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Protein

Tripartite motif-containing protein 6

Gene

Trim6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • protein binding, bridging Source: MGI
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase binding Source: MGI
  • transcription factor binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 6 (EC:6.3.2.-1 Publication)
Gene namesi
Name:Trim6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2137352. Trim6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Tripartite motif-containing protein 6PRO_0000056203Add
BLAST

Proteomic databases

PaxDbiQ8BGE7.
PRIDEiQ8BGE7.

PTM databases

iPTMnetiQ8BGE7.
PhosphoSiteiQ8BGE7.

Expressioni

Gene expression databases

BgeeiQ8BGE7.
CleanExiMM_TRIM6.
ExpressionAtlasiQ8BGE7. baseline and differential.
GenevisibleiQ8BGE7. MM.

Interactioni

Subunit structurei

Homotrimer. Forms heteromultimers (via B30.2/SPRY domain) with TRIM5 (By similarity). Interacts with MYC (PubMed:22328504). Interacts (via SPRY domain) with IKBKE (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: MGI
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase binding Source: MGI
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095782.

Structurei

3D structure databases

ProteinModelPortaliQ8BGE7.
SMRiQ8BGE7. Positions 5-79, 93-131, 135-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 488207B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili132 – 22392Sequence analysisAdd
BLAST

Domaini

The B-box zinc finger and the linker region between the coiled coil and B30.2/SPRY domains contribute to higher order self-association.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13342B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG7. Eukaryota.
ENOG410XWDC. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ8BGE7.
KOiK11999.
OMAiLEVIFCA.
OrthoDBiEOG7RJPR6.
PhylomeDBiQ8BGE7.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTVLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQVCII GNSNNSVFGQ
60 70 80 90 100
GGRSSCPVCR TSYQPGNLRP NRHLAAIVKR LREVALCPGK QLEVIFCALH
110 120 130 140 150
GEKLQLFCKE DGKLICWLCE RSQEHRGHHT FLMEEVAQEY QDMFQESLKK
160 170 180 190 200
LRREQQEAEK LKALIQEKRE SWKSQVEPEK RRIQTEFKQL RSILDREEQR
210 220 230 240 250
ELKKLEVEER KGLSIIEKAE GDLIHQSQSL KDLISDLEHR CQGSTVELLQ
260 270 280 290 300
DVGDVTKRSE FWTLRKPQAL PTKLKSLFRA PDLRKMLKVF RELTDVQSYW
310 320 330 340 350
VDVTLNPQTA NLNLVLSKNR RQVRFVGAQL SEPSSLEEHY DCSVLGSQHF
360 370 380 390 400
SSGKYYWEVD VSKKTAWILG VCSTPVDPMF SFSQYSSKQG AYSRYQPQCG
410 420 430 440 450
YWVIGLQCKH EYRAYEDSSP SLLLSMTVPP RRIGIFLDCE AGTVSFYNVT
460 470 480
NHGLPIYTFS KYYFPSALCP YFNPCSCIVP MTLRRPTS
Length:488
Mass (Da):56,152
Last modified:March 1, 2003 - v1
Checksum:iA1FDC42D8DD4A531
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033396 mRNA. Translation: BAC28267.1.
AK049238 mRNA. Translation: BAC33629.1.
BC138965 mRNA. Translation: AAI38966.1.
AF220031 mRNA. Translation: AAG53485.1.
CCDSiCCDS40065.1.
RefSeqiNP_001013637.1. NM_001013616.2.
XP_006508427.1. XM_006508364.2.
XP_006508428.1. XM_006508365.2.
XP_006508429.1. XM_006508366.2.
UniGeneiMm.274843.

Genome annotation databases

EnsembliENSMUST00000098180; ENSMUSP00000095782; ENSMUSG00000072244.
GeneIDi94088.
KEGGimmu:94088.
UCSCiuc009ivq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033396 mRNA. Translation: BAC28267.1.
AK049238 mRNA. Translation: BAC33629.1.
BC138965 mRNA. Translation: AAI38966.1.
AF220031 mRNA. Translation: AAG53485.1.
CCDSiCCDS40065.1.
RefSeqiNP_001013637.1. NM_001013616.2.
XP_006508427.1. XM_006508364.2.
XP_006508428.1. XM_006508365.2.
XP_006508429.1. XM_006508366.2.
UniGeneiMm.274843.

3D structure databases

ProteinModelPortaliQ8BGE7.
SMRiQ8BGE7. Positions 5-79, 93-131, 135-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095782.

PTM databases

iPTMnetiQ8BGE7.
PhosphoSiteiQ8BGE7.

Proteomic databases

PaxDbiQ8BGE7.
PRIDEiQ8BGE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098180; ENSMUSP00000095782; ENSMUSG00000072244.
GeneIDi94088.
KEGGimmu:94088.
UCSCiuc009ivq.1. mouse.

Organism-specific databases

CTDi117854.
MGIiMGI:2137352. Trim6.

Phylogenomic databases

eggNOGiENOG410ITG7. Eukaryota.
ENOG410XWDC. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ8BGE7.
KOiK11999.
OMAiLEVIFCA.
OrthoDBiEOG7RJPR6.
PhylomeDBiQ8BGE7.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi352065.
PROiQ8BGE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGE7.
CleanExiMM_TRIM6.
ExpressionAtlasiQ8BGE7. baseline and differential.
GenevisibleiQ8BGE7. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-205.
  4. "TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells."
    Sato T., Okumura F., Ariga T., Hatakeyama S.
    J. Cell Sci. 125:1544-1555(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYC.
  5. "Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response."
    Rajsbaum R., Versteeg G.A., Schmid S., Maestre A.M., Belicha-Villanueva A., Martinez-Romero C., Patel J.R., Morrison J., Pisanelli G., Miorin L., Laurent-Rolle M., Moulton H.M., Stein D.A., Fernandez-Sesma A., tenOever B.R., Garcia-Sastre A.
    Immunity 40:880-895(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTRIM6_MOUSE
AccessioniPrimary (citable) accession number: Q8BGE7
Secondary accession number(s): B2RSQ8, Q99PQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.