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Q8BGG0

- ZNT8_MOUSE

UniProt

Q8BGG0 - ZNT8_MOUSE

Protein

Zinc transporter 8

Gene

Slc30a8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells By similarity.By similarity

    GO - Molecular functioni

    1. protein homodimerization activity Source: BHF-UCL
    2. zinc ion transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular zinc ion homeostasis Source: BHF-UCL
    2. insulin secretion Source: BHF-UCL
    3. positive regulation of insulin secretion Source: Ensembl
    4. regulation of sequestering of zinc ion Source: Ensembl
    5. regulation of vesicle-mediated transport Source: Ensembl
    6. response to glucose Source: BHF-UCL
    7. response to interferon-gamma Source: Ensembl
    8. response to interleukin-1 Source: Ensembl
    9. sequestering of zinc ion Source: Ensembl

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 8
    Short name:
    ZnT-8
    Alternative name(s):
    Solute carrier family 30 member 8
    Gene namesi
    Name:Slc30a8
    Synonyms:Znt8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2442682. Slc30a8.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Associated with the insulin and glucagon secretory granules.1 Publication

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell
    4. secretory granule Source: Ensembl
    5. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Zinc transporter 8PRO_0000281741Add
    BLAST

    Proteomic databases

    PaxDbiQ8BGG0.
    PRIDEiQ8BGG0.

    PTM databases

    PhosphoSiteiQ8BGG0.

    Expressioni

    Tissue specificityi

    Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

    Gene expression databases

    BgeeiQ8BGG0.
    GenevestigatoriQ8BGG0.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000035257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGG0.
    SMRiQ8BGG0. Positions 71-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 1023ExtracellularSequence Analysis
    Topological domaini124 – 13916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 17414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 21621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 2447ExtracellularSequence Analysis
    Topological domaini266 – 367102CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi196 – 2049HXXXXX[HY]NHBy similarity

    Domaini

    Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    GeneTreeiENSGT00550000074381.
    HOGENOMiHOG000079023.
    HOVERGENiHBG003345.
    InParanoidiQ8BGG0.
    KOiK14695.
    OMAiVYLACER.
    OrthoDBiEOG7S4X68.
    PhylomeDBiQ8BGG0.
    TreeFamiTF313382.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BGG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY    50
    HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL 100
    TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI 150
    WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF 200
    GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC 250
    TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH 300
    SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE 350
    SAADQDPSCL LCEDPQD 367
    Length:367
    Mass (Da):40,223
    Last modified:March 1, 2003 - v1
    Checksum:i9C9484A561DE58E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050482 mRNA. Translation: BAC34281.1.
    AK050494 mRNA. Translation: BAC34289.1.
    BC117544 mRNA. Translation: AAI17545.1.
    BC118521 mRNA. Translation: AAI18522.1.
    CCDSiCCDS27464.1.
    RefSeqiNP_766404.1. NM_172816.3.
    UniGeneiMm.208831.

    Genome annotation databases

    EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
    GeneIDi239436.
    KEGGimmu:239436.
    UCSCiuc007vrf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050482 mRNA. Translation: BAC34281.1 .
    AK050494 mRNA. Translation: BAC34289.1 .
    BC117544 mRNA. Translation: AAI17545.1 .
    BC118521 mRNA. Translation: AAI18522.1 .
    CCDSi CCDS27464.1.
    RefSeqi NP_766404.1. NM_172816.3.
    UniGenei Mm.208831.

    3D structure databases

    ProteinModelPortali Q8BGG0.
    SMRi Q8BGG0. Positions 71-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000035257.

    PTM databases

    PhosphoSitei Q8BGG0.

    Proteomic databases

    PaxDbi Q8BGG0.
    PRIDEi Q8BGG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037240 ; ENSMUSP00000035257 ; ENSMUSG00000022315 .
    GeneIDi 239436.
    KEGGi mmu:239436.
    UCSCi uc007vrf.1. mouse.

    Organism-specific databases

    CTDi 169026.
    MGIi MGI:2442682. Slc30a8.

    Phylogenomic databases

    eggNOGi COG1230.
    GeneTreei ENSGT00550000074381.
    HOGENOMi HOG000079023.
    HOVERGENi HBG003345.
    InParanoidi Q8BGG0.
    KOi K14695.
    OMAi VYLACER.
    OrthoDBi EOG7S4X68.
    PhylomeDBi Q8BGG0.
    TreeFami TF313382.

    Miscellaneous databases

    NextBioi 384127.
    PROi Q8BGG0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGG0.
    Genevestigatori Q8BGG0.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion."
      Chimienti F., Devergnas S., Pattou F., Schuit F., Garcia-Cuenca R., Vandewalle B., Kerr-Conte J., Van Lommel L., Grunwald D., Favier A., Seve M.
      J. Cell Sci. 119:4199-4206(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells."
      Gyulkhandanyan A.V., Lu H., Lee S.C., Bhattacharjee A., Wijesekara N., Fox J.E., MacDonald P.E., Chimienti F., Dai F.F., Wheeler M.B.
      J. Biol. Chem. 283:10184-10197(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands."
      Murgia C., Devirgiliis C., Mancini E., Donadel G., Zalewski P., Perozzi G.
      Nutr. Metab. Cardiovasc. Dis. 19:431-439(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiZNT8_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3