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Protein

Relaxin-3 receptor 1

Gene

Rxfp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3 receptor 1
Short name:
RLN3 receptor 1
Alternative name(s):
G protein-coupled receptor SALPR homolog
Relaxin family peptide receptor 3
Gene namesi
Name:Rxfp3
Synonyms:Rln3r1, Salpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2441827. Rxfp3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81ExtracellularSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 119CytoplasmicSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini141 – 156ExtracellularSequence analysisAdd BLAST16
Transmembranei157 – 177Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini178 – 215CytoplasmicSequence analysisAdd BLAST38
Transmembranei216 – 236Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini237 – 270ExtracellularSequence analysisAdd BLAST34
Transmembranei271 – 291Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini292 – 298CytoplasmicSequence analysis7
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini320 – 332ExtracellularSequence analysisAdd BLAST13
Transmembranei333 – 353Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini354 – 472CytoplasmicSequence analysisAdd BLAST119

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701051 – 472Relaxin-3 receptor 1Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi155 ↔ 247PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BGE9.
PRIDEiQ8BGE9.

PTM databases

iPTMnetiQ8BGE9.
PhosphoSitePlusiQ8BGE9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060735.
CleanExiMM_RXFP3.
ExpressionAtlasiQ8BGE9. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997631.
STRINGi10090.ENSMUSP00000062741.

Structurei

3D structure databases

ProteinModelPortaliQ8BGE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Gly4
Compositional biasi308 – 311Poly-Ala4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ8BGE9.
KOiK08397.
OMAiWVVCALG.
OrthoDBiEOG091G0BQS.
PhylomeDBiQ8BGE9.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVASATPAA TVRKAAAGDE LSEFFALTPD LLEVANASGN ASLQLQDLWW
60 70 80 90 100
ELGLELPDGA APGHPPGGGG AESTDTEARV RILISAVYWV VCALGLAGNL
110 120 130 140 150
LVLYLMKSKQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF
160 170 180 190 200
GKAMCKIVSM VTSMNMYASV FFLTAMSVAR YHSVASALKS HRTRGRGRGD
210 220 230 240 250
CCGQSLRESC CFSAKVLCGL IWASAALASL PNAIFSTTIR VLGEELCLMH
260 270 280 290 300
FPDKLLGWDR QFWLGLYHLQ KVLLGFLLPL SIISLCYLLL VRFISDRRVV
310 320 330 340 350
GTTDAVGAAA APGGGLSTAS ARRRSKVTKS VTIVVLSFFL CWLPNQALTT
360 370 380 390 400
WSILIKFNAV PFSQEYFQCQ VYAFPVSVCL AHSNSCLNPI LYCLVRREFR
410 420 430 440 450
KALKNLLWRI ASPSLTNMRP FTATTKPEPE DHGLQALAPL NAAAEPDLIY
460 470
YPPGVVVYSG GRYDLLPSSS AY
Length:472
Mass (Da):51,573
Last modified:March 1, 2003 - v1
Checksum:iA0688FCBE06022B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043414 mRNA. Translation: BAC31542.1.
AK046367 mRNA. Translation: BAC32691.1.
AK084001 mRNA. Translation: BAC39091.1.
BC053073 mRNA. Translation: AAH53073.1.
CCDSiCCDS27383.1.
RefSeqiNP_848832.1. NM_178717.3.
UniGeneiMm.209312.

Genome annotation databases

EnsembliENSMUST00000058007; ENSMUSP00000062741; ENSMUSG00000060735.
GeneIDi239336.
KEGGimmu:239336.
UCSCiuc007vgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043414 mRNA. Translation: BAC31542.1.
AK046367 mRNA. Translation: BAC32691.1.
AK084001 mRNA. Translation: BAC39091.1.
BC053073 mRNA. Translation: AAH53073.1.
CCDSiCCDS27383.1.
RefSeqiNP_848832.1. NM_178717.3.
UniGeneiMm.209312.

3D structure databases

ProteinModelPortaliQ8BGE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997631.
STRINGi10090.ENSMUSP00000062741.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8BGE9.
PhosphoSitePlusiQ8BGE9.

Proteomic databases

PaxDbiQ8BGE9.
PRIDEiQ8BGE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058007; ENSMUSP00000062741; ENSMUSG00000060735.
GeneIDi239336.
KEGGimmu:239336.
UCSCiuc007vgy.1. mouse.

Organism-specific databases

CTDi51289.
MGIiMGI:2441827. Rxfp3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ8BGE9.
KOiK08397.
OMAiWVVCALG.
OrthoDBiEOG091G0BQS.
PhylomeDBiQ8BGE9.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Miscellaneous databases

PROiQ8BGE9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060735.
CleanExiMM_RXFP3.
ExpressionAtlasiQ8BGE9. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL3R1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.