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Q8BGG0

- ZNT8_MOUSE

UniProt

Q8BGG0 - ZNT8_MOUSE

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Protein
Zinc transporter 8
Gene
Slc30a8, Znt8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells By similarity.

GO - Molecular functioni

  1. protein homodimerization activity Source: BHF-UCL
  2. zinc ion transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cellular zinc ion homeostasis Source: BHF-UCL
  2. insulin secretion Source: BHF-UCL
  3. positive regulation of insulin secretion Source: Ensembl
  4. regulation of sequestering of zinc ion Source: Ensembl
  5. regulation of vesicle-mediated transport Source: Ensembl
  6. response to glucose Source: BHF-UCL
  7. response to interferon-gamma Source: Ensembl
  8. response to interleukin-1 Source: Ensembl
  9. sequestering of zinc ion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
Gene namesi
Name:Slc30a8
Synonyms:Znt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2442682. Slc30a8.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle membrane; Multi-pass membrane protein By similarity
Note: Associated with the insulin and glucagon secretory granules.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei79 – 9921Helical; Reviewed prediction
Add
BLAST
Topological domaini100 – 1023Extracellular Reviewed prediction
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 13916Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Topological domaini161 – 17414Extracellular Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Reviewed prediction
Add
BLAST
Topological domaini196 – 21621Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 2447Extracellular Reviewed prediction
Transmembranei245 – 26521Helical; Reviewed prediction
Add
BLAST
Topological domaini266 – 367102Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. secretory granule Source: Ensembl
  5. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Zinc transporter 8
PRO_0000281741Add
BLAST

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

PTM databases

PhosphoSiteiQ8BGG0.

Expressioni

Tissue specificityi

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

Gene expression databases

BgeeiQ8BGG0.
GenevestigatoriQ8BGG0.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

Structurei

3D structure databases

ProteinModelPortaliQ8BGG0.
SMRiQ8BGG0. Positions 71-169.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 2049HXXXXX[HY]NH By similarity

Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc (By similarity).

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiVYLACER.
OrthoDBiEOG7S4X68.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGG0-1 [UniParc]FASTAAdd to Basket

« Hide

MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY    50
HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL 100
TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI 150
WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF 200
GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC 250
TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH 300
SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE 350
SAADQDPSCL LCEDPQD 367
Length:367
Mass (Da):40,223
Last modified:March 1, 2003 - v1
Checksum:i9C9484A561DE58E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050482 mRNA. Translation: BAC34281.1 .
AK050494 mRNA. Translation: BAC34289.1 .
BC117544 mRNA. Translation: AAI17545.1 .
BC118521 mRNA. Translation: AAI18522.1 .
CCDSi CCDS27464.1.
RefSeqi NP_766404.1. NM_172816.3.
UniGenei Mm.208831.

3D structure databases

ProteinModelPortali Q8BGG0.
SMRi Q8BGG0. Positions 71-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035257.

PTM databases

PhosphoSitei Q8BGG0.

Proteomic databases

PaxDbi Q8BGG0.
PRIDEi Q8BGG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037240 ; ENSMUSP00000035257 ; ENSMUSG00000022315 .
GeneIDi 239436.
KEGGi mmu:239436.
UCSCi uc007vrf.1. mouse.

Organism-specific databases

CTDi 169026.
MGIi MGI:2442682. Slc30a8.

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi Q8BGG0.
KOi K14695.
OMAi VYLACER.
OrthoDBi EOG7S4X68.
PhylomeDBi Q8BGG0.
TreeFami TF313382.

Miscellaneous databases

NextBioi 384127.
PROi Q8BGG0.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGG0.
Genevestigatori Q8BGG0.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion."
    Chimienti F., Devergnas S., Pattou F., Schuit F., Garcia-Cuenca R., Vandewalle B., Kerr-Conte J., Van Lommel L., Grunwald D., Favier A., Seve M.
    J. Cell Sci. 119:4199-4206(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells."
    Gyulkhandanyan A.V., Lu H., Lee S.C., Bhattacharjee A., Wijesekara N., Fox J.E., MacDonald P.E., Chimienti F., Dai F.F., Wheeler M.B.
    J. Biol. Chem. 283:10184-10197(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands."
    Murgia C., Devirgiliis C., Mancini E., Donadel G., Zalewski P., Perozzi G.
    Nutr. Metab. Cardiovasc. Dis. 19:431-439(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiZNT8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi