Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter 8

Gene

Slc30a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL
  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • insulin secretion Source: BHF-UCL
  • positive regulation of insulin secretion Source: Ensembl
  • regulation of sequestering of zinc ion Source: GO_Central
  • regulation of vesicle-mediated transport Source: Ensembl
  • response to glucose Source: BHF-UCL
  • response to interferon-gamma Source: Ensembl
  • response to interleukin-1 Source: Ensembl
  • response to zinc ion Source: GO_Central
  • sequestering of zinc ion Source: MGI
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
Gene namesi
Name:Slc30a8
Synonyms:Znt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2442682. Slc30a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 102ExtracellularSequence analysis3
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 139CytoplasmicSequence analysisAdd BLAST16
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 174ExtracellularSequence analysisAdd BLAST14
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 216CytoplasmicSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 244ExtracellularSequence analysis7
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 367CytoplasmicSequence analysisAdd BLAST102

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817411 – 367Zinc transporter 8Add BLAST367

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

PTM databases

PhosphoSitePlusiQ8BGG0.

Expressioni

Tissue specificityi

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.3 Publications

Gene expression databases

BgeeiENSMUSG00000022315.
GenevisibleiQ8BGG0. MM.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

Structurei

3D structure databases

ProteinModelPortaliQ8BGG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi196 – 204HXXXXX[HY]NHBy similarity9

Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiSVLCIWV.
OrthoDBiEOG091G07UN.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR033572. ZnT-8.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PTHR11562:SF37. PTHR11562:SF37. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLERTYLV NDQATKMYAF PLDRELRQKP VNKDQCPGDR PEHPEAGGIY
60 70 80 90 100
HCHNSAKATG NRSSKQAHAK WRLCAASAIC FIFMVAEVVG GHVAGSLAIL
110 120 130 140 150
TDAAHLLIDL TSFLLSLFSL WLSSRPPSKR LTFGWYRAEI LGALLSVLCI
160 170 180 190 200
WVVTGVLLYL ACERLLYPDY QIQAGIMITV SGCAVAANIV LTMILHQRNF
210 220 230 240 250
GYNHKDVQAN ASVRAAFVHA LGDVFQSISV LISALIIYFK PDYKIADPVC
260 270 280 290 300
TFIFSILVLA STVMILKDFS ILLMEGVPKG LSYNSVKEII LAVDGVISVH
310 320 330 340 350
SLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIAQALSSF DLHSLTIQIE
360
SAADQDPSCL LCEDPQD
Length:367
Mass (Da):40,223
Last modified:March 1, 2003 - v1
Checksum:i9C9484A561DE58E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050482 mRNA. Translation: BAC34281.1.
AK050494 mRNA. Translation: BAC34289.1.
BC117544 mRNA. Translation: AAI17545.1.
BC118521 mRNA. Translation: AAI18522.1.
CCDSiCCDS27464.1.
RefSeqiNP_766404.1. NM_172816.3.
UniGeneiMm.208831.

3D structure databases

ProteinModelPortaliQ8BGG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035257.

PTM databases

PhosphoSitePlusiQ8BGG0.

Proteomic databases

PaxDbiQ8BGG0.
PRIDEiQ8BGG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037240; ENSMUSP00000035257; ENSMUSG00000022315.
GeneIDi239436.
KEGGimmu:239436.
UCSCiuc007vrf.1. mouse.

Organism-specific databases

CTDi169026.
MGIiMGI:2442682. Slc30a8.

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ8BGG0.
KOiK14695.
OMAiSVLCIWV.
OrthoDBiEOG091G07UN.
PhylomeDBiQ8BGG0.
TreeFamiTF313382.

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ8BGG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022315.
GenevisibleiQ8BGG0. MM.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR033572. ZnT-8.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PTHR11562:SF37. PTHR11562:SF37. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.