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Q8BGG0

- ZNT8_MOUSE

UniProt

Q8BGG0 - ZNT8_MOUSE

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Protein

Zinc transporter 8

Gene

Slc30a8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity).By similarity

GO - Molecular functioni

  1. protein homodimerization activity Source: BHF-UCL
  2. zinc ion transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cellular zinc ion homeostasis Source: BHF-UCL
  2. insulin secretion Source: BHF-UCL
  3. positive regulation of insulin secretion Source: Ensembl
  4. regulation of sequestering of zinc ion Source: Ensembl
  5. regulation of vesicle-mediated transport Source: Ensembl
  6. response to glucose Source: BHF-UCL
  7. response to interferon-gamma Source: Ensembl
  8. response to interleukin-1 Source: Ensembl
  9. sequestering of zinc ion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
Gene namesi
Name:Slc30a8
Synonyms:Znt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2442682. Slc30a8.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Associated with the insulin and glucagon secretory granules.1 Publication

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Zinc transporter 8PRO_0000281741Add
BLAST

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

PTM databases

PhosphoSiteiQ8BGG0.

Expressioni

Tissue specificityi

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

Gene expression databases

BgeeiQ8BGG0.
GenevestigatoriQ8BGG0.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

Structurei

3D structure databases

ProteinModelPortaliQ8BGG0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini100 – 1023ExtracellularSequence Analysis
Topological domaini124 – 13916CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 17414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini196 – 21621CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini238 – 2447ExtracellularSequence Analysis
Topological domaini266 – 367102CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 2049HXXXXX[HY]NHBy similarity

Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiVYLACER.
OrthoDBiEOG7S4X68.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY
60 70 80 90 100
HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL
110 120 130 140 150
TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI
160 170 180 190 200
WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF
210 220 230 240 250
GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC
260 270 280 290 300
TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH
310 320 330 340 350
SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE
360
SAADQDPSCL LCEDPQD
Length:367
Mass (Da):40,223
Last modified:March 1, 2003 - v1
Checksum:i9C9484A561DE58E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050482 mRNA. Translation: BAC34281.1 .
AK050494 mRNA. Translation: BAC34289.1 .
BC117544 mRNA. Translation: AAI17545.1 .
BC118521 mRNA. Translation: AAI18522.1 .
CCDSi CCDS27464.1.
RefSeqi NP_766404.1. NM_172816.3.
UniGenei Mm.208831.

3D structure databases

ProteinModelPortali Q8BGG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035257.

PTM databases

PhosphoSitei Q8BGG0.

Proteomic databases

PaxDbi Q8BGG0.
PRIDEi Q8BGG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037240 ; ENSMUSP00000035257 ; ENSMUSG00000022315 .
GeneIDi 239436.
KEGGi mmu:239436.
UCSCi uc007vrf.1. mouse.

Organism-specific databases

CTDi 169026.
MGIi MGI:2442682. Slc30a8.

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi Q8BGG0.
KOi K14695.
OMAi VYLACER.
OrthoDBi EOG7S4X68.
PhylomeDBi Q8BGG0.
TreeFami TF313382.

Miscellaneous databases

NextBioi 384127.
PROi Q8BGG0.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGG0.
Genevestigatori Q8BGG0.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion."
    Chimienti F., Devergnas S., Pattou F., Schuit F., Garcia-Cuenca R., Vandewalle B., Kerr-Conte J., Van Lommel L., Grunwald D., Favier A., Seve M.
    J. Cell Sci. 119:4199-4206(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells."
    Gyulkhandanyan A.V., Lu H., Lee S.C., Bhattacharjee A., Wijesekara N., Fox J.E., MacDonald P.E., Chimienti F., Dai F.F., Wheeler M.B.
    J. Biol. Chem. 283:10184-10197(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands."
    Murgia C., Devirgiliis C., Mancini E., Donadel G., Zalewski P., Perozzi G.
    Nutr. Metab. Cardiovasc. Dis. 19:431-439(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiZNT8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3