA Translation: BAB29453.1
AK040411 mRNA Translation: BAC30589.1
AK042663 mRNA Translation: BAC31324.1
AK044186 mRNA Translation: BAC31808.1
AK087637 mRNA Translation: BAC39952.1
AK147925 mRNA Translation: BAE28233.1
BC019144 mRNA Translation: AAH19144.1
BC058694 mRNA Translation: AAH58694.1
CCDSiCCDS20488.1 [Q8BGI5-1]
CCDS80603.1 [Q8BGI5-2]
RefSeqiNP_001291702.1, NM_001304773.1 [Q8BGI5-2]
NP_001291703.1, NM_001304774.1
NP_083006.1, NM_028730.6 [Q8BGI5-1]
UniGeneiMm.491240

Genome annotation databases

EnsembliENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825 [Q8BGI5-1]
ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825 [Q8BGI5-2]
ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825 [Q8BGI5-1]
GeneIDi74043
KEGGimmu:74043
UCSCiuc009dod.2 mouse [Q8BGI5-1]
uc009doe.2 mouse [Q8BGI5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiPEX26_MOUSE
AccessioniPrimary (citable) accession number: Q8BGI5
Secondary accession number(s): Q3UGH5, Q9D661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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