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Protein

ELMO domain-containing protein 2

Gene

Elmod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
ELMO domain-containing protein 2
Gene namesi
Name:Elmod2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2445165. Elmod2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002250181 – 293ELMO domain-containing protein 2Add BLAST293

Proteomic databases

MaxQBiQ8BGF6.
PaxDbiQ8BGF6.
PeptideAtlasiQ8BGF6.
PRIDEiQ8BGF6.

PTM databases

iPTMnetiQ8BGF6.
PhosphoSitePlusiQ8BGF6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035151.
CleanExiMM_ELMOD2.
ExpressionAtlasiQ8BGF6. baseline and differential.
GenevisibleiQ8BGF6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052287.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 282ELMOPROSITE-ProRule annotationAdd BLAST157

Phylogenomic databases

eggNOGiKOG2998. Eukaryota.
ENOG410XRXC. LUCA.
GeneTreeiENSGT00390000006017.
HOGENOMiHOG000007810.
HOVERGENiHBG056692.
InParanoidiQ8BGF6.
OMAiKPESIMY.
OrthoDBiEOG091G0E2U.
PhylomeDBiQ8BGF6.
TreeFamiTF323472.

Family and domain databases

InterProiView protein in InterPro
IPR006816. ELMO_dom.
IPR030724. ELMOD2.
PANTHERiPTHR12771:SF33. PTHR12771:SF33. 1 hit.
PfamiView protein in Pfam
PF04727. ELMO_CED12. 1 hit.
PROSITEiView protein in PROSITE
PS51335. ELMO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVSLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYGG AQRTYRIENS
60 70 80 90 100
LTYSKNKVLQ NATRVAQSEL DRCIANIMKE KNICSEKDTS FQICMRTCLL
110 120 130 140 150
QITGYKQLYH DVENVRKKPY DSANAQHEKM LLKLWSLLMP TKKLTARISK
160 170 180 190 200
QWADIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL
210 220 230 240 250
GYSYAIVGIN LTEMAYSLLK SEALKLHLYN FVPGVPTMEH FHQFYCYLVY
260 270 280 290
EFDKFWLEEE PESIMYFNLY REKFHERIKG LLMDCNAVLT LKT
Length:293
Mass (Da):34,747
Last modified:March 1, 2003 - v1
Checksum:i9DA5E0665FF9012C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47I → T in AAH79654 (PubMed:15489334).Curated1
Sequence conflicti222E → G in BAC29561 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029044 mRNA. Translation: BAC26262.1.
AK036746 mRNA. Translation: BAC29561.1.
AK041137 mRNA. Translation: BAC30834.1.
AK084950 mRNA. Translation: BAC39319.1.
BC079654 mRNA. Translation: AAH79654.1.
CCDSiCCDS22450.1.
RefSeqiNP_001164162.1. NM_001170691.1.
NP_848851.3. NM_178736.5.
XP_006531042.1. XM_006530979.2.
UniGeneiMm.38762.

Genome annotation databases

EnsembliENSMUST00000053902; ENSMUSP00000052287; ENSMUSG00000035151.
ENSMUST00000177594; ENSMUSP00000137044; ENSMUSG00000035151.
GeneIDi244548.
KEGGimmu:244548.
UCSCiuc009mjz.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiELMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGF6
Secondary accession number(s): Q6AXC7, Q8BHP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot