Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 35 member D3

Gene

Slc35d3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.1 Publication

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • energy homeostasis Source: MGI
  • positive regulation of protein exit from endoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member D3
Alternative name(s):
Fringe connection-like protein 1
Gene namesi
Name:Slc35d3
Synonyms:Frcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923407. Slc35d3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • early endosome Source: MGI
  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Solute carrier family 35 member D3PRO_0000307728Add
BLAST

Proteomic databases

MaxQBiQ8BGF8.
PaxDbiQ8BGF8.
PRIDEiQ8BGF8.

PTM databases

PhosphoSiteiQ8BGF8.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiQ8BGF8.
CleanExiMM_SLC35D3.
ExpressionAtlasiQ8BGF8. baseline and differential.
GenevisibleiQ8BGF8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060589.

Structurei

3D structure databases

ProteinModelPortaliQ8BGF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000090215.
HOVERGENiHBG106477.
InParanoidiQ8BGF8.
KOiK15281.
OMAiWAFPGWK.
OrthoDBiEOG7JMGDN.
PhylomeDBiQ8BGF8.
TreeFamiTF313307.

Sequencei

Sequence statusi: Complete.

Q8BGF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS
60 70 80 90 100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS
110 120 130 140 150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD
160 170 180 190 200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL
210 220 230 240 250
LVICSFASTD SIHAWTFPGW KDPAMVSIFV ACILIGCAMN FTTLHCTYIN
260 270 280 290 300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
310 320 330 340 350
KFLETRRQSN YEDLESQAEG EERQPSGDQL PFVMEELPAK SGNSEPESAE
360 370 380 390 400
GAGDSVQQGG QESRGSIRGI SLAARSSRAE GHSDEVGRRS LKDTYLEVWR
410 420
LVRGTKYMKK DYLMENEALP SP
Length:422
Mass (Da):44,917
Last modified:March 1, 2003 - v1
Checksum:i9CACD625C45507D8
GO

Sequence cautioni

The sequence BAB31067.1 differs from that shown. Reason: Frameshift at position 264. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti383 – 3831S → F in BAB31067 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018094 mRNA. Translation: BAB31067.1. Sequence problems.
AK042761 mRNA. Translation: BAC31356.1.
AK044973 mRNA. Translation: BAC32165.1.
AK047610 mRNA. Translation: BAC33098.1.
CCDSiCCDS23719.1.
RefSeqiNP_083805.1. NM_029529.3.
UniGeneiMm.74324.

Genome annotation databases

EnsembliENSMUST00000059805; ENSMUSP00000060589; ENSMUSG00000050473.
GeneIDi76157.
KEGGimmu:76157.
UCSCiuc007enk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018094 mRNA. Translation: BAB31067.1. Sequence problems.
AK042761 mRNA. Translation: BAC31356.1.
AK044973 mRNA. Translation: BAC32165.1.
AK047610 mRNA. Translation: BAC33098.1.
CCDSiCCDS23719.1.
RefSeqiNP_083805.1. NM_029529.3.
UniGeneiMm.74324.

3D structure databases

ProteinModelPortaliQ8BGF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060589.

PTM databases

PhosphoSiteiQ8BGF8.

Proteomic databases

MaxQBiQ8BGF8.
PaxDbiQ8BGF8.
PRIDEiQ8BGF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059805; ENSMUSP00000060589; ENSMUSG00000050473.
GeneIDi76157.
KEGGimmu:76157.
UCSCiuc007enk.1. mouse.

Organism-specific databases

CTDi340146.
MGIiMGI:1923407. Slc35d3.

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000090215.
HOVERGENiHBG106477.
InParanoidiQ8BGF8.
KOiK15281.
OMAiWAFPGWK.
OrthoDBiEOG7JMGDN.
PhylomeDBiQ8BGF8.
TreeFamiTF313307.

Miscellaneous databases

NextBioi344687.
PROiQ8BGF8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGF8.
CleanExiMM_SLC35D3.
ExpressionAtlasiQ8BGF8. baseline and differential.
GenevisibleiQ8BGF8. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Corpus striatum and Embryo.
  2. "The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules."
    Chintala S., Tan J., Gautam R., Rusiniak M.E., Guo X., Li W., Gahl W.A., Huizing M., Spritz R.A., Hutton S., Novak E.K., Swank R.T.
    Blood 109:1533-1540(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS35D3_MOUSE
AccessioniPrimary (citable) accession number: Q8BGF8
Secondary accession number(s): Q9CXD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.