ID   RNF24_MOUSE             Reviewed;         148 AA.
AC   Q8BGI1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 138.
DE   RecName: Full=RING finger protein 24;
GN   Name=Rnf24;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: May play a role in TRPCs intracellular trafficking.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass membrane protein {ECO:0000250}.
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DR   EMBL; AK048813; BAC33467.1; -; mRNA.
DR   EMBL; AK083665; BAC38987.1; -; mRNA.
DR   EMBL; AK089207; BAC40793.1; -; mRNA.
DR   CCDS; CCDS16762.1; -.
DR   RefSeq; NP_848722.1; NM_178607.4.
DR   AlphaFoldDB; Q8BGI1; -.
DR   SMR; Q8BGI1; -.
DR   BioGRID; 206255; 1.
DR   STRING; 10090.ENSMUSP00000058630; -.
DR   iPTMnet; Q8BGI1; -.
DR   PhosphoSitePlus; Q8BGI1; -.
DR   SwissPalm; Q8BGI1; -.
DR   MaxQB; Q8BGI1; -.
DR   PaxDb; 10090-ENSMUSP00000058630; -.
DR   ProteomicsDB; 300499; -.
DR   Antibodypedia; 23773; 134 antibodies from 19 providers.
DR   DNASU; 51902; -.
DR   Ensembl; ENSMUST00000059372.11; ENSMUSP00000058630.5; ENSMUSG00000048911.16.
DR   Ensembl; ENSMUST00000110194.8; ENSMUSP00000105823.2; ENSMUSG00000048911.16.
DR   Ensembl; ENSMUST00000165420.8; ENSMUSP00000129843.2; ENSMUSG00000048911.16.
DR   GeneID; 51902; -.
DR   KEGG; mmu:51902; -.
DR   UCSC; uc008mlk.2; mouse.
DR   AGR; MGI:1261771; -.
DR   CTD; 11237; -.
DR   MGI; MGI:1261771; Rnf24.
DR   VEuPathDB; HostDB:ENSMUSG00000048911; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   GeneTree; ENSGT00940000159443; -.
DR   HOGENOM; CLU_142341_0_0_1; -.
DR   InParanoid; Q8BGI1; -.
DR   OMA; HNKQDHG; -.
DR   OrthoDB; 5474929at2759; -.
DR   PhylomeDB; Q8BGI1; -.
DR   BioGRID-ORCS; 51902; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Rnf24; mouse.
DR   PRO; PR:Q8BGI1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8BGI1; Protein.
DR   Bgee; ENSMUSG00000048911; Expressed in animal zygote and 209 other cell types or tissues.
DR   ExpressionAtlas; Q8BGI1; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd16675; RING-H2_RNF24; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR048025; RNF24_RING-H2.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR011016; Znf_RING-CH.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22763:SF196; RING FINGER PROTEIN 24 ISOFORM X1; 1.
DR   PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00744; RINGv; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   Genevisible; Q8BGI1; MM.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Metal-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..148
FT                   /note="RING finger protein 24"
FT                   /id="PRO_0000056064"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         78..119
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   148 AA;  17254 MW;  96DFD3E31B6CC5C8 CRC64;
     MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAVFVFILSL LFCCYLIRLR HQAHKEFYAY
     KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLVKWLE VRKVCPLCNM
     PVLQLAQLHS KQDRGPPQEP LPGAENIV
//