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Protein

Sushi domain-containing protein 6

Gene

Susd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (By similarity). Plays a role in preventing tumor onset (PubMed:24652652).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 6By similarityImported
Alternative name(s):
Drago
Gene namesi
Name:Susd6By similarityImported
Synonyms:Kiaa0247Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2444661. Susd6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile and do not show any notable developmental defect or spontaneous tumor development within 2 years. SUSD6 and TP53 double knockout mice show an increase in tumor development and a decrease in lifespan compared to TP53 knockout mice carrying wild-type SUSD6 (PubMed:24652652).1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Chaini40 – 302263Sushi domain-containing protein 6Sequence analysisPRO_0000432223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 89PROSITE-ProRule annotation
Disulfide bondi74 ↔ 102PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8BGE4.
PaxDbiQ8BGE4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021133.
GenevisibleiQ8BGE4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064961.

Structurei

3D structure databases

ProteinModelPortaliQ8BGE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 10465SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYD. Eukaryota.
ENOG410YAB5. LUCA.
GeneTreeiENSGT00530000063768.
HOVERGENiHBG052175.
OMAiLCEAWGS.
OrthoDBiEOG091G0E24.
TreeFamiTF332459.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHGKIAPKS SSEFVVTSVG HGVFLQLVIL CALLGDGLAS VCPLPPEPEN
60 70 80 90 100
GGYICHPRPC KDPLTAGSVI EYLCAEGYML KGDYKYLTCK NGEWTPAMEV
110 120 130 140 150
SCHLIEDKET HALGVPALSI VASTASSVAL ILLLVVLFVL LQPKLKSFHH
160 170 180 190 200
SRREQGVSGD QVSIMVDGVQ VALPSYEEAV YGSSGHCMPP ADPRVQIVLS
210 220 230 240 250
EGSAPSGRNM PREQQLQGQE ACSSAGGEDE APGHSGLCEA WGSQGSETVM
260 270 280 290 300
VHQATTSSWV AGSGSSRPTH KDTADSENSD IQSLLSLTSE EYTDDIPLLK

EA
Length:302
Mass (Da):31,978
Last modified:March 1, 2003 - v1
Checksum:iA2360FDC71B69F23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054203 mRNA. Translation: BAC35691.1.
AK161132 mRNA. Translation: BAE36207.1.
AC127337 Genomic DNA. No translation available.
CH466590 Genomic DNA. Translation: EDL02681.1.
BC040401 mRNA. Translation: AAH40401.1.
CCDSiCCDS26016.1.
RefSeqiNP_001229348.1. NM_001242419.1.
NP_848797.1. NM_178682.4.
UniGeneiMm.341776.

Genome annotation databases

EnsembliENSMUST00000068519; ENSMUSP00000064961; ENSMUSG00000021133.
GeneIDi217684.
KEGGimmu:217684.
UCSCiuc007obi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054203 mRNA. Translation: BAC35691.1.
AK161132 mRNA. Translation: BAE36207.1.
AC127337 Genomic DNA. No translation available.
CH466590 Genomic DNA. Translation: EDL02681.1.
BC040401 mRNA. Translation: AAH40401.1.
CCDSiCCDS26016.1.
RefSeqiNP_001229348.1. NM_001242419.1.
NP_848797.1. NM_178682.4.
UniGeneiMm.341776.

3D structure databases

ProteinModelPortaliQ8BGE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064961.

Proteomic databases

MaxQBiQ8BGE4.
PaxDbiQ8BGE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068519; ENSMUSP00000064961; ENSMUSG00000021133.
GeneIDi217684.
KEGGimmu:217684.
UCSCiuc007obi.2. mouse.

Organism-specific databases

CTDi9766.
MGIiMGI:2444661. Susd6.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGYD. Eukaryota.
ENOG410YAB5. LUCA.
GeneTreeiENSGT00530000063768.
HOVERGENiHBG052175.
OMAiLCEAWGS.
OrthoDBiEOG091G0E24.
TreeFamiTF332459.

Miscellaneous databases

ChiTaRSi4933426M11Rik. mouse.
PROiQ8BGE4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021133.
GenevisibleiQ8BGE4. MM.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUSD6_MOUSE
AccessioniPrimary (citable) accession number: Q8BGE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.