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Q8BGI5

- PEX26_MOUSE

UniProt

Q8BGI5 - PEX26_MOUSE

Protein

Peroxisome assembly protein 26

Gene

Pex26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence By similarity.By similarity

    GO - Biological processi

    1. protein import into peroxisome matrix Source: Ensembl
    2. protein import into peroxisome membrane Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome assembly protein 26
    Alternative name(s):
    Peroxin-26
    Gene namesi
    Name:Pex26
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1921293. Pex26.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Peroxisome assembly protein 26PRO_0000058342Add
    BLAST

    Proteomic databases

    PaxDbiQ8BGI5.
    PRIDEiQ8BGI5.

    PTM databases

    PhosphoSiteiQ8BGI5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BGI5.
    BgeeiQ8BGI5.
    CleanExiMM_PEX26.
    GenevestigatoriQ8BGI5.

    Interactioni

    Subunit structurei

    Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000117444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 246246CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 30538Peroxisomal matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-26 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44501.
    GeneTreeiENSGT00510000049725.
    HOGENOMiHOG000294153.
    HOVERGENiHBG053574.
    InParanoidiQ8BGI5.
    KOiK13340.
    OMAiLLYSKVG.
    OrthoDBiEOG712TWV.
    PhylomeDBiQ8BGI5.
    TreeFamiTF332318.

    Family and domain databases

    InterProiIPR010797. Pex26.
    [Graphical view]
    PfamiPF07163. Pex26. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BGI5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD    50
    FHAALETCER AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS 100
    WVLRYYQVPE KLPPKVLELC ILLYSKMKEP GAVLDVASAW LQDPDNQGLP 150
    DYGSLARLHV FRLLLPSGRL SEAEELAVRS AAFSEEQRVE ALQAIHLARQ 200
    QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW GSVVSHLLSQ 250
    PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP 300
    LALRD 305
    Length:305
    Mass (Da):34,016
    Last modified:May 24, 2004 - v2
    Checksum:i501128B88CE4DB36
    GO
    Isoform 2 (identifier: Q8BGI5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-272: Missing.

    Show »
    Length:304
    Mass (Da):33,945
    Checksum:i957EBA701891D35B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei272 – 2721Missing in isoform 2. 1 PublicationVSP_010444

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014598 mRNA. Translation: BAB29453.1.
    AK040411 mRNA. Translation: BAC30589.1.
    AK042663 mRNA. Translation: BAC31324.1.
    AK044186 mRNA. Translation: BAC31808.1.
    AK087637 mRNA. Translation: BAC39952.1.
    AK147925 mRNA. Translation: BAE28233.1.
    BC019144 mRNA. Translation: AAH19144.1.
    BC058694 mRNA. Translation: AAH58694.1.
    CCDSiCCDS20488.1. [Q8BGI5-1]
    RefSeqiNP_083006.1. NM_028730.5. [Q8BGI5-1]
    XP_006506765.1. XM_006506702.1. [Q8BGI5-2]
    UniGeneiMm.491240.

    Genome annotation databases

    EnsembliENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
    ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
    ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
    GeneIDi74043.
    KEGGimmu:74043.
    UCSCiuc009dod.1. mouse. [Q8BGI5-1]
    uc009doe.1. mouse. [Q8BGI5-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014598 mRNA. Translation: BAB29453.1 .
    AK040411 mRNA. Translation: BAC30589.1 .
    AK042663 mRNA. Translation: BAC31324.1 .
    AK044186 mRNA. Translation: BAC31808.1 .
    AK087637 mRNA. Translation: BAC39952.1 .
    AK147925 mRNA. Translation: BAE28233.1 .
    BC019144 mRNA. Translation: AAH19144.1 .
    BC058694 mRNA. Translation: AAH58694.1 .
    CCDSi CCDS20488.1. [Q8BGI5-1 ]
    RefSeqi NP_083006.1. NM_028730.5. [Q8BGI5-1 ]
    XP_006506765.1. XM_006506702.1. [Q8BGI5-2 ]
    UniGenei Mm.491240.

    3D structure databases

    ProteinModelPortali Q8BGI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000117444.

    PTM databases

    PhosphoSitei Q8BGI5.

    Proteomic databases

    PaxDbi Q8BGI5.
    PRIDEi Q8BGI5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088561 ; ENSMUSP00000085921 ; ENSMUSG00000067825 . [Q8BGI5-1 ]
    ENSMUST00000120066 ; ENSMUSP00000113233 ; ENSMUSG00000067825 . [Q8BGI5-2 ]
    ENSMUST00000125633 ; ENSMUSP00000117444 ; ENSMUSG00000067825 . [Q8BGI5-1 ]
    GeneIDi 74043.
    KEGGi mmu:74043.
    UCSCi uc009dod.1. mouse. [Q8BGI5-1 ]
    uc009doe.1. mouse. [Q8BGI5-2 ]

    Organism-specific databases

    CTDi 55670.
    MGIi MGI:1921293. Pex26.

    Phylogenomic databases

    eggNOGi NOG44501.
    GeneTreei ENSGT00510000049725.
    HOGENOMi HOG000294153.
    HOVERGENi HBG053574.
    InParanoidi Q8BGI5.
    KOi K13340.
    OMAi LLYSKVG.
    OrthoDBi EOG712TWV.
    PhylomeDBi Q8BGI5.
    TreeFami TF332318.

    Miscellaneous databases

    NextBioi 339614.
    PROi Q8BGI5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BGI5.
    Bgeei Q8BGI5.
    CleanExi MM_PEX26.
    Genevestigatori Q8BGI5.

    Family and domain databases

    InterProi IPR010797. Pex26.
    [Graphical view ]
    Pfami PF07163. Pex26. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Brain cortex, Cerebellum, Oviduct, Skin and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain and Liver.

    Entry informationi

    Entry nameiPEX26_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGI5
    Secondary accession number(s): Q3UGH5, Q9D661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3