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Protein

Carnitine O-palmitoyltransferase 1, brain isoform

Gene

Cpt1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in lipid metabolic process.By similarity

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei469Proton acceptorBy similarity1
Binding sitei585CarnitineBy similarity1
Binding sitei587CarnitineBy similarity1
Binding sitei598CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.21 3474
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 1, brain isoform (EC:2.3.1.21)
Short name:
CPT1-B
Alternative name(s):
CPT IC
Carnitine O-palmitoyltransferase I, brain isoform
Short name:
CPTI-B
Carnitine palmitoyltransferase 1C
Gene namesi
Name:Cpt1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2446526 Cpt1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 75HelicalSequence analysisAdd BLAST23
Topological domaini76 – 103Mitochondrial intermembraneSequence analysisAdd BLAST28
Transmembranei104 – 126HelicalSequence analysisAdd BLAST23
Topological domaini127 – 798CytoplasmicSequence analysisAdd BLAST672

Keywords - Cellular componenti

Cell junction, Cell projection, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101671 – 798Carnitine O-palmitoyltransferase 1, brain isoformAdd BLAST798

Proteomic databases

MaxQBiQ8BGD5
PaxDbiQ8BGD5
PeptideAtlasiQ8BGD5
PRIDEiQ8BGD5

PTM databases

iPTMnetiQ8BGD5
PhosphoSitePlusiQ8BGD5
SwissPalmiQ8BGD5

Expressioni

Tissue specificityi

Predominantly expressed in brain (at protein level) and testis. Expressed in motor neurons (PubMed:25751282). Expressed in the ventral horn from spinal cords (PubMed:25751282).3 Publications

Gene expression databases

BgeeiENSMUSG00000007783
CleanExiMM_CPT1C
ExpressionAtlasiQ8BGD5 baseline and differential
GenevisibleiQ8BGD5 MM

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with ATL1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069539

Structurei

3D structure databases

ProteinModelPortaliQ8BGD5
SMRiQ8BGD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni551 – 563Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3717 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00760000119220
HOGENOMiHOG000233542
HOVERGENiHBG003458
InParanoidiQ8BGD5
KOiK19524
OMAiGQFCLTY
OrthoDBiEOG091G026C
PhylomeDBiQ8BGD5
TreeFamiTF313836

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR032476 CPT_N
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PF16484 CPT_N, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAHQASSL LSSLSSDGAE VELSSPVWQE IYLCALRSWK RHLWRVWNDF
60 70 80 90 100
LAGVVPATPL SWLFLFSTIQ LACLLQLDPS LGLMEKIKEL LPDWGGQHHQ
110 120 130 140 150
LQGFLSAAVF ASCLWGALIF TLHVALRLLL SHHGWLLEPH GAMSSPTKTW
160 170 180 190 200
LALVRIFSGR HPRLFSFQRA LPRQPVPSAQ ETVRKYLESV RPVLGDDAFD
210 220 230 240 250
RATALANDFL RLHAPRLQLY LQLKSWCTSN YVSDWWEEFV YLRSRGSLIN
260 270 280 290 300
STYYMMDFLY VTPTPLQAAR AGNAVHTLLL YRHLLNRQEI SPTLLMGMRP
310 320 330 340 350
LCSAQYERMF NTTRIPGVEK DHLRHLQDSR HVAVFHRGRF FRVGTHSPNG
360 370 380 390 400
LLSPRALEQQ FQDILDDPSP ACPLEEHLAA LTAAPRSMWA QVRESVKTHA
410 420 430 440 450
ATALEAVEGA AFFVSLDSEP AGLTREDPAA SLDAYAHALL AGRGHDRWFD
460 470 480 490 500
KSFTLIVFSN GKLGLSVEHS WADCPVSGHL WEFTLATECF QLGYATDGHC
510 520 530 540 550
KGHPDPTLPQ PQRLQWDLPE QIQPSISLAL RGAKTLSGNI DCHVFPFSHF
560 570 580 590 600
GKSFIKCCHV SSDSFIQLVL QLAHFRDRGQ FCLTYESAMT RLFLEGRTET
610 620 630 640 650
VRSCTREACQ FVRAMDNKET DQHCLALFRV AVDKHQALLK AAMSGQGIDR
660 670 680 690 700
HLFALYIMSR LLHMQSPFLT QVQSQQWLLS TSQVPVQQTH LIDVHNYPDY
710 720 730 740 750
VSSGGGFGPA HDHGYGISYI FMGENAITFH ISSKKSSTET DSHRLGQHIE
760 770 780 790
NALLDVASLF RVGQHFKRQF RGENSDYRYN FLSCKTVDPN TPTSSTNL
Length:798
Mass (Da):90,030
Last modified:March 1, 2003 - v1
Checksum:iA4886121168E8046
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104F → L in AAH66155 (PubMed:15489334).Curated1
Sequence conflicti195G → R in AAH66155 (PubMed:15489334).Curated1
Sequence conflicti324R → C in AAH66155 (PubMed:15489334).Curated1
Sequence conflicti559H → Q in AAH66155 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320000 mRNA Translation: AAN39013.1
AK032101 mRNA Translation: BAC27700.1
AK035790 mRNA Translation: BAC29187.1
BC066155 mRNA Translation: AAH66155.1
CCDSiCCDS21221.1
RefSeqiNP_001239399.1, NM_001252470.1
NP_710146.1, NM_153679.2
UniGeneiMm.231465

Genome annotation databases

EnsembliENSMUST00000063761; ENSMUSP00000069539; ENSMUSG00000007783
ENSMUST00000212836; ENSMUSP00000148815; ENSMUSG00000007783
GeneIDi78070
KEGGimmu:78070
UCSCiuc009gsb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCPT1C_MOUSE
AccessioniPrimary (citable) accession number: Q8BGD5
Secondary accession number(s): Q6NZF8, Q8C071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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