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Protein

Zinc transporter 8

Gene

Slc30a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL
  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • insulin secretion Source: BHF-UCL
  • response to glucose Source: BHF-UCL
  • sequestering of zinc ion Source: MGI
  • zinc II ion transmembrane transport Source: MGI
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_298481. Insulin processing.
REACT_354348. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
Gene namesi
Name:Slc30a8
Synonyms:Znt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2442682. Slc30a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 1023ExtracellularSequence Analysis
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 13916CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 17414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 21621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Topological domaini238 – 2447ExtracellularSequence Analysis
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST
Topological domaini266 – 367102CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Zinc transporter 8PRO_0000281741Add
BLAST

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

PTM databases

PhosphoSiteiQ8BGG0.

Expressioni

Tissue specificityi

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

Gene expression databases

BgeeiQ8BGG0.
GenevisibleiQ8BGG0. MM.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

Structurei

3D structure databases

ProteinModelPortaliQ8BGG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 2049HXXXXX[HY]NHBy similarity

Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiCFIFMIA.
OrthoDBiEOG7S4X68.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY
60 70 80 90 100
HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL
110 120 130 140 150
TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI
160 170 180 190 200
WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF
210 220 230 240 250
GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC
260 270 280 290 300
TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH
310 320 330 340 350
SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE
360
SAADQDPSCL LCEDPQD
Length:367
Mass (Da):40,223
Last modified:March 1, 2003 - v1
Checksum:i9C9484A561DE58E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

3D structure databases

ProteinModelPortaliQ8BGG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

PTM databases

PhosphoSiteiQ8BGG0.

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Organism-specific databases

CTDi169026.
MGIiMGI:2442682. Slc30a8.

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiCFIFMIA.
OrthoDBiEOG7S4X68.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Enzyme and pathway databases

ReactomeiREACT_298481. Insulin processing.
REACT_354348. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

NextBioi384127.
PROiQ8BGG0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGG0.
GenevisibleiQ8BGG0. MM.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion."
    Chimienti F., Devergnas S., Pattou F., Schuit F., Garcia-Cuenca R., Vandewalle B., Kerr-Conte J., Van Lommel L., Grunwald D., Favier A., Seve M.
    J. Cell Sci. 119:4199-4206(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells."
    Gyulkhandanyan A.V., Lu H., Lee S.C., Bhattacharjee A., Wijesekara N., Fox J.E., MacDonald P.E., Chimienti F., Dai F.F., Wheeler M.B.
    J. Biol. Chem. 283:10184-10197(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands."
    Murgia C., Devirgiliis C., Mancini E., Donadel G., Zalewski P., Perozzi G.
    Nutr. Metab. Cardiovasc. Dis. 19:431-439(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiZNT8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.