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Protein

Zinc transporter 8

Gene

Slc30a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • insulin secretion Source: BHF-UCL
  • positive regulation of insulin secretion Source: Ensembl
  • regulation of sequestering of zinc ion Source: GO_Central
  • regulation of vesicle-mediated transport Source: Ensembl
  • response to glucose Source: BHF-UCL
  • response to interferon-gamma Source: Ensembl
  • response to interleukin-1 Source: Ensembl
  • response to zinc ion Source: GO_Central
  • sequestering of zinc ion Source: MGI
  • zinc ion transport Source: MGI

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-435368 Zinc efflux and compartmentalization by the SLC30 family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
Gene namesi
Name:Slc30a8
Synonyms:Znt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2442682 Slc30a8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 102ExtracellularSequence analysis3
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 139CytoplasmicSequence analysisAdd BLAST16
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 174ExtracellularSequence analysisAdd BLAST14
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 216CytoplasmicSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 244ExtracellularSequence analysis7
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 367CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817411 – 367Zinc transporter 8Add BLAST367

Proteomic databases

PaxDbiQ8BGG0
PRIDEiQ8BGG0

PTM databases

iPTMnetiQ8BGG0
PhosphoSitePlusiQ8BGG0

Expressioni

Tissue specificityi

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

Gene expression databases

BgeeiENSMUSG00000022315
GenevisibleiQ8BGG0 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257

Structurei

3D structure databases

ProteinModelPortaliQ8BGG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi196 – 204HXXXXX[HY]NHBy similarity9

Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiQ8BGG0
KOiK14695
OMAiHSLTIQM
OrthoDBiEOG091G07UN
PhylomeDBiQ8BGG0
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
IPR033572 ZnT-8
PANTHERiPTHR11562:SF37 PTHR11562:SF37, 1 hit
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY
60 70 80 90 100
HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL
110 120 130 140 150
TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI
160 170 180 190 200
WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF
210 220 230 240 250
GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC
260 270 280 290 300
TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH
310 320 330 340 350
SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE
360
SAADQDPSCL LCEDPQD
Length:367
Mass (Da):40,223
Last modified:March 1, 2003 - v1
Checksum:i9C9484A561DE58E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050482 mRNA Translation: BAC34281.1
AK050494 mRNA Translation: BAC34289.1
BC117544 mRNA Translation: AAI17545.1
BC118521 mRNA Translation: AAI18522.1
CCDSiCCDS27464.1
RefSeqiNP_766404.1, NM_172816.3
UniGeneiMm.208831

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315
GeneIDi239436
KEGGimmu:239436
UCSCiuc007vrf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZNT8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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